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ES8405761A1 - PROCEDURE FOR THE PREPARATION OF TRANS-1- (1,3-DISUSTITUTED-4-OXO-2-ACETIDINYL ACID DERIVATIVES. - Google Patents

PROCEDURE FOR THE PREPARATION OF TRANS-1- (1,3-DISUSTITUTED-4-OXO-2-ACETIDINYL ACID DERIVATIVES.

Info

Publication number
ES8405761A1
ES8405761A1 ES518720A ES518720A ES8405761A1 ES 8405761 A1 ES8405761 A1 ES 8405761A1 ES 518720 A ES518720 A ES 518720A ES 518720 A ES518720 A ES 518720A ES 8405761 A1 ES8405761 A1 ES 8405761A1
Authority
ES
Spain
Prior art keywords
compound
formula
acetidinyl
trans
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518720A
Other languages
Spanish (es)
Other versions
ES518720A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES518720A0 publication Critical patent/ES518720A0/en
Publication of ES8405761A1 publication Critical patent/ES8405761A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE ACIDO ACETICO TRANS-1-(1,3-DISUSTITUIDO-4-OX O-2-ACETIDINILO).CONSISTE EN: A) ACTIVAR CON ETIL CLOROFORMATO EL GRUPO CARBOXI DEL COMPUESTO DE FORMULA (III) Y A CONTINUACION SE LE HACE REACCIONAR CON DIAZOMETANO PARA OBTENER EL COMPUESTO DE FORMULA (II); B) SOMETER A INTERCAMBIO DE DIAZOCETONA EN PRESENCIA DE AGUA Y EFECTUANDOSE BAJO IRRADIACION CON LUZ ULTRAVIOLETA EL COMPUESTO DE FORMULA (II) PARA DAR EL COMPUESTO DE FORMULA (I), DONDE Y E Y SON UN GRUPO PROTECTOR CARBONILO SEPARABLE, TAL COMO UN GRUPO CETAL O UN TIO-; Y R ES UN GRUPOPROTECTOR AMIDO SEPARABLE, TAL COMO UN GRUPO BENCILO O FENILO.TIENE APLICACION COMO ANTIBIOTICO.PROCEDURE FOR THE PREPARATION OF TRANS-1-(1,3-DISUBSTITUTED-4-OX O-2-ACETIDINYL) ACETIC ACID DERIVATIVES. CONSISTS OF: A) ACTIVATING THE CARBOXY GROUP OF THE COMPOUND OF FORMULA (III) WITH ETHYL CHLOROFORMATE AND CONTINUED, IT IS REACTED WITH DIAZOMETHANE TO OBTAIN THE COMPOUND OF FORMULA (II); B) SUBJECTING THE COMPOUND OF FORMULA (II) TO THE EXCHANGE OF DIAZOCETONE IN THE PRESENCE OF WATER AND CARRYING OUT UNDER IRRADIATION WITH UV LIGHT TO GIVE THE COMPOUND OF FORMULA (I), WHERE AND AND AND AND ARE A SEPARABLE CARBONYL PROTECTIVE GROUP, SUCH AS A CETAL GROUP OR AN UNCLE-; AND R IS A SEPARABLE AMIDO PROTECTIVE GROUP, SUCH AS A BENZYL OR PHENYL GROUP. IT HAS APPLICATION AS AN ANTIBIOTIC.

ES518720A 1981-12-30 1982-12-30 PROCEDURE FOR THE PREPARATION OF TRANS-1- (1,3-DISUSTITUTED-4-OXO-2-ACETIDINYL ACID DERIVATIVES. Expired ES8405761A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU814012A HU184495B (en) 1981-12-30 1981-12-30 Process for preparing new azetidinone-acetic acids

Publications (2)

Publication Number Publication Date
ES518720A0 ES518720A0 (en) 1984-06-16
ES8405761A1 true ES8405761A1 (en) 1984-06-16

Family

ID=10966505

Family Applications (1)

Application Number Title Priority Date Filing Date
ES518720A Expired ES8405761A1 (en) 1981-12-30 1982-12-30 PROCEDURE FOR THE PREPARATION OF TRANS-1- (1,3-DISUSTITUTED-4-OXO-2-ACETIDINYL ACID DERIVATIVES.

Country Status (19)

Country Link
JP (1) JPS58118566A (en)
AT (1) AT379147B (en)
AU (1) AU554739B2 (en)
BE (1) BE895489A (en)
CA (1) CA1189865A (en)
CH (1) CH655926A5 (en)
DE (1) DE3248672A1 (en)
ES (1) ES8405761A1 (en)
FI (1) FI824516A7 (en)
FR (1) FR2518998B1 (en)
GB (1) GB2112393B (en)
GR (1) GR78428B (en)
HU (1) HU184495B (en)
IT (1) IT1210968B (en)
LU (1) LU84568A1 (en)
NL (1) NL8205064A (en)
PL (1) PL137593B1 (en)
SE (1) SE453083B (en)
ZA (1) ZA829593B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU190404B (en) * 1982-07-30 1986-09-29 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for preparing amino-lactone-carboxylic acid
HU187424B (en) * 1982-11-05 1986-01-28 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for preparing new azetidinyl-acetic acids

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT71553B (en) * 1979-07-23 1981-12-14 Merck & Co Inc Process for the preparation of thienamycin and intermediates
JPS57167964A (en) * 1981-04-09 1982-10-16 Toyama Chem Co Ltd Preparation of (4r)-3-substituted-4-(substituted or unsubstituted carboxymethyl)-2-azetidinone derivative
JPS57176982A (en) * 1981-04-24 1982-10-30 Shionogi & Co Ltd Dioxolanylazetidinone compound, its preparation and use

Also Published As

Publication number Publication date
JPS58118566A (en) 1983-07-14
SE453083B (en) 1988-01-11
IT1210968B (en) 1989-09-29
CA1189865A (en) 1985-07-02
FR2518998B1 (en) 1986-02-28
ZA829593B (en) 1983-10-26
GB2112393B (en) 1985-08-14
FI824516A0 (en) 1982-12-30
SE8207475L (en) 1983-07-01
CH655926A5 (en) 1986-05-30
PL239885A1 (en) 1984-01-02
IT8225060A0 (en) 1982-12-30
HU184495B (en) 1984-08-28
BE895489A (en) 1983-06-28
ATA450782A (en) 1985-04-15
AT379147B (en) 1985-11-25
ES518720A0 (en) 1984-06-16
DE3248672A1 (en) 1983-07-07
AU554739B2 (en) 1986-09-04
FR2518998A1 (en) 1983-07-01
FI824516L (en) 1983-07-01
LU84568A1 (en) 1984-10-22
PL137593B1 (en) 1986-06-30
NL8205064A (en) 1983-07-18
AU9196882A (en) 1983-07-07
SE8207475D0 (en) 1982-12-29
GR78428B (en) 1984-09-27
GB2112393A (en) 1983-07-20
FI824516A7 (en) 1983-07-01

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