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ES8801919A1 - Procedimiento para la obtencion de acidos 1-ciclopropil-1,4-dihidro-4-oxo-1,8-naftiridin-3-carboxilicos - Google Patents

Procedimiento para la obtencion de acidos 1-ciclopropil-1,4-dihidro-4-oxo-1,8-naftiridin-3-carboxilicos

Info

Publication number
ES8801919A1
ES8801919A1 ES557514A ES557514A ES8801919A1 ES 8801919 A1 ES8801919 A1 ES 8801919A1 ES 557514 A ES557514 A ES 557514A ES 557514 A ES557514 A ES 557514A ES 8801919 A1 ES8801919 A1 ES 8801919A1
Authority
ES
Spain
Prior art keywords
naphthyridine
disubstituted
cyclopropyl
dihydro
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557514A
Other languages
English (en)
Other versions
ES557514A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES557514A0 publication Critical patent/ES557514A0/es
Publication of ES8801919A1 publication Critical patent/ES8801919A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C07D213/77—Hydrazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ACIDOS 1-CICLOPROPIL-1,4-DIHIDRO-4-OXO-1,8-NAFTIRIDIN-3-CARBOXILICOS. EL COMPUESTO (I), DONDE X ES HALOGENO O NITRO Y A ES UN COMPUESTO (II), DONDE R1 ES UN ALQUILO C1-4 O UN RESTO (III), R2 Y R3 HIDROGENO, METILO U OTROS; SE PREPARA HACIENDO REACCIONAR ACIDOS (IV) CON COMPUESTOS R1-Z, DONDE R1 ES COMO ANTES Y Z HALOGENO, OH ETOXI U OTROS, EN UN DISOLVENTE COMO EL DIMETILSULFOXIDO, DIOXANO, N,N-DIMETILFORMAMIDA U OTROS, EN PRESENCIA DE UN ACEPTOR DE ACIDO Y UNA TEMPERATURA ENTRE 20 Y 180JC, PARA OBTENER EL ACIDO (I) U OPCIONALMENTE SUS SALES ESTERES Y OTRAS FORMAS PRODRUG. DE APLICACION EN MEDICINA Y VETERINARIA, ESPECIALMENTE PARA EL TRATAMIENTO Y PROFILAXIS DE INFECCIONES BACTERIANAS EN PECES.
ES557514A 1985-01-10 1987-04-29 Procedimiento para la obtencion de acidos 1-ciclopropil-1,4-dihidro-4-oxo-1,8-naftiridin-3-carboxilicos Expired ES8801919A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3500562 1985-01-10
DE19853508816 DE3508816A1 (de) 1985-01-10 1985-03-13 6,7-disubstituierte 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtyridin-3-carbonsaeuren

Publications (2)

Publication Number Publication Date
ES557514A0 ES557514A0 (es) 1988-03-01
ES8801919A1 true ES8801919A1 (es) 1988-03-01

Family

ID=25828438

Family Applications (5)

Application Number Title Priority Date Filing Date
ES550767A Expired ES8802520A1 (es) 1985-01-10 1986-01-09 Procedimiento para la obtencion de acidos 1-ciclopropil-1,4-dihidro-4-oxo-1,8 naftiridin-3-carboxilicos.
ES557514A Expired ES8801919A1 (es) 1985-01-10 1987-04-29 Procedimiento para la obtencion de acidos 1-ciclopropil-1,4-dihidro-4-oxo-1,8-naftiridin-3-carboxilicos
ES557516A Expired ES8800222A1 (es) 1985-01-10 1987-04-29 Procedimiento para la obtencion del acido 2,6-dicloro-5-fluor-piridin-3-carboxilico
ES557515A Expired ES8801796A1 (es) 1985-01-10 1987-04-29 Procedimiento para la obtencion de derivados del acido piridin-3-carboxilico
ES557785A Expired ES8802225A1 (es) 1985-01-10 1987-12-15 Procedimiento para la obtencion de acidos 1-ciclopropil-1,4-dihidro-4-oxo-1,8-naftiridein-3-carboxilicos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES550767A Expired ES8802520A1 (es) 1985-01-10 1986-01-09 Procedimiento para la obtencion de acidos 1-ciclopropil-1,4-dihidro-4-oxo-1,8 naftiridin-3-carboxilicos.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES557516A Expired ES8800222A1 (es) 1985-01-10 1987-04-29 Procedimiento para la obtencion del acido 2,6-dicloro-5-fluor-piridin-3-carboxilico
ES557515A Expired ES8801796A1 (es) 1985-01-10 1987-04-29 Procedimiento para la obtencion de derivados del acido piridin-3-carboxilico
ES557785A Expired ES8802225A1 (es) 1985-01-10 1987-12-15 Procedimiento para la obtencion de acidos 1-ciclopropil-1,4-dihidro-4-oxo-1,8-naftiridein-3-carboxilicos

Country Status (21)

Country Link
US (1) US4840954A (es)
EP (1) EP0187376B1 (es)
JP (1) JPH0653741B2 (es)
KR (1) KR910002645B1 (es)
CN (1) CN1003236B (es)
AT (1) ATE76076T1 (es)
AU (3) AU574550B2 (es)
CA (2) CA1339373C (es)
DE (2) DE3508816A1 (es)
DK (1) DK168439B1 (es)
ES (5) ES8802520A1 (es)
FI (2) FI892675A0 (es)
GR (1) GR860031B (es)
HU (1) HU193623B (es)
IE (1) IE58412B1 (es)
IL (2) IL77538A (es)
NO (2) NO163331C (es)
NZ (2) NZ229861A (es)
PH (2) PH25055A (es)
PL (2) PL148759B1 (es)
PT (1) PT81810B (es)

Families Citing this family (17)

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Publication number Priority date Publication date Assignee Title
US5153204A (en) * 1986-03-01 1992-10-06 Bayer Aktiengesellschaft 7-(1-Pyrrolidinyl)-quinolonecarboxylic acid derivatives
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
FR2650276B1 (fr) * 1989-07-28 1991-10-18 Bellon Labor Sa Roger Nouveaux derives de benzonaphtyridine-1,8 leur preparation et les compositions qui les contiennent
EP0449445A3 (en) * 1990-03-27 1993-08-25 Pfizer Inc. Preparation of beta-ketoesters useful in preparing quinolone antibiotics
US5290794A (en) * 1992-10-27 1994-03-01 Warner Lambert Co. Soluble calcium lactate antibacterial complexes as non-irritating parenteral forms
JPH09503783A (ja) * 1993-10-14 1997-04-15 アボツト・ラボラトリーズ キノリジノン型化合物
EP0828738B1 (de) * 1995-05-26 2003-12-17 Bayer CropScience AG Pyridyl-thiazole und deren verwendung zum schutz von pflanzen gegen befall durch mikroorganismen
US5739342A (en) * 1997-03-03 1998-04-14 Abbott Laboratories Process for the preparation of nicotinic acids
AU763636C (en) * 1998-01-29 2004-05-27 Daiichi Asubio Pharma Co., Ltd. 1-cycloalkyl-1,8-naphthyridin-4-one derivatives with phosphodiesterase IV inhibitory activity
KR100364226B1 (ko) * 1998-03-18 2003-01-24 주식회사 엘지생명과학 7-할로-1-시클로프로필-6-플루오로-4-옥소-1,4-디히드로-[1.8]나프티리딘-3-카복실레이트의 제조방법
HUP0402310A2 (hu) * 2001-09-26 2005-02-28 Bayer Pharmaceuticals Corporation 1,6-Naftiridin-származékok mint antidiabetikumok és ezeket tartalmazó gyógyszerkészítmények
EP1436263B1 (en) * 2001-10-15 2007-09-19 LG Life Sciences Ltd. A process for preparing beta-ketoester compound
AR096135A1 (es) 2013-05-02 2015-12-09 Actelion Pharmaceuticals Ltd Derivados de la quinolona
EP3296298A1 (de) 2016-09-14 2018-03-21 Bayer Pharma Aktiengesellschaft 7-substituierte 1-aryl-naphthyridin-3-carbonsäureamide und ihre verwendung
JOP20190045A1 (ar) 2016-09-14 2019-03-14 Bayer Ag مركبات أميد حمض 1- أريل-نفثيريدين-3-كربوكسيليك مستبدلة في الموضع 7 واستخدامها.
CN109206424A (zh) * 2018-09-18 2019-01-15 佳木斯大学 依诺沙星-邻苯二甲酸药物盐单晶体及其制备方法
CN115784988B (zh) * 2022-12-13 2025-10-21 湖北省生物农药工程研究中心 一种多取代含氮杂环衍生物及其制备方法与应用

