FI102758B1 - Menetelmä puhtaan syklosporiinimuodon valmistamiseksi - Google Patents

Menetelmä puhtaan syklosporiinimuodon valmistamiseksi

Info

Publication number: FI102758B1
Authority: FI; Finland
Prior art keywords: pct; cyclosporin; sec; chromatography column; pure
Prior art date: 1995-03-03

Application number

FI950983A

Other languages

English (en)

Swedish (sv)

Other versions

FI950983L (fi

FI950983A0 (fi

FI102758B (fi

Inventor

Juhani Lundell

Jarkko Ruohonen

Olli Aaltonen

Martti Alkio

Anneli Hase

Tapani Suortti

Original Assignee

Santen Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-03

Filing date

1995-03-03

Publication date

1999-02-15

1995-03-03 Application filed by Santen Oy filed Critical Santen Oy

1995-03-03 Publication of FI950983A0 publication Critical patent/FI950983A0/fi

1995-03-03 Priority to FI950983A priority Critical patent/FI102758B/fi

1996-03-01 Priority to JP8526631A priority patent/JPH11501042A/ja

1996-03-01 Priority to PT96903038T priority patent/PT815122E/pt

1996-03-01 Priority to DK96903038T priority patent/DK0815122T3/da

1996-03-01 Priority to DE69618772T priority patent/DE69618772T2/de

1996-03-01 Priority to US08/894,957 priority patent/US5976381A/en

1996-03-01 Priority to PCT/FI1996/000120 priority patent/WO1996027607A1/en

1996-03-01 Priority to AT96903038T priority patent/ATE212353T1/de

1996-03-01 Priority to EP96903038A priority patent/EP0815122B1/en

1996-03-01 Priority to HK98108994.2A priority patent/HK1007882B/en

1996-03-01 Priority to ES96903038T priority patent/ES2171649T3/es

1996-09-04 Publication of FI950983L publication Critical patent/FI950983L/fi

1999-02-15 Application granted granted Critical

1999-02-15 Publication of FI102758B1 publication Critical patent/FI102758B1/fi

1999-02-15 Publication of FI102758B publication Critical patent/FI102758B/fi

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical group CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 5
238000000034 method Methods 0.000 title abstract 3
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 2
229930105110 Cyclosporin A Natural products 0.000 abstract 2
108010036949 Cyclosporine Proteins 0.000 abstract 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
238000004587 chromatography analysis Methods 0.000 abstract 2
229960001265 ciclosporin Drugs 0.000 abstract 2
229930182912 cyclosporin Natural products 0.000 abstract 2
239000003480 eluent Substances 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000002671 adjuvant Substances 0.000 abstract 1
229910002092 carbon dioxide Inorganic materials 0.000 abstract 1
239000001569 carbon dioxide Substances 0.000 abstract 1
238000000855 fermentation Methods 0.000 abstract 1
230000004151 fermentation Effects 0.000 abstract 1
239000002245 particle Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
239000000377 silicon dioxide Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)

FI950983A 1995-03-03 1995-03-03 Menetelmä puhtaan syklosporiinimuodon valmistamiseksi FI102758B (fi)

Priority Applications (11)

