FI854536L - Foerfarande foer framstaellning av isosilybinfri silibin och silibin innehaollande laekemedel. - Google Patents

Foerfarande foer framstaellning av isosilybinfri silibin och silibin innehaollande laekemedel. Download PDF

Info

Publication number: FI854536L
Authority: FI; Finland
Prior art keywords: silibin; isosilibinfri; och; foerfarande foer; foer framstaellning
Prior art date: 1984-11-22

Application number

FI854536A

Other languages

English (en)

Other versions

FI84065C (fi

FI854536A0 (fi

FI84065B (fi

Inventor

Rolf Madaus

Klaus Goerler

Hartwig Soicke

Original Assignee

Madaus & Co Dr

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-11-22

Filing date

1985-11-18

Publication date

1986-05-23

1985-11-18 Application filed by Madaus & Co Dr filed Critical Madaus & Co Dr

1985-11-18 Publication of FI854536A0 publication Critical patent/FI854536A0/fi

1986-05-23 Publication of FI854536L publication Critical patent/FI854536L/fi

1990-07-31 Priority to FI903812A priority Critical patent/FI85855C/fi

1991-06-28 Application granted granted Critical

1991-06-28 Publication of FI84065B publication Critical patent/FI84065B/fi

1991-10-10 Publication of FI84065C publication Critical patent/FI84065C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L59/00—Thermal insulation in general
- F16L59/04—Arrangements using dry fillers, e.g. using slag wool

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Mechanical Engineering (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Plural Heterocyclic Compounds (AREA)
Cephalosporin Compounds (AREA)

FI854536A 1984-11-22 1985-11-18 Foerfarande foer framstaellning av isosilybinfri silibinin. FI84065C (fi)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
FI903812A FI85855C (fi)	1984-11-22	1990-07-31	Foerfarande foer framstaellning av isosilybinfri silibin och silibin innehaollande laekemedel.

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DE3442641		1984-11-22
DE3442641		1984-11-22
DE3537656		1985-10-23
DE19853537656 DE3537656A1 (de)	1984-11-22	1985-10-23	Verfahren zur herstellung von isosilybinfreiem silibinin und arzneimittel, enthaltend silibinin

Publications (4)

Publication Number	Publication Date
FI854536A0 FI854536A0 (fi)	1985-11-18
FI854536L true FI854536L (fi)	1986-05-23
FI84065B FI84065B (fi)	1991-06-28
FI84065C FI84065C (fi)	1991-10-10

Family

ID=25826741

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI854536A FI84065C (fi)	1984-11-22	1985-11-18	Foerfarande foer framstaellning av isosilybinfri silibinin.

Country Status (26)

