[go: up one dir, main page]

FI4051688T3 - Cd73:n estäjiä - Google Patents

Cd73:n estäjiä Download PDF

Info

Publication number
FI4051688T3
FI4051688T3 FIEP20883288.1T FI20883288T FI4051688T3 FI 4051688 T3 FI4051688 T3 FI 4051688T3 FI 20883288 T FI20883288 T FI 20883288T FI 4051688 T3 FI4051688 T3 FI 4051688T3
Authority
FI
Finland
Prior art keywords
compound
pharmaceutically acceptable
cancer
acceptable salt
salt
Prior art date
Application number
FIEP20883288.1T
Other languages
English (en)
Inventor
Xiaohui Du
John Eksterowicz
Valeria R Fantin
Daqing Sun
Qiuping Ye
Jared Moore
Tatiana Zavorotinskaya
Brian R Blank
Yosup Rew
Kejia Wu
Liusheng Zhu
Johnny Pham
Hiroyuki Kawai
Chien-Hung Yeh
Original Assignee
Oric Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oric Pharmaceuticals Inc filed Critical Oric Pharmaceuticals Inc
Application granted granted Critical
Publication of FI4051688T3 publication Critical patent/FI4051688T3/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Psychology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Claims (20)

EP4051688 1 Patenttivaatimukset
1. Yhdiste, joka valitaan seuraavista: NNH Å No - N J 4 ON ¢ = A 2 N NN JO e MÄ A 6 PUN vo HÖ ÖH , O HEN "O Na | i Yeo VTX O A G N i . Ho NT N OS HO OH . HN-N HN NA ot AA 0 Lin 0 J 2 5 o eli HO ST HO OH , Sap N p” i HN 35° m O NEN Ou KR Oil A woh ONT N a OH = HÖ OH NN HN, J D NN HN oJ" MYÖ 4 Z O. Ni A -P 0 N Te ma TNT KÖ OM , NN KN MN <A > NÖN År ÖL OH A o NT A n A O pun Ho-P NJ Ne HO HÖ ÖH ,
EP4051688 2 2 D s JN mn a X YTY VT OH f p < OVAN | Aa HOI Vi OH Ft HG OH . OH HN 8 OT NOY Öö O ST HG OH on 0 Oa NH NES N Ho PH OL A PRO Y No O W — | HÖ OH Neg HN A A D NI NON Q O N i A Ho-P Nr Ne HO - - HÖ OH , NaN A N r HM, <. AN NÄS o_o n A = NT N Oz n O JNA oe HO < i HÖ OK , ja n EN SN ne N ~/ n LA Rt of yt Na HO OH € HO OH : tai sen farmaseuttisesti hyväksyttävä suola.
2. Patenttivaatimuksen 1 mukainen yhdiste, jolloin kyseinen yhdiste on
EP4051688 3 Non 3 JA QO op D ON FT 7 N OX O YI Pp G e: 3 OT N a HÖ OH : tai sen farmaseuttisesti hyväksyttävä suola.
3. Patenttivaatimuksen 1 mukainen yhdiste, jolloin kyseinen yhdiste on OI NI "O HO oN yi wa HÖ OH ; tai sen farmaseuttisesti hyväksyttävä suola.
4. Patenttivaatimuksen 1 mukainen yhdiste, jolloin kyseinen yhdiste on HN-N HN 195 KÄY as Ko”? ON OSAN a HÖ ON : tai sen farmaseuttisesti hyväksyttävä suola.
5. Patenttivaatimuksen 1 mukainen yhdiste, jolloin kyseinen yhdiste on Sn Å ~ LN Ww a K WC N M O i G of, © NY Va HO OH : tai sen farmaseuttisesti hyväksyttävä suola.
6. Patenttivaatimuksen 1 mukainen yhdiste, jolloin kyseinen yhdiste on Ne ! MA JO OL OH NA N NYA Ho HÖ OH : tai sen farmaseuttisesti hyväksyttävä suola.
EP4051688
4
7. Patenttivaatimuksen 1 mukainen yhdiste, jolloin kyseinen yhdiste on NN CA \ A uy S ÖL OH ” A N a NZ | TN i N A 2 0 N Ci "hd OT HÖ ÖH ; tai sen farmaseuttisesti hyväksyttävä suola.
