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ES8602761A1 - Un procedimiento para preparar un derivado de primidona - Google Patents

Un procedimiento para preparar un derivado de primidona

Info

Publication number
ES8602761A1
ES8602761A1 ES534452A ES534452A ES8602761A1 ES 8602761 A1 ES8602761 A1 ES 8602761A1 ES 534452 A ES534452 A ES 534452A ES 534452 A ES534452 A ES 534452A ES 8602761 A1 ES8602761 A1 ES 8602761A1
Authority
ES
Spain
Prior art keywords
formula
amino
procedure
solvent
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES534452A
Other languages
English (en)
Other versions
ES534452A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of ES534452A0 publication Critical patent/ES534452A0/es
Publication of ES8602761A1 publication Critical patent/ES8602761A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Luminescent Compositions (AREA)
  • Impact Printers (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Treating Waste Gases (AREA)
  • Steroid Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PIRIMIDONA Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE HAL ES UN ATOMO DE HALOGENO;R5 ES AMINO O DERIVADO DEL MISMO; R6 ES ALQUILENO C1-3; Y R7 PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), O UNA DE SUS SALES, CON UN COMPUESTO DE FORMULA (III), EN LAS QUE R8 ES AMINO O UN GRUPO AMINO PROTEGIDO, R9 ES UN GRUPO DESPLAZABLE CON AMINA Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN AUSENCIA DE DISOLVENTE O EN UN DISOLVENTE INERTE A UNA TEMPERATURA COMPRENDIDA ENTRE 80C Y LA DE EBULLICION DEL DISOLVENTE ELEGIDO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DEL ASMA BRONQUIAL, RINITIS, FIEBRE DEL HENO Y ECZEMAS ALERGICOS.
ES534452A 1983-07-23 1984-07-19 Un procedimiento para preparar un derivado de primidona Expired ES8602761A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838319874A GB8319874D0 (en) 1983-07-23 1983-07-23 Compounds

Publications (2)

Publication Number Publication Date
ES534452A0 ES534452A0 (es) 1985-12-01
ES8602761A1 true ES8602761A1 (es) 1985-12-01

Family

ID=10546171

Family Applications (1)

Application Number Title Priority Date Filing Date
ES534452A Expired ES8602761A1 (es) 1983-07-23 1984-07-19 Un procedimiento para preparar un derivado de primidona

Country Status (23)

Country Link
US (1) US4665078A (es)
EP (1) EP0134091B1 (es)
JP (1) JPS6048986A (es)
KR (1) KR850001194A (es)
AT (1) ATE27818T1 (es)
AU (1) AU3080984A (es)
CS (1) CS244446B2 (es)
DD (1) DD216463A5 (es)
DE (1) DE3464249D1 (es)
DK (1) DK359184A (es)
ES (1) ES8602761A1 (es)
FI (1) FI842907A7 (es)
GB (1) GB8319874D0 (es)
GR (1) GR79961B (es)
HU (1) HUT34745A (es)
IL (1) IL72448A0 (es)
JO (1) JO1326B1 (es)
NO (1) NO842963L (es)
NZ (1) NZ208956A (es)
PL (1) PL248859A1 (es)
PT (1) PT78961A (es)
RO (1) RO89219A (es)
ZA (1) ZA845622B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT78358B (en) * 1983-04-07 1986-05-30 Smith Kline French Lab Chemical process
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
CN1312807A (zh) 1998-06-19 2001-09-12 希龙公司 糖元合成酶激酶3的抑制剂
US10596401B2 (en) 2016-08-11 2020-03-24 Victaulic Company Modular valve assembly
US20180193681A1 (en) 2017-01-06 2018-07-12 Globe Fire Sprinkler Corporation Control valve assembly with test, drain and adjustable pressure relief valve
MX2020010222A (es) 2018-03-29 2021-01-15 Victaulic Co Of America Ensamble de válvula de retención y control de combinación para un sistema de tuberías húmedas.
CA3151291A1 (en) 2019-09-20 2021-03-25 Yoram Ringer Ball valve assembly

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4154834A (en) * 1975-12-29 1979-05-15 Smith Kline & French Laboratories Limited Substituted isocytosines having histamine H2 -antagonist activity
IN151188B (es) * 1978-02-13 1983-03-05 Smith Kline French Lab
ZW21281A1 (en) * 1980-10-01 1981-11-18 Smith Kline French Lab Amine derivatives
PT75074B (en) * 1981-06-27 1986-02-26 Smith Kline French Lab Process for preparing certain pyrimidone derivatives and compositions containing them

Also Published As

Publication number Publication date
KR850001194A (ko) 1985-03-16
DD216463A5 (de) 1984-12-12
AU3080984A (en) 1985-01-24
DE3464249D1 (de) 1987-07-23
HUT34745A (en) 1985-04-28
US4665078A (en) 1987-05-12
FI842907A0 (fi) 1984-07-19
ES534452A0 (es) 1985-12-01
JO1326B1 (en) 1986-11-30
FI842907L (fi) 1985-01-24
ATE27818T1 (de) 1987-07-15
CS557184A2 (en) 1985-08-15
FI842907A7 (fi) 1985-01-24
JPS6048986A (ja) 1985-03-16
EP0134091B1 (en) 1987-06-16
PL248859A1 (en) 1985-07-16
DK359184A (da) 1985-01-24
EP0134091A1 (en) 1985-03-13
GR79961B (es) 1984-10-31
IL72448A0 (en) 1984-11-30
PT78961A (en) 1984-08-01
ZA845622B (en) 1985-07-31
NZ208956A (en) 1987-03-06
RO89219A (ro) 1986-03-15
GB8319874D0 (en) 1983-08-24
CS244446B2 (en) 1986-07-17
NO842963L (no) 1985-01-24
DK359184D0 (da) 1984-07-20

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