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ES8504179A1 - "PROCEDURE FOR PREPARING 1,4-DIHYDROPYRIDINE DERIVATIVES". - Google Patents

"PROCEDURE FOR PREPARING 1,4-DIHYDROPYRIDINE DERIVATIVES".

Info

Publication number
ES8504179A1
ES8504179A1 ES523243A ES523243A ES8504179A1 ES 8504179 A1 ES8504179 A1 ES 8504179A1 ES 523243 A ES523243 A ES 523243A ES 523243 A ES523243 A ES 523243A ES 8504179 A1 ES8504179 A1 ES 8504179A1
Authority
ES
Spain
Prior art keywords
preparing
procedure
dihydropyridine derivatives
radical
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES523243A
Other languages
Spanish (es)
Other versions
ES523243A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES8504179A1 publication Critical patent/ES8504179A1/en
Publication of ES523243A0 publication Critical patent/ES523243A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE 1,4-DIHIDROPIRIDINA, DE FORMULA GENERAL (I), EN LA QUE R1 Y R2 REPRESENTAN METILO, UNO DE ELLOS, Y N-BUTILO O ISOPROPILO, EL OTRO; R3 REPRESENTA HIDROGENO O ALQUILO, Y SUS SALES.CONSISTE EN REEMPLAZAR EL RADICAL R4 ES UN ISOMERO OPTICO DE UN COMPUESTO DE FORMULA (II), POR UN RADICAL: OR2.DE APLICACION EN MEDICINA Y FARMACIA.PROCEDURE FOR PREPARING 1,4-DIHYDROPYRIDINE DERIVATIVES, OF GENERAL FORMULA (I), IN WHICH R1 AND R2 REPRESENT METHYL, ONE OF THEM, AND N-BUTILE OR ISOPROPYLE, THE OTHER; R3 REPRESENTS HYDROGEN OR ALKYL, AND ITS SALTS. IT CONSISTS OF REPLACING THE RADICAL R4 IS AN OPTICAL ISOMER OF A COMPOUND OF FORMULA (II), WITH A RADICAL: OR2. FOR APPLICATION IN MEDICINE AND PHARMACY.

ES523243A 1982-06-15 1983-06-14 "PROCEDURE FOR PREPARING 1,4-DIHYDROPYRIDINE DERIVATIVES". Granted ES523243A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH369382 1982-06-15
CH369282 1982-06-15

Publications (2)

Publication Number Publication Date
ES8504179A1 true ES8504179A1 (en) 1985-04-01
ES523243A0 ES523243A0 (en) 1985-04-01

Family

ID=25693638

Family Applications (2)

Application Number Title Priority Date Filing Date
ES523243A Granted ES523243A0 (en) 1982-06-15 1983-06-14 "PROCEDURE FOR PREPARING 1,4-DIHYDROPYRIDINE DERIVATIVES".
ES538157A Expired ES8604578A1 (en) 1982-06-15 1984-11-30 PROCEDURE FOR PREPARING 1,4-DIHYDROPYRIDINE DERIVATIVES

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES538157A Expired ES8604578A1 (en) 1982-06-15 1984-11-30 PROCEDURE FOR PREPARING 1,4-DIHYDROPYRIDINE DERIVATIVES

Country Status (19)

