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ES2606546T3 - Compuesto destinado a la absorción bucal de nicotina con el objetivo de dejar de fumar - Google