ES2756173T3 - Un índice transcriptómico para la caracterización de la respuesta de reparación celular después de una lesión de los tejidos blandos en articulaciones diartrodiales - Google Patents
Un índice transcriptómico para la caracterización de la respuesta de reparación celular después de una lesión de los tejidos blandos en articulaciones diartrodiales Download PDFInfo
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- ES2756173T3 ES2756173T3 ES14844103T ES14844103T ES2756173T3 ES 2756173 T3 ES2756173 T3 ES 2756173T3 ES 14844103 T ES14844103 T ES 14844103T ES 14844103 T ES14844103 T ES 14844103T ES 2756173 T3 ES2756173 T3 ES 2756173T3
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- genes
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- repair
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- 230000008439 repair process Effects 0.000 title abstract 10
- 208000026137 Soft tissue injury Diseases 0.000 title 1
- 230000001413 cellular effect Effects 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 10
- 108020004999 messenger RNA Proteins 0.000 abstract 5
- 230000002650 habitual effect Effects 0.000 abstract 2
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un método para la clasificación de la calidad de una respuesta de reparación después de una lesión en una articulación de un sujeto humano o veterinario, que comprende: la determinación de los niveles de expresión del ARNm de una pluralidad de genes expresados en una muestra de tejido tomada de una región intraarticular de la articulación, comprendiendo la pluralidad de genes al menos los genes indicados en la TABLA 1, en la TABLA 2 y en la TABLA 3; y el cálculo de una puntuación del índice de reparación sobre la base de los niveles de expresión del ARNm de la pluralidad de genes, en el que el cálculo de la puntuación del índice de reparación comprende: la comparación de los niveles de expresión del ARNm con los primeros niveles de expresión convencionales de la pluralidad de genes y los segundos niveles de expresión convencionales de la pluralidad de genes, en el que se sabe que los primeros niveles de expresión convencionales son indicativos de un perfil reparador y en el que se sabe que los segundos niveles de expresión convencionales son indicativos de un perfil no reparador; la asignación de una subpuntuación para cada uno de la pluralidad de genes, en el que la subpuntuación es una medida del nivel de expresión del ARNm de ese gen con respecto al primer nivel de expresión habitual y al segundo nivel de expresión habitual para ese gen, y la suma de las subpuntuaciones para obtener la puntuación del índice de reparación; en el que la puntuación del índice de reparación es indicativa de la calidad del proceso de reparación, y en el que la puntuación del índice de reparación es indicativa de un perfil no reparador si la puntuación del índice de reparación es indicativa de un elevado nivel de expresión del ARNm de cada uno de la pluralidad de genes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361877011P | 2013-09-12 | 2013-09-12 | |
| PCT/US2014/054550 WO2015038474A1 (en) | 2013-09-12 | 2014-09-08 | A transcriptomic index for characterizing the cellular repair response after soft tissue injury in diarthrodial joints |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2756173T3 true ES2756173T3 (es) | 2020-04-27 |
Family
ID=52666189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14844103T Active ES2756173T3 (es) | 2013-09-12 | 2014-09-08 | Un índice transcriptómico para la caracterización de la respuesta de reparación celular después de una lesión de los tejidos blandos en articulaciones diartrodiales |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9994903B2 (es) |
| EP (1) | EP3044336B1 (es) |
| CN (1) | CN105531378B (es) |
| CA (1) | CA2922143C (es) |
