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ES8103015A1 - Procedimiento para preparar derivados de polioles - Google Patents

Procedimiento para preparar derivados de polioles

Info

Publication number
ES8103015A1
ES8103015A1 ES489250A ES489250A ES8103015A1 ES 8103015 A1 ES8103015 A1 ES 8103015A1 ES 489250 A ES489250 A ES 489250A ES 489250 A ES489250 A ES 489250A ES 8103015 A1 ES8103015 A1 ES 8103015A1
Authority
ES
Spain
Prior art keywords
procedure
formula
carbon atoms
polyol derivatives
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES489250A
Other languages
English (en)
Other versions
ES489250A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of ES489250A0 publication Critical patent/ES489250A0/es
Publication of ES8103015A1 publication Critical patent/ES8103015A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20—Free hydroxyl or mercaptan
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE POLIOLES. SE EMPLEA PRINCIPALMENTE PARA LA OBTENCION POR ESTERIFICACION DE MONO- DI- TRI- Y ETRAESTERES DE UN ACIDO DE FORMULA GENERAL: Y DE ALCOHOL ELEGIDO EN UN CONJUNTO DE LOS MISMOS ENTRE LOS QUE SE ENCUENTRAN LOS SIGUIENTES: GLICEROL, DIETILENGLICOL, DIETANOLAMINA, PENTAERITROL, TIOGLICOL Y LOS DIVERSOS PROPANODIOLES, BUTANODIOLES Y CICLOHEXANODIOLES. LOS SIMBOLOS DE LA FORMULA I TIENEN LOS SIGUIENTES SIGNIFICADOS: <N> ES O O 1; <M> ES 0,1,2,3 O 4; R1 Y R2 PUEDEN SER, INDEPENDIENTEMENTE, RADICALES ALQUILO DE CADENA RECTA O RAMIFICADA DE HASTA 5 ATOMOS DE CARBONO, O CONJUNTAMENTE, UN RADICAL TETRAMETILENO, PENTAMETILENO O HEXA METILENO; Y R3 ES UN RADICAL ALQUILO DE MENOS DE 6 ATOMOS DE CARBONO. LOS DERIVADOS POLIOLICOS OBTENIDOS PRESENTAN ACTIVIDAD FARMACOLOGICA Y SON DE EMPLEO DE NEUROPSIQUIATRIA PARA EL TRATAMIENTO DE TRASTARNOS NERVISOS. *FORMULA*.
ES489250A 1979-03-06 1980-03-06 Procedimiento para preparar derivados de polioles Expired ES8103015A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7907932 1979-03-06

Publications (2)

Publication Number Publication Date
ES489250A0 ES489250A0 (es) 1981-02-16
ES8103015A1 true ES8103015A1 (es) 1981-02-16

Family

ID=10503667

Family Applications (1)

Application Number Title Priority Date Filing Date
ES489250A Expired ES8103015A1 (es) 1979-03-06 1980-03-06 Procedimiento para preparar derivados de polioles

Country Status (29)

Country Link
US (1) US4423071A (es)
EP (1) EP0018342B1 (es)
JP (1) JPS55141436A (es)
AR (1) AR224394A1 (es)
AU (1) AU534007B2 (es)
CA (1) CA1162928A (es)
CS (1) CS216526B2 (es)
CY (1) CY1209A (es)
DD (2) DD151931A5 (es)
DE (1) DE3061960D1 (es)
DK (1) DK93880A (es)
ES (1) ES8103015A1 (es)
FI (1) FI69449C (es)
GR (1) GR70703B (es)
HK (1) HK22384A (es)
HU (2) HU183072B (es)
IE (1) IE49539B1 (es)
IL (1) IL59407A (es)
IN (1) IN152492B (es)
MY (1) MY8500075A (es)
NO (1) NO152899C (es)
NZ (1) NZ192944A (es)
OA (1) OA06568A (es)
PL (1) PL124023B1 (es)
PT (1) PT70904A (es)
SG (1) SG61583G (es)
SU (3) SU1195901A3 (es)
YU (2) YU41699B (es)
ZA (1) ZA801081B (es)

