ES8305750A1 - "procedimiento de preparacion de nuevas 2-(4-(difenilmetilen)-1-piperidinil)-acetamidas". - Google Patents
"procedimiento de preparacion de nuevas 2-(4-(difenilmetilen)-1-piperidinil)-acetamidas".Info
- Publication number
- ES8305750A1 ES8305750A1 ES513867A ES513867A ES8305750A1 ES 8305750 A1 ES8305750 A1 ES 8305750A1 ES 513867 A ES513867 A ES 513867A ES 513867 A ES513867 A ES 513867A ES 8305750 A1 ES8305750 A1 ES 8305750A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- procedure
- difenilmetilen
- acetamidas
- piperidinil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000000043 antiallergic agent Substances 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 229940125715 antihistaminic agent Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Catching Or Destruction (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 2- 4-(DIFENILMETILEN)-1-PIPERIDINIL -ACETAMIDAS Y DE SUS SALES DE ADICION DE ACIDOS NO TOXICOS FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE X, R Y R PUEDEN SER VARIOS RADICALES; Y M Y N VALEN 0-2 Y 1 O 2, RESPECTIVAMENTE. CONSISTE EN LA REACCION DE UNA 4-(DIFENILMETILEN)PIPERIDINA DE FORMULA (II), CON UNA OMEGA-HALOGENOACETAMIDA DE FORMULA (III), EN LAS QUE Z REPRESENTA UN ATOMO DE HALOGENO Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION TIENE LUGAR EN UN DISOLVENTE INERTE, EN PRESENCIA DE UN ACEPTOR DE ACIDO, A UNA TEMPERATURA COMPRENDIDA ENTRE 80 C Y 150 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIALERGICOS, ANTIHISTAMINICOS, BROCODILATADORES Y ANTIESPASMODICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8030194 | 1980-09-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES513867A0 ES513867A0 (es) | 1983-04-16 |
| ES8305750A1 true ES8305750A1 (es) | 1983-04-16 |
Family
ID=10516149
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES505568A Expired ES8301213A1 (es) | 1980-09-18 | 1981-09-17 | Procedimiento de preparacion de nuevos acidos 2-(4-(difenilmetilen)-1-piperidinil)-aleticos. |
| ES513867A Expired ES8305750A1 (es) | 1980-09-18 | 1982-07-09 | "procedimiento de preparacion de nuevas 2-(4-(difenilmetilen)-1-piperidinil)-acetamidas". |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES505568A Expired ES8301213A1 (es) | 1980-09-18 | 1981-09-17 | Procedimiento de preparacion de nuevos acidos 2-(4-(difenilmetilen)-1-piperidinil)-aleticos. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4443460A (es) |
| EP (1) | EP0048705B1 (es) |
| JP (1) | JPS5782369A (es) |
| AT (1) | ATE8388T1 (es) |
| AU (1) | AU539568B2 (es) |
| CA (1) | CA1167446A (es) |
| CY (1) | CY1312A (es) |
| DE (1) | DE3164741D1 (es) |
| DK (1) | DK149133C (es) |
| ES (2) | ES8301213A1 (es) |
| FI (1) | FI74950C (es) |
| HK (1) | HK14086A (es) |
| HU (1) | HU185313B (es) |
| MY (1) | MY8600341A (es) |
| NO (1) | NO157931C (es) |
| PL (2) | PL128590B1 (es) |
| SU (3) | SU1176836A3 (es) |
| YU (1) | YU43038B (es) |
| ZA (1) | ZA816462B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH665637A5 (fr) * | 1984-12-24 | 1988-05-31 | Wakamoto Pharma Co Ltd | 5-(3-n-butyloxalylaminophenyl)tetrazole comme agent antiasthmatique, composition le contenant et procede de preparation de la composition. |
| EP0228893A3 (en) * | 1985-12-20 | 1990-01-03 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl group in allergy treatment |
| US4810713A (en) * | 1985-12-20 | 1989-03-07 | A. H. Robins Company, Incorporated | Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment |
| JPS6344570A (ja) * | 1986-08-12 | 1988-02-25 | Wakamoto Pharmaceut Co Ltd | ３−（１ｈ−テトラゾ−ル−５−イル）オキサニリツクアシツド及びその製造法 |
| FR2603583B1 (fr) * | 1986-09-05 | 1988-12-09 | Andre Buzas | Derives de la benzhydryloxyethyl-piperidine, procede d'obtention et compositions pharmaceutiques les contenant |
| AU620996B2 (en) * | 1989-07-04 | 1992-02-27 | Hokuriku Pharmaceutical Co. Ltd. | 4-{(dibenzocycloheptene) or (dibenzoxepin)}-1-substituted piperidines |
| US5000436A (en) * | 1990-02-26 | 1991-03-19 | Paper Converting Machine Company | Rotary stacker and method |
| US5631375A (en) * | 1992-04-10 | 1997-05-20 | Merrell Pharmaceuticals, Inc. | Process for piperidine derivatives |
| US5654433A (en) * | 1993-01-26 | 1997-08-05 | Merrell Pharmaceuticals Inc. | Process for piperidine derivatives |
| CZ168896A3 (en) * | 1995-06-27 | 1997-01-15 | Egyt Gyogyszervegyeszeti Gyar | Oxaindene derivatives and process for preparing thereof |
| JP4730096B2 (ja) * | 2003-05-20 | 2011-07-20 | 味の素株式会社 | 新規ピペリジン誘導体 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2898339A (en) * | 1957-07-29 | 1959-08-04 | Wm S Merrell Co | N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine |
| US3221017A (en) * | 1964-04-07 | 1965-11-30 | Aldrich Chem Co Inc | Aralkoxyamides of 4-phenyl-1,2,5,6-tetrahydropyridino alkanoic acids and intermediates thereof |
| US3221018A (en) * | 1964-04-07 | 1965-11-30 | Aldrich Chem Co Inc | N-cyclopropyl amides of 4-phenyl-1,2,5,6-tetrahydropyridino alkanoic acids and intermediates thereof |
| US3576810A (en) * | 1968-06-20 | 1971-04-27 | Robins Co Inc A H | 1-substituted-3-(-4)-aroylpiperidines |
| GB1242169A (en) * | 1969-04-09 | 1971-08-11 | Ucb Sa | Piperidine derivatives |
| US3806526A (en) * | 1972-01-28 | 1974-04-23 | Richardson Merrell Inc | 1-aroylalkyl-4-diphenylmethyl piperidines |
| US3922276A (en) * | 1974-12-11 | 1975-11-25 | Robins Co Inc A H | 1-Substituted-4-benzylidenepiperidines |
| US4251655A (en) * | 1978-03-29 | 1981-02-17 | Mcneilab, Inc. | Substituted N-iminomethylpiperidines |
| US4285958A (en) * | 1979-04-10 | 1981-08-25 | Richardson-Merrell Inc. | 1-Piperidine-alkylene ketones, pharmaceutical compositions thereof and method of use thereof |
| CH647235A5 (de) * | 1980-02-13 | 1985-01-15 | Sandoz Ag | 4-(2,2-dialkylindan-1-yliden)piperidin derivate, ihre herstellung und verwendung. |
-
1981
- 1981-09-14 FI FI812852A patent/FI74950C/fi not_active IP Right Cessation
- 1981-09-14 NO NO813119A patent/NO157931C/no unknown
- 1981-09-14 DK DK408781A patent/DK149133C/da not_active IP Right Cessation
- 1981-09-16 SU SU813331800A patent/SU1176836A3/ru active
- 1981-09-16 JP JP56146044A patent/JPS5782369A/ja active Granted
- 1981-09-16 DE DE8181870037T patent/DE3164741D1/de not_active Expired
- 1981-09-16 YU YU2224/81A patent/YU43038B/xx unknown
- 1981-09-16 AT AT81870037T patent/ATE8388T1/de active
- 1981-09-16 EP EP81870037A patent/EP0048705B1/fr not_active Expired
- 1981-09-16 CY CY1312A patent/CY1312A/xx unknown
- 1981-09-17 US US06/303,522 patent/US4443460A/en not_active Expired - Lifetime
- 1981-09-17 CA CA000386145A patent/CA1167446A/en not_active Expired
- 1981-09-17 ES ES505568A patent/ES8301213A1/es not_active Expired
- 1981-09-17 AU AU75436/81A patent/AU539568B2/en not_active Ceased
- 1981-09-17 PL PL1981236692A patent/PL128590B1/pl unknown
- 1981-09-17 HU HU812684A patent/HU185313B/hu not_active IP Right Cessation
- 1981-09-17 PL PL1981233059A patent/PL128505B1/pl unknown
- 1981-09-17 ZA ZA816462A patent/ZA816462B/xx unknown
-
1982
- 1982-03-18 SU SU823406384A patent/SU1108090A1/ru active
- 1982-07-09 ES ES513867A patent/ES8305750A1/es not_active Expired
-
1983
- 1983-07-29 SU SU833622785A patent/SU1179922A3/ru active
-
1986
- 1986-02-27 HK HK140/86A patent/HK14086A/xx not_active IP Right Cessation
- 1986-12-30 MY MY341/86A patent/MY8600341A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US4443460A (en) | 1984-04-17 |
| SU1108090A1 (ru) | 1984-08-15 |
| ZA816462B (en) | 1982-09-29 |