8. Patenttivaatimuksen 1 mukainen yhdiste, jolloin kyseinen yhdiste on o n JM uy S Hori, Nr Noi HO OH ; tai sen farmaseuttisesti hyväksyttävä suola.
9. Patenttivaatimuksen 1 mukainen yhdiste, jolloin kyseinen yhdiste on on A Jy NN NEN SON? NR | HÖ ÖH ; tai sen farmaseuttisesti hyväksyttävä suola.
10. Patenttivaatimuksen 1 mukainen yhdiste, jolloin kyseinen yhdiste on A OH HNT OY OM NH NEN OH od ofl ITÄ, Q a - HS OH tai sen farmaseuttisesti hyväksyttävä suola.
11. Patenttivaatimuksen 1 mukainen yhdiste, jolloin kyseinen yhdiste on
EP4051688 Nan NA m S MYY JA OLA Ho i n. Noi HÖ OR ; tai sen farmaseuttisesti hyväksyttävä suola.
12. Patenttivaatimuksen 1 mukainen yhdiste, jolloin kyseinen yhdiste on SN HN, | > NN m < oo” N AA SK UPN "he CT 5 HO OH : tai sen farmaseuttisesti hyväksyttävä suola.
13. Patenttivaatimuksen 1 mukainen yhdiste, jolloin kyseinen yhdiste on i HN=N vB KA > v0 0, KA O II A no NY NG HÖ OH i tai sen farmaseuttisesti hyväksyttävä suola.
14. Lääkekoostumus, joka käsittää jonkin patenttivaatimuksen 1-13 mukaista yhdistettä tai sen farmaseuttisesti hyväksyttävää suolaa ja farmaseuttisesti hyväksyttävää apuainetta.
15. Jonkin patenttivaatimuksen 1-13 mukainen yhdiste tai suola tai patenttivaatimuksen 14 mukainen lääkekoostumus käytettäväksi menetelmässä hoidettavan syövän hoitamiseksi, jolloin menetelmä käsittää kyseisen yhdisteen, suolan tai koostumuksen antamisen hoidettavalle.
16. Patenttivaatimuksen 15 mukaisesti käytettävä yhdiste, suola tai koostumus, jolloin
EP4051688 6 syöpä on keuhkosyöpä, melanooma, rintasyöpä, munasarjasyöpä, kolorektaalinen syöpä, mahasyöpä, sappirakon syöpä, eturauhassyöpä, munuaissyöpä tai lymfooma ja/tai jolloin syöpä ilmentää CD73:a tai CD73:n ilmentyminen lisääntyy syövässä.
17. Patenttivaatimuksen 15 mukaisesti käytettävä yhdiste, suola tai koostumus, jolloin syöpä on leukemia tai multippeli myelooma.
18. Patenttivaatimuksen 15 mukaisesti käytettävä yhdiste, suola tai koostumus, jolloin syöpä on multippeli myelooma.
19. Patenttivaatimuksen 15 mukaisesti käytettävä yhdiste, suola tai koostumus, jolloin syöpä on ainoastaan seurantaa vaativa multippeli myelooma, ei-sekretorinen myelooma, osteoskleroottinen myelooma, plasmasoluleukemia, — yksittäinen plasmasytooma tai ekstramedullaarinen plasmasytooma.
20. Jonkin patenttivaatimuksen 15—19 mukaisesti käytettävä yhdiste, suola tai koostumus, jolloin menetelmä käsittää lisäksi toisen terapeuttisen aineen antamisen; jolloin valinnaisesti toinen terapeuttinen aine on kemoterapeuttinen aine tai immunoterapia-aine.
FIEP20883288.1T 2019-10-30 2020-10-29 Cd73:n estäjiä FI4051688T3 (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962928138P 2019-10-30 2019-10-30
US202062987806P 2020-03-10 2020-03-10
US202063088646P 2020-10-07 2020-10-07
PCT/US2020/057996 WO2021087136A1 (en) 2019-10-30 2020-10-29 Cd73 inhibitors

