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ES8802040A1 - Un procedimiento para la preparacion de fenialquil-2,3-dihidrobenzofuranos y los correspondientes dihidrobenzopiranos - Google Patents

Un procedimiento para la preparacion de fenialquil-2,3-dihidrobenzofuranos y los correspondientes dihidrobenzopiranos

Info

Publication number
ES8802040A1
ES8802040A1 ES554335A ES554335A ES8802040A1 ES 8802040 A1 ES8802040 A1 ES 8802040A1 ES 554335 A ES554335 A ES 554335A ES 554335 A ES554335 A ES 554335A ES 8802040 A1 ES8802040 A1 ES 8802040A1
Authority
ES
Spain
Prior art keywords
compounds
reduction
fenialquil
dihidrobenzopiranos
dihidrobenzofuranos
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554335A
Other languages
English (en)
Other versions
ES554335A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES8802040A1 publication Critical patent/ES8802040A1/es
Publication of ES554335A0 publication Critical patent/ES554335A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE FENILALQUIL-2,3-DIHIDROBENZOFURANOS Y LOS CORRESPONDIENTES DIHIDROBENZOPIRANOS, DE FORMULA GENERAL (I), Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN TRATAR UN COMPUESTO DE FORMULA GENERAL (II) CON UN HALURO DE FORMULA GENERAL (III), EN LAS QUE X ES CLORO, BROMO O YODO; A ES FENILO SUSTITUIDO; M ES UN NUMERO DE 1 A 4; N ES 2 O 3; Y R ES 1, 2 O 3, BAJO CONDICIONES DE ALQUILACION, Y EN REDUCIR EL PRODUCTO OBTENIDO CON UN REACTIVO REDUCTOR SELECCIONADO ENTRE NABH4 Y H2/PD. DE APLICACION COMO AGENTES ANTI-INFLAMATORIOS.
ES554335A 1985-04-25 1986-04-24 Un procedimiento para la preparacion de fenialquil-2,3-dihidrobenzofuranos y los correspondientes dihidrobenzopiranos Expired ES8802040A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/727,317 US4713393A (en) 1985-04-25 1985-04-25 Phenylpropyl-2,3-dihydrobenzofurans useful as anti-inflammatory agents

Publications (2)

Publication Number Publication Date
ES8802040A1 true ES8802040A1 (es) 1988-03-16
ES554335A0 ES554335A0 (es) 1988-03-16

Family

ID=24922190

Family Applications (2)

Application Number Title Priority Date Filing Date
ES554335A Expired ES8802040A1 (es) 1985-04-25 1986-04-24 Un procedimiento para la preparacion de fenialquil-2,3-dihidrobenzofuranos y los correspondientes dihidrobenzopiranos
ES557784A Expired ES8801910A1 (es) 1985-04-25 1987-12-15 Un procedimiento para la preparacion de fenilalquil-2,3-dihidrobenzofuranos y los correspondientes dihidrobenzopiranos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557784A Expired ES8801910A1 (es) 1985-04-25 1987-12-15 Un procedimiento para la preparacion de fenilalquil-2,3-dihidrobenzofuranos y los correspondientes dihidrobenzopiranos

Country Status (7)

Country Link
US (1) US4713393A (es)
EP (1) EP0199235B1 (es)
JP (1) JPS61251679A (es)
CA (1) CA1308416C (es)
DE (1) DE3673217D1 (es)
DK (1) DK188286A (es)
ES (2) ES8802040A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0753725B2 (ja) * 1987-10-08 1995-06-07 富山化学工業株式会社 ４ｈ―１―ベンゾピラン―４―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤
US4966907A (en) * 1988-08-12 1990-10-30 Merck & Co., Inc. 6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis
US4975457A (en) * 1989-09-25 1990-12-04 Merck & Co., Inc. Trans 2,3-disubstituted-2,3-dihydro-5-hydroxy-benzofurans as inhibitors of leukotriene biosynthesis
US5091533A (en) * 1990-03-12 1992-02-25 Merck Frosst Canada, Inc. 5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors
EP0640609A1 (en) * 1993-08-24 1995-03-01 Ono Pharmaceutical Co., Ltd. Fused phenol derivatives having inhibitory activity on TXA2 synthetase, and 5-lipoxygenase and scavenging activity on oxygen species
JP4202250B2 (ja) 2001-07-25 2008-12-24 バイオマリン ファーマシューティカル インコーポレイテッド 血液脳関門輸送を調節するための組成物および方法
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
EP1830186A1 (en) * 2006-03-01 2007-09-05 ETH Zürich High-throughput cell-based screening system
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
US7632119B1 (en) * 2008-08-11 2009-12-15 Cheng Uei Precision Industry Co., Ltd. Power adapter
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
CN110075069A (zh) 2009-05-06 2019-08-02 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE650987A (es) * 1963-07-25 1965-01-25
DE2315349A1 (de) * 1973-03-28 1974-10-03 Bayer Ag Nicht verfaerbende alterungsschutzmittel
US4100294A (en) * 1976-12-06 1978-07-11 Merck & Co., Inc. 5-(Hydroxy (substituted) methyl)-2,3-dihydrobenzo furan-2-carboxylic acid and its derivatives
DE2803544A1 (de) * 1978-01-27 1979-08-02 Sandoz Ag Neue benzofuran- und benzoxepinderivate
US4189496A (en) * 1978-02-16 1980-02-19 Merck & Co., Inc. 2,3-Dihydro-5-thienylmethyl and furylmethyl-6-substituted and 6,7-disubstituted-benzofuran-2-carboxylic acid
GR75101B (es) * 1980-10-23 1984-07-13 Pfizer
US4490531A (en) * 1981-07-01 1984-12-25 The Upjohn Company Pyridyl-substituted-benzofurans
US4495357A (en) * 1981-07-01 1985-01-22 The Upjohn Company Pyridyl-substituted-benzofurans
US4435422A (en) * 1982-09-15 1984-03-06 Abbott Laboratories 5-Substituted 2,3-dihydrobenzofuran-2-carboxylic acids and their use in diuretic compositions
US4537903A (en) * 1983-10-12 1985-08-27 Merck & Co., Inc. Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as anti-inflammatory agents

Also Published As

Publication number Publication date
EP0199235A3 (en) 1987-08-05
JPH0415230B2 (es) 1992-03-17
ES8801910A1 (es) 1988-03-01
CA1308416C (en) 1992-10-06
DK188286A (da) 1986-10-26
US4713393A (en) 1987-12-15
DE3673217D1 (de) 1990-09-13
ES554335A0 (es) 1988-03-16
JPS61251679A (ja) 1986-11-08
DK188286D0 (da) 1986-04-24
EP0199235B1 (en) 1990-08-08
EP0199235A2 (en) 1986-10-29
ES557784A0 (es) 1988-03-01

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