| ES (1) | ES2756173T3 (es) |
| WO (1) | WO2015038474A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015038474A1 (en) | 2013-09-12 | 2015-03-19 | Rush University Medical Center | A transcriptomic index for characterizing the cellular repair response after soft tissue injury in diarthrodial joints |
| WO2016205259A1 (en) * | 2015-06-14 | 2016-12-22 | Hoke Glenn Dale | Methods of diagnosing and treating wounds |
| WO2017151726A1 (en) * | 2016-03-04 | 2017-09-08 | Rush University Medical Center | Methods for characterizing the cellular repair response after soft tissue injury |
| WO2022132666A1 (en) | 2020-12-14 | 2022-06-23 | Regeneron Pharmaceuticals, Inc. | Methods of treating metabolic disorders and cardiovascular disease with inhibin subunit beta e (inhbe) inhibitors |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2334075A1 (en) * | 1998-07-15 | 2000-01-27 | Human Genome Sciences, Inc. | Bone morphogenic protein |
| EP1404868A2 (en) * | 2001-02-28 | 2004-04-07 | Chondrogene Inc. | Compositions and methods relating to osteoarthritis |
| DE10127572A1 (de) | 2001-05-30 | 2002-12-05 | Pathoarray Gmbh | Werkzeuge zur Diagnostik, molekularen Definition und Therapieentwicklung chronischer entzündlicher Gelenkerkrankungen |
| CN103497993A (zh) | 2005-02-07 | 2014-01-08 | 基因信息公司 | 轻度骨关节炎生物标志物及其用途 |
| CA2604985A1 (en) | 2006-10-02 | 2008-04-02 | The University Of Western Ontario | Methods of diagnosing osteoarthritis |
| EP2304052A2 (en) * | 2008-05-02 | 2011-04-06 | Interleukin Genetics, Inc. | Detecting genetic predisposition to osteoarthritis associated conditions |
| ES2351456B1 (es) | 2009-06-24 | 2011-11-28 | Fundacio Institut De Recerca De L'hospital Universitari Vall D'hebron | Metodo in vitro para el pronostico o prediccion de la respuesta por parte de pacientes con artritis reumatoide al tratamiento con agentes que reconocen el receptor de membrana cd20 de los linfocitos b |
| WO2012037356A2 (en) | 2010-09-15 | 2012-03-22 | Rush University Medical Center | Gene expression profiles and products for the diagnosis and prognosis of post-injury synovitis and osteoarthritis |
| WO2012061821A1 (en) | 2010-11-06 | 2012-05-10 | Crescendo Bioscience | Biomarkers for predicting progressive joint damage |
| CN102321574B (zh) * | 2011-08-10 | 2012-11-21 | 郭风劲 | Xbp1s，一种新型促进软骨修复的转录因子 |
| WO2015015000A1 (en) | 2013-08-02 | 2015-02-05 | Université Catholique de Louvain | Signature of cycling hypoxia and use thereof for the prognosis of cancer |
| WO2015038474A1 (en) | 2013-09-12 | 2015-03-19 | Rush University Medical Center | A transcriptomic index for characterizing the cellular repair response after soft tissue injury in diarthrodial joints |
| WO2017151726A1 (en) | 2016-03-04 | 2017-09-08 | Rush University Medical Center | Methods for characterizing the cellular repair response after soft tissue injury |
-
2014
- 2014-09-08 WO PCT/US2014/054550 patent/WO2015038474A1/en not_active Ceased
- 2014-09-08 US US14/916,817 patent/US9994903B2/en active Active
- 2014-09-08 ES ES14844103T patent/ES2756173T3/es active Active
- 2014-09-08 EP EP14844103.3A patent/EP3044336B1/en active Active
- 2014-09-08 CA CA2922143A patent/CA2922143C/en active Active
- 2014-09-08 CN CN201480049533.7A patent/CN105531378B/zh active Active
-
2018
- 2018-05-09 US US15/974,941 patent/US12297500B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2922143C (en) | 2022-03-08 |
| EP3044336B1 (en) | 2019-11-06 |
| EP3044336A1 (en) | 2016-07-20 |
| CN105531378B (zh) | 2021-04-09 |
| US20180291455A1 (en) | 2018-10-11 |
| US12297500B2 (en) | 2025-05-13 |
| US9994903B2 (en) | 2018-06-12 |
| WO2015038474A1 (en) | 2015-03-19 |
| US20160215342A1 (en) | 2016-07-28 |
| CA2922143A1 (en) | 2015-03-19 |
| CN105531378A (zh) | 2016-04-27 |
| EP3044336A4 (en) | 2017-04-19 |
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