Publications (1)

Publication Number Publication Date
FI4051688T3 true FI4051688T3 (fi) 2025-06-27

Family

ID=75686256

Family Applications (1)

Application Number Title Priority Date Filing Date
FIEP20883288.1T FI4051688T3 (fi) 2019-10-30 2020-10-29 Cd73:n estäjiä

Country Status (18)

Country Link
US (6) US11530236B2 (fi)
EP (2) EP4596048A3 (fi)
JP (2) JP7544815B2 (fi)
KR (2) KR102653726B1 (fi)
CN (2) CN116854758A (fi)
AU (1) AU2020375914B2 (fi)
CA (1) CA3159248C (fi)
DK (1) DK4051688T3 (fi)
ES (1) ES3034168T3 (fi)
FI (1) FI4051688T3 (fi)
IL (2) IL308293B1 (fi)
MX (1) MX2022005256A (fi)
PL (1) PL4051688T3 (fi)
PT (1) PT4051688T (fi)
SI (1) SI4051688T1 (fi)
TW (1) TWI830962B (fi)
WO (1) WO2021087136A1 (fi)
ZA (1) ZA202204941B (fi)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018208980A1 (en) 2017-05-10 2018-11-15 Oric Pharmaceuticals, Inc. Cd73 inhibitors
US11377469B2 (en) 2017-11-03 2022-07-05 Oric Pharmaceuticals, Inc. CD73 inhibitors
SG11202010790XA (en) 2018-04-30 2020-11-27 Oric Pharmaceuticals Inc Cd73 inhibitors
EP4596048A3 (en) * 2019-10-30 2025-11-19 Oric Pharmaceuticals, Inc. Cd73 inhibitors
CN119173276A (zh) 2022-04-13 2024-12-20 吉利德科学公司 用于治疗表达Trop-2的癌症的组合疗法
WO2024059609A1 (en) * 2022-09-14 2024-03-21 Oric Pharmaceuticals, Inc. Pharmaceutical forms of a cd73 inhibitor
WO2025111247A1 (en) * 2023-11-20 2025-05-30 Oric Pharmaceuticals, Inc. Treatment of refractory multiple myeloma
WO2025137640A1 (en) 2023-12-22 2025-06-26 Gilead Sciences, Inc. Azaspiro wrn inhibitors
WO2025233264A1 (en) 2024-05-07 2025-11-13 Innate Pharma Use of cd73 blocking agents in combination with anti-cd20 x cd3 t cell engagers

