ATE212353T1 - Verfahren zur aufarbeitung von chromatographisches reinem cyclosporin, durch gebrauch eines eluenten, der im wesentlichen zusammengesetzt ist aus carbondioxid unter hohem druck - Google Patents
Verfahren zur aufarbeitung von chromatographisches reinem cyclosporin, durch gebrauch eines eluenten, der im wesentlichen zusammengesetzt ist aus carbondioxid unter hohem druckInfo
- Publication number
- ATE212353T1 ATE212353T1 AT96903038T AT96903038T ATE212353T1 AT E212353 T1 ATE212353 T1 AT E212353T1 AT 96903038 T AT96903038 T AT 96903038T AT 96903038 T AT96903038 T AT 96903038T AT E212353 T1 ATE212353 T1 AT E212353T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclosporin
- eluent
- pct
- carbon dioxide
- high pressure
- Prior art date
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 title abstract 4
- 229930105110 Cyclosporin A Natural products 0.000 title abstract 3
- 108010036949 Cyclosporine Proteins 0.000 title abstract 3
- 229960001265 ciclosporin Drugs 0.000 title abstract 3
- 229930182912 cyclosporin Natural products 0.000 title abstract 3
- 239000003480 eluent Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 229910002092 carbon dioxide Inorganic materials 0.000 title abstract 2
- 239000001569 carbon dioxide Substances 0.000 title abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 238000004587 chromatography analysis Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000002671 adjuvant Substances 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI950983A FI102758B (fi) | 1995-03-03 | 1995-03-03 | Menetelmä puhtaan syklosporiinimuodon valmistamiseksi |
| PCT/FI1996/000120 WO1996027607A1 (en) | 1995-03-03 | 1996-03-01 | Process for preparation of pure cyclosporin chromatographically using an eluent consisting essentially of high pressure carbon dioxide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE212353T1 true ATE212353T1 (de) | 2002-02-15 |
Family
ID=8542963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96903038T ATE212353T1 (de) | 1995-03-03 | 1996-03-01 | Verfahren zur aufarbeitung von chromatographisches reinem cyclosporin, durch gebrauch eines eluenten, der im wesentlichen zusammengesetzt ist aus carbondioxid unter hohem druck |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5976381A (de) |
| EP (1) | EP0815122B1 (de) |
| JP (1) | JPH11501042A (de) |
| AT (1) | ATE212353T1 (de) |
| DE (1) | DE69618772T2 (de) |
| DK (1) | DK0815122T3 (de) |
| ES (1) | ES2171649T3 (de) |
| FI (1) | FI102758B (de) |
| PT (1) | PT815122E (de) |
| WO (1) | WO1996027607A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7026290B1 (en) | 1998-12-30 | 2006-04-11 | Dexcel Ltd. | Dispersible concentrate for the delivery of cyclosprin |
| US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| CA2518265A1 (en) | 2003-03-17 | 2004-09-30 | Albany Molecular Research, Inc. | Novel cyclosporins |
| JP2008514701A (ja) | 2004-09-29 | 2008-05-08 | エーエムアール テクノロジー インコーポレイテッド | シクロスポリンアルキン類似体およびそれらの薬学的使用 |
| US7511013B2 (en) | 2004-09-29 | 2009-03-31 | Amr Technology, Inc. | Cyclosporin analogues and their pharmaceutical uses |
| WO2006041631A2 (en) | 2004-10-06 | 2006-04-20 | Amr Technology, Inc. | Novel cyclosporin alkynes and their utility as pharmaceutical agents |
| US7862552B2 (en) | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
