FR2273533A1 - Nouveaux derives n-substitues d'acides pyrrolidones-2 carboxyliques-5 - Google Patents
Nouveaux derives n-substitues d'acides pyrrolidones-2 carboxyliques-5Info
- Publication number
- FR2273533A1 FR2273533A1 FR7419152A FR7419152A FR2273533A1 FR 2273533 A1 FR2273533 A1 FR 2273533A1 FR 7419152 A FR7419152 A FR 7419152A FR 7419152 A FR7419152 A FR 7419152A FR 2273533 A1 FR2273533 A1 FR 2273533A1
- Authority
- FR
- France
- Prior art keywords
- normolipemics
- substd
- carboxylic acid
- analgesics
- pyrrolidone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229940035676 analgesics Drugs 0.000 title 1
- 239000000730 antalgic agent Substances 0.000 title 1
- 229940125692 cardiovascular agent Drugs 0.000 title 1
- 239000002327 cardiovascular agent Substances 0.000 title 1
- 229940125723 sedative agent Drugs 0.000 title 1
- 239000000932 sedative agent Substances 0.000 title 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- VSZPIIMZVZQSKS-UHFFFAOYSA-N 2-aminochromen-4-one Chemical compound C1=CC=C2OC(N)=CC(=O)C2=C1 VSZPIIMZVZQSKS-UHFFFAOYSA-N 0.000 abstract 1
- PXPNSQMWVPLERM-UHFFFAOYSA-N 2-methylchromen-4-one Chemical compound C1=CC=C2OC(C)=CC(=O)C2=C1 PXPNSQMWVPLERM-UHFFFAOYSA-N 0.000 abstract 1
- 101100134922 Gallus gallus COR5 gene Proteins 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000005792 cardiovascular activity Effects 0.000 abstract 1
- 125000004617 chromonyl group Chemical group O1C(=CC(C2=CC=CC=C12)=O)* 0.000 abstract 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7419152A FR2273533A1 (fr) | 1974-06-04 | 1974-06-04 | Nouveaux derives n-substitues d'acides pyrrolidones-2 carboxyliques-5 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7419152A FR2273533A1 (fr) | 1974-06-04 | 1974-06-04 | Nouveaux derives n-substitues d'acides pyrrolidones-2 carboxyliques-5 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2273533A1 true FR2273533A1 (fr) | 1976-01-02 |
Family
ID=9139572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7419152A Withdrawn FR2273533A1 (fr) | 1974-06-04 | 1974-06-04 | Nouveaux derives n-substitues d'acides pyrrolidones-2 carboxyliques-5 |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2273533A1 (fr) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4652567A (en) * | 1985-03-13 | 1987-03-24 | Hoechst-Roussel Pharmaceuticals Inc. | Benzo(c)-1,5-naphthyridines useful for treating a patient having drug induced memory impairment in need of memory enhancement |
| US4742061A (en) * | 1985-03-13 | 1988-05-03 | Hoechst-Roussel Pharmaceuticals Inc. | Benzoc[c]-1,5-naphthyridines and related compounds as memory enhancing agents |
| EP0325984A3 (fr) * | 1988-01-25 | 1991-01-02 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-/4-(1-pyrolidinyl)-2-butynyl/-2-pyrrolidones 5-substituées et ses dérivés, procédé pour leur préparation et leur utilisation comme médicaments |
| WO2008003697A1 (fr) * | 2006-07-06 | 2008-01-10 | Glaxo Group Limited | N-phenylmethyl -5-oxo-proline-2-amides substitués tenant lieu d'antagonistes du récepteur p2x7 et procédés d'utilisation |
| WO2019185868A1 (fr) * | 2018-03-29 | 2019-10-03 | Centre National De La Recherche Scientifique | Modulateurs p2rx7 utilisés en thérapie |
-
1974
- 1974-06-04 FR FR7419152A patent/FR2273533A1/fr not_active Withdrawn
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4652567A (en) * | 1985-03-13 | 1987-03-24 | Hoechst-Roussel Pharmaceuticals Inc. | Benzo(c)-1,5-naphthyridines useful for treating a patient having drug induced memory impairment in need of memory enhancement |
| US4742061A (en) * | 1985-03-13 | 1988-05-03 | Hoechst-Roussel Pharmaceuticals Inc. | Benzoc[c]-1,5-naphthyridines and related compounds as memory enhancing agents |
| EP0325984A3 (fr) * | 1988-01-25 | 1991-01-02 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-/4-(1-pyrolidinyl)-2-butynyl/-2-pyrrolidones 5-substituées et ses dérivés, procédé pour leur préparation et leur utilisation comme médicaments |
| WO2008003697A1 (fr) * | 2006-07-06 | 2008-01-10 | Glaxo Group Limited | N-phenylmethyl -5-oxo-proline-2-amides substitués tenant lieu d'antagonistes du récepteur p2x7 et procédés d'utilisation |
| JP2009542595A (ja) * | 2006-07-06 | 2009-12-03 | グラクソ グループ リミテッド | Ｐ２ｘ７受容体アンタゴニストとしての置換ｎ−フェニルメチル−５−オキソ−プロリン−２−アミドおよびそれらの使用方法 |
| US7718693B2 (en) | 2006-07-06 | 2010-05-18 | Glaxo Group Limited | Receptor antagonists and their methods of use |
| US8048907B2 (en) | 2006-07-06 | 2011-11-01 | Glaxo Group Limited | Receptor antagonists and their methods of use |
| EA016076B1 (ru) * | 2006-07-06 | 2012-01-30 | Глэксо Груп Лимитед | Замещенные n-фенилметил-5-оксопролин-2-амиды в качестве антагонистов р2х7-рецептора и способы их применения |
| AU2007271182B2 (en) * | 2006-07-06 | 2012-03-15 | Glaxo Group Limited | Substituted N-phenylmethyl -5-oxo-proline-2-amides as P2X7-receptor antagonists and their methods of use |
| WO2019185868A1 (fr) * | 2018-03-29 | 2019-10-03 | Centre National De La Recherche Scientifique | Modulateurs p2rx7 utilisés en thérapie |
| CN112512520A (zh) * | 2018-03-29 | 2021-03-16 | 国家科学研究中心 | 治疗中的p2rx7调节剂 |
| JP2021520405A (ja) * | 2018-03-29 | 2021-08-19 | サントル ナショナル ドゥ ラ ルシェルシュ シアンティフィック | 療法におけるｐ２ｒｘ７モジュレーター |
| CN112512520B (zh) * | 2018-03-29 | 2023-10-24 | 国家科学研究中心 | 治疗中的p2rx7调节剂 |
| IL277602B1 (en) * | 2018-03-29 | 2024-02-01 | Centre Nat Rech Scient | P2rx7 modulators in therapy |
| US11919854B2 (en) | 2018-03-29 | 2024-03-05 | Centre National De La Recherche Scientifique | P2RX7 modulators in therapy |
| IL277602B2 (en) * | 2018-03-29 | 2024-06-01 | Centre Nat Rech Scient | P2RX7 modulators in therapy |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |