ES8801269A1 - Un procedimiento para preparar benzo(c)-1,5-naftiridinas - Google Patents
Un procedimiento para preparar benzo(c)-1,5-naftiridinasInfo
- Publication number
- ES8801269A1 ES8801269A1 ES557207A ES557207A ES8801269A1 ES 8801269 A1 ES8801269 A1 ES 8801269A1 ES 557207 A ES557207 A ES 557207A ES 557207 A ES557207 A ES 557207A ES 8801269 A1 ES8801269 A1 ES 8801269A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- naphthyridines
- medicaments
- benzo
- intermediates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- XKEGLCXDDCXTKZ-UHFFFAOYSA-N benzo[c][1,5]naphthyridine Chemical class C1=CN=C2C3=CC=CC=C3C=NC2=C1 XKEGLCXDDCXTKZ-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 238000006722 reduction reaction Methods 0.000 abstract 2
- -1 HYDROGEN HYDROGEN Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- ZOCHARZZJNPSEU-UHFFFAOYSA-N diboron Chemical compound B#B ZOCHARZZJNPSEU-UHFFFAOYSA-N 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Display Devices Of Pinball Game Machines (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE BENZOC-1,5-NAFTIRIDINAS Y DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I). COMPRENDE LA REACCION DE REDUCCION DE UN COMPUESTO DE FORMULA (I), EN LA QUE R1 REPRESENTA OXIGENO Y R ES ALQUILO, ARILALQUILO O DIARILALQUILO INFERIORES, PARA FORMAR UN COMPUESTO DE FORMULA (I) EN LA QUE R Y R1 SON HIDROGENO Y X PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. LA REDUCCION SE EFECT''A CON DIBORANO, EN TETRAHIDROFURANO ANHIDRO, A LA TEMPERATURA AMBIENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA REFORZAR LA MEMORIA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/711,327 US4652567A (en) | 1985-03-13 | 1985-03-13 | Benzo(c)-1,5-naphthyridines useful for treating a patient having drug induced memory impairment in need of memory enhancement |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES557207A0 ES557207A0 (es) | 1988-01-01 |
| ES8801269A1 true ES8801269A1 (es) | 1988-01-01 |
Family
ID=24857642
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES552874A Expired ES8707528A1 (es) | 1985-03-13 | 1986-03-11 | Un procedimiento para preparar benzo (c)-1,5-naftiridinas |
| ES557208A Expired ES8800941A1 (es) | 1985-03-13 | 1986-11-17 | Un procedimiento para preparar derivados de dihidropirrol (112-b)-isoquinoleina |
| ES557207A Expired ES8801269A1 (es) | 1985-03-13 | 1986-11-17 | Un procedimiento para preparar benzo(c)-1,5-naftiridinas |
| ES557768A Expired ES8801270A1 (es) | 1985-03-13 | 1987-10-15 | Un procedimiento para preparar benzo (c)-1,5-naftiridinas |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES552874A Expired ES8707528A1 (es) | 1985-03-13 | 1986-03-11 | Un procedimiento para preparar benzo (c)-1,5-naftiridinas |
| ES557208A Expired ES8800941A1 (es) | 1985-03-13 | 1986-11-17 | Un procedimiento para preparar derivados de dihidropirrol (112-b)-isoquinoleina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES557768A Expired ES8801270A1 (es) | 1985-03-13 | 1987-10-15 | Un procedimiento para preparar benzo (c)-1,5-naftiridinas |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4652567A (es) |
| EP (1) | EP0197318B1 (es) |
| JP (1) | JPS61212585A (es) |
| KR (1) | KR860007255A (es) |
| AT (1) | ATE52510T1 (es) |
| AU (1) | AU590748B2 (es) |
| CA (1) | CA1248108A (es) |
| DE (1) | DE3671017D1 (es) |
| DK (1) | DK114386A (es) |
| ES (4) | ES8707528A1 (es) |
| FI (1) | FI861001A7 (es) |
| GR (1) | GR860681B (es) |
| HU (2) | HU201756B (es) |
| IL (1) | IL78117A0 (es) |
| NO (1) | NO163489B (es) |
| NZ (1) | NZ215439A (es) |
| PH (1) | PH22279A (es) |
| PT (1) | PT82187B (es) |
| ZA (1) | ZA861837B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4766217A (en) * | 1984-01-13 | 1988-08-23 | Boehringer Ingelheim Kg | Preparation of 5,6-dihydro-pyrrolo[2,1-a]isoquinolines |
| US5202440A (en) * | 1987-10-05 | 1993-04-13 | Pfizer Inc. | Certain 9-amino-2-(or 4)-oxa 1,2,3,4-tetrahydro- or 1,2,3,4,5,6,7,8-octahydro-acridines |
| WO1989002739A1 (en) * | 1987-10-05 | 1989-04-06 | Pfizer Inc. | 4-aminopyridine derivatives |
| US5994367A (en) * | 1997-03-07 | 1999-11-30 | The University Of North Carolina At Chapel Hill | Method for treating tumors using 2-aryl-naphthyridin-4-ones |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2273533A1 (fr) * | 1974-06-04 | 1976-01-02 | Ferlux Sa | Nouveaux derives n-substitues d'acides pyrrolidones-2 carboxyliques-5 |
| US4297358A (en) * | 1979-01-16 | 1981-10-27 | Ciba-Geigy Corporation | Novel 4,7-phenanthroline derivatives and pharmaceutical compositions containing them and their use |
| BE880455A (fr) * | 1979-01-22 | 1980-06-06 | Sandoz Sa | Compositions pharmaceutiques a base d'une benzo (c) (1,6) naphtyridine |
-
1985
- 1985-03-13 US US06/711,327 patent/US4652567A/en not_active Expired - Lifetime
-
1986
- 1986-03-07 DE DE8686103085T patent/DE3671017D1/de not_active Expired - Fee Related
- 1986-03-07 EP EP86103085A patent/EP0197318B1/en not_active Expired - Lifetime
- 1986-03-07 AT AT86103085T patent/ATE52510T1/de not_active IP Right Cessation
- 1986-03-11 HU HU885579A patent/HU201756B/hu not_active IP Right Cessation
- 1986-03-11 ES ES552874A patent/ES8707528A1/es not_active Expired
- 1986-03-11 FI FI861001A patent/FI861001A7/fi not_active Application Discontinuation
- 1986-03-11 CA CA000503758A patent/CA1248108A/en not_active Expired
- 1986-03-11 IL IL78117A patent/IL78117A0/xx unknown
- 1986-03-11 NZ NZ215439A patent/NZ215439A/xx unknown
- 1986-03-11 PH PH33508A patent/PH22279A/en unknown
- 1986-03-11 HU HU861028A patent/HU197007B/hu not_active IP Right Cessation
- 1986-03-12 NO NO860933A patent/NO163489B/no unknown
- 1986-03-12 GR GR860681A patent/GR860681B/el unknown
- 1986-03-12 AU AU54658/86A patent/AU590748B2/en not_active Ceased
- 1986-03-12 JP JP61052750A patent/JPS61212585A/ja active Pending
- 1986-03-12 DK DK114386A patent/DK114386A/da not_active Application Discontinuation
- 1986-03-12 ZA ZA861837A patent/ZA861837B/xx unknown
- 1986-03-13 PT PT82187A patent/PT82187B/pt unknown
- 1986-03-13 KR KR1019860001804A patent/KR860007255A/ko not_active Ceased
- 1986-11-17 ES ES557208A patent/ES8800941A1/es not_active Expired
- 1986-11-17 ES ES557207A patent/ES8801269A1/es not_active Expired
-
1987
- 1987-10-15 ES ES557768A patent/ES8801270A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| HU201756B (en) | 1990-12-28 |
| HUT40658A (en) | 1987-01-28 |
| CA1248108A (en) | 1989-01-03 |
| ES557208A0 (es) | 1987-12-01 |
| IL78117A0 (en) | 1986-07-31 |
| US4652567A (en) | 1987-03-24 |
| NZ215439A (en) | 1990-03-27 |
| AU5465886A (en) | 1986-09-18 |
| DK114386A (da) | 1986-09-14 |
| DE3671017D1 (de) | 1990-06-13 |
| HU197007B (en) | 1989-02-28 |
| ATE52510T1 (de) | 1990-05-15 |
| ES8800941A1 (es) | 1987-12-01 |
| NO163489B (no) | 1990-02-26 |
| ES557207A0 (es) | 1988-01-01 |
| ES8707528A1 (es) | 1987-08-01 |
| FI861001A7 (fi) | 1986-09-14 |
| DK114386D0 (da) | 1986-03-12 |
| KR860007255A (ko) | 1986-10-10 |
| EP0197318A1 (en) | 1986-10-15 |
| AU590748B2 (en) | 1989-11-16 |
| PT82187B (en) | 1988-01-07 |
| ZA861837B (en) | 1987-06-24 |
| ES8801270A1 (es) | 1988-01-01 |
| NO860933L (no) | 1986-09-15 |
| EP0197318B1 (en) | 1990-05-09 |
| JPS61212585A (ja) | 1986-09-20 |
| GR860681B (en) | 1986-07-14 |
| ES557768A0 (es) | 1988-01-01 |
| FI861001A0 (fi) | 1986-03-11 |
| PT82187A (en) | 1986-04-01 |
| PH22279A (en) | 1988-07-14 |
| ES552874A0 (es) | 1987-08-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |
Effective date: 19960401 |