[go: up one dir, main page]

ES8506639A1 - PROCEDURE TO PREPARE NEW AZOLS - Google Patents

PROCEDURE TO PREPARE NEW AZOLS

Info

Publication number
ES8506639A1
ES8506639A1 ES530461A ES530461A ES8506639A1 ES 8506639 A1 ES8506639 A1 ES 8506639A1 ES 530461 A ES530461 A ES 530461A ES 530461 A ES530461 A ES 530461A ES 8506639 A1 ES8506639 A1 ES 8506639A1
Authority
ES
Spain
Prior art keywords
procedure
group
prepare new
azols
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530461A
Other languages
Spanish (es)
Other versions
ES530461A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES530461A0 publication Critical patent/ES530461A0/en
Publication of ES8506639A1 publication Critical patent/ES8506639A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVOS AZOLES.CONSISTE EN ACILAR UN COMPUESTO DE FORMULA (II) Y RECUPERAR LOS COMPUESTOS EN FORMA LIBRE O EN LA FORMA DE UNA SAL DE ADICION DE ACIDOS DE FORMULA (I), DONDE R1 Y R2 REPRESENTAN, INDEPENDIENTEMENTE UNA DE OTRA, UN GRUPO ALIFATICO, ARILO O HETEROARILO EVENTUALMENTE SUSTITUIDOS, O R1 TAMBIEN PUEDE REPRESENTAR H; R3 Y R4 REPRESENTAN, INDEPENDIENTEMENTE UNA DE OTRA, H, HALOGENO, NITRO, UN GRUPO ALIFATICO EVENTUALMENTE SUSTITUIDO, GRUPO QUE, EN CASO DADO, ESTA UNIDO VIA S, O, SO O SO2, O UN GRUPO FENILO O FENOXI EVENTUALMENTE SUSTITUIDOS, Y X REPRESENTA N O CH.PRESENTAN ACTIVIDAD QUIMIOTERAPEUTICA Y ANTI-MICOSIS, UTILIZANDOSE COMO FARMACOS.PROCEDURE TO PREPARE NEW BLOSSES CONSISTS OF ACILLATING A COMPOUND OF FORMULA (II) AND RECOVERING THE COMPOUNDS IN A FREE FORM OR IN THE FORM OF A SALT OF ADDITION OF ACIDS OF FORMULA (I), WHERE R1 AND R2 INDEPENDENTLY REPRESENT ONE OF OTHER , AN ALIPHATIC, ARYL OR HETEROARYL GROUP EVENTUALLY SUBSTITUTED, OR R1 MAY ALSO REPRESENT H; R3 AND R4 INDEPENDENTLY REPRESENT ONE OF THE OTHER, H, HALOGENO, NITRO, AN EVENTUALLY SUBSTITUTED ALIPHATIC GROUP, A GROUP WHICH, WHEREAS, IS UNITED VIA S, O, SO OR SO2, OR A PHENYL OR SUBSTITUTE PHENYL GROUP, AND EVENTUALLY PHENOXY. REPRESENTS NO CH. PRESENTING CHEMOTHERAPEUTIC AND ANTI-MYCOSIS ACTIVITY, USED AS DRUGS.

ES530461A 1983-03-11 1984-03-09 PROCEDURE TO PREPARE NEW AZOLS Expired ES8506639A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1332/83A CH655103A5 (en) 1983-03-11 1983-03-11 AZOLE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE.

Publications (2)

Publication Number Publication Date
ES530461A0 ES530461A0 (en) 1985-07-16
ES8506639A1 true ES8506639A1 (en) 1985-07-16

Family

ID=4207992

Family Applications (1)

Application Number Title Priority Date Filing Date
ES530461A Expired ES8506639A1 (en) 1983-03-11 1984-03-09 PROCEDURE TO PREPARE NEW AZOLS

Country Status (24)

