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ES8800949A1 - Chemical compounds - Google Patents

Chemical compounds

Info

Publication number
ES8800949A1
ES8800949A1 ES557060A ES557060A ES8800949A1 ES 8800949 A1 ES8800949 A1 ES 8800949A1 ES 557060 A ES557060 A ES 557060A ES 557060 A ES557060 A ES 557060A ES 8800949 A1 ES8800949 A1 ES 8800949A1
Authority
ES
Spain
Prior art keywords
chemical compounds
processes
image
quaternaryammonio
iminoacetamido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557060A
Other languages
Spanish (es)
Other versions
ES557060A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES8800949A1 publication Critical patent/ES8800949A1/en
Publication of ES557060A0 publication Critical patent/ES557060A0/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/79—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

7-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(substituted)-iminoacetamido]-3 -[3-(quaternaryammonio)-1 - propen-1-yl]-3-cephem-4-carboxylates of the formula < IMAGE > in which R<1> and R<2> are as defined herein and < IMAGE > is a quaternary ammonio group as defined herein, and salts, solvates, hydrates and esters thereof, are potent antibacterial agents. Processes for their preparation and intermediates in such processes are described.
ES557060A 1984-04-09 1986-09-10 Chemical compounds Expired ES8800949A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59794184A 1984-04-09 1984-04-09

Publications (2)

Publication Number Publication Date
ES8800949A1 true ES8800949A1 (en) 1987-12-01
ES557060A0 ES557060A0 (en) 1987-12-01

Family

ID=24393575

Family Applications (4)

Application Number Title Priority Date Filing Date
ES542013A Expired ES8607318A1 (en) 1984-04-09 1985-04-08 Chemical compounds
ES551550A Expired ES8706155A1 (en) 1984-04-09 1986-01-31 Chemical compounds
ES551551A Expired ES8706694A1 (en) 1984-04-09 1986-01-31 Chemical compounds
ES557060A Expired ES8800949A1 (en) 1984-04-09 1986-09-10 Chemical compounds

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES542013A Expired ES8607318A1 (en) 1984-04-09 1985-04-08 Chemical compounds
ES551550A Expired ES8706155A1 (en) 1984-04-09 1986-01-31 Chemical compounds
ES551551A Expired ES8706694A1 (en) 1984-04-09 1986-01-31 Chemical compounds

Country Status (31)

Country Link
JP (4) JPS615084A (en)
KR (1) KR870002166B1 (en)
AR (1) AR244694A1 (en)
AT (1) AT388735B (en)
AU (2) AU580990B2 (en)
BE (1) BE902148A (en)
CA (3) CA1276929C (en)
CH (1) CH669197A5 (en)
DD (3) DD249024A5 (en)
DE (1) DE3512225A1 (en)
DK (1) DK155985A (en)
ES (4) ES8607318A1 (en)
FI (1) FI84830C (en)
FR (1) FR2563832B1 (en)
GB (3) GB2157293B (en)
GR (1) GR850883B (en)
HU (2) HU193750B (en)
IE (2) IE58408B1 (en)
IL (1) IL74826A (en)
IT (1) IT1190353B (en)
LU (1) LU85840A1 (en)
MY (1) MY101940A (en)
NL (1) NL192925C (en)
NZ (1) NZ211659A (en)
OA (1) OA07985A (en)
PT (1) PT80246B (en)
RU (1) RU2056425C1 (en)
SE (4) SE466205B (en)
SU (4) SU1367858A3 (en)
YU (2) YU46151B (en)
ZA (1) ZA852236B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61145186A (en) * 1984-12-20 1986-07-02 Meiji Seika Kaisha Ltd Novel cephem compound and preparation thereof
US4708955A (en) * 1985-06-24 1987-11-24 Bristol-Myers Company 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof
ATE114657T1 (en) * 1985-12-26 1994-12-15 Eisai Co Ltd CEPHALOSPORIN COMPOUNDS.
AU614723B2 (en) * 1986-10-13 1991-09-12 Eisai Co. Ltd. 3-propenylcephem derivative
IL84128A (en) * 1986-10-13 1992-12-01 Eisai Co Ltd 3-propenylcephem derivatives, their preparation and pharmaceutical compositions containing them
JPH085897B2 (en) * 1986-11-06 1996-01-24 エーザイ株式会社 3-propenyl cephem derivative
FR2622585B1 (en) * 1987-11-03 1991-04-19 Roussel Uclaf NOVEL CEPHALOSPORINS COMPRISING IN POSITION 3 A SUBSTITUTED VINYL RADICAL, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS, THE COMPOSITIONS CONTAINING THEM AND THE NEW INTERMEDIATES OBTAINED
JPH0699449B2 (en) * 1988-03-16 1994-12-07 エーザイ株式会社 Synthetic intermediate of cephem derivative
DE68928174T2 (en) * 1988-03-16 1997-12-18 Eisai Co., Ltd., Tokio/Tokyo Process for the preparation of cephem derivatives
FR2655042B1 (en) * 1989-11-29 1994-01-21 Adir Cie NOVEL SUBSTITUTED BENZOTHIAZOLINONES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2663332B1 (en) * 1990-06-15 1997-11-07 Roussel Uclaf NOVEL CEPHALOSPORINS COMPRISING IN POSITION 3 A RADICAL PROPENYL SUBSTITUTED BY A QUATERNARY AMMONIUM, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS, THE COMPOSITIONS CONTAINING THEM AND THE NEW INTERMEDIATES OBTAINED.
US5126336A (en) * 1990-08-23 1992-06-30 Bristol-Myers Squibb Company Antibiotic c-3 catechol-substituted cephalosporin compounds, compositions and method of use thereof
AT396108B (en) * 1991-08-21 1993-06-25 Biochemie Gmbh NEW PROCESS AND NEW INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF 7-AMINOCEPHALOSPORANIC ACID DERIVATIVES
JPH0741484A (en) * 1993-07-29 1995-02-10 Katayama Seiyakushiyo:Kk Cephem compound and antimicrobial agent
WO1996005205A1 (en) * 1994-08-16 1996-02-22 Meiji Seika Kabushiki Kaisha Novel cephem derivative
ID28433A (en) 1998-06-22 2001-05-24 Hoffmann La Roche PROPENIL SEFALOSPORIN DEPOSITS
CN100398547C (en) 2003-09-09 2008-07-02 日本化学工业株式会社 Process for producing 3-chloromethyl-3-cephem derivatives

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1342241A (en) * 1970-01-23 1974-01-03 Glaxo Lab Ltd Cephalosporin compounds
US4390534A (en) * 1978-12-29 1983-06-28 Fujisawa Pharmaceutical Co., Ltd. Cephem and cepham compounds
EP0025017A1 (en) * 1979-08-28 1981-03-11 Ciba-Geigy Ag Polyazathia compounds, process for their preparation, pharmaceutical preparations containing such compounds and use of the latter
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
GR75644B (en) * 1980-06-18 1984-08-02 Fujisawa Pharmaceutical Co
GR78245B (en) * 1980-09-12 1984-09-26 Ciba Geigy Ag
US4521413A (en) * 1981-09-14 1985-06-04 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4486586A (en) * 1983-02-10 1984-12-04 Bristol-Myers Company Cephalosporin derivatives

Also Published As

Publication number Publication date
ES8607318A1 (en) 1986-06-16
DK155985D0 (en) 1985-04-03
SE8901226L (en) 1989-04-06
FI84830B (en) 1991-10-15
ATA103985A (en) 1989-01-15
DD249024A5 (en) 1987-08-26
KR850007424A (en) 1985-12-04
NZ211659A (en) 1988-11-29
IT1190353B (en) 1988-02-16
GB8508846D0 (en) 1985-05-09
IE58408B1 (en) 1993-09-22
GR850883B (en) 1985-11-25
JPS61143390A (en) 1986-07-01
CH669197A5 (en) 1989-02-28
SE8901225D0 (en) 1989-04-06
YU46151B (en) 1993-05-28
SE8901224L (en) 1989-04-06
JPS61143387A (en) 1986-07-01
SU1487814A3 (en) 1989-06-15
DK155985A (en) 1985-10-10
YU60085A (en) 1987-12-31
SE8901225L (en) 1989-04-06
IE850866L (en) 1985-10-09
KR870002166B1 (en) 1987-12-14
SE8901224D0 (en) 1989-04-06
CA1340672C (en) 1999-07-20
GB8721347D0 (en) 1987-10-14
FI851379L (en) 1985-10-10
FR2563832A1 (en) 1985-11-08
ES551550A0 (en) 1987-06-01
OA07985A (en) 1987-01-31
CA1276929C (en) 1990-11-27
SE470260B (en) 1993-12-20
SU1367858A3 (en) 1988-01-15
SU1375140A3 (en) 1988-02-15
AU580990B2 (en) 1989-02-09
YU118987A (en) 1988-10-31
DD251752A5 (en) 1987-11-25
DE3512225C2 (en) 1990-02-22
ES557060A0 (en) 1987-12-01
GB2194790A (en) 1988-03-16
AU4086285A (en) 1985-10-17
LU85840A1 (en) 1985-12-16
JPH0262557B2 (en) 1990-12-26
CA1340638C (en) 1999-07-06
ES8706694A1 (en) 1987-07-01
NL192925C (en) 1998-05-07
JPH0357106B2 (en) 1991-08-30
ES8706155A1 (en) 1987-06-01
SE505256C2 (en) 1997-07-21
JPS615084A (en) 1986-01-10
AR244694A1 (en) 1993-11-30
GB2194789A (en) 1988-03-16
BE902148A (en) 1985-10-09
GB2157293A (en) 1985-10-23
SU1436882A3 (en) 1988-11-07
PT80246A (en) 1985-05-01
AU610278B2 (en) 1991-05-16
NL192925B (en) 1998-01-05
IL74826A (en) 1990-01-18
AT388735B (en) 1989-08-25
RU2056425C1 (en) 1996-03-20
GB2194790B (en) 1988-10-05
SE8501680D0 (en) 1985-04-03
DD236735A5 (en) 1986-06-18
ES551551A0 (en) 1987-07-01
FI84830C (en) 1992-01-27
IT8520267A0 (en) 1985-04-05
IL74826A0 (en) 1985-07-31
GB2157293B (en) 1988-10-05
YU46213B (en) 1993-05-28
PT80246B (en) 1987-10-20
HUT37622A (en) 1986-01-23
MY101940A (en) 1992-02-15
SE8901226D0 (en) 1989-04-06
SE8501680L (en) 1985-10-10
ZA852236B (en) 1985-11-27
JPH0351716B2 (en) 1991-08-07
GB8721346D0 (en) 1987-10-14
HU204277B (en) 1991-12-30
NL8501002A (en) 1985-11-01
SE466205B (en) 1992-01-13
JPS61143391A (en) 1986-07-01
IE58403B1 (en) 1993-09-22
SE470259B (en) 1993-12-20
AU2504188A (en) 1989-03-02
HU193750B (en) 1987-11-30
DE3512225A1 (en) 1985-10-17
JPH0350754B2 (en) 1991-08-02
FI851379A0 (en) 1985-04-04
ES542013A0 (en) 1986-06-16
GB2194789B (en) 1988-10-12
FR2563832B1 (en) 1989-08-18

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20070711