Application Number	Priority Date	Filing Date	Title
FI950983A FI102758B (fi)	1995-03-03	1995-03-03	Menetelmä puhtaan syklosporiinimuodon valmistamiseksi
PCT/FI1996/000120 WO1996027607A1 (en)	1995-03-03	1996-03-01	Process for preparation of pure cyclosporin chromatographically using an eluent consisting essentially of high pressure carbon dioxide
EP96903038A EP0815122B1 (en)	1995-03-03	1996-03-01	Process for preparation of pure cyclosporin chromatographically using an eluent consisting essentially of high pressure carbon dioxide
DK96903038T DK0815122T3 (da)	1995-03-03	1996-03-01	Fremgangsmåde til fremstilling af chromatografisk ren cyclosporin ved brug af en eluent, der i alt væsentligt er sammensat af carbondioxid under høj tryk
DE69618772T DE69618772T2 (de)	1995-03-03	1996-03-01	Verfahren zur aufarbeitung von chromatographisches reinem cyclosporin, durch gebrauch eines eluenten, der im wesentlichen zusammengesetzt ist aus carbondioxid unter hohem druck
US08/894,957 US5976381A (en)	1995-03-03	1996-03-01	Chromatographic purification of cyclosporing using a high pressure carbon dioxide eluent
JP8526631A JPH11501042A (ja)	1995-03-03	1996-03-01	高圧二酸化炭素を本質的に含む溶離剤を用いて純粋なサイクロスポリンをクロマトグラフィーによって製造する方法
AT96903038T ATE212353T1 (de)	1995-03-03	1996-03-01	Verfahren zur aufarbeitung von chromatographisches reinem cyclosporin, durch gebrauch eines eluenten, der im wesentlichen zusammengesetzt ist aus carbondioxid unter hohem druck
PT96903038T PT815122E (pt)	1995-03-03	1996-03-01	Processo para a preparacao de ciclosporina pura por cromatografia utilizando um eluente que consiste essencialmente em dioxido de carbono de alta pressao
HK98108994.2A HK1007882B (en)	1995-03-03	1996-03-01	Process for preparation of pure cyclosporin chromatographically using an eluent consisting essentially of high pressure carbon dioxide
ES96903038T ES2171649T3 (es)	1995-03-03	1996-03-01	Procedimiento para la preparacion de ciclosporina cromatograficamente pura utilizando un eluyente que consta esencialmente de dioxido de carbono a alta presion.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FI950983A FI102758B (fi)	1995-03-03	1995-03-03	Menetelmä puhtaan syklosporiinimuodon valmistamiseksi

Publications (4)

Publication Number	Publication Date
FI950983A0 FI950983A0 (fi)	1995-03-03
FI950983L FI950983L (fi)	1996-09-04
FI102758B1 true FI102758B1 (fi)	1999-02-15
FI102758B FI102758B (fi)	1999-02-15

Family

ID=8542963

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI950983A FI102758B (fi)	1995-03-03	1995-03-03	Menetelmä puhtaan syklosporiinimuodon valmistamiseksi

Country Status (10)

Country	Link
US (1)	US5976381A (fi)
EP (1)	EP0815122B1 (fi)
JP (1)	JPH11501042A (fi)
AT (1)	ATE212353T1 (fi)
DE (1)	DE69618772T2 (fi)
DK (1)	DK0815122T3 (fi)
ES (1)	ES2171649T3 (fi)
FI (1)	FI102758B (fi)
PT (1)	PT815122E (fi)
WO (1)	WO1996027607A1 (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7026290B1 (en)	1998-12-30	2006-04-11	Dexcel Ltd.	Dispersible concentrate for the delivery of cyclosprin
US7732404B2 (en)	1999-12-30	2010-06-08	Dexcel Ltd	Pro-nanodispersion for the delivery of cyclosporin
CA2518265A1 (en)	2003-03-17	2004-09-30	Albany Molecular Research, Inc.	Novel cyclosporins
JP2008514701A (ja)	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	シクロスポリンアルキン類似体およびそれらの薬学的使用
US7511013B2 (en)	2004-09-29	2009-03-31	Amr Technology, Inc.	Cyclosporin analogues and their pharmaceutical uses
WO2006041631A2 (en)	2004-10-06	2006-04-20	Amr Technology, Inc.	Novel cyclosporin alkynes and their utility as pharmaceutical agents
US7862552B2 (en)	2005-05-09	2011-01-04	Boston Scientific Scimed, Inc.	Medical devices for treating urological and uterine conditions
FR2889077B1 (fr) *	2005-07-26	2007-10-12	Novasep Soc Par Actions Simpli	Procede et dispositif de separation chromatographique de fractions d'un melange
US11913685B2 (en)	2014-08-19	2024-02-27	Supercritical Fluid Technologies, Inc.	Cooling loop with a supercritical fluid system using compressed refrigerant fluid flow with a positive Joule Thomson coefficient
US10765968B2 (en)	2014-08-19	2020-09-08	Supercritical Fluid Technologies, Inc.	Systems and methods for supercritical fluid chromatography
WO2016028521A2 (en) *	2014-08-19	2016-02-25	Supercritical Fluid Technologies, Inc.	Supercritical fluid chromatography system
CN105566381A (zh) *	2015-12-29	2016-05-11	成都普思生物科技股份有限公司	一种注射用磷脂酰胆碱的制备方法
AU2017342549B2 (en)	2016-10-14	2022-02-17	Supercritical Fluid Technologies, Inc.	Cooling loop with a supercritical fluid system using compressed refrigerant fluid flow with a positive joule-thomson coefficient
US11946915B2 (en)	2019-01-04	2024-04-02	Supercritical Fluid Technologies, Inc.	Interchangeable chromatography cartridgeadapter system