Country Link
JP (1) JPS59175472A (en)
KR (1) KR890000377B1 (en)
AU (1) AU571494B2 (en)
BE (1) BE899073A (en)
CA (1) CA1242723A (en)
CH (1) CH655103A5 (en)
DE (1) DE3408127A1 (en)
DK (1) DK149784A (en)
ES (1) ES8506639A1 (en)
FI (1) FI840968L (en)
FR (1) FR2542315B1 (en)
GB (1) GB2136801B (en)
GR (1) GR81869B (en)
HU (1) HUT36098A (en)
IL (1) IL71203A (en)
IT (1) IT1199085B (en)
LU (1) LU85245A1 (en)
NL (1) NL8400730A (en)
NZ (1) NZ207453A (en)
PH (1) PH24667A (en)
PL (1) PL146072B1 (en)
PT (1) PT78226B (en)
SE (1) SE8401321L (en)
ZA (1) ZA841782B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8618188D0 (en) * 1986-07-25 1986-09-03 Ici Plc Diamine compounds
DE3644615A1 (en) * 1986-12-29 1988-07-07 Lentia Gmbh IMIDAZOLE AND TRIAZOLE DERIVATIVES FOR USE AS AN ANTIMYCOTIC AGENTS
DE3644616A1 (en) * 1986-12-29 1988-07-07 Lentia Gmbh IMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF
US5252594A (en) * 1992-06-17 1993-10-12 Rohm And Haas Company Fungicidal (2-aryl-2-substituted)ethyl-1,2,4-triazoles
US5358939A (en) * 1992-06-25 1994-10-25 Rohm And Haas Company Fungicidal 2-aryl-2,2-disubstituted ethyl-1,2,4-triazoles
DE4412358A1 (en) * 1994-04-11 1995-10-12 Bayer Ag Cyclopropyl ethyl azoles
GB9409882D0 (en) * 1994-05-18 1994-07-06 Sandoz Ltd Organic compounds
JP3214987B2 (en) * 1994-09-05 2001-10-02 日本碍子株式会社 Semiconductor device and method of manufacturing the same
US7125997B2 (en) * 2002-12-20 2006-10-24 Irm Llc Differential tumor cytotoxicity compounds and compositions
WO2004056744A1 (en) * 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors
ES2525319T3 (en) 2004-05-07 2014-12-22 Janssen Pharmaceutica Nv Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta-hydroxysteroid dehydrogenase inhibitors
CN101039908B (en) 2004-08-30 2010-06-23 詹森药业有限公司 Tricyclic lactam derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
DE602005017159D1 (en) 2004-08-30 2009-11-26 Janssen Pharmaceutica Nv OXYSTEROID DEHYDROGENASE INHIBITORS
KR101197674B1 (en) 2004-08-30 2012-11-07 얀센 파마슈티카 엔.브이. N-2 adamantanyl-2-phenoxy-acetamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
EP1830837B1 (en) 2004-09-20 2013-09-04 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
AR051093A1 (en) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc HETEROCICLIC DERIVATIVES AND THEIR USE AS INHIBITORS OF ESTEAROIL-COA DESATURASA
AR051090A1 (en) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc HETEROCICLIC DERIVATIVES AND THEIR USE AS INHIBITORS OF ESTEAROIL-COA DESATURASA
MX2007003332A (en) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors.
JP5149009B2 (en) 2004-09-20 2013-02-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド Pyridazine derivatives for inhibiting human stearoyl-CoA desaturase
MX2007003325A (en) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors.
AU2005286728A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
EP2029138A1 (en) 2005-06-03 2009-03-04 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
HUE048905T2 (en) * 2014-12-05 2020-08-28 Pulmocide Ltd Antimycotic compound
CN104530038A (en) * 2014-12-10 2015-04-22 沈阳药科大学 Amide imidazole derivative and application thereof
CN112142673B (en) * 2020-09-18 2023-06-30 聊城大学 Aryl alkene azole derivatives, preparation method and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU557755A3 (en) * 1968-08-19 1977-05-05 Янссен Фармасьютика Н.В. (Фирма) Method for preparing imidazole derivatives
CA1189857A (en) * 1981-03-27 1985-07-02 Janssen Pharmaceutica Naamloze Vennootschap Antimicrobial triazole derivatives
AU8314482A (en) * 1981-05-19 1982-11-25 Imperial Chemical Industries Plc 3-triazolyl(imidazolyl)-2,2 bis phenyl-propionamides
EP0117462A3 (en) * 1983-02-28 1986-08-20 American Cyanamid Company N-(2-4-(1h-imidazol-1-yl)alkyl)arylamides

