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ES8605514A1 - Procedimiento para preparar nuevas 8 a-acilaminoergolinas - Google Patents

Procedimiento para preparar nuevas 8 a-acilaminoergolinas

Info

Publication number
ES8605514A1
ES8605514A1 ES539511A ES539511A ES8605514A1 ES 8605514 A1 ES8605514 A1 ES 8605514A1 ES 539511 A ES539511 A ES 539511A ES 539511 A ES539511 A ES 539511A ES 8605514 A1 ES8605514 A1 ES 8605514A1
Authority
ES
Spain
Prior art keywords
formula
compound
acylaminoergolines
alpha
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES539511A
Other languages
English (en)
Other versions
ES539511A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES8605514A1 publication Critical patent/ES8605514A1/es
Publication of ES539511A0 publication Critical patent/ES539511A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVAS 8A-ACILAMINOERGOLINAS. COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II) EN PRESENCIA DE TRIETILAMINA CON UN COMPUESTO DE FORMULA (III), PARA OBTENER UN COMPUESTO DE FORMULA (I); B) SOMETER UN COMPUESTO DE FORMULA (I), DONDE R2 SIGNIFICA HIDROGENO, A UNA CLORACION O BROMACION, EN PRESENCIA DE TETRAHIDROFURANO, PARA PRODUCIR EL COMPUESTO DE FORMULA (I) CORRESPONDIENTE EN LA QUE R2 SIGNIFICA UN ATOMO DE CLORO O DE BROMO; C) SE N(ALQUILA C1-C4) UN COMPUESTO DE FORMULA (I), EN PRESENCIA DE DIMETILSULFOXIDO E HIDROXIDO POTASICO, EN LA QUE R1 SIGNIFICA HIDROGENO, PARA PRODUCIR UN COMPUESTO DE FORMULA (I) CORRESPONDIENTE EN LA QUE R1 SIGNIFICA ALQUILO C1-C4; Y SE RECUPERA EL COMPUESTO DE FORMULA (I) BAJO LA FORMA DE BASE LIBRE O BAJO LA FORMA DE SU SAL DE ADICION DE UN ACIDO. SIENDO: R1, H O ALQUILO DE C 1 A 4; R2, H, CLORO, BROMO O METILO; R3, ALQUILO DE C 1 A 5, ALQUILENO DE C 3 A 5; R4, ALQUILO DE C 3 A 7, CICLOALQUILO DE C 3 A 7, ADAMANTILO, Y OTROS. SE UTILIZAN COMO DOPAMINERGICOS EN FARMACOLOGIA.
ES539511A 1984-01-12 1985-01-11 Procedimiento para preparar nuevas 8 a-acilaminoergolinas Expired ES8605514A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3400853 1984-01-12

Publications (2)

Publication Number Publication Date
ES8605514A1 true ES8605514A1 (es) 1986-03-16
ES539511A0 ES539511A0 (es) 1986-03-16

Family

ID=6224786

Family Applications (1)

Application Number Title Priority Date Filing Date
ES539511A Expired ES8605514A1 (es) 1984-01-12 1985-01-11 Procedimiento para preparar nuevas 8 a-acilaminoergolinas

Country Status (28)

Country Link
US (2) US4950672A (es)
JP (1) JPH0655739B2 (es)
AT (1) AT391317B (es)
AU (3) AU583489B2 (es)
BE (1) BE901456A (es)
CA (1) CA1245640A (es)
CH (1) CH664568A5 (es)
CY (1) CY1542A (es)
DE (1) DE3500251C2 (es)
DK (1) DK169891B1 (es)
ES (1) ES8605514A1 (es)
FI (1) FI82466C (es)
FR (1) FR2560196B1 (es)
GB (1) GB2152507B (es)
GR (1) GR850065B (es)
HK (1) HK48590A (es)
HU (1) HU197569B (es)
IE (1) IE58228B1 (es)
IL (1) IL74043A (es)
IT (1) IT1214648B (es)
LU (1) LU85725A1 (es)
NL (1) NL193541C (es)
NZ (1) NZ210818A (es)
PH (1) PH23286A (es)
PT (1) PT79818B (es)
SE (1) SE460420B (es)
SG (1) SG32390G (es)
ZA (1) ZA85276B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL193541C (nl) * 1984-01-12 2000-01-04 Novartis Ag 8 Alfa-acylaminoergolinen, werkwijzen voor de bereiding daarvan en preparaten die ze bevatten.
ATE107647T1 (de) * 1984-04-09 1994-07-15 Schering Ag 2-substituierte ergolin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
NL8700046A (nl) * 1986-01-24 1987-08-17 Sandoz Ag 8 alfa-acylaminoergolinen, werkwijzen voor hun bereiding en farmaceutische preparaten die ze bevatten.
US4931447A (en) * 1987-06-15 1990-06-05 Eli Lilly And Company Cycloalkylamides of (8β)-1-alkyl-6-(substituted) ergolines
US4981859A (en) * 1987-06-15 1991-01-01 Cycloalkylamides of (8 beta )-1-alkyl-6-(substituted)ergolines
IT1219652B (it) * 1987-06-23 1990-05-24 Sandoz Ag 8-acilamminoergolina,la sua preparazione e il suo impiego come medicamneto
DE3820159A1 (de) * 1987-06-23 1989-01-05 Sandoz Ag 8(alpha)-acylaminoergolin, seine herstellung und dieses enthaltende arzneimittel
DK338789A (da) * 1988-07-15 1990-01-16 Schering Ag 2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
GB8824744D0 (en) * 1988-10-21 1988-11-30 Erba Carlo Spa Antiemesis ergoline derivatives
DE3915950A1 (de) * 1989-05-12 1990-11-15 Schering Ag 8(alpha)-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel
CA2974113A1 (en) 2015-01-20 2016-07-28 Xoc Pharmaceuticals, Inc. Isoergoline compounds and uses thereof
BR112017015487A2 (pt) 2015-01-20 2018-01-30 Xoc Pharmaceuticals Inc Composto; composição; método de tratamento e/ou prevenção de enxaqueca, als, doença de alzheimer, doença de parkinson, distúrbios extrapirimidais, depressão, náusea, êmese, síndrome das pernas inquietas, insônia, agressão, doença de huntington, doença cardiopulmonar, fibrogênese, hipertensão arterial pulmonar, ansiedade, dependências a drogas, distonia, parassonia ou hiperlactinemia em um indivíduo; métodos de agonização dos receptores d2, 5-ht1d, 5-ht1a e 5-ht2c, em um indivíduo; método de antagonização do receptor d3 em um indivíduo; métodos de agonização seletiva dos receptores 5 -ht1d, e 5-ht2c, método de fornecimento de atividade de antagonista funcional no receptor 5 -ht2b ou no receptor 5-ht7, ou em ambos, em um indivíduo; método de fornecimento de atividade de antagonista funcional nos receptores adrenérgicos em um indivíduo
CA3064274A1 (en) 2017-06-01 2018-12-06 Xoc Pharmaceuticals, Inc. Ergoline derivatives for use in medicine