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1023991A (en) 1911-07-29 1912-04-23 Firm B Byers Anti-rail-creeper and splice-bar.
EP0477454A1 (en) 1990-09-28 1992-04-01 Merrell Dow Pharmaceuticals Inc. Novel phosphonate derivatives of certain nucleosides
AU2002232660A1 (en) 2000-12-15 2002-06-24 Pharmasset Ltd. Antiviral agents for treatment of flaviviridae infections
US20040229839A1 (en) 2003-05-14 2004-11-18 Biocryst Pharmaceuticals, Inc. Substituted nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
WO2005020885A2 (en) 2003-05-21 2005-03-10 Isis Pharmaceuticals, Inc. Compositions and methods for the treatment of severe acute respiratory syndrome (sars)
US20090029949A1 (en) 2006-05-25 2009-01-29 Parrill-Baker Abby L GPCR Ligands Identified by Computational Modeling
DE102007001370A1 (de) 2007-01-09 2008-07-10 Curevac Gmbh RNA-kodierte Antikörper
WO2009127230A1 (en) 2008-04-16 2009-10-22 Curevac Gmbh MODIFIED (m)RNA FOR SUPPRESSING OR AVOIDING AN IMMUNOSTIMULATORY RESPONSE AND IMMUNOSUPPRESSIVE COMPOSITION
US20090274686A1 (en) 2008-05-02 2009-11-05 Yat Sun Or Nucleoside phosphonate derivatives
MA39986A (fr) 2014-04-25 2017-03-01 Vitae Pharmaceuticals Inc Dérivés de purine en tant qu'inhibiteurs de cd73 pour le traitement du cancer
CN104530166B (zh) 2014-12-04 2016-08-24 陕西汉江药业集团股份有限公司 选择性还原4,6-共轭双烯-3-酮甾体化合物的方法
CN112358551B (zh) * 2014-12-12 2024-02-02 2赛文缇生物公司 Bcma嵌合抗原受体
WO2017098421A1 (en) 2015-12-08 2017-06-15 Glaxosmithkline Intellectual Property Development Limited Benzothiadiazine compounds
LT3399984T (lt) 2016-01-08 2023-11-10 Arcus Biosciences, Inc. 5'-nukleotidazės, ekto moduliatoriai ir jų panaudojimas
TWI767937B (zh) 2016-09-09 2022-06-21 美商卡利泰拉生物科技公司 外核苷酸酶抑制劑及其使用方法
WO2018067424A1 (en) * 2016-10-03 2018-04-12 Arcus Biosciences, Inc. Inhibitors of adenosine 5'-nucleotidase
EP3541396A4 (en) * 2016-11-18 2020-07-22 Arcus Biosciences, Inc. CD73-MEDIATED IMMUNOSUPPRESSION INHIBITORS
WO2018119284A1 (en) 2016-12-22 2018-06-28 Calithera Biosciences, Inc. Ectonucleotidase inhibitors and methods of use thereof
EP3600273A4 (en) * 2017-03-31 2021-01-20 Peloton Therapeutics, Inc. CD73 INHIBITORS AND USES THEREOF
WO2018208727A1 (en) 2017-05-08 2018-11-15 Eternity Bioscience Inc. Nucleoside and nucleotide analogues as cd73 inhibitors and therapeutic uses thereof
WO2018208980A1 (en) * 2017-05-10 2018-11-15 Oric Pharmaceuticals, Inc. Cd73 inhibitors
US11377469B2 (en) 2017-11-03 2022-07-05 Oric Pharmaceuticals, Inc. CD73 inhibitors
CN111094317B (zh) 2017-12-29 2023-03-31 上海和誉生物医药科技有限公司 一种具有cd73抑制活性的膦酸衍生物、其制备方法和应用
SG11202010790XA (en) 2018-04-30 2020-11-27 Oric Pharmaceuticals Inc Cd73 inhibitors
TW202017569A (zh) 2018-05-31 2020-05-16 美商佩樂敦治療公司 用於抑制cd73之組合物及方法
EP3810617A4 (en) 2018-06-21 2022-06-29 Calithera Biosciences, Inc. Ectonucleotidase inhibitors and methods of use thereof
EP3843714B1 (en) 2018-08-27 2025-11-12 Arcus Biosciences, Inc. Cd73 inhibitors
KR20220024629A (ko) 2019-06-20 2022-03-03 칼리테라 바이오사이언시즈, 인코포레이티드 엑토뉴클레오티다제 억제제 및 이의 사용 방법
EP3999517A4 (en) 2019-07-16 2023-07-12 Oric Pharmaceuticals, Inc. CD73 INHIBITORS
EP4596048A3 (en) * 2019-10-30 2025-11-19 Oric Pharmaceuticals, Inc. Cd73 inhibitors

Also Published As

Publication number Publication date
CA3159248A1 (en) 2021-05-06
DK4051688T3 (da) 2025-06-30
US20210130389A1 (en) 2021-05-06
ZA202204941B (en) 2024-10-30
IL308293B1 (en) 2025-08-01
EP4051688A4 (en) 2024-03-06
US12454544B2 (en) 2025-10-28
KR20220088786A (ko) 2022-06-28
BR122023021184A2 (pt) 2024-02-27
AU2020375914B2 (en) 2024-05-23
EP4596048A2 (en) 2025-08-06
CA3159248C (en) 2024-05-28
IL292570A (en) 2022-06-01
IL292570B2 (en) 2024-04-01
US20210214387A1 (en) 2021-07-15
WO2021087136A1 (en) 2021-05-06
PL4051688T3 (pl) 2025-09-22
PT4051688T (pt) 2025-06-30
US11130778B2 (en) 2021-09-28
US12018043B2 (en) 2024-06-25
JP2024164093A (ja) 2024-11-26
CN116854758A (zh) 2023-10-10
JP2023500483A (ja) 2023-01-06
EP4051688B1 (en) 2025-04-23
AU2020375914A1 (en) 2022-06-02
ES3034168T3 (en) 2025-08-13
IL308293A (en) 2024-01-01
TW202130353A (zh) 2021-08-16
SI4051688T1 (sl) 2025-08-29
US20210130390A1 (en) 2021-05-06
EP4051688A1 (en) 2022-09-07
NZ788133A (en) 2024-03-22
CN114929721B (zh) 2023-07-18
US11530236B2 (en) 2022-12-20
IL292570B1 (en) 2023-12-01
TWI830962B (zh) 2024-02-01
KR20240042573A (ko) 2024-04-02
US20250034198A1 (en) 2025-01-30
US20230131747A1 (en) 2023-04-27
EP4596048A3 (en) 2025-11-19
JP7544815B2 (ja) 2024-09-03
KR102653726B1 (ko) 2024-04-01
KR102727229B1 (ko) 2024-11-06
US20220411459A1 (en) 2022-12-29
CN114929721A (zh) 2022-08-19
JP7688769B2 (ja) 2025-06-04
BR112022008365A2 (pt) 2023-03-28
US11028120B2 (en) 2021-06-08
MX2022005256A (es) 2022-08-25

Similar Documents

Publication Publication Date Title
FI4051688T3 (fi) Cd73:n estäjiä
MY199730A (en) Piperidine-substituted mnk inhibitors and methods related thereto
IL295569A (en) Tetralin and tetrahydroquinoline compounds as inhibitors of hif-2alpha
FI3727461T3 (fi) EPHA2:lle spesifisiä bisyklisiä peptidiligandeja
IL257219A (en) Prodrugs of glutamine analogs
JP2019535720A5 (fi)
CR20210083A (es) Compuestos de anillo fusionado
FI4249456T3 (fi) Psma:ta sitova kaksoismuotoinen radioaktiivinen merkkiaine ja terapeuttinen aine
AU2016256469A8 (en) Methods for treating cancer
UY38296A (es) Derivados de 3–(5–amino–1–oxoisoindolin–2–il)piperidin–2,6–diona y sus usos
JP2019529500A5 (fi)
GEP20247627B (en) Macrocyclic compounds as sting agonists and methods and uses thereof
MX2019006296A (es) Métodos de uso de compuestos de pirazol y pirazol sustituido y para el tratamiento de enfermedades hiperproliferativas.
MX2020007974A (es) Inhibidores de complejo represivo polycomb 2 (prc2).
WO2018044937A3 (en) Compositions and methods for treating a tumor suppressor deficient cancer
EP4446301A3 (en) Heterocyclic compounds for cancer imaging and treatment and methods for their use
AU2020234961C1 (en) Charged ion channel blockers and methods for use
AR108265A1 (es) Derivados de feniltriazol sustituidos con amida y usos de estos
RU2017138468A (ru) Антитела против человеческого her3, имеющие низкое содержание фукозы, и области их применения
FI3837256T3 (fi) Ureayhdisteitä ja koostumuksia smarca2/brm-atpaasiestäjinä
EA201891241A1 (ru) 1,3,4-тиадиазольные соединения и их применение в лечении рака
MX2016002795A (es) Compuestos de triazolona y usos de los mismos.
PH12020550984B1 (en) Metallic material surface treatment agent, metallic material having surface treatment coating, and manufacturing method therefor
MX2024001424A (es) Compuesto radiomarcado y uso del mismo.
JP2017530947A5 (fi)