ES8602002A1 - Procedimiento para preparar nuevas 4-fenil-tetrahidrofurano-(2,3-c)priridinas - Google Patents
Procedimiento para preparar nuevas 4-fenil-tetrahidrofurano-(2,3-c)priridinasInfo
- Publication number
- ES8602002A1 ES8602002A1 ES538617A ES538617A ES8602002A1 ES 8602002 A1 ES8602002 A1 ES 8602002A1 ES 538617 A ES538617 A ES 538617A ES 538617 A ES538617 A ES 538617A ES 8602002 A1 ES8602002 A1 ES 8602002A1
- Authority
- ES
- Spain
- Prior art keywords
- pyridines
- phenyl
- formula
- furano
- tetrahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- GVKNYQJRDBULBK-UHFFFAOYSA-N 4-phenyl-3,3a,5,6-tetrahydro-2h-furo[3,2-b]pyridine Chemical class C1CC=C2OCCC2N1C1=CC=CC=C1 GVKNYQJRDBULBK-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 abstract 1
- CQGVPYYFEIFRKZ-UHFFFAOYSA-N 3-phenyloxolane Chemical compound C1OCCC1C1=CC=CC=C1 CQGVPYYFEIFRKZ-UHFFFAOYSA-N 0.000 abstract 1
- RQMWVVBHJMUJNZ-UHFFFAOYSA-N 4-chloropyridin-2-amine Chemical compound NC1=CC(Cl)=CC=N1 RQMWVVBHJMUJNZ-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000006482 condensation reaction Methods 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 4-FENIL-TETRAHIDROFURANO 3,2-C PIRIDINAS Y DE SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R2 REPRESENTA HIDROGENO; Y R1, R3, R4 Y R5 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE CONDENSACION DE UN 2-FURFURILAMINO-1-FENILETANO DE FORMULA (I), EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON ACIDO TRIFLUOROACETICO O ACIDO TRIFUOROSULFONICO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, TAL COMO CLORURO DE ETILENO, A LA TEMPERATURA DE REFLUJO DE LA MEZCLA DE REACCION. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS PROPIEDADES ANTIDEPRESIVAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833315157 DE3315157A1 (de) | 1983-04-27 | 1983-04-27 | 4-phenyl-tetrahydro-furano-pyridine, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES538617A0 ES538617A0 (es) | 1985-11-01 |
| ES8602002A1 true ES8602002A1 (es) | 1985-11-01 |
Family
ID=6197430
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES531927A Granted ES531927A0 (es) | 1983-04-27 | 1984-04-26 | Procedimiento para preparar nuevas 4-fenil-tetrahidrofurano (2, 3-c) piridinas |
| ES538617A Expired ES8602002A1 (es) | 1983-04-27 | 1984-12-14 | Procedimiento para preparar nuevas 4-fenil-tetrahidrofurano-(2,3-c)priridinas |
| ES538616A Granted ES538616A0 (es) | 1983-04-27 | 1984-12-14 | Procedimiento para preparar nuevas 4-fenil-tetrahidrofurano-(2,3-c)priridinas |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES531927A Granted ES531927A0 (es) | 1983-04-27 | 1984-04-26 | Procedimiento para preparar nuevas 4-fenil-tetrahidrofurano (2, 3-c) piridinas |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES538616A Granted ES538616A0 (es) | 1983-04-27 | 1984-12-14 | Procedimiento para preparar nuevas 4-fenil-tetrahidrofurano-(2,3-c)priridinas |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4636510A (es) |
| EP (1) | EP0123998A3 (es) |
| JP (1) | JPS59205383A (es) |
| KR (1) | KR840008357A (es) |
| AU (1) | AU566073B2 (es) |
| DE (1) | DE3315157A1 (es) |
| DK (1) | DK209384A (es) |
| ES (3) | ES531927A0 (es) |
| FI (1) | FI841615A7 (es) |
| GB (1) | GB2138817B (es) |
| GR (1) | GR79573B (es) |
| IL (1) | IL71661A0 (es) |
| NO (1) | NO841661L (es) |
| NZ (1) | NZ207943A (es) |
| PH (1) | PH19896A (es) |
| PT (1) | PT78487B (es) |
| ZA (1) | ZA843084B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2566775B1 (fr) * | 1984-06-27 | 1986-10-31 | Synthelabo | Derives de tetrahydro-4,5,6,7 furo ou 1h-pyrrolo(2,3-c)pyridine, leur preparation et leur application en therapeutique |
