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ES8504793A1 - Un procedimiento para la preparacion de una quinazolina - Google Patents

Un procedimiento para la preparacion de una quinazolina

Info

Publication number
ES8504793A1
ES8504793A1 ES528481A ES528481A ES8504793A1 ES 8504793 A1 ES8504793 A1 ES 8504793A1 ES 528481 A ES528481 A ES 528481A ES 528481 A ES528481 A ES 528481A ES 8504793 A1 ES8504793 A1 ES 8504793A1
Authority
ES
Spain
Prior art keywords
quinazoline
formula
cardiac stimulants
compound
cardiac
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528481A
Other languages
English (en)
Other versions
ES528481A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Publication of ES528481A0 publication Critical patent/ES528481A0/es
Publication of ES8504793A1 publication Critical patent/ES8504793A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UNA QUINAZOLINA.CONSISTE EN HACER REACCIONAR UNA QUINAZOLINA DE FORMULA (II) CON UNA SAL DE FORMULA MB YC PROCEDENTE DEL COMPUESTO DE FORMULA (YH), PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO: X ALQUILENO DE CADENA LINEAL O RAMIFICADA DE C 1 A 4; Y UN GRUPO DE FORMULA (III), (IV) Y OTROS; Q, CL, BR, I U -O-TOSILO; Y M, NA, K, LI.SE UTILIZAN COMO ESTIMULANTE CARDIACO.
ES528481A 1982-05-15 1983-12-28 Un procedimiento para la preparacion de una quinazolina Expired ES8504793A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8214206 1982-05-15

Publications (2)

Publication Number Publication Date
ES528481A0 ES528481A0 (es) 1985-05-01
ES8504793A1 true ES8504793A1 (es) 1985-05-01

Family

ID=10530384

Family Applications (3)

Application Number Title Priority Date Filing Date
ES522278A Granted ES522278A0 (es) 1982-05-15 1983-05-11 Un procedimiento para preparacion de una quinalozina.
ES528481A Expired ES8504793A1 (es) 1982-05-15 1983-12-28 Un procedimiento para la preparacion de una quinazolina
ES528482A Expired ES8504794A1 (es) 1982-05-15 1983-12-28 Un procedimiento para la preparacion de una quinazolina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES522278A Granted ES522278A0 (es) 1982-05-15 1983-05-11 Un procedimiento para preparacion de una quinalozina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES528482A Expired ES8504794A1 (es) 1982-05-15 1983-12-28 Un procedimiento para la preparacion de una quinazolina

Country Status (22)

Country Link
US (1) US4489075A (es)
EP (1) EP0094766B1 (es)
JP (1) JPS58208289A (es)
KR (1) KR840004747A (es)
AU (1) AU538171B2 (es)
CA (1) CA1195977A (es)
DD (2) DD216018A5 (es)
DE (1) DE3368631D1 (es)
DK (1) DK210183A (es)
ES (3) ES522278A0 (es)
FI (1) FI831684A7 (es)
GR (1) GR77498B (es)
IL (1) IL68668A0 (es)
IN (1) IN160680B (es)
NO (1) NO831728L (es)
NZ (1) NZ204225A (es)
PH (1) PH18763A (es)
PL (2) PL247054A1 (es)
PT (1) PT76687B (es)
SU (1) SU1194257A3 (es)
YU (1) YU105083A (es)
ZA (1) ZA833422B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8320958D0 (en) * 1983-08-03 1983-09-07 Pfizer Ltd Quinazoline cardiac stimulants
JPS61215389A (ja) * 1985-03-20 1986-09-25 Kyowa Hakko Kogyo Co Ltd キナゾリン誘導体およびそれを含有する強心剤
US5138062A (en) * 1989-10-03 1992-08-11 Philip Morris Incorporated Nicotine analogs
ES2188584T3 (es) * 1991-03-28 2003-07-01 Eisai Co Ltd Derivados heterociclicos de amina.
KR101817889B1 (ko) * 2014-05-15 2018-01-11 화이자 인코포레이티드 6-[(4r)-4-메틸-1,2-다이옥사이도-1,2,6-티아다이아지난-2-일]이소퀴놀린-1-카보니트릴의 결정질 형태

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971783A (en) * 1973-03-07 1976-07-27 Pfizer Inc. 4-Aminoquinazoline derivatives as cardiac stimulants
GB1460389A (en) * 1974-07-25 1977-01-06 Pfizer Ltd 4-substituted quinazoline cardiac stimulants
US4171363A (en) * 1977-02-22 1979-10-16 Bristol-Myers Company 1,2,3-Thiadiazole process
CA1086735A (en) * 1977-11-03 1980-09-30 John C. Danilewicz Piperidino-quinazolines

Also Published As

Publication number Publication date
DE3368631D1 (de) 1987-02-05
ES528481A0 (es) 1985-05-01
AU538171B2 (en) 1984-08-02
ES8407039A1 (es) 1984-08-16
ZA833422B (en) 1984-02-29
ES528482A0 (es) 1985-05-01
PL241968A1 (en) 1984-08-13
GR77498B (es) 1984-09-24
ES522278A0 (es) 1984-08-16
FI831684A0 (fi) 1983-05-13
DD216018A5 (de) 1984-11-28
CA1195977A (en) 1985-10-29
PT76687B (en) 1986-03-27
JPS58208289A (ja) 1983-12-03
NZ204225A (en) 1985-12-13
KR840004747A (ko) 1984-10-24
PL247054A1 (en) 1985-03-26
DK210183A (da) 1983-11-16
FI831684L (fi) 1983-11-16
YU105083A (en) 1986-02-28
EP0094766A2 (en) 1983-11-23
PT76687A (en) 1983-06-01
NO831728L (no) 1983-11-16
ES8504794A1 (es) 1985-05-01
IN160680B (es) 1987-07-25
AU1452283A (en) 1983-11-17
PH18763A (en) 1985-09-20
IL68668A0 (en) 1983-09-30
DK210183D0 (da) 1983-05-11
DD210269A5 (de) 1984-06-06
EP0094766A3 (en) 1984-12-12
EP0094766B1 (en) 1986-12-30
FI831684A7 (fi) 1983-11-16
SU1194257A3 (ru) 1985-11-23
US4489075A (en) 1984-12-18

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