Country	Link
US (1)	US4871763A (fi)
JP (1)	JPH0678228B2 (fi)
AR (1)	AR241268A1 (fi)
AT (1)	AT391315B (fi)
BE (1)	BE903694A (fi)
CA (1)	CA1337125C (fi)
CH (1)	CH660008A5 (fi)
CS (1)	CS271321B2 (fi)
DE (1)	DE3537656A1 (fi)
DK (3)	DK166541B1 (fi)
EG (1)	EG17710A (fi)
ES (2)	ES8609312A1 (fi)
FI (1)	FI84065C (fi)
FR (1)	FR2573426B1 (fi)
GB (1)	GB2167746B (fi)
HU (1)	HU195504B (fi)
IE (1)	IE59209B1 (fi)
IT (1)	IT1207508B (fi)
LU (1)	LU86164A1 (fi)
MX (1)	MX172175B (fi)
NL (1)	NL192204C (fi)
NO (1)	NO160206C (fi)
PL (1)	PL146889B1 (fi)
PT (1)	PT81531B (fi)
SE (1)	SE457957B (fi)
YU (1)	YU43690B (fi)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3357383B2 (ja) *	1991-08-14	2002-12-16	昌宏黒田	低分子化植物性組成物
DE4401902C2 (de) *	1994-01-24	2000-02-03	Madaus Ag	Verwendung von Flavolignanen als Adjuvans in der Tumortherapie
FR2719451B1 (fr) *	1994-05-04	1996-07-26	Apcis Sa	Utilisation de la silybinine dans le gavage des palmipèdes, en vue de l'obtention d'un foie gras de meilleure qualité.
DE19501266A1 (de) *	1995-01-18	1996-07-25	Madaus Ag	Verfahren zur Herstellung von Flavano-Lignan-Zubereitungen mit verbesserter Freisetzung und Resorbierbarkeit danach erhältliche Zubereitungen und deren Verwendung zur Herstellung von Arzneimitteln
US6379714B1 (en)	1995-04-14	2002-04-30	Pharmaprint, Inc.	Pharmaceutical grade botanical drugs
DE69824223T2 (de)	1997-03-19	2004-09-30	Unilever N.V.	Vorrichtung zum Handhaben von Gegenständen
GB2327607B8 (en) *	1997-07-31	2005-03-30	Litton Internat Company Ltd	A process for producing a herbal extract composition
DE10053384A1 (de) *	2000-10-27	2002-05-08	Bionorica Arzneimittel Gmbh	Pharmazeutische Zubereitung aus Mariendistel und Terpenen
US6699900B2 (en) *	2001-04-07	2004-03-02	Jan E. Zielinski	Hydrophilic and lipophilic silibinin pro-forms
DE10360954B3 (de) *	2003-12-23	2005-08-18	Esparma Gmbh	Verwendung von Silibinin, dessen Salzen und/oder dessen Prodrugs zusammen mit α-Liponsäure zur Behandlung chronisch obstruktiver Lungenerkrankungen
BG65997B1 (bg) *	2005-03-29	2010-09-30	"Софарма" Ад	Метод за получаване на силибинин
CN102300570B (zh) *	2007-11-15	2015-01-14	马道斯有限责任公司	用于治疗肝炎的水飞蓟宾组分
PT2430017T (pt)	2009-05-14	2016-10-12	Madaus Gmbh	Método para a preparação de silibinina amorfa
WO2011051742A1 (en) *	2009-10-28	2011-05-05	Modutech S.A.	Preparation comprising amino acids and plants and its activity in the alcohol detoxification
CN103408539B (zh) *	2013-08-28	2016-04-06	天津泰阳制药有限公司	高纯度水飞蓟宾的生产方法
KR20190031425A (ko) *	2016-01-15	2019-03-26	함부르크대학교	O-람노실 잔기를 보유하는 플라보노이드-유형 화합물
US20240024399A1 (en)	2020-09-29	2024-01-25	Munisekhar Medasani	Bioactive compounds extraction from plant matters of silybum marianum and usage

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3773932A (en) *	1968-06-01	1973-11-20	Madaus & Co Dr	Method for recovering silymarin comprising polyhydroxyphenyl chromanones
DE1767666C3 (de) *	1968-06-01	1986-07-31	Dr. Madaus & Co, 5000 Koeln	Pharmazeutische Zubereitung gegen Lebererkrankungen
DE1923082C3 (de) *	1969-05-06	1985-08-22	Dr. Madaus & Co, 5000 Koeln	Verfahren zur Gewinnung von Polyhydroxyphenylchromanonen (Silymarin I-IV) und Arzneimittel enthaltend das Polyhydroxyphenylchromanon (Silymarin I-IV = Silymarin I-IV-Gruppe)Gemisch
DE2416302B2 (de) *	1974-04-04	1978-02-02	Dr. Madaus & Co, 5000 Köln	Dimeres sowie trimeres silybin und deren n-methylglucaminsalz und verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
BE885558A (fr) *	1980-10-07	1981-04-07	Madaus & Co Dr	Procede pour l'extraction de silymarine a partir des plantes silymarine ainsi obtenue et son utilisation en therapeutique
DE3225688A1 (de) *	1982-07-09	1984-01-12	Suschnik Matthias Dr	Verfahren zur gewinnung von silymarin aus silybum marianum