| FR2889077B1 (fr) * | 2005-07-26 | 2007-10-12 | Novasep Soc Par Actions Simpli | Procede et dispositif de separation chromatographique de fractions d'un melange |
| US11913685B2 (en) | 2014-08-19 | 2024-02-27 | Supercritical Fluid Technologies, Inc. | Cooling loop with a supercritical fluid system using compressed refrigerant fluid flow with a positive Joule Thomson coefficient |
| US10765968B2 (en) | 2014-08-19 | 2020-09-08 | Supercritical Fluid Technologies, Inc. | Systems and methods for supercritical fluid chromatography |
| WO2016028521A2 (en) * | 2014-08-19 | 2016-02-25 | Supercritical Fluid Technologies, Inc. | Supercritical fluid chromatography system |
| CN105566381A (zh) * | 2015-12-29 | 2016-05-11 | 成都普思生物科技股份有限公司 | 一种注射用磷脂酰胆碱的制备方法 |
| AU2017342549B2 (en) | 2016-10-14 | 2022-02-17 | Supercritical Fluid Technologies, Inc. | Cooling loop with a supercritical fluid system using compressed refrigerant fluid flow with a positive joule-thomson coefficient |
| US11946915B2 (en) | 2019-01-04 | 2024-04-02 | Supercritical Fluid Technologies, Inc. | Interchangeable chromatography cartridgeadapter system |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2729462A1 (de) * | 1977-06-30 | 1979-01-18 | Wolfgang Dr Hartmann | Vorrichtung und verfahren zur chromatographischen trennung von substanzen geringen dampfdrucks |
| FR2527934A1 (fr) * | 1982-06-03 | 1983-12-09 | Elf Aquitaine | Procede de fractionnement de melanges par chromatographie d'elution avec fluide en etat supercritique et installation pour sa mise en oeuvre |
| DE3318194C2 (de) * | 1983-05-19 | 1987-01-22 | Fried. Krupp Gmbh, 4300 Essen | Verfahren zur Isolierung und Reinigung von Antibiotika |
| ATE127528T1 (de) * | 1991-04-06 | 1995-09-15 | Dresden Arzneimittel | Verfahren zur fermentativen herstellung und isolierung von cyclosporin a sowie neue cyclosporin- bildende stämme. |
| FI93833C (fi) * | 1992-05-14 | 1995-06-12 | Orion Yhtymae Oy | Menetelmä propionihappojohdosten valmistamiseksi |
| CA2108655A1 (en) * | 1993-10-18 | 1995-04-19 | Argyrios Margaritis | Supercritical co2 extraction of cyclosporin a |
-
1995
- 1995-03-03 FI FI950983A patent/FI102758B/fi not_active IP Right Cessation
-
1996
- 1996-03-01 PT PT96903038T patent/PT815122E/pt unknown
- 1996-03-01 EP EP96903038A patent/EP0815122B1/de not_active Expired - Lifetime
- 1996-03-01 JP JP8526631A patent/JPH11501042A/ja not_active Ceased
- 1996-03-01 DK DK96903038T patent/DK0815122T3/da active
- 1996-03-01 AT AT96903038T patent/ATE212353T1/de not_active IP Right Cessation
- 1996-03-01 ES ES96903038T patent/ES2171649T3/es not_active Expired - Lifetime
- 1996-03-01 US US08/894,957 patent/US5976381A/en not_active Expired - Fee Related
- 1996-03-01 DE DE69618772T patent/DE69618772T2/de not_active Expired - Fee Related
- 1996-03-01 WO PCT/FI1996/000120 patent/WO1996027607A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| FI950983L (fi) | 1996-09-04 |
| FI102758B1 (fi) | 1999-02-15 |
| EP0815122B1 (de) | 2002-01-23 |
| WO1996027607A1 (en) | 1996-09-12 |
| DE69618772D1 (de) | 2002-03-14 |
| HK1007882A1 (en) | 1999-04-30 |
| PT815122E (pt) | 2002-06-28 |
| ES2171649T3 (es) | 2002-09-16 |
| EP0815122A1 (de) | 1998-01-07 |
| DK0815122T3 (da) | 2002-04-22 |
| FI950983A0 (fi) | 1995-03-03 |
| US5976381A (en) | 1999-11-02 |
| DE69618772T2 (de) | 2002-08-29 |
| JPH11501042A (ja) | 1999-01-26 |
| FI102758B (fi) | 1999-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |