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ES8609352A1 - Un procedimiento para preparar una substancia antibiotica glicopeptidica de la clase de vancomicina. - Google Patents

Un procedimiento para preparar una substancia antibiotica glicopeptidica de la clase de vancomicina.

Info

Publication number
ES8609352A1
ES8609352A1 ES547766A ES547766A ES8609352A1 ES 8609352 A1 ES8609352 A1 ES 8609352A1 ES 547766 A ES547766 A ES 547766A ES 547766 A ES547766 A ES 547766A ES 8609352 A1 ES8609352 A1 ES 8609352A1
Authority
ES
Spain
Prior art keywords
preparing
procedure
antibiotic
filtration
conditions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES547766A
Other languages
English (en)
Other versions
ES547766A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Gruppo Lepetit SpA
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruppo Lepetit SpA, Lepetit SpA filed Critical Gruppo Lepetit SpA
Publication of ES547766A0 publication Critical patent/ES547766A0/es
Publication of ES8609352A1 publication Critical patent/ES8609352A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/03—Actinomadura

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

METODO DE PREPARACION DE SUSTANCIAS ANTIBIOTICAS GLICOPEPTIDICAS DE LA CLASE DE LA VANCOMICINA, CONSTITUIDAS POR UN COMPLEJO ANTIBIOTICO A Y DE SUS SALES DE ADICION. CONSISTE EN EL CULTIVO DE LA CEPA ACTINOMADURA SP2 ATCC 39727, UNO DE SUS MUTANTES O VARIANTES PRODUCTORES DE ANTIBIOTICO A 40926 EN UN MEDIO QUE CONTIENE FUENTES ASIMILABLES DE CARBONO, NITROGENO Y SALES INORGANICAS, EN CONDICIONES AEROBIAS SUMERGIDAS, A UNA TEMPERATURA COMPRENDIDA ENTRE 20JC Y 40JC; SEGUIDO DE SEPARACION POR ALCALINIZACION A PH ENTRE 8,5 Y 10,5. FILTRACION, ACIDIFICACION DEL FILTRADO HASTA PH 2,5-4,5 Y FILTRACION; Y PURIFICACION MEDIANTE CROMATOGRAFIA DE AFINIDAD SOBRE D-ALANIL-D-ALANINA INMOVILIZADA, DE REPARTO, DE FASE INVERSA O DE INTERCAMBIO IONICO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES INFECCIOSAS.
ES547766A 1984-10-11 1985-10-10 Un procedimiento para preparar una substancia antibiotica glicopeptidica de la clase de vancomicina. Expired ES8609352A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848425685A GB8425685D0 (en) 1984-10-11 1984-10-11 Antibiotic a 40926 complex

Publications (2)

Publication Number Publication Date
ES547766A0 ES547766A0 (es) 1986-09-01
ES8609352A1 true ES8609352A1 (es) 1986-09-01

Family

ID=10568022

Family Applications (1)

Application Number Title Priority Date Filing Date
ES547766A Expired ES8609352A1 (es) 1984-10-11 1985-10-10 Un procedimiento para preparar una substancia antibiotica glicopeptidica de la clase de vancomicina.

Country Status (22)

Country Link
US (1) US4935238A (es)
EP (1) EP0177882B1 (es)
JP (2) JPH0637508B2 (es)
KR (1) KR940009280B1 (es)
AT (1) ATE49215T1 (es)
AU (1) AU599308B2 (es)
CA (1) CA1317900C (es)
DE (1) DE3575145D1 (es)
DK (1) DK161092C (es)
ES (1) ES8609352A1 (es)
FI (1) FI81117C (es)
GB (1) GB8425685D0 (es)
GR (1) GR852442B (es)
HU (1) HU194317B (es)
IE (1) IE58708B1 (es)
IL (1) IL76596A (es)
MY (1) MY100880A (es)
NO (1) NO164111C (es)
NZ (1) NZ213775A (es)
PH (1) PH23013A (es)
PT (1) PT81288B (es)
ZA (1) ZA857697B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8531846D0 (en) * 1985-12-30 1986-02-05 Lepetit Spa Antibiotic a 40926 mannosyl aglycon
GB8608809D0 (en) * 1986-04-11 1986-05-14 Lepetit Spa Antibiotic
GB8608798D0 (en) * 1986-04-11 1986-05-14 Lepetit Spa Recovery of glycopeptide antibiotics from aqueous solutions
DK363587A (da) * 1986-07-30 1988-01-31 Smithkline Beckman Corp Antibiotika og fremstilling heraf under anvendelseaf actinomadura parvosata
GB8621912D0 (en) * 1986-09-11 1986-10-15 Lepetit Spa Increasing ratio of components of anti-biotic complex
GR871488B (en) * 1986-10-10 1987-11-12 Lepetit Spa New antibiotics
US5135857A (en) * 1987-07-03 1992-08-04 Gruppo Lepetit S.P.A. Process for the preparation of de-mannosyl teicoplanin derivatives
PH27266A (en) * 1989-03-14 1993-05-04 Fujisawa Pharmaceutical Co WS7622, A,B,C and D substances and pharmaceutical composition containing same
HUT63860A (en) * 1990-12-05 1993-10-28 Lepetit Spa Process for producing 39-decarboxy-38-(hydroxymethyl) derivatives of teikoplanin antibiotics
US5606036A (en) * 1991-03-27 1997-02-25 Gruppo Lepetit Spa Antibiotic A 40926 ester derivatives
ES2095459T3 (es) 1991-03-27 1997-02-16 Lepetit Spa Derivados ester del antibiotico a 40926.
US5750509A (en) * 1991-07-29 1998-05-12 Gruppo Lepetit S.P.A. Amide derivatives of antibiotic A 40926
US5939523A (en) * 1995-07-05 1999-08-17 Gruppo Lepetit Spa Purification of dalbaheptide antibiotics by isoelectric focusing
CA2250578C (en) 1996-04-23 2003-06-24 Versicor Inc. Improved chemical process for preparing amide derivatives of antibiotic a 40926
RU2124895C1 (ru) * 1998-05-28 1999-01-20 Головкина Любовь Павловна Противопаразитарная мазь "авермектиновая"
EP1413626A1 (en) * 2002-10-23 2004-04-28 Vicuron Pharmaceuticals, Inc. Genes and proteins for the biosynthesis of the glycopeptide antibiotic A40926
US20060074014A1 (en) * 2002-11-18 2006-04-06 Vicuron Pharmaceuticals Inc. Dalbavancin compositions for treatment of bacterial infections
WO2004045637A1 (en) * 2002-11-18 2004-06-03 Vicuron Pharmaceuticals Inc. Dalbavancin compositions for treatment of bacterial infections
US7119061B2 (en) 2002-11-18 2006-10-10 Vicuron Pharmaceuticals, Inc. Dalbavancin compositions for treatment of bacterial infections
CN110183519B (zh) * 2019-05-06 2023-04-11 大邦(湖南)生物制药有限公司 一种达巴万星关键中间体a40926的分离纯化方法
CN110156876A (zh) * 2019-05-25 2019-08-23 聊城大学 一种适合工业化生产的高纯度a40926b0制备方法
BR112021024417A2 (pt) * 2019-06-13 2022-01-18 Regeneron Pharma Métodos para remoção de componentes indesejados durante processos cromatográficos de múltiplos estágios
CN110940763B (zh) * 2019-12-19 2022-07-26 宜昌东阳光生化制药有限公司 分离纯化达巴万星前体a40926的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4195079A (en) * 1979-01-31 1980-03-25 Pfizer Inc. New polycyclic ether antibiotic
CA1183789A (en) * 1981-08-04 1985-03-12 Kiyoshi Isono Antibiotic 76-11, process for the production thereof, anticoccidiosis agent and domestic animals growth accelerator comprising the same as an effective ingredient
US4578271A (en) * 1982-05-24 1986-03-25 Fujisawa Pharmaceutical Co., Ltd. Biologically active WS 6049 substances, a process for the production thereof and their pharmaceutical compositions
GR78648B (es) * 1982-07-26 1984-09-27 Bristol Myers Co

Also Published As

Publication number Publication date
GB8425685D0 (en) 1984-11-14
IL76596A (en) 1992-05-25
JPH06225757A (ja) 1994-08-16
DK161092C (da) 1991-11-18
NO164111B (no) 1990-05-21
IE58708B1 (en) 1993-11-03
PH23013A (en) 1989-03-03
DE3575145D1 (de) 1990-02-08
ES547766A0 (es) 1986-09-01
AU599308B2 (en) 1990-07-19
EP0177882B1 (en) 1990-01-03
FI853914A0 (fi) 1985-10-08
FI81117C (fi) 1990-09-10
FI853914L (fi) 1986-04-12
JP2572937B2 (ja) 1997-01-16
KR860003342A (ko) 1986-05-23
NO164111C (no) 1990-08-29
JPH0637508B2 (ja) 1994-05-18
PT81288B (pt) 1987-10-20
MY100880A (en) 1991-05-16
NZ213775A (en) 1989-03-29
DK161092B (da) 1991-05-27
IE852489L (en) 1986-04-11
HUT39480A (en) 1986-09-29
HU194317B (en) 1988-01-28
AU4819585A (en) 1986-04-17
DK457385D0 (da) 1985-10-08
EP0177882A2 (en) 1986-04-16
NO854018L (no) 1986-04-14
DK457385A (da) 1986-04-12
ATE49215T1 (de) 1990-01-15
FI81117B (fi) 1990-05-31
CA1317900C (en) 1993-05-18
ZA857697B (en) 1986-07-30
PT81288A (en) 1985-11-01
EP0177882A3 (en) 1987-05-27
KR940009280B1 (ko) 1994-10-06
US4935238A (en) 1990-06-19
JPS61148188A (ja) 1986-07-05
GR852442B (es) 1986-02-03
IL76596A0 (en) 1986-02-28

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20050418