1985
- 1985-10-23 DE DE19853537656 patent/DE3537656A1/de active Granted
- 1985-11-11 GB GB08527809A patent/GB2167746B/en not_active Expired
- 1985-11-12 CH CH4854/85A patent/CH660008A5/de not_active IP Right Cessation
- 1985-11-13 LU LU86164A patent/LU86164A1/de unknown
- 1985-11-14 NL NL8503136A patent/NL192204C/nl not_active IP Right Cessation
- 1985-11-18 FI FI854536A patent/FI84065C/fi not_active IP Right Cessation
- 1985-11-19 AT AT0337285A patent/AT391315B/de not_active IP Right Cessation
- 1985-11-20 SE SE8505488A patent/SE457957B/sv not_active IP Right Cessation
- 1985-11-20 CS CS858379A patent/CS271321B2/cs unknown
- 1985-11-20 CA CA000495805A patent/CA1337125C/en not_active Expired - Fee Related
- 1985-11-20 YU YU1812/85A patent/YU43690B/xx unknown
- 1985-11-21 PL PL1985256373A patent/PL146889B1/pl unknown
- 1985-11-21 IT IT8522933A patent/IT1207508B/it active
- 1985-11-21 NO NO854657A patent/NO160206C/no unknown
- 1985-11-21 ES ES549119A patent/ES8609312A1/es not_active Expired
- 1985-11-21 DK DK537685A patent/DK166541B1/da not_active IP Right Cessation
- 1985-11-21 EG EG741/85A patent/EG17710A/xx active
- 1985-11-21 HU HU854449A patent/HU195504B/hu not_active IP Right Cessation
- 1985-11-21 PT PT81531A patent/PT81531B/pt not_active IP Right Cessation
- 1985-11-21 IE IE292785A patent/IE59209B1/en not_active IP Right Cessation
- 1985-11-22 FR FR8517320A patent/FR2573426B1/fr not_active Expired
- 1985-11-22 AR AR85302358A patent/AR241268A1/es active
- 1985-11-22 MX MX009231A patent/MX172175B/es unknown
- 1985-11-22 BE BE2/60851A patent/BE903694A/fr not_active IP Right Cessation
1986
- 1986-04-16 ES ES554022A patent/ES8704482A1/es not_active Expired
1988
- 1988-03-18 US US07/171,176 patent/US4871763A/en not_active Expired - Fee Related
1991
- 1991-01-29 JP JP3009169A patent/JPH0678228B2/ja not_active Expired - Lifetime
- 1991-11-20 DK DK189491A patent/DK164866C/da not_active IP Right Cessation
1992
- 1992-09-17 DK DK199201145A patent/DK172879B1/da active

Also Published As

Publication number	Publication date
FI84065C (fi)	1991-10-10
DE3537656A1 (de)	1986-05-22
ES8609312A1 (es)	1986-09-01
DE3537656C2 (fi)	1989-03-16
IT1207508B (it)	1989-05-25
FR2573426B1 (fr)	1988-06-10
BE903694A (fr)	1986-05-22
DK164866C (da)	1993-01-18
ATA337285A (de)	1990-03-15
US4871763A (en)	1989-10-03
FI854536A0 (fi)	1985-11-18
PL256373A1 (en)	1986-12-02
NO160206B (no)	1988-12-12
MX172175B (es)	1993-12-07
CH660008A5 (de)	1987-03-13
DK537685D0 (da)	1985-11-21
CS837985A2 (en)	1990-02-12
IE852927L (en)	1986-05-22
IE59209B1 (en)	1994-01-26
PT81531B (pt)	1987-11-11
YU181285A (en)	1987-12-31
NO160206C (no)	1989-03-22
NL192204C (nl)	1997-03-04
CA1337125C (en)	1995-09-26
DK164866B (da)	1992-08-31
LU86164A1 (de)	1986-03-24
AR241268A1 (es)	1992-04-30
PL146889B1 (en)	1989-03-31
GB2167746A (en)	1986-06-04
YU43690B (en)	1989-10-31
DK114592A (da)	1992-09-17
JPH0678228B2 (ja)	1994-10-05
DK537685A (da)	1986-05-23
HUT40115A (en)	1986-11-28
DK172879B1 (da)	1999-09-06
GB8527809D0 (en)	1985-12-18
PT81531A (de)	1985-12-01
ES8704482A1 (es)	1987-04-01
ES549119A0 (es)	1986-09-01
DK189491A (da)	1991-11-20
SE457957B (sv)	1989-02-13
NL192204B (nl)	1996-11-01
NO854657L (no)	1986-05-23
DK114592D0 (da)	1992-09-17
FR2573426A1 (fr)	1986-05-23
GB2167746B (en)	1989-01-11
HU195504B (en)	1988-05-30
DK189491D0 (da)	1991-11-20
ES554022A0 (es)	1987-04-01
AT391315B (de)	1990-09-25
SE8505488D0 (sv)	1985-11-20
FI84065B (fi)	1991-06-28
EG17710A (en)	1990-10-30
SE8505488L (sv)	1986-05-23
CS271321B2 (en)	1990-09-12
NL8503136A (nl)	1986-06-16
DK166541B1 (da)	1993-06-07
JPH05271071A (ja)	1993-10-19
IT8522933A0 (it)	1985-11-21

Publication	Publication Date	Title
FI843880A7 (fi)	1986-04-04	Foerfarande foer drivning av en glashaerdningsanlaeggning och glashaerdningsanlaeggning foer utfoerande av foerfarandet.
FI854536L (fi)	1986-05-23	Foerfarande foer framstaellning av isosilybinfri silibin och silibin innehaollande laekemedel.
FI840217A7 (fi)	1985-07-20	Foerfarande och glidgjutningsmaskin foer gjutning av haolelement av betong.
FI851584L (fi)	1985-10-27	Foerenade skumplastfoeremaol och foerfarande foer framstaellning av dessa foeremaol.
FI841440A0 (fi)	1984-04-11	Foerfarande foer sortering och stroelaeggning av saogat virke.
FI840481L (fi)	1985-08-07	Foerfarande och anordning foer tagande av producentvist mjoelkprov.
FI842579A0 (fi)	1984-06-27	Foerfarande och anordning foer framstaellning av metallroer bestaoende kokiller foer straenggjutningsmaskiner.
FI841100A0 (fi)	1984-03-19	Foerfarande och anordning foer inbromsning av rulltrappor.
FI841310A0 (fi)	1984-04-02	Foerfarande och anlaeggning foer tillverkning av en foerspaend betongprodukt.
FI841798L (fi)	1985-11-05	Foerfarande och lastningsanordning foer behandling av cylindriska foeremaol saosom pappersrullar.
FI843577A0 (fi)	1984-09-12	Koppling foer skyddning av mekanism och reglering av drivmaskinens effekt.
FI852431A0 (fi)	1985-06-19	Nytt stabilt procaterolderivat och foerfarande foer framstaellning av detsamma.
FI843520L (fi)	1986-03-08	Foerfarande och anordning foer framstaellning av traematerialskiva.
FI841413L (fi)	1985-10-11	Foerfarande och anordning foer maetning av fiberkoncentration.
FI843604A0 (fi)	1984-09-14	Foerfarande och anordning foer framstaellning av rundstockar.
FI844045A0 (fi)	1984-10-15	Elektrod foer elektrolys av loesningar av elektrolyter och foerfarande foer framstaellning av elektroden.
FI844077A0 (fi)	1984-10-17	Foerfarande och anordning foer behandling av tjaerhaltiga gaser.
FI842580A0 (fi)	1984-06-27	Foerfarande och anordning foer reparering av kroekta straenggjutningskokiller.
FI843458A7 (fi)	1986-03-05	Foerfarande och anordning foer braenning av avfallsvattenslam.
FI843250A7 (fi)	1986-02-17	Foerfarande foer uppbyggning av jord foer odling och en enligt foerfarandet uppbyggd odlingsjord.
FI842991A0 (fi)	1984-07-26	Foerfarande och barkpress foer torking av traedbark.
FI842864A0 (fi)	1984-07-17	Foerfarande och anordning foer maetning av en kopplings slitage.
FI842657A0 (fi)	1984-07-02	Foerfarande och regleringskrets foer reglering av foerstaerkning.
FI841309A0 (fi)	1984-04-02	Foerfarande och gjutunderlag foer kontinuerlig gjutning av betong.
FI840809L (fi)	1985-08-30	Foerfarande foer framstaellning av en ligninaddukt och anvaendning daerav faergaemneskompositioner.

Legal Events

Date	Code	Title	Description
1997-06-16	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: MADAUS AKTIENGESELLSCHAFT