| US4572911A (en) * | 1984-08-02 | 1986-02-25 | Mcneilab, Inc. | Hexahydroindolinzine compounds, pharmaceutical compositions and methods and intermediates |
| US5221792A (en) * | 1989-02-21 | 1993-06-22 | Agrimont S.P.A. | Derivatives from 3,4-dehydro-piperidin-5-one exhibiting a herbicidal activity |
| IT1230768B (it) * | 1989-02-21 | 1991-10-29 | Agrimont Spa | Derivati del 3,4 deidro piperidin 5 one ad attivita' erbicida. |
| CA2200469A1 (en) * | 1994-10-11 | 1996-04-18 | Takeda Chemical Industries, Ltd. | Condensed compounds, their production and use |
| AU2002333655A1 (en) | 2001-09-25 | 2003-04-07 | Smithkline Beecham Corporation | Bicyclic heterocycles as rxr ligands |
| US20060074102A1 (en) * | 2004-05-14 | 2006-04-06 | Kevin Cusack | Kinase inhibitors as therapeutic agents |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2358150A1 (fr) * | 1976-07-13 | 1978-02-10 | Parcor | Nouvelles thieno (2,3-c) et (3,2-c) pyridines, leur procede de preparation et leur application |
| AT368504B (de) * | 1977-10-15 | 1982-10-25 | Boehringer Sohn Ingelheim | Verfahren zur herstellung neuer 4-phenyl-thieno- (2,3-c)-piperidine |
| FR2414048A1 (fr) * | 1978-01-04 | 1979-08-03 | Parcor | Benzofuro (2,3-c) pyridines, leur procede de preparation et leur application en therapeutique |
| US4282227A (en) * | 1980-05-22 | 1981-08-04 | Smithkline Corporation | Renal vasodilating 3,4-dihydroxyphenyltetrahydrothienopyridines |
-
1983
- 1983-04-26 IL IL71661A patent/IL71661A0/xx unknown
- 1983-04-27 DE DE19833315157 patent/DE3315157A1/de not_active Withdrawn
-
1984
- 1984-04-14 EP EP84104256A patent/EP0123998A3/de not_active Withdrawn
- 1984-04-17 PH PH30614A patent/PH19896A/en unknown
- 1984-04-19 US US06/601,910 patent/US4636510A/en not_active Expired - Fee Related
- 1984-04-25 FI FI841615A patent/FI841615A7/fi not_active Application Discontinuation
- 1984-04-26 NZ NZ207943A patent/NZ207943A/en unknown
- 1984-04-26 JP JP59085089A patent/JPS59205383A/ja active Pending
- 1984-04-26 DK DK209384A patent/DK209384A/da not_active Application Discontinuation
- 1984-04-26 PT PT78487A patent/PT78487B/pt unknown
- 1984-04-26 GR GR74509A patent/GR79573B/el unknown
- 1984-04-26 NO NO841661A patent/NO841661L/no unknown
- 1984-04-26 ES ES531927A patent/ES531927A0/es active Granted
- 1984-04-26 ZA ZA843084A patent/ZA843084B/xx unknown
- 1984-04-27 AU AU27436/84A patent/AU566073B2/en not_active Ceased
- 1984-04-27 KR KR1019840002270A patent/KR840008357A/ko not_active Withdrawn
- 1984-04-27 GB GB08410840A patent/GB2138817B/en not_active Expired
- 1984-12-14 ES ES538617A patent/ES8602002A1/es not_active Expired
- 1984-12-14 ES ES538616A patent/ES538616A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FI841615A7 (fi) | 1984-10-28 |
| AU566073B2 (en) | 1987-10-08 |
| GR79573B (es) | 1984-10-30 |
| ES538617A0 (es) | 1985-11-01 |
| GB2138817A (en) | 1984-10-31 |
| DK209384A (da) | 1984-10-28 |
| ES8504807A1 (es) | 1985-04-16 |
| KR840008357A (ko) | 1984-12-14 |
| NO841661L (no) | 1984-10-29 |
| ES8602001A1 (es) | 1985-11-01 |
| DE3315157A1 (de) | 1984-10-31 |
| GB2138817B (en) | 1986-10-01 |
| PT78487B (de) | 1986-07-22 |
| NZ207943A (en) | 1986-10-08 |
| EP0123998A2 (de) | 1984-11-07 |
| ES531927A0 (es) | 1985-04-16 |
| IL71661A0 (en) | 1984-07-31 |
| FI841615A0 (fi) | 1984-04-25 |
| PT78487A (de) | 1984-05-01 |
| US4636510A (en) | 1987-01-13 |
| JPS59205383A (ja) | 1984-11-20 |
| PH19896A (en) | 1986-08-13 |
| DK209384D0 (da) | 1984-04-26 |
| ES538616A0 (es) | 1985-11-01 |
| EP0123998A3 (de) | 1987-09-30 |
| GB8410840D0 (en) | 1984-06-06 |
| ZA843084B (en) | 1985-12-24 |
| AU2743684A (en) | 1984-11-01 |
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