ES8205858A1 - Process for Preparing Insulin Esters - Google Patents
Process for Preparing Insulin EstersInfo
- Publication number
- ES8205858A1 ES8205858A1 ES499238A ES499238A ES8205858A1 ES 8205858 A1 ES8205858 A1 ES 8205858A1 ES 499238 A ES499238 A ES 499238A ES 499238 A ES499238 A ES 499238A ES 8205858 A1 ES8205858 A1 ES 8205858A1
- Authority
- ES
- Spain
- Prior art keywords
- insulin
- preparing insulin
- insulin esters
- esters
- threonine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 101000976075 Homo sapiens Insulin Proteins 0.000 abstract 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Natural products C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 2
- 239000004473 Threonine Substances 0.000 abstract 2
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 2
- 230000002608 insulinlike Effects 0.000 abstract 2
- 229960002898 threonine Drugs 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- -1 L-threonine ester Chemical class 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 102000004142 Trypsin Human genes 0.000 abstract 1
- 108090000631 Trypsin Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 239000012588 trypsin Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Forklifts And Lifting Vehicles (AREA)
Abstract
Insulin and insulin-like compounds from certain species can in the presence of an L-threonine ester, water, a water miscible organic solvent, and trypsin be transpeptidized into a threonine<B30> ester of human insulin in which the protecting group(s) can be removed whereby human insulin is formed.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK57480A DK147109C (en) | 1980-02-11 | 1980-02-11 | METHOD FOR PREPARING HUMAN INSULIN OR HUMAN INSULINESTERS OR A SALT OR COMPLEX THEREOF |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8205858A1 true ES8205858A1 (en) | 1982-08-01 |
| ES499238A0 ES499238A0 (en) | 1982-08-01 |
Family
ID=8095095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES499238A Granted ES499238A0 (en) | 1980-02-11 | 1981-02-09 | A PROCEDURE FOR THE PREPARATION OF HUMAN INSULIN OR INSULIN ESTERS. |
Country Status (19)
| Country | Link |
|---|---|
| JP (1) | JPS56135452A (en) |
| AR (1) | AR231277A1 (en) |
| AU (1) | AU541528B2 (en) |
| BE (1) | BE887480A (en) |
| CA (1) | CA1162868A (en) |
| CH (1) | CH655949A5 (en) |
| DE (1) | DE3104949C2 (en) |
| DK (3) | DK147109C (en) |
| ES (1) | ES499238A0 (en) |
| FI (1) | FI77876C (en) |
| GB (1) | GB2069502B (en) |
| GR (1) | GR73844B (en) |
| IT (1) | IT1195038B (en) |
| NL (1) | NL178797C (en) |
| NO (1) | NO156247C (en) |
| NZ (1) | NZ196224A (en) |
| PT (1) | PT72485B (en) |
| SE (2) | SE427025B (en) |
| ZA (1) | ZA81898B (en) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK147437A (en) | 1980-02-11 | 1900-01-01 | Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof | |
| DE3101382A1 (en) * | 1981-01-17 | 1982-09-02 | Hoechst Ag, 6000 Frankfurt | "METHOD FOR PRODUCING HUMANISULIN OR ITS DERIVATIVES FROM PIG INSULIN OR ITS DERIVATIVES" |
| AU551174B2 (en) * | 1981-09-15 | 1986-04-17 | Nordisk Insulinlaboratorium | Enzymatic preparation of human insulin or b-30 esters thereof |
| DK149824C (en) * | 1982-01-22 | 1987-03-16 | Carlsberg Biotechnology Ltd | PROCEDURE FOR ENZYMATIC REPLACEMENT OF B-30 AMINO ACIDS IN INSULINES |
| EP0087238A1 (en) * | 1982-02-08 | 1983-08-31 | Biogen N.V. | Am improved method for preparing human insulin from non-human insulin |
| DE3209184A1 (en) * | 1982-03-13 | 1983-09-15 | Hoechst Ag, 6230 Frankfurt | METHOD FOR CONVERTING PRAEPROINSULIN ANALOGS TO INSULINES |
| NL8201650A (en) * | 1982-04-21 | 1983-11-16 | Akzo Nv | SEMISYNTHETIC PREPARATION OF HUMANE INSULIN. |
| EP0092829B1 (en) * | 1982-04-23 | 1990-11-07 | Wako Pure Chemical Industries, Ltd. | Process for semi-synthesis of human insulin and alkaline protease for use therein |
| DK55183D0 (en) * | 1983-02-09 | 1983-02-09 | Nordisk Insulinlab | METHOD OF MANUFACTURING HUMAN INSULIN |
| DE3334407A1 (en) * | 1983-09-23 | 1985-04-04 | Hoechst Ag, 6230 Frankfurt | INSULINE DERIVATIVES MODIFIED IN POSITION B 30, METHOD FOR THE PRODUCTION AND USE THEREOF AND PHARMACEUTICAL AGENTS FOR THE TREATMENT OF THE DIABETES MELLITUS |
| DK119785D0 (en) * | 1985-03-15 | 1985-03-15 | Nordisk Gentofte | INSULIN PREPARATION |
| US5157021A (en) * | 1985-03-15 | 1992-10-20 | Novo Nordisk A/S | Insulin derivatives and pharmaceutical preparations containing these derivatives |
| SE449472B (en) * | 1985-10-15 | 1987-05-04 | Mth Gruppen Ab | EQUIPMENT AT FLOOR STORES |
| PT86819B (en) * | 1987-02-25 | 1992-05-29 | Novo Industri As | A process for the preparation of new derivatives of insulin and pharmaceutical compositions containing them |
| DK134189D0 (en) * | 1989-03-20 | 1989-03-20 | Nordisk Gentofte | INSULIN COMPOUNDS |
| FI96503C (en) * | 1994-08-26 | 1996-07-10 | Hymatic Ltd Oy | Method and apparatus for controlling a mast |
| US7658721B2 (en) | 2004-01-16 | 2010-02-09 | Biodel Inc. | Sublingual drug delivery device |
| US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
| US8084420B2 (en) | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
| US7713929B2 (en) | 2006-04-12 | 2010-05-11 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
| JP2009533471A (en) | 2006-04-12 | 2009-09-17 | バイオデル， インコーポレイテッド | Rapid-acting and long-acting combined insulin preparations |
| US9060927B2 (en) | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0017938B1 (en) * | 1979-04-13 | 1983-08-03 | Shionogi & Co., Ltd. | Process for preparing a b30-threonine insulin |
| DK147437A (en) | 1980-02-11 | 1900-01-01 | Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof | |
| DE3101382A1 (en) * | 1981-01-17 | 1982-09-02 | Hoechst Ag, 6000 Frankfurt | "METHOD FOR PRODUCING HUMANISULIN OR ITS DERIVATIVES FROM PIG INSULIN OR ITS DERIVATIVES" |
-
0
- DK DK147437D patent/DK147437A/en unknown
-
1980
- 1980-02-11 DK DK57480A patent/DK147109C/en not_active IP Right Cessation
-
1981
- 1981-02-09 ES ES499238A patent/ES499238A0/en active Granted
- 1981-02-09 DK DK54081A patent/DK147437C/en not_active IP Right Cessation
- 1981-02-10 JP JP1758081A patent/JPS56135452A/en active Granted
- 1981-02-10 NO NO810443A patent/NO156247C/en unknown
- 1981-02-10 PT PT72485A patent/PT72485B/en not_active IP Right Cessation
- 1981-02-10 IT IT19620/81A patent/IT1195038B/en active
- 1981-02-10 CA CA000370483A patent/CA1162868A/en not_active Expired
- 1981-02-10 NL NLAANVRAGE8100624,A patent/NL178797C/en not_active IP Right Cessation
- 1981-02-10 FI FI810385A patent/FI77876C/en not_active IP Right Cessation
- 1981-02-10 AR AR284258A patent/AR231277A1/en active
- 1981-02-10 NZ NZ196224A patent/NZ196224A/en unknown
- 1981-02-10 SE SE8100926A patent/SE427025B/en not_active IP Right Cessation
- 1981-02-10 GB GB8104114A patent/GB2069502B/en not_active Expired
- 1981-02-10 SE SE8100928A patent/SE451143B/en not_active IP Right Cessation
- 1981-02-11 AU AU67180/81A patent/AU541528B2/en not_active Ceased
- 1981-02-11 CH CH910/81A patent/CH655949A5/en not_active IP Right Cessation
- 1981-02-11 DE DE3104949A patent/DE3104949C2/en not_active Expired
- 1981-02-11 ZA ZA00810898A patent/ZA81898B/en unknown
- 1981-02-11 BE BE6/47396A patent/BE887480A/en not_active IP Right Cessation
- 1981-02-11 GR GR64097A patent/GR73844B/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20020304 |