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JPS60126284A (ja) * 1983-12-09 1985-07-05 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体およびその塩
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CA1285279C (en) * 1984-02-17 1991-06-25 Joseph P. Sanchez 7-amine derivatives of 1-cyclopropyl-6,8-difluoro-1,4- dihydro-4-oxo-3-quinolinecarboxylic acids and 1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine- 3-carboxylic acidsas antibacterial agents
DE3574380D1 (en) * 1984-02-17 1989-12-28 Daiichi Seiyaku Co 1,8-naphthyridine derivatives
JPS60197686A (ja) * 1984-03-19 1985-10-07 Dai Ichi Seiyaku Co Ltd １，８−ナフチリジン誘導体
JPS60172981A (ja) * 1984-02-17 1985-09-06 Dai Ichi Seiyaku Co Ltd １，８−ナフチリジン誘導体
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
JPS6172753A (ja) * 1984-09-18 1986-04-14 Dainippon Pharmaceut Co Ltd ピリジルケトン誘導体
US4663457A (en) * 1985-01-23 1987-05-05 Warner-Lambert Company 1-cyclopropyl-6,7-dihalo-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid and their esters, useful as intermediates for preparing the 7-amine substituted naphthyridines
DE3525108A1 (de) * 1985-06-07 1986-12-11 Bayer Ag, 5090 Leverkusen Antibakteriell wirksame chinoloncarbonsaeureester
DE3685157D1 (de) * 1985-06-26 1992-06-11 Daiichi Seiyaku Co Pyridoncarbonsaeurederivate.

Also Published As

Publication number Publication date
EP0187376A3 (en) 1988-05-04
JPS61161284A (ja) 1986-07-21
ES557785A0 (es) 1988-04-16
ES550767A0 (es) 1988-06-16
AU574550B2 (en) 1988-07-07
CA1320206C (en) 1993-07-13
FI86721B (fi) 1992-06-30
AU1835988A (en) 1988-09-15
EP0187376A2 (de) 1986-07-16
ES8800222A1 (es) 1987-10-16
PH24769A (en) 1990-10-01
FI860073A7 (fi) 1986-07-11
CN86100126A (zh) 1986-07-09
DK168439B1 (da) 1994-03-28
NO163331C (no) 1990-05-09
NO163331B (no) 1990-01-29
DK9186A (da) 1986-07-11
DK9186D0 (da) 1986-01-09
ES557516A0 (es) 1987-10-16
IE58412B1 (en) 1993-09-22
FI892675A7 (fi) 1989-06-01
KR860005818A (ko) 1986-08-13
IL89168A0 (en) 1989-09-10
FI892675L (fi) 1989-06-01
CN1003236B (zh) 1989-02-08
GR860031B (en) 1986-04-29
ATE76076T1 (de) 1992-05-15
FI86721C (fi) 1992-10-12
PT81810A (en) 1986-02-01
DE3586048D1 (en) 1992-06-17
PL148191B1 (en) 1989-09-30
PL148759B1 (en) 1989-11-30
KR910002645B1 (ko) 1991-04-27
NZ214746A (en) 1989-10-27
NO855134L (no) 1986-07-11
EP0187376B1 (de) 1992-05-13
AU7311887A (en) 1987-09-10
JPH0653741B2 (ja) 1994-07-20
FI860073A0 (fi) 1986-01-08
HUT40126A (en) 1986-11-28
AU5216486A (en) 1987-01-22
NZ229861A (en) 1989-10-27
PL264565A1 (en) 1988-01-07
ES557515A0 (es) 1988-02-16
PL257419A1 (en) 1987-07-27
ES8801796A1 (es) 1988-02-16
ES557514A0 (es) 1988-03-01
IL77538A (en) 1992-05-25
IE860062L (en) 1986-07-10
PT81810B (pt) 1988-05-27
PH25055A (en) 1991-01-28
AU576449B2 (en) 1988-08-25
FI892675A0 (fi) 1989-06-01
HU193623B (en) 1987-11-30
US4840954A (en) 1989-06-20
DE3508816A1 (de) 1986-07-10
ES8802225A1 (es) 1988-04-16
NO860199L (no) 1986-07-11
ES8802520A1 (es) 1988-06-16
CA1339373C (en) 1997-08-26

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