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IL72381A (en) * 1983-07-20 1988-03-31 Sanofi Sa Pharmaceutical composition based on valproic acid
US5185159A (en) * 1983-07-20 1993-02-09 Sanofi Pharmaceutical composition based on valproic acid and a process for preparing it
US4590282A (en) * 1984-09-24 1986-05-20 Sandoz Ltd. Pest control agents
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FR2627487B1 (fr) * 1988-02-19 1991-03-29 Martin Laboratoires Nouveau derive de l'acide valproique, procede de preparation de ce compose ainsi que medicament antiepileptique le contenant
US5011977A (en) * 1988-04-08 1991-04-30 Eastman Kodak Company Transesterification of alkoxyesters
JPH01299222A (ja) * 1988-05-26 1989-12-04 Otsuka Pharmaceut Factory Inc 抗腫瘍剤
FR2641986B1 (fr) * 1989-01-26 1991-05-03 Oreal Procede de preparation de tensio-actifs non ioniques a partir de l'isopropylidene-1,2 epoxypropyl-3 glycerol et d'un acide carboxylique, nouveaux tensio-actifs non ioniques et leur utilisation
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WO1996034858A1 (en) * 1995-05-01 1996-11-07 Scotia Holdings Plc Nicotinic acid esters and pharmaceutical compositions containing them
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US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
CA2446904A1 (en) 2001-05-24 2003-04-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
JP4526741B2 (ja) * 2001-07-18 2010-08-18 花王株式会社 エーテルカルボキシレートモノグリセリド
FR2828487B1 (fr) 2001-08-09 2005-05-27 Genfit S A Nouveaux composes derives d'acides gras, preparation et utilisations
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
FR2850650B1 (fr) * 2003-01-31 2005-03-25 Genfit S A Utilisation therapeutique d'acylglycerols et de leurs analogues azotes et sulfures
JP2007516404A (ja) 2003-05-21 2007-06-21 アレックザ ファーマシューティカルズ， インコーポレイテッド 光学点火されたかまたは電気点火された内蔵式加熱ユニットおよびそれを使用する薬剤供給ユニット
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EP2121088B1 (en) 2007-03-09 2016-07-13 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
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US9744542B2 (en) 2013-07-29 2017-08-29 Apeel Technology, Inc. Agricultural skin grafting
CN107709349B (zh) 2015-05-20 2022-01-28 阿比尔技术公司 植物提取物组合物和制备其的方法
JP7049245B2 (ja) 2015-09-16 2022-04-06 アピール テクノロジー，インコーポレイテッド 分子コーティングのための前駆体化合物
ES2939007T3 (es) 2015-12-10 2023-04-18 Apeel Tech Inc Composiciones de extractos de plantas para formar recubrimientos protectores
JP6913110B2 (ja) 2016-01-26 2021-08-04 アピール テクノロジー，インコーポレイテッド 衛生化された産物を調製および保存するための方法
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CN110087475B (zh) 2016-11-17 2023-04-11 阿比尔技术公司 由植物提取物形成的组合物及其制备方法
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KR102852740B1 (ko) 2018-02-02 2025-08-29 알렉스자 파마스티칼즈, 인크. 전기적 응축 에어로졸 디바이스
US12245605B2 (en) 2018-09-05 2025-03-11 Apeel Technology, Inc. Compounds and formulations for protective coatings
EP4114181A1 (en) 2020-03-04 2023-01-11 Apeel Technology, Inc. Coated agricultural products and corresponding methods
WO2022094339A1 (en) 2020-10-30 2022-05-05 Apeel Technology, Inc. Compositions and methods of preparation thereof
JP2024532457A (ja) 2021-09-08 2024-09-05 アピール テクノロジー，インコーポレイテッド 保護コーティング用の化合物及び配合物

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IL59407A (en) * 1979-03-06 1983-12-30 Sanofi Sa Di-n-propylacetic acid diesters of glycerol,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FI69449C (fi) 1986-02-10
YU41699B (en) 1987-12-31
NZ192944A (en) 1984-07-06
IE49539B1 (en) 1985-10-30
ZA801081B (en) 1981-03-25
FI800683A7 (fi) 1980-09-07
HU188840B (en) 1986-05-28
FI69449B (fi) 1985-10-31
SU1225481A3 (ru) 1986-04-15
DD158773A5 (de) 1983-02-02
HK22384A (en) 1984-03-23
SU1195901A3 (ru) 1985-11-30
DE3061960D1 (en) 1983-03-24
YU42064B (en) 1988-04-30
PL124023B1 (en) 1982-12-31
GR70703B (es) 1983-01-04
IE800445L (en) 1980-09-06
IL59407A (en) 1983-12-30
CY1209A (en) 1983-12-31
NO152899C (no) 1985-12-11
HU183072B (en) 1984-04-28
JPS55141436A (en) 1980-11-05
SU1052507A1 (ru) 1983-11-07
JPS6315256B2 (es) 1988-04-04
CS216526B2 (en) 1982-11-26
ES489250A0 (es) 1981-02-16
MY8500075A (en) 1985-12-31
CA1162928A (en) 1984-02-28
IL59407A0 (en) 1980-05-30
AU5587280A (en) 1980-09-11
OA06568A (fr) 1981-08-31
NO800626L (no) 1980-09-08
PT70904A (en) 1980-04-01
EP0018342B1 (fr) 1983-02-16
DK93880A (da) 1980-09-07
YU61580A (en) 1983-04-30
AU534007B2 (en) 1983-12-22
US4423071A (en) 1983-12-27
NO152899B (no) 1985-09-02
IN152492B (es) 1984-01-28
DD151931A5 (de) 1981-11-11
YU292382A (en) 1983-09-30
AR224394A1 (es) 1981-11-30
SG61583G (en) 1985-02-15
EP0018342A1 (fr) 1980-10-29
PL222446A1 (es) 1981-01-30

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