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ES8401025A1 - Procedimiento para la obtencion de acidos 1-carboxi-(azaalcanoil o azaaralcanoil)-indolin-2-carboxilicos. - Google Patents

Procedimiento para la obtencion de acidos 1-carboxi-(azaalcanoil o azaaralcanoil)-indolin-2-carboxilicos.

Info

Publication number
ES8401025A1
ES8401025A1 ES516555A ES516555A ES8401025A1 ES 8401025 A1 ES8401025 A1 ES 8401025A1 ES 516555 A ES516555 A ES 516555A ES 516555 A ES516555 A ES 516555A ES 8401025 A1 ES8401025 A1 ES 8401025A1
Authority
ES
Spain
Prior art keywords
formula
indolin
carboxylic acids
azaalkyl
carboxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES516555A
Other languages
English (en)
Other versions
ES516555A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8401025A1 publication Critical patent/ES8401025A1/es
Publication of ES516555A0 publication Critical patent/ES516555A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ACIDOS 1-CARBOXI-(AZAALCANOIL O AZAARALCANOIL)-INDOLIN-2-CARBOXI LICOS Y DE SUS AMIDAS, ESTERES Y SALES DE FORMULA (I), EN LA QUE PH ES 1,2-FENILENO SUSTITUIDO O SIN SUSTITUIR; R1 Y R2 PUEDEN SER VARIOS RADICALES; Y R3, R4 Y R5 SON HIDROGENO O ALQUILO INFERIOR.CONSISTE EN LA REACCION DE CONDENSACION DE UN COMPUESTO DE FORMULA (II) O SUS DERIVADOS FUNCIONALES, CON UN DERIVADO FUNCIONAL REACTIVO DE FORMULA R2CHYCOOH, EN LA QUE X E Y PUEDEN SER VARIOS TIPOS DE RADICALES Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA(I); SEGUIDA DE LA HIDROLISIS ACIDA.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS EFECTOS ANTIHIPERTENSIVOS.
ES516555A 1980-11-03 1982-10-15 Procedimiento para la obtencion de acidos 1-carboxi-(azaalcanoil o azaaralcanoil)-indolin-2-carboxilicos. Granted ES516555A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20376980A 1980-11-03 1980-11-03
US23991881A 1981-03-03 1981-03-03

Publications (2)

Publication Number Publication Date
ES8401025A1 true ES8401025A1 (es) 1983-12-01
ES516555A0 ES516555A0 (es) 1983-12-01

Family

ID=26898886

Family Applications (3)

Application Number Title Priority Date Filing Date
ES506784A Granted ES506784A0 (es) 1980-11-03 1981-11-02 Procedimiento para la obtencion de acidos 1-carboxi-(azaal- canoil o azaaralcanoil)-indolin-2-carboxilicos.
ES516556A Expired ES8401026A1 (es) 1980-11-03 1982-10-15 Procedimiento para la obtencion de acidos 1-carboxi-(azaalcanoil o azaaralcanoil)-indolin-2-carboxilicos.
ES516555A Granted ES516555A0 (es) 1980-11-03 1982-10-15 Procedimiento para la obtencion de acidos 1-carboxi-(azaalcanoil o azaaralcanoil)-indolin-2-carboxilicos.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES506784A Granted ES506784A0 (es) 1980-11-03 1981-11-02 Procedimiento para la obtencion de acidos 1-carboxi-(azaal- canoil o azaaralcanoil)-indolin-2-carboxilicos.
ES516556A Expired ES8401026A1 (es) 1980-11-03 1982-10-15 Procedimiento para la obtencion de acidos 1-carboxi-(azaalcanoil o azaaralcanoil)-indolin-2-carboxilicos.

Country Status (13)

Country Link
EP (1) EP0051301A1 (es)
AU (1) AU7702281A (es)
CA (1) CA1172258A (es)
DD (1) DD201888A5 (es)
DK (1) DK483681A (es)
ES (3) ES506784A0 (es)
FI (1) FI813422L (es)
GB (1) GB2086390B (es)
GR (1) GR74689B (es)
HU (1) HU185324B (es)
IL (1) IL64185A0 (es)
NO (1) NO813694L (es)
PT (1) PT73916B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN156096B (es) * 1981-03-19 1985-05-11 Usv Pharma Corp
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
CA1341296C (en) * 1981-12-29 2001-09-25 Hansjorg Urbach 2-azabicycloalkane-3-carboxylic acid derivatives, processes for their preparation, agents containing these compounds and their use
ATE25244T1 (de) * 1981-12-29 1987-02-15 Hoechst Ag Neue derivate bicyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung.
DE3210496A1 (de) * 1982-03-23 1983-10-06 Hoechst Ag Neue derivate bicyclischer aminsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
US4520205A (en) * 1982-06-28 1985-05-28 American Home Products Corporation Chemical resolution of (+)-2,3-dihydroindole-2-carboxylic acid
US5175306A (en) * 1983-01-31 1992-12-29 Hoechst Aktiengesellschaft Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
FR2546886B2 (fr) * 1983-06-06 1986-05-16 Adir Derives d'acides isoindoledicarboxyliques, leur preparation et compositions pharmaceutiques les contenant
DE3324263A1 (de) * 1983-07-06 1985-01-17 Hoechst Ag, 6230 Frankfurt Derivate der 2-azabicyclo(3.1.0)hexan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-azabicyclo(3.1.0)hexan-derivate als zwischenprodukte und verfahren zu deren herstellung
DE3333455A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung n-alkylierter dipeptide und deren estern
DE3333454A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
DE3431541A1 (de) * 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
DE3639879A1 (de) * 1986-11-21 1988-06-01 Hoechst Ag Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung
DE3722007A1 (de) * 1987-07-03 1989-01-12 Hoechst Ag Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
TW197945B (es) * 1990-11-27 1993-01-11 Hoechst Ag
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
EP0706525A1 (en) * 1993-06-30 1996-04-17 Novartis AG Antihypertensive tricyclic azepine derivatives useful as inhibitors of enkephalinase and ace

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4303583A (en) * 1979-08-13 1981-12-01 American Home Products Corporation 1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids

Also Published As

Publication number Publication date
DD201888A5 (de) 1983-08-17
PT73916A (en) 1981-12-01
GR74689B (es) 1984-07-03
ES8303329A1 (es) 1983-02-01
FI813422A7 (fi) 1982-05-04
CA1172258A (en) 1984-08-07
AU7702281A (en) 1982-05-13
NO813694L (no) 1982-05-04
FI813422L (fi) 1982-05-04
HU185324B (en) 1985-01-28
ES516556A0 (es) 1983-12-01
IL64185A0 (en) 1982-02-28
GB2086390A (en) 1982-05-12
DK483681A (da) 1982-05-04
GB2086390B (en) 1984-06-06
PT73916B (en) 1983-11-30
ES506784A0 (es) 1983-02-01
ES8401026A1 (es) 1983-12-01
ES516555A0 (es) 1983-12-01
EP0051301A1 (de) 1982-05-12

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001009