| YU222481A (en) | 1984-02-29 |
| ES513867A0 (es) | 1983-04-16 |
| ES505568A0 (es) | 1982-11-16 |
| YU43038B (en) | 1989-02-28 |
| NO157931B (no) | 1988-03-07 |
| NO157931C (no) | 1988-06-15 |
| DK149133C (da) | 1986-09-08 |
| ES8301213A1 (es) | 1982-11-16 |
| DK149133B (da) | 1986-02-10 |
| DE3164741D1 (en) | 1984-08-16 |
| MY8600341A (en) | 1986-12-31 |
| AU539568B2 (en) | 1984-10-04 |
| FI812852L (fi) | 1982-03-19 |
| EP0048705B1 (fr) | 1984-07-11 |
| CY1312A (en) | 1986-03-28 |
| FI74950C (fi) | 1988-04-11 |
| PL128505B1 (en) | 1984-02-29 |
| ATE8388T1 (de) | 1984-07-15 |
| PL128590B1 (en) | 1984-02-29 |
| FI74950B (fi) | 1987-12-31 |
| SU1179922A3 (ru) | 1985-09-15 |
| HU185313B (en) | 1985-01-28 |
| AU7543681A (en) | 1982-03-25 |
| PL233059A1 (es) | 1982-10-11 |
| JPS5782369A (en) | 1982-05-22 |
| EP0048705A1 (fr) | 1982-03-31 |
| DK408781A (da) | 1982-03-19 |
| JPH0121144B2 (es) | 1989-04-19 |
| SU1176836A3 (ru) | 1985-08-30 |
| NO813119L (no) | 1982-03-19 |
| CA1167446A (en) | 1984-05-15 |
| HK14086A (en) | 1986-03-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BG38639A3 (en) | Method for preparing ester derivatives of 6- beta- hydroxymethylpenicillanic acid | |
| SE7703263L (sv) | Forfarande for framstellning av nya acetohydroxaminsyror | |
| ES8305750A1 (es) | "procedimiento de preparacion de nuevas 2-(4-(difenilmetilen)-1-piperidinil)-acetamidas". | |
| ES8801642A1 (es) | Un procedimiento para la preparacion de l,2,4-triazoles | |
| ES8801222A1 (es) | Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina | |
| ES8301980A1 (es) | Procedimiento para la preparacion de 8-arilalcohil-3-fenil-3-nortropanoles . | |
| ES8404317A1 (es) | Metodo de preparar aminoaminoacidos y analogos. | |
| ES8303427A1 (es) | "un procedimiento para preparar compuestos de cefem". | |
| ES8205837A1 (es) | Un procedimiento para la produccion de derivados de halogeno-triacinilo. | |
| ES8606321A1 (es) | Un procedimiento para preparar un derivado de 2-hidroxi-3- (4-fenilpiperazimil)propoxi-benzofurano | |
| ES8609246A1 (es) | Un procedimiento para preparar un derivado de 3-carbonil-1- aminoalquil-1h-indol | |
| DK425177A (da) | 2-(3-phenyl-2-amino-proprionyloxy)-eddikesyrederivater | |
| ES8200884A1 (es) | Un metodo de preparar derivados de fenil-piperazina farma- ceuticamente activos | |
| ATE19058T1 (de) | Substituierte hydroxymalonsaeurediamide, verfahren zu ihrer herstellung sowie ihre verwendung als schaedlingsbekaempfungsmittel. | |
| BG32849A3 (en) | Method for obtaining of 2- chlor- 4- substituated derivatives of thiazolcarbonic acids | |
| ES8608516A1 (es) | Procedimiento para la preparacion de acidos 4-isoxazolil- tiazol-2-oxamicos y sus derivados | |
| ES8205750A1 (es) | Un procedimiento para la preparacion de nuevos derivados de fenetilamina. | |
| ES8601209A1 (es) | Procedimiento para preparar derivados de 5h-(1)-benzopirano-(2,3-d)pirimidina | |
| ES8304085A1 (es) | "un procedimiento para la preparacion de esteres de oxima". | |
| ES8200887A1 (es) | Procedimiento para la preparacion de nuevas 2-(perhi- dro-1,4-diazino)-pirimido(5,4-d)pirimidinas | |
| ES8300722A1 (es) | Procedimiento para la preparacion de carbamoiloxiamino-1,4- benzodiazepinas | |
| ES2089097T3 (es) | Procedimiento para la fabricacion de derivados de bencilftalacinona y sales de la misma. | |
| ES8602001A1 (es) | Procedimiento para preparar nuevas 4-fenil-tetrahidrofurano-(2,3-c)priridinas | |
| BG24803A3 (bg) | Метод за получаване на изобутилов естер на 2,6-диметил-3-метоксикарбонил 4-(2'-нитрофенил)-1,4-дихидропиридин -5-карбоновата киселина | |
| GR33644B (el) | Μεθοδος δια την παρασκευην νεων αλογονουποκατεστημενων τετραυδρο-κιναζολινων. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19990301 |