ES8201526A1 - Un procedimiento para la preparacion de nuevos derivados de 1,1'-binefil-2-il-alquilamina - Google Patents
Un procedimiento para la preparacion de nuevos derivados de 1,1'-binefil-2-il-alquilaminaInfo
- Publication number
- ES8201526A1 ES8201526A1 ES497207A ES497207A ES8201526A1 ES 8201526 A1 ES8201526 A1 ES 8201526A1 ES 497207 A ES497207 A ES 497207A ES 497207 A ES497207 A ES 497207A ES 8201526 A1 ES8201526 A1 ES 8201526A1
- Authority
- ES
- Spain
- Prior art keywords
- biphenyl
- carbon atoms
- production
- preparations containing
- containing same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 1,1'-Biphenyl-2-yl alkylamine Chemical class 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 230000002526 effect on cardiovascular system Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 238000006722 reduction reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 1,1''-BIFENIL-2-IL-ALQUILAMINA, DE FORMULA GENERAL (I), DONDE X ES HIDROGENO O UN SUSTITUYENTE HALOGENO EN CUALQUIER POSICION DEL ANILLO DE FENILO; R1 ES HIDROXI; R2 ES HIDROGENO; Z ES -(CH2)N- O -CH2-CHOH-CH2-, EN DONDE N ES 2, 3 O 4; R3 Y R4 INDEPENDIENTEMENTE SON HIDROGENO, ALQUILO DE 1 A 6 ATOMOS DE CARBONO, CH2-ALQUENILO DE 2 A 5 ATOMOS DE CARBONO, O FENILALQUILO DE 1 A 3 ATOMOS DE CARBONO; Y SUS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN SOMETER A UNA REACCION DE REDUCCION UNA CETONA DE FORMULA (II), DONDE X, Z, R3 Y R4 TIENEN LOS SIGNIFICADOS YA INDICADOS. LOS COMPUESTOS DE FORMULA (I), TRATADOS CON ACIDOS ORGANICOS O INORGANICOS ADECUADOS, SE TRANSFORMAN EN LAS CORRESPONDIENTES SALES FARMACEUTICAMENTE ACEPTABLES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1953479A | 1979-03-12 | 1979-03-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8201526A1 true ES8201526A1 (es) | 1981-12-16 |
| ES497207A0 ES497207A0 (es) | 1981-12-16 |
Family
ID=21793713
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES489469A Expired ES8105262A1 (es) | 1979-03-12 | 1980-03-12 | Un procedimiento para la preparacion de 1, 1'-bifenil-2-il- alquilamina. |
| ES497208A Granted ES497208A0 (es) | 1979-03-12 | 1980-11-27 | Un procedimiento para las preparaciones de nuevos derivados de 1,1'-bifenil-2-il-alquilamina |
| ES497210A Expired ES8201529A1 (es) | 1979-03-12 | 1980-11-27 | Un procedimiento para la preparacion de nuevos derivados de 1-1'-bifenil-2-il-alquilamina |
| ES497207A Granted ES497207A0 (es) | 1979-03-12 | 1980-11-27 | Un procedimiento para la preparacion de nuevos derivados de 1,1'-binefil-2-il-alquilamina |
| ES497206A Granted ES497206A0 (es) | 1979-03-12 | 1980-11-27 | Un procedimiento para la preparacion de nuevos derivados de 1,1'-bifenil-2-il-alquilamina |
| ES497209A Expired ES8201528A1 (es) | 1979-03-12 | 1980-11-27 | Un procedimiento para la preparacion de nuevos derivados de 1,1'-bifenil-2-il-alquilamina |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES489469A Expired ES8105262A1 (es) | 1979-03-12 | 1980-03-12 | Un procedimiento para la preparacion de 1, 1'-bifenil-2-il- alquilamina. |
| ES497208A Granted ES497208A0 (es) | 1979-03-12 | 1980-11-27 | Un procedimiento para las preparaciones de nuevos derivados de 1,1'-bifenil-2-il-alquilamina |
| ES497210A Expired ES8201529A1 (es) | 1979-03-12 | 1980-11-27 | Un procedimiento para la preparacion de nuevos derivados de 1-1'-bifenil-2-il-alquilamina |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES497206A Granted ES497206A0 (es) | 1979-03-12 | 1980-11-27 | Un procedimiento para la preparacion de nuevos derivados de 1,1'-bifenil-2-il-alquilamina |
| ES497209A Expired ES8201528A1 (es) | 1979-03-12 | 1980-11-27 | Un procedimiento para la preparacion de nuevos derivados de 1,1'-bifenil-2-il-alquilamina |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP0015776B1 (es) |
| JP (1) | JPS55127347A (es) |
| KR (1) | KR840000103B1 (es) |
| AR (1) | AR228852A1 (es) |
| AT (1) | AT367395B (es) |
| AU (1) | AU528060B2 (es) |
| BE (1) | BE882167A (es) |
| CA (1) | CA1144926A (es) |
| CH (1) | CH644094A5 (es) |
| CS (1) | CS215052B2 (es) |
| DD (1) | DD149664A5 (es) |
| DE (1) | DE3060611D1 (es) |
| DK (1) | DK103480A (es) |
| ES (6) | ES8105262A1 (es) |
| FI (1) | FI800736A7 (es) |
| FR (1) | FR2451363A1 (es) |
| GB (1) | GB2046256B (es) |
| GR (1) | GR68036B (es) |
| HU (1) | HU180334B (es) |
| IE (1) | IE49552B1 (es) |
| IL (1) | IL59557A (es) |
| IT (1) | IT1140773B (es) |
| LU (1) | LU82237A1 (es) |
| MX (1) | MX6219E (es) |
| NZ (1) | NZ193079A (es) |
| PH (1) | PH14749A (es) |
| PL (1) | PL121662B1 (es) |
| PT (1) | PT70928A (es) |
| RO (1) | RO79906A (es) |
| SU (2) | SU940645A3 (es) |
| ZA (1) | ZA801421B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100470454B1 (ko) * | 2002-05-14 | 2005-02-05 | 대한민국 | 돼지 사료공급을 위한 자동조절급이기 |
| JP2008515768A (ja) * | 2004-06-17 | 2008-05-15 | エム ユー エス シー ファンデーション フォー リサーチ ディベロップメント | 非天然アミノ酸 |
| EP2511273B8 (en) * | 2011-04-15 | 2019-06-26 | Hivih | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| EP2821104A1 (en) | 2013-07-05 | 2015-01-07 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES236010A1 (es) * | 1956-06-29 | 1957-12-16 | Lab Pharmaceutica Dr C Janssen | UN PROCEDIMIENTO PARA PREPARAR NUEVOS DERIVADOS PARASIMPATICOLiTICAMENTE ACTIVOS DE ALFAS-DEFENIL PROPANO |
| US3433836A (en) * | 1966-01-14 | 1969-03-18 | Rexall Drug Chemical | Alpha-diaryl alpha,omega-alkylene glycol-dilower-alkylamines |
| GB1475314A (en) * | 1973-11-02 | 1977-06-01 | Cm Ind | Phenyl-propylamine derivatives |
| IL48319A0 (en) * | 1974-10-26 | 1975-12-31 | Merck Patent Gmbh | Araliphatic nitrogen compounds and a process for their preparation |
| GB1523655A (en) * | 1975-02-10 | 1978-09-06 | Armour Pharma | 4-(4-biphenylyl) butylamines and treatment of the animal organism therewith |
-
1980
- 1980-03-09 IL IL59557A patent/IL59557A/xx unknown
- 1980-03-10 PT PT70928A patent/PT70928A/pt unknown
- 1980-03-10 FR FR8005311A patent/FR2451363A1/fr active Granted
- 1980-03-10 PH PH23743A patent/PH14749A/en unknown
- 1980-03-10 RO RO80100427A patent/RO79906A/ro unknown
- 1980-03-10 HU HU8080563A patent/HU180334B/hu unknown
- 1980-03-10 NZ NZ193079A patent/NZ193079A/xx unknown
- 1980-03-10 CH CH186880A patent/CH644094A5/fr not_active IP Right Cessation
- 1980-03-10 GR GR61387A patent/GR68036B/el unknown
- 1980-03-10 AU AU56302/80A patent/AU528060B2/en not_active Ceased
- 1980-03-10 LU LU82237A patent/LU82237A1/fr unknown
- 1980-03-10 CA CA000347365A patent/CA1144926A/en not_active Expired
- 1980-03-11 GB GB8008170A patent/GB2046256B/en not_active Expired
- 1980-03-11 IT IT20503/80A patent/IT1140773B/it active
- 1980-03-11 DK DK103480A patent/DK103480A/da not_active Application Discontinuation
- 1980-03-11 CS CS801665A patent/CS215052B2/cs unknown
- 1980-03-11 AT AT0134580A patent/AT367395B/de not_active IP Right Cessation
- 1980-03-11 EP EP80300744A patent/EP0015776B1/en not_active Expired
- 1980-03-11 JP JP3256880A patent/JPS55127347A/ja active Pending
- 1980-03-11 DE DE8080300744T patent/DE3060611D1/de not_active Expired
- 1980-03-11 PL PL1980222601A patent/PL121662B1/pl unknown
- 1980-03-11 ZA ZA00801421A patent/ZA801421B/xx unknown
- 1980-03-11 IE IE493/80A patent/IE49552B1/en unknown
- 1980-03-11 FI FI800736A patent/FI800736A7/fi not_active Application Discontinuation
- 1980-03-11 BE BE1/9747A patent/BE882167A/fr not_active IP Right Cessation
- 1980-03-12 KR KR1019800001023A patent/KR840000103B1/ko not_active Expired
- 1980-03-12 AR AR280280A patent/AR228852A1/es active
- 1980-03-12 MX MX808706U patent/MX6219E/es unknown
- 1980-03-12 ES ES489469A patent/ES8105262A1/es not_active Expired
- 1980-03-12 SU SU802892804A patent/SU940645A3/ru active
- 1980-03-12 DD DD80219615A patent/DD149664A5/de unknown
- 1980-11-27 ES ES497208A patent/ES497208A0/es active Granted
- 1980-11-27 ES ES497210A patent/ES8201529A1/es not_active Expired
- 1980-11-27 ES ES497207A patent/ES497207A0/es active Granted
- 1980-11-27 ES ES497206A patent/ES497206A0/es active Granted
- 1980-11-27 ES ES497209A patent/ES8201528A1/es not_active Expired
-
1981
- 1981-01-14 SU SU813229052A patent/SU1022655A3/ru active
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