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ES8606373A1 - Procedimiento para la preparacion de derivados de esfingosina - Google Patents

Procedimiento para la preparacion de derivados de esfingosina

Info

Publication number
ES8606373A1
ES8606373A1 ES548901A ES548901A ES8606373A1 ES 8606373 A1 ES8606373 A1 ES 8606373A1 ES 548901 A ES548901 A ES 548901A ES 548901 A ES548901 A ES 548901A ES 8606373 A1 ES8606373 A1 ES 8606373A1
Authority
ES
Spain
Prior art keywords
formula
group
procedure
esterification
separation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES548901A
Other languages
English (en)
Other versions
ES548901A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ICN Switzerland AG
Original Assignee
Solco Basel AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH6493/83A external-priority patent/CH679209A5/de
Application filed by Solco Basel AG filed Critical Solco Basel AG
Publication of ES8606373A1 publication Critical patent/ES8606373A1/es
Publication of ES548901A0 publication Critical patent/ES548901A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ESFINGOSINA, DE FORMULA (I), EN LA QUE R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES. COMPRENDE LA REACCION DE UN COMPUESTO RACEMICO DE FORMULA (II) O (III), EN LAS QUE R1 Y R2 TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I), CON UN REACTIVO ORGANICO SELECTIVO DEL GRUPO HIDROXILICO PRIMARIOI, QUE INTRODUZCA EL GRUPO PROTECTOR R; ESTERIFICACION DEL COMPUESTO RESULTANTE CON UN ACIDO CARBOXILICO, OPTICAMENTE ACTIVO Y SEPARAR LOS DIASTEREOMEROS. DESACILACION DEL DIASTEREOMERO D, ESTERIFICACION PARA FORMAR ENANTIOMEROS Y LIBERACION DEL GRUPO R; REACCION DEL COMPUESTO OBTENIDO CON O-TRIFLUORO U O-TRICLORO-ACETAMIDATO DE UNA D-GLUCOSA CON LOS HIDROXILOS 2,3,4 Y 6 PROTEGIDOS; Y SEPARACION DE LOS GRUPOS PROTECTORES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE HERIDAS O ULCERACIONES DE CURACION DIFICIL O LENTA.
ES548901A 1983-12-05 1985-11-02 Procedimiento para la preparacion de derivados de esfingosina Expired ES8606373A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH6493/83A CH679209A5 (en) 1983-12-05 1983-12-05 New neutral glyco-sphingolipid derivs.
CH467184 1984-09-28

Publications (2)

Publication Number Publication Date
ES8606373A1 true ES8606373A1 (es) 1986-04-16
ES548901A0 ES548901A0 (es) 1986-04-16

Family

ID=25696036

Family Applications (2)

Application Number Title Priority Date Filing Date
ES538231A Expired ES8604986A1 (es) 1983-12-05 1984-12-04 Procedimiento para la preparacion de derivado de esfingosina.
ES548901A Expired ES8606373A1 (es) 1983-12-05 1985-11-02 Procedimiento para la preparacion de derivados de esfingosina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES538231A Expired ES8604986A1 (es) 1983-12-05 1984-12-04 Procedimiento para la preparacion de derivado de esfingosina.

Country Status (11)

Country Link
US (1) US4952683A (es)
EP (1) EP0146810A3 (es)
AU (1) AU570087B2 (es)
CA (1) CA1259610A (es)
DK (1) DK573384A (es)
ES (2) ES8604986A1 (es)
FI (1) FI844775L (es)
HU (1) HU195516B (es)
NO (1) NO844815L (es)
PL (1) PL143901B1 (es)
YU (2) YU202784A (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1199116B (it) * 1984-07-03 1988-12-30 Fidia Farmaceutici Derivati di gangliosidi
DK17885D0 (da) * 1985-01-14 1985-01-14 Karlsson Karl Anders Antiviralt middel
ATE71104T1 (de) * 1985-08-13 1992-01-15 Solco Basel Ag Neues verfahren zur herstellung von sphingosinderivaten.
US4769362A (en) * 1985-10-01 1988-09-06 Trustees Of Boston University Increased vascular perfusion following administration of lipids
JPH07116209B2 (ja) * 1986-04-11 1995-12-13 メクト株式会社 シアロシルセラミド類及びその製造方法
EP0255717A3 (en) * 1986-08-06 1990-12-05 Mect Corporation Ganglioside related compounds and method of producing the same
EP0299201A3 (de) * 1987-06-12 1990-08-22 Wilhelm Dr. Hoerrmann Fett-Aminoalkohol enthaltendes Arzneimittel
DE3852526D1 (de) * 1987-06-26 1995-02-02 Solco Basel Ag Neue pharmazeutische Präparate sowie neue Lactosylverbindungen und ihre Herstellung.
US4957741A (en) * 1988-08-02 1990-09-18 Angio-Medical Corp. Method for the treatment of gastric ulcer
US5066496A (en) * 1988-08-03 1991-11-19 Angio-Medical Corporation Composition and method for treatment of gastric and duodenal ulcers and mucosal erosions
IT1235162B (it) * 1988-12-02 1992-06-22 Fidia Farmaceutici Derivati di lisosfingolipidi
DE3916072A1 (de) * 1989-05-17 1990-11-22 Thera Ges Fuer Patente Ceramidderivate und ihre verwendung als inhibitoren der sphingolipidsynthese
DE4102817A1 (de) * 1991-01-31 1992-08-06 Merck Patent Gmbh Verfahren zur stereoselektiven herstellung von (beta)-fucopyranosyl-phosphaten und sehr reiner gdp-fucose
US5936076A (en) * 1991-08-29 1999-08-10 Kirin Beer Kabushiki Kaisha αgalactosylceramide derivatives
TW261533B (es) * 1992-07-16 1995-11-01 Kirin Brewery
EP0666268B1 (en) * 1992-10-22 2000-04-19 Kirin Beer Kabushiki Kaisha Novel sphingoglycolipid and use thereof
CA2160566C (en) * 1993-04-15 2004-07-13 Tatsuo Higa Novel sphingoglycolipids and uses thereof
EP0716589A4 (en) * 1993-07-23 1997-06-11 Morris Herstein COSMETIC COMPOSITION STIMULATING THE RENEWAL OF THE SKIN WITH A PROLONGED IRRITATION ELIMINATION EFFECT
US5663151A (en) * 1994-03-04 1997-09-02 Bristol-Myers Squibb Company Sulfated α-glycolipid derivatives as cell adhesion inhibitors
CA2142153A1 (en) * 1994-03-04 1995-09-05 Jacques Banville Sulfated .beta.-glycolipid derivatives as cell adhesion inhibitors
US5686426A (en) * 1994-11-17 1997-11-11 Bristol-Myers Squibb Company Dicarboxymethylated glycolipid derivatives as cell adhesion inhibitors
WO1996023523A1 (en) * 1995-02-03 1996-08-08 Korea Institute Of Science And Technology Novel hemostatic composition
CA2230738A1 (en) * 1997-03-03 1998-09-03 Hiromichi Ohta Production of optically active sphingoid compound
WO2000017216A1 (fr) 1998-09-21 2000-03-30 Otsuka Pharmaceutical Co., Ltd. Derives de carboxymethylgalactose
US20040180852A1 (en) * 2003-03-10 2004-09-16 Cara-Lynne Schengrund Use of multivalent glycodendrimers to inhibit the activity of human immunodeficiency virus
DE102004025000A1 (de) * 2004-05-21 2005-12-08 Bayer Technology Services Gmbh Verfahren zur Herstellung von chemischen und pharmazeutischen Produkten mit integrierter Mehrsäulen-Chromatographie