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2729462A1 (de) *	1977-06-30	1979-01-18	Wolfgang Dr Hartmann	Vorrichtung und verfahren zur chromatographischen trennung von substanzen geringen dampfdrucks
FR2527934A1 (fr) *	1982-06-03	1983-12-09	Elf Aquitaine	Procede de fractionnement de melanges par chromatographie d'elution avec fluide en etat supercritique et installation pour sa mise en oeuvre
DE3318194C2 (de) *	1983-05-19	1987-01-22	Fried. Krupp Gmbh, 4300 Essen	Verfahren zur Isolierung und Reinigung von Antibiotika
ATE127528T1 (de) *	1991-04-06	1995-09-15	Dresden Arzneimittel	Verfahren zur fermentativen herstellung und isolierung von cyclosporin a sowie neue cyclosporin- bildende stämme.
FI93833C (fi) *	1992-05-14	1995-06-12	Orion Yhtymae Oy	Menetelmä propionihappojohdosten valmistamiseksi
CA2108655A1 (en) *	1993-10-18	1995-04-19	Argyrios Margaritis	Supercritical co2 extraction of cyclosporin a

1995
- 1995-03-03 FI FI950983A patent/FI102758B/fi not_active IP Right Cessation
1996
- 1996-03-01 PT PT96903038T patent/PT815122E/pt unknown
- 1996-03-01 EP EP96903038A patent/EP0815122B1/en not_active Expired - Lifetime
- 1996-03-01 JP JP8526631A patent/JPH11501042A/ja not_active Ceased
- 1996-03-01 DK DK96903038T patent/DK0815122T3/da active
- 1996-03-01 AT AT96903038T patent/ATE212353T1/de not_active IP Right Cessation
- 1996-03-01 ES ES96903038T patent/ES2171649T3/es not_active Expired - Lifetime
- 1996-03-01 US US08/894,957 patent/US5976381A/en not_active Expired - Fee Related
- 1996-03-01 DE DE69618772T patent/DE69618772T2/de not_active Expired - Fee Related
- 1996-03-01 WO PCT/FI1996/000120 patent/WO1996027607A1/en not_active Ceased

Also Published As

Publication number	Publication date
FI950983L (fi)	1996-09-04
EP0815122B1 (en)	2002-01-23
WO1996027607A1 (en)	1996-09-12
DE69618772D1 (de)	2002-03-14
HK1007882A1 (en)	1999-04-30
ATE212353T1 (de)	2002-02-15
PT815122E (pt)	2002-06-28
ES2171649T3 (es)	2002-09-16
EP0815122A1 (en)	1998-01-07
DK0815122T3 (da)	2002-04-22
FI950983A0 (fi)	1995-03-03
US5976381A (en)	1999-11-02
DE69618772T2 (de)	2002-08-29
JPH11501042A (ja)	1999-01-26
FI102758B (fi)	1999-02-15

Publication	Publication Date	Title
FI102758B (fi)	1999-02-15	Menetelmä puhtaan syklosporiinimuodon valmistamiseksi
MY116330A (en)	2004-01-31	Hydrogen and carbon monoxide production by hydrocarbon steam reforming and pressure swing adsorption purification
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FR2625690B1 (fr)	1993-04-23	Procede de separation des constituants d'un melange en phase gazeuse au moyen d'une membrane composite
GEP20012581B (en)	2001-11-26	Method for Purifying Taxoids
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PL329113A1 (en)	1999-03-15	Chromatographic method of obtaining cyclosporin a of high purity and related cyclosporins
US4977083A (en)	1990-12-11	Processes for preparing A54145 compounds
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ATE327488T1 (de)	2006-06-15	Verfahren zur herstellung von sauerstoff unter mittlerem druck
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IL139120A0 (en)	2001-11-25	Method for separating and /or isolating plasma proteins by annular chromatography

Legal Events

Date	Code	Title	Description
1997-08-25	GB	Transfer or assigment of application	Owner name: SANTEN OY
2006-09-30	MA	Patent expired