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ES2638294T3 - Método de detección de cáncer - Google Patents

Método de detección de cáncer Download PDF

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Publication number
ES2638294T3
ES2638294T3 ES09843193T ES09843193T ES2638294T3 ES 2638294 T3 ES2638294 T3 ES 2638294T3 ES 09843193 T ES09843193 T ES 09843193T ES 09843193 T ES09843193 T ES 09843193T ES 2638294 T3 ES2638294 T3 ES 2638294T3
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ES
Spain
Prior art keywords
cancer
target gene
test sample
methylation index
index
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES09843193T
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English (en)
Inventor
Hung-Cheng Lai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nat Defense Medical Center
National Defense Medical Center
Original Assignee
Nat Defense Medical Center
National Defense Medical Center
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Filing date
Publication date
Application filed by Nat Defense Medical Center, National Defense Medical Center filed Critical Nat Defense Medical Center
Application granted granted Critical
Publication of ES2638294T3 publication Critical patent/ES2638294T3/es
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/164—Methylation detection other then bisulfite or methylation sensitive restriction endonucleases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

Método de detección de cáncer, basado en detectar el índice de metilación de un gen objetivo en una muestra de prueba, y utilizar el índice de metilación como el índice de detección para determinar el riesgo de tener cáncer, y dicho método comprende los pasos siguientes: paso 1: proporcionar una muestra de prueba aislada; paso 2: detectar el índice de metilación de la secuencia CpG en al menos un gen objetivo de dicha muestra de prueba, donde el gen objetivo comprende al menos uno del grupo que consiste en DBC1, PTPRR y ZNF582 y paso 3: determinar si hay cáncer o no en la muestra basándose en el índice de metilación en el gen objetivo, donde el cáncer es seleccionado del grupo consistente en cáncer de cuello de útero, cáncer de colon y cáncer de ovario.
ES09843193T 2009-04-17 2009-04-17 Método de detección de cáncer Active ES2638294T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2009/000411 WO2010118559A1 (zh) 2009-04-17 2009-04-17 一种癌症筛检的方法

Publications (1)

Publication Number Publication Date
ES2638294T3 true ES2638294T3 (es) 2017-10-19

Family

ID=42982108

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09843193T Active ES2638294T3 (es) 2009-04-17 2009-04-17 Método de detección de cáncer

Country Status (12)

Country Link
EP (1) EP2420578B1 (es)
JP (1) JP6043185B2 (es)
KR (2) KR101530498B1 (es)
AU (1) AU2009344468B2 (es)
BR (1) BRPI0924013A2 (es)
CA (1) CA2758437C (es)
DK (1) DK2420578T3 (es)
ES (1) ES2638294T3 (es)
IL (1) IL215669A0 (es)
NZ (1) NZ595640A (es)
SG (1) SG175183A1 (es)
WO (1) WO2010118559A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101385783B1 (ko) * 2012-06-25 2014-04-16 가톨릭대학교 산학협력단 간암 진단 마커 및 치료제로서의 ｄｂｃ１
JP2016201999A (ja) * 2013-08-26 2016-12-08 北海道公立大学法人 札幌医科大学 大腸癌を検出する方法
US10829820B2 (en) 2015-08-31 2020-11-10 The United States Government As Represented By The Secretary Of The Army Methods for molecularly characterizing cervical cell samples
JP7299158B2 (ja) 2017-03-10 2023-06-27 セルフ－スクリーン ベー．フェー． Ｈｐｖ誘発浸潤がん、非ｈｐｖ誘発婦人科がん及び肛門性器がん、並びにその高度前駆病変を検出するためのメチル化分類子
CN109468381B (zh) * 2018-11-19 2022-11-25 兰州市第一人民医院 用于宫颈癌筛查的甲基化位点及其检测引物
US11001898B2 (en) 2019-05-31 2021-05-11 Universal Diagnostics, S.L. Detection of colorectal cancer
US11396679B2 (en) 2019-05-31 2022-07-26 Universal Diagnostics, S.L. Detection of colorectal cancer
US11898199B2 (en) 2019-11-11 2024-02-13 Universal Diagnostics, S.A. Detection of colorectal cancer and/or advanced adenomas
WO2021228418A1 (en) 2020-05-15 2021-11-18 Universal Diagnostics, S.L. Methods and systems for identifying methylation biomarkers
GB202009220D0 (en) * 2020-06-17 2020-07-29 Ucl Business Ltd Methods for detecting and predicting cancer
WO2022002424A1 (en) 2020-06-30 2022-01-06 Universal Diagnostics, S.L. Systems and methods for detection of multiple cancer types
CN114561461B (zh) * 2020-11-27 2024-01-30 广州达健生物科技有限公司 用于检测宫颈癌的组合物及其试剂盒和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE373673T1 (de) * 2003-01-29 2007-10-15 Hoffmann La Roche Verbessertes verfahren zur behandlung durch bisulfit
GB0413688D0 (en) * 2004-06-18 2004-07-21 Novartis Forschungsstiftung Analysis of methylated nucleic acid
US20090275633A1 (en) * 2006-04-13 2009-11-05 Oncomethylome Sciences Sa Novel Tumour Suppressor
TW200831900A (en) 2007-01-23 2008-08-01 Hong-Zheng Lai Cancer screen method
US7820386B2 (en) 2007-06-15 2010-10-26 National Defense Medical Center Cancer screening method
CN101250588A (zh) * 2008-04-09 2008-08-27 王道荣 一种利用粪便中sfrp2基因超甲基化筛查大肠癌的方法

Also Published As

Publication number Publication date
KR101636596B1 (ko) 2016-07-11
AU2009344468A1 (en) 2011-11-03
EP2420578A1 (en) 2012-02-22
JP6043185B2 (ja) 2017-02-22
NZ595640A (en) 2014-01-31
BRPI0924013A2 (pt) 2015-11-24
CA2758437C (en) 2018-10-09
SG175183A1 (en) 2011-12-29
EP2420578B1 (en) 2017-06-14
KR20120016201A (ko) 2012-02-23
CA2758437A1 (en) 2010-10-21
IL215669A0 (en) 2012-01-31
KR20140017704A (ko) 2014-02-11
AU2009344468B2 (en) 2015-02-12
KR101530498B1 (ko) 2015-06-19
JP2012523822A (ja) 2012-10-11
DK2420578T3 (en) 2017-10-02
EP2420578A4 (en) 2012-09-26
WO2010118559A1 (zh) 2010-10-21

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