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3218323A (en) * 1965-11-16 Esters of i,g-dimethyl-b-ergolenyl carbamic acid
US2864822A (en) * 1956-10-22 1958-12-16 Lilly Co Eli 9-amino-7-methyl-belta10-ergolene and derivatives thereof
CH622519A5 (en) * 1974-07-05 1981-04-15 Hoechst Ag Process for the preparation of hydroxyalkylxanthines
US4348392A (en) * 1974-07-19 1982-09-07 Sandoz Ltd. 8α-Substituted ergoline-I derivatives
GB1517973A (en) * 1974-07-19 1978-07-19 Sandoz Ltd 6-methyl-8alpha-n,n-dimethylsulphamoylaminoergoline i
US3922347A (en) * 1974-12-19 1975-11-25 Lilly Co Eli Method of inhibiting prolactin secretion with 8-acylaminoergolenes
CH615929A5 (en) * 1975-06-02 1980-02-29 Sandoz Ag Process for the preparation of novel ergoline compounds
DE2656344A1 (de) * 1975-12-23 1977-07-07 Sandoz Ag Ergolinderivate, ihre verwendung und herstellung
CH622518A5 (en) * 1976-12-14 1981-04-15 Sandoz Ag Process for the preparation of novel ergoline compounds
CH644606A5 (de) * 1980-09-23 1984-08-15 Sandoz Ag Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.
DE3151912A1 (de) * 1981-12-23 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
NL193541C (nl) * 1984-01-12 2000-01-04 Novartis Ag 8 Alfa-acylaminoergolinen, werkwijzen voor de bereiding daarvan en preparaten die ze bevatten.
HU195810B (en) * 1984-12-24 1988-07-28 Sandoz Ag Process for preparing new 8alpha-acyl-amino-ergoline derivatives and pharmaceutical compositions containing such compounds
IT1219652B (it) * 1987-06-23 1990-05-24 Sandoz Ag 8-acilamminoergolina,la sua preparazione e il suo impiego come medicamneto

Also Published As

Publication number Publication date
GB8500454D0 (en) 1985-02-13
GB2152507B (en) 1987-07-15
AU618290B2 (en) 1991-12-19
HUT37148A (en) 1985-11-28
AT391317B (de) 1990-09-25
CY1542A (en) 1991-03-22
SE460420B (sv) 1989-10-09
GR850065B (es) 1985-05-03
AU609539B2 (en) 1991-05-02
ZA85276B (en) 1986-08-27
IL74043A0 (en) 1985-04-30
AU3760985A (en) 1985-07-18
FI850130L (fi) 1985-07-13
HK48590A (en) 1990-06-29
IE850064L (en) 1985-07-12
HU197569B (en) 1989-04-28
SE8500107D0 (sv) 1985-01-10
DK12685D0 (da) 1985-01-10
FI850130A0 (fi) 1985-01-11
JPH0655739B2 (ja) 1994-07-27
DE3500251A1 (de) 1985-07-18
FI82466C (fi) 1991-03-11
SG32390G (en) 1990-08-03
PT79818A (en) 1985-02-01
PT79818B (en) 1987-01-07
IT1214648B (it) 1990-01-18
IE58228B1 (en) 1993-08-11
DK169891B1 (da) 1995-03-27
ATA5985A (de) 1990-03-15
FR2560196A1 (fr) 1985-08-30
NL8500008A (nl) 1985-08-01
DK12685A (da) 1985-07-13
IT8547538A0 (it) 1985-01-11
FI82466B (fi) 1990-11-30
GB2152507A (en) 1985-08-07
AU583489B2 (en) 1989-05-04
CA1245640A (en) 1988-11-29
NL193541B (nl) 1999-09-01
PH23286A (en) 1989-06-30
FR2560196B1 (fr) 1986-07-18
ES539511A0 (es) 1986-03-16
US5077298A (en) 1991-12-31
DE3500251C2 (de) 1995-01-26
AU2506788A (en) 1989-03-02
JPS60174783A (ja) 1985-09-09
SE8500107L (sv) 1985-07-13
AU2506688A (en) 1989-02-23
IL74043A (en) 1988-10-31
US4950672A (en) 1990-08-21
CH664568A5 (de) 1988-03-15
LU85725A1 (fr) 1985-10-22
NZ210818A (en) 1989-02-24
NL193541C (nl) 2000-01-04
BE901456A (fr) 1985-07-08

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20011110