Also Published As

Publication number Publication date
NZ207453A (en) 1987-09-30
DK149784D0 (en) 1984-02-29
FI840968A7 (en) 1984-09-12
NL8400730A (en) 1984-10-01
FI840968A0 (en) 1984-03-09
CA1242723A (en) 1988-10-04
IT8447817A1 (en) 1985-09-08
LU85245A1 (en) 1984-11-14
HUT36098A (en) 1985-08-28
PT78226B (en) 1986-07-15
GB2136801A (en) 1984-09-26
PL146072B1 (en) 1988-12-31
CH655103A5 (en) 1986-03-27
IL71203A (en) 1988-10-31
KR850006386A (en) 1985-10-05
ZA841782B (en) 1985-10-30
IL71203A0 (en) 1984-06-29
JPS59175472A (en) 1984-10-04
FI840968L (en) 1984-09-12
GR81869B (en) 1984-12-12
ES530461A0 (en) 1985-07-16
PL246600A1 (en) 1985-03-12
FR2542315B1 (en) 1986-02-07
IT1199085B (en) 1988-12-30
DK149784A (en) 1984-09-12
BE899073A (en) 1984-09-05
IT8447817A0 (en) 1984-03-08
DE3408127A1 (en) 1984-09-13
SE8401321L (en) 1984-09-12
PT78226A (en) 1984-04-01
FR2542315A1 (en) 1984-09-14
AU571494B2 (en) 1988-04-21
GB8405900D0 (en) 1984-04-11
GB2136801B (en) 1987-03-04
KR890000377B1 (en) 1989-03-15
SE8401321D0 (en) 1984-03-09
PH24667A (en) 1990-09-07
AU2547584A (en) 1984-09-13

Similar Documents

Publication Publication Date Title
ES8506639A1 (en) PROCEDURE TO PREPARE NEW AZOLS
ES2066864T3 (en) ARALKYLAMINE DERIVATIVES AND FUNGICIDES THAT CONTAIN THEM.
NO863581D0 (en) HYDROXIC ACID BASED COLLAGENASE INHIBITORS.
ES2061975T3 (en) DERIVATIVES OF TRIAZOL, ITS PREPARATION AND USE AS FUNGICIDES.
DK24389A (en) (CYCLOALKYLAMINO) METHYLENBIS (PHOSPHONIC ACID) AND PHARMACEUTICAL PREPARATIONS CONTAINING THE COMPOUND
DE3586250D1 (en) COPPER SALTS OF AMBER ACID DERIVATIVES.
FI873413L (en) PHENOXYACETIC ACID DERIVATIVES OCH DERAS FRAMSTAELLNING.
DK413783D0 (en) METHOD OF PREPARING 20-AMINO-MACROLIDE DERIVATIVES OR ACID ADDITION SALTS.
FI841670A7 (en) Mixed long-chain alkyl ammonium salts of N-phosphonomethylglycine.
LU84491A1 (en) ANTI-ACNE COMPOSITION CONTAINING AS AN ACTIVE COMPOUND A DERIVATIVE OF ISOTHIAZOLO- (5,4B) PYRIDINE ONE-3
ES8707539A1 (en) Antibacterial 7-oxo-4-thia-1-azabicyclo not 3,2,0 hept-2-ene derivatives
ES8304952A1 (en) Alkanolamine derivatives.
DE3675778D1 (en) (2-AMINO-4-ARYL-THIAZOL-5-YL) AETHANOL, AND THEIR DERIVATIVES WITH DIURETIC ACTIVITY AND METHOD FOR THE PRODUCTION THEREOF.
BR8600484A (en) PRECISION TREE SET, SUB-ASSEMBLY OF THE SAME FOR COUPLING TO A TREE ASSEMBLY BEARING ASSEMBLY
AR240825A2 (en) Cephalosporin ester derivatives, their production and use
DK300583D0 (en) RACEMIC OR OPTICALLY ACTIVE EBURNANOXIMER DERIVATIVES OR ACID ADDITIONAL SALTS THEREOF, THEIR PREPARATION AND USE
ES529736A0 (en) A PROCEDURE FOR THE PREPARATION OF 3-FORMIL-2-NITROMETILEN-TETRAHIDRO-2H-1, 3-TIAZINA
ES8504793A1 (en) Quinazoline cardiac stimulants.
ES8606258A1 (en) PROCEDURE FOR THE PREPARATION OF BASIC OXIME ETHER, AND ITS ADDITIONAL SALTS PHARMACEUTICALLY ACCEPTABLE ACIDS
DE3564577D1 (en) 7-D-MANDELAMIDO-3- (1-SULFOMETHYLTETRAZOL-5-YL) THIOMETHYL-3-CEPHEM-4-CARBOXYLIC ACID MONOSODIUM SALT
FR2555450B1 (en) ANTI-ACNE COMPOSITION CONTAINING AS AN ACTIVE COMPOUND A DERIVATIVE OF ISOTHIAZOLO- (5,4B) PYRIDINE ONE-3
DE3660426D1 (en) UREA ACRYL DERIVATIVES
DE68912914D1 (en) Production of thiophosphate salts.
FI843611A7 (en) Method for preparing salts of antimalarial phenanthrenemethanol compounds.
FI841773A7 (en) Bis-alkylphosphonium salts of N-phosphonomethylglycine.