Country Link
AU (1) AU1575383A (en)
BE (1) BE897000A (en)
CA (1) CA1208639A (en)
CH (1) CH660593A5 (en)
DE (1) DE3320616A1 (en)
DK (1) DK271183A (en)
ES (2) ES523243A0 (en)
FI (1) FI832072L (en)
FR (1) FR2528431B1 (en)
GB (1) GB2122192B (en)
HU (1) HU191853B (en)
IT (1) IT1178353B (en)
NL (1) NL8302067A (en)
NZ (1) NZ204536A (en)
PH (1) PH23436A (en)
PT (1) PT76870B (en)
SE (1) SE8303385L (en)
WO (1) WO1984000033A1 (en)
ZA (1) ZA834409B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3431152A1 (en) * 1984-08-24 1986-03-06 Cassella Ag, 6000 Frankfurt METHOD FOR PRODUCING OPTICALLY ACTIVE, SUBSTITUTED 1,4-DIHYDROPYRIDINE AND THEIR USE AS A MEDICINAL PRODUCT
GB8428552D0 (en) * 1984-11-12 1984-12-19 Sandoz Ltd Organic compounds
US5260321A (en) * 1984-11-12 1993-11-09 Sandoz Ltd. Use of 1,4-dihydropyridine derivatives and combinations thereof with calcitonins
DE3447169A1 (en) * 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen OPTICALLY ACTIVE NITRODIHYDROPYRIDINE, METHOD FOR THE PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS
US4920225A (en) * 1986-12-22 1990-04-24 Laboratoires Syntex S.A. Resolution of 1,4-dihydropyridine derivatives
AU1570588A (en) * 1987-03-27 1988-11-02 Byk Gulden Lomberg Chemische Fabrik Gmbh New intermediate products and process
DE4041814A1 (en) * 1990-12-24 1992-07-02 Byk Gulden Lomberg Chem Fab METHOD FOR PRODUCING DIHYDROPHYRIDINE CARBONIC ACIDS
US5135936A (en) * 1991-03-05 1992-08-04 Marion Merrell Dow Inc. Isomers of 1-azabicyclo[2.2.2]oct-3-yl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinediacarboxylic and their use as calcium antagonists
CN100425599C (en) * 2005-12-31 2008-10-15 清华大学 Organic electroluminescent material and its application

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH639659A5 (en) * 1978-12-18 1983-11-30 Sandoz Ag NEW 1,4-DIHYDROPYRIDINE DERIVATIVES, THEIR PRODUCTION AND USE.
DK149855C (en) * 1977-06-20 1987-04-21 Sandoz Ag METHOD OF ANALOGY FOR THE PREPARATION OF 1,4-DIHYDROPYRIDINE DERIVATIVES
DE2949464A1 (en) * 1978-12-18 1980-06-26 Sandoz Ag BENZOXADIAZOLES AND BENZOTHIADIAZOLES, THEIR PRODUCTION AND USE
FI813460L (en) * 1980-11-10 1982-05-11 Sandoz Ag NYA 4- (2,1,3-BENZOXADIAZOL-4-YL) -1,4-DIHYDRO-PYRIDIN DERIVATIVES DERAS FRAMSTAELLNINGSFOERFARANDE OCH DESSA INNEHAOLLANDE PHARMACEUTICAL COMPOSITION

Also Published As

Publication number Publication date
GB8316054D0 (en) 1983-07-20
ES538157A0 (en) 1986-02-01
FI832072A7 (en) 1983-12-16
PT76870A (en) 1983-07-01
DE3320616A1 (en) 1983-12-15
GB2122192A (en) 1984-01-11
PH23436A (en) 1989-08-07
AU1575383A (en) 1983-12-22
CA1208639A (en) 1986-07-29
DK271183A (en) 1983-12-16
SE8303385L (en) 1983-12-16
PT76870B (en) 1986-02-27
NL8302067A (en) 1984-01-02
GB2122192B (en) 1985-12-18
FI832072L (en) 1983-12-16
FR2528431B1 (en) 1986-01-10
IT8348488A0 (en) 1983-06-13
IT1178353B (en) 1987-09-09
FR2528431A1 (en) 1983-12-16
DK271183D0 (en) 1983-06-13
SE8303385D0 (en) 1983-06-14
HU191853B (en) 1987-04-28
ZA834409B (en) 1985-02-27
WO1984000033A1 (en) 1984-01-05
CH660593A5 (en) 1987-05-15
ES523243A0 (en) 1985-04-01
BE897000A (en) 1983-12-09
ES8604578A1 (en) 1986-02-01
NZ204536A (en) 1986-09-10
FI832072A0 (en) 1983-06-08

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