ES470916A1 - un procedimiento para la preparacion de derivados de acidos4-hidroxi-2-quinolinon-3-carboxilicos - Google Patents
un procedimiento para la preparacion de derivados de acidos4-hidroxi-2-quinolinon-3-carboxilicosInfo
- Publication number
- ES470916A1 ES470916A1 ES470916A ES470916A ES470916A1 ES 470916 A1 ES470916 A1 ES 470916A1 ES 470916 A ES470916 A ES 470916A ES 470916 A ES470916 A ES 470916A ES 470916 A1 ES470916 A1 ES 470916A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- alkyl
- quinolinone
- hydroxy
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 16
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Chemical group 0.000 abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Chemical group 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
Un procedimiento para la preparación de derivados de ácidos 4- hidroxi-2-quinolinon-3-carboxílicos de fórmula I, **(Fórmula)** donde a) Ro es cicloalquil de 3 a 6 átomos de carbono, cicloalquilalquilo donde el radical cicloalquilo es de 3 a 6 átomos de carbono, y el radical alquilo es de 1 ó 2 átomos de carbono, alquenilo o alquinilo de 3 a 6 átomos de carbono. b) R es hidrógeno, R1 es hidrógeno, flúor, cloro, bromo, alquilo de 1 a 4 átomos de carbono o alcoxi de 1 a 4 átomos de carbono y R2 es flúor, cloro, bromo, alquilo de 1 a 4 átomos de carbono, alcoxi de 1 a 4 átomos de carbono, nitro o trifluormetilo, c) Ro es alquilo de 1 a 6 átomos de carbono y R1 y R2 son independientemente alcoxi de 1 a 4 átomos de carbono o d) Ro es hidrógeno, alquilo de 1 a 6 átomos de carbono, cicloalquilo de 3 a 6 átomos de carbono, cicloalquialquilo donde el radical cicloalquilo es de 3 a 6 átomos de carbono y el radical alquilo es de 1 a 2 átomos de carbono, alquenilo o alquinilo de 3 a 6 átomos de carbono.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/807,914 US4187309A (en) | 1977-06-20 | 1977-06-20 | 4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES470916A1 true ES470916A1 (es) | 1979-10-01 |
Family
ID=25197418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES470916A Expired ES470916A1 (es) | 1977-06-20 | 1978-06-19 | un procedimiento para la preparacion de derivados de acidos4-hidroxi-2-quinolinon-3-carboxilicos |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4187309A (es) |
| EP (1) | EP0000153A1 (es) |
| JP (1) | JPS5495578A (es) |
| AT (1) | AT367403B (es) |
| AU (1) | AU521418B2 (es) |
| CA (1) | CA1105462A (es) |
| DK (1) | DK262678A (es) |
| ES (1) | ES470916A1 (es) |
| FI (1) | FI781885A7 (es) |
| IL (1) | IL54949A (es) |
| IT (1) | IT7849938A0 (es) |
| NZ (1) | NZ187618A (es) |
| PT (1) | PT68192B (es) |
| ZA (1) | ZA783515B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE27451T1 (de) * | 1981-03-24 | 1987-06-15 | Ciba Geigy Ag | Acyl-chinolinonderivate, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische praeparate und ihre verwendung. |
| WO1992004327A1 (en) * | 1990-09-07 | 1992-03-19 | Schering Corporation | Antiviral compounds and antihypertensive compounds |
| US5179107A (en) * | 1990-09-07 | 1993-01-12 | Schering Corporation | Antiviral quinolinone compounds |
| US5179093A (en) * | 1991-05-10 | 1993-01-12 | Schering Corporation | Quinoline-diones |
| TW505634B (en) * | 1998-01-19 | 2002-10-11 | Dainippon Ink & Amp Chemicals | Quinolinone glucoside, the process for preparing thereof and antiallergic |
| US8003122B2 (en) | 2004-03-31 | 2011-08-23 | Cordis Corporation | Device for local and/or regional delivery employing liquid formulations of therapeutic agents |
| US7846940B2 (en) | 2004-03-31 | 2010-12-07 | Cordis Corporation | Solution formulations of sirolimus and its analogs for CAD treatment |
| US8420110B2 (en) | 2008-03-31 | 2013-04-16 | Cordis Corporation | Drug coated expandable devices |
| US8409601B2 (en) | 2008-03-31 | 2013-04-02 | Cordis Corporation | Rapamycin coated expandable devices |
| CN119143671B (zh) * | 2024-11-21 | 2025-05-16 | 九洲药业(杭州)有限公司 | 一种插羰反应一锅法简便合成喹啉酮衍生物的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR814843A (fr) | 1936-12-12 | 1937-06-30 | Askania Werke Ag | Perfectionnements aux appareils cinématographiques de prise de vues |
| CH471784A (de) | 1966-01-26 | 1969-04-30 | Bayer Ag | Verfahren zur Herstellung von Carbostyrilderivaten |
| US3657223A (en) * | 1969-01-17 | 1972-04-18 | Hoffmann La Roche | Process for the preparation of benzodiazepin-2-one derivatives |
| BE806848A (fr) * | 1972-11-02 | 1974-04-30 | Sandoz Sa | Medicament a base d'un derive de la quinoleine |
| CA1034124A (en) * | 1973-05-11 | 1978-07-04 | Ciba-Geigy Ag | Process for the manufacture of new quinolines |
| GB1480737A (en) * | 1973-10-11 | 1977-07-20 | Beecham Group Ltd | Isocoumarins thiaisocoumarins and isocarbostyrils and pharmaceutical compositions containing them |
| GB1504709A (en) | 1974-12-07 | 1978-03-22 | Fisons Ltd | N-substituted quinolinone-2-carboxyl. acid der |
| FR2340735A1 (fr) * | 1976-02-11 | 1977-09-09 | Roussel Uclaf | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
| ES456325A1 (es) * | 1976-02-27 | 1978-05-01 | Sandoz Ag | Un procedimiento para la preparacion de nuevos derivados delacido 4-hidroxi-2-quinolinon-3-carboxilico. |
| US4119720A (en) * | 1977-07-06 | 1978-10-10 | Sandoz, Inc. | Unsaturated esters of 4-hydroxy-2-quinolinone-3-carboxylic acids and salts thereof |
-
1977
- 1977-06-20 US US05/807,914 patent/US4187309A/en not_active Expired - Lifetime
-
1978
- 1978-06-12 DK DK262678A patent/DK262678A/da not_active Application Discontinuation
- 1978-06-13 FI FI781885A patent/FI781885A7/fi not_active Application Discontinuation
- 1978-06-15 EP EP78100168A patent/EP0000153A1/en not_active Ceased
- 1978-06-19 JP JP7332878A patent/JPS5495578A/ja active Pending
- 1978-06-19 IT IT7849938A patent/IT7849938A0/it unknown
- 1978-06-19 PT PT68192A patent/PT68192B/pt unknown
- 1978-06-19 NZ NZ187618A patent/NZ187618A/xx unknown
- 1978-06-19 AU AU37251/78A patent/AU521418B2/en not_active Expired
- 1978-06-19 ES ES470916A patent/ES470916A1/es not_active Expired
- 1978-06-19 IL IL54949A patent/IL54949A/xx unknown
- 1978-06-19 CA CA305,757A patent/CA1105462A/en not_active Expired
- 1978-06-19 AT AT0443078A patent/AT367403B/de not_active IP Right Cessation
- 1978-06-20 ZA ZA783515A patent/ZA783515B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA1105462A (en) | 1981-07-21 |
| IT7849938A0 (it) | 1978-06-19 |
| US4187309A (en) | 1980-02-05 |
| IL54949A (en) | 1982-04-30 |
| AU521418B2 (en) | 1982-04-01 |
| FI781885A7 (fi) | 1978-12-21 |
| EP0000153A1 (en) | 1979-01-10 |
| PT68192B (pt) | 1981-06-11 |
| ATA443078A (de) | 1981-11-15 |
| PT68192A (en) | 1978-07-01 |
| AU3725178A (en) | 1980-01-03 |
| DK262678A (da) | 1978-12-21 |
| ZA783515B (en) | 1980-02-27 |
| IL54949A0 (en) | 1978-08-31 |
| AT367403B (de) | 1982-07-12 |
| JPS5495578A (en) | 1979-07-28 |
| NZ187618A (en) | 1981-02-11 |
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