CN101460458A (zh) 2006-02-15 2009-06-17 阿勒根公司 具有1－磷酸－鞘氨醇(s1p)受体拮抗剂生物活性的带芳基或者杂芳基基团的吲哚－3－羧酸的酰胺、酯、硫代酰胺和硫羟酸酯化合物
WO2007112322A2 (en) * 2006-03-28 2007-10-04 Allergan, Inc. Indole compounds having sphingosine-1-phosphate (s1p) receptor agonist and/or antagonist biological activity
US7794722B2 (en) * 2006-06-30 2010-09-14 The Scripps Research Institute Adjuvants and methods of use
US8524917B2 (en) * 2007-01-11 2013-09-03 Allergan, Inc. 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
WO2008089015A1 (en) 2007-01-11 2008-07-24 Allergan, Inc. 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (s1p) receptor antagonist biological activity
KR20100067677A (ko) * 2007-09-24 2010-06-21 알러간, 인코포레이티드 스핑고신-1-포스페이트 (ｓｐ1) 생물학적 활성을 갖는 아릴 또는 헤테로아릴 기를 함유하는 인돌 화합물
US8143291B2 (en) 2008-05-09 2012-03-27 Allergan, Inc. Indole compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor biological activity
AU2009282017B2 (en) * 2008-08-12 2014-08-07 Allergan, Inc. Sphingosine-1-phosphate (S1P) receptor antagonists and methods for use thereof
US20120088800A1 (en) 2009-06-30 2012-04-12 Allergan, Inc. 2-(SUBSTITUTED) (ARYLMETHYL, ARYLOXY and ARYLTHIO))-N-(SUBSTITUTED PYRIDIN-2-YL)-2-(SUBSTITUTED ARYL) COMPOUNDS AS SUBTYPE-SELECTIVE MODULATORS OF SPHINGOSINE-1-PHOSPHATE-3 (S1P3) RECEPTORS
US8168795B2 (en) * 2009-08-11 2012-05-01 Allergan, Inc. Selective sphingosine-1-phosphate receptor antagonists
WO2011028927A1 (en) 2009-09-04 2011-03-10 Allergan, Inc. Selective sphingosine-1-phosphate receptor antagonists
MX2012003718A (es) 2009-09-29 2012-06-28 Allergan Inc Compuestos de piridina de anillo condensado como moduladores selectivos de subtipo de receptores de esfingosina-1-fosfato-2 (s1p2).
JP2013512243A (ja) 2009-11-24 2013-04-11 アラーガン インコーポレイテッド 治療的有用性を有する受容体調節物質としての新規化合物
US8741875B2 (en) 2009-11-24 2014-06-03 Allergan, Inc. Compounds as receptor modulators with therapeutic utility
JP2014503501A (ja) 2010-11-22 2014-02-13 アラーガン インコーポレイテッド 治療的有用性を伴う受容体調節因子としての新規化合物
BR112015023558A2 (pt) 2013-03-15 2017-07-18 Cerenis Therapeutics Holding Sa métodos para a síntese de esfingomielinas e dihidroesfingomielinas
US9708354B2 (en) 2013-03-15 2017-07-18 Cerenis Therapeutics Holding Sa Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
EP4281435A1 (en) 2021-01-25 2023-11-29 Carbocode S.A. Method for the production of d-erythro-sphingosine and analogs thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1495548A (en) * 1974-04-16 1977-12-21 Tate & Lyle Ltd Sugar derivative containing vinyl groups and copolymers thereof
US4362720A (en) * 1977-04-14 1982-12-07 Chembiomed Ltd. Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-deoxyglycosides from glycals

Also Published As

Publication number Publication date
CA1259610A (en) 1989-09-19
NO844815L (no) 1985-06-06
FI844775A7 (fi) 1985-06-06
AU3628684A (en) 1985-06-13
AU570087B2 (en) 1988-03-03
YU202784A (en) 1987-02-28
PL250710A1 (en) 1985-07-16
EP0146810A2 (de) 1985-07-03
EP0146810A3 (de) 1987-05-13
ES538231A0 (es) 1986-03-16
HU195516B (en) 1988-05-30
ES8604986A1 (es) 1986-03-16
YU189686A (en) 1987-12-31
HUT36833A (en) 1985-10-28
US4952683A (en) 1990-08-28
DK573384D0 (da) 1984-12-03
DK573384A (da) 1985-06-06
FI844775L (fi) 1985-06-06
ES548901A0 (es) 1986-04-16
FI844775A0 (fi) 1984-12-04
PL143901B1 (en) 1988-03-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203