ES325019A1 - A PROCEDURE FOR THE PREPARATION OF HETEROCICLIC COMPOUNDS. - Google Patents
A PROCEDURE FOR THE PREPARATION OF HETEROCICLIC COMPOUNDS.Info
- Publication number
- ES325019A1 ES325019A1 ES0325019A ES325019A ES325019A1 ES 325019 A1 ES325019 A1 ES 325019A1 ES 0325019 A ES0325019 A ES 0325019A ES 325019 A ES325019 A ES 325019A ES 325019 A1 ES325019 A1 ES 325019A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- hydrogen
- lower alkyl
- general formula
- see formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 239000002253 acid Substances 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004149 thio group Chemical group *S* 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005059 halophenyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- -1 sulfonyloxy group Chemical group 0.000 abstract 1
Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
A process for the preparation of heterocyclic compounds, of the general formula ** (See formula) ** where Z represents one of the groups ** (See formula) ** R1, R2 and R3 are each hydrogen, halogen, lower alkyl or lower alkoxy, R4 and R5 are, individually, hydrogen, lower alkyl or benzyl, wherein at least one of the symbols R4 and R5 is hydrogen, or either R4 and R5, taken together with the nitrogen atom, are a monoheterocyclic ring structure that includes at most one other heteroatom, chosen in the group consisting of nitrogen and oxygen, and which carries at most one single substituent in the nucleus of the heterocyclic ring, R6 is hydrogen or lower alkyl, R7 is hydrogen, lower alkyl, phenyl or halophenyl, R8 is hydrogen, lower alkyl or lower carboxyalkyl, R9 is hydrogen, lower alkyl or lower alkanoyloxy, n is an integer per value from 2 to 6, A is a carbonyl group or a methylene group and B is a thio group, a sulfinyl group or a sulfonyl group, and its acid addition salts with pharmaceutically acceptable acids, which consists in reacting a compound of the general formula wherein R1, R2, R3, R6, R7, A, B and Z have the meaning set forth above, with a compound of the general formula ** (See formula) ** or first with a compound of the general formula ** (See formula) ** and then with an amine of the general formula ** (See formula) ** (in formulas III, IV and V above, R4, R5 and n have the meaning already stated, X is Hal or a sulfonyloxy group and Hal is chlorine, bromine or iodine), and converting, if desired, a carbonyl group of the resulting product into a methylene group, in oxidizing, if desired, a thio group, in introducing, if desired, a lower alkanoyloxy group as a substituent R9 and in converting, if desired , in a salt of acid addition a resulting base. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44526465A | 1965-04-02 | 1965-04-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES325019A1 true ES325019A1 (en) | 1967-02-16 |
Family
ID=59283871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0325019A Expired ES325019A1 (en) | 1965-04-02 | 1966-04-01 | A PROCEDURE FOR THE PREPARATION OF HETEROCICLIC COMPOUNDS. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES325019A1 (en) |
-
1966
- 1966-04-01 ES ES0325019A patent/ES325019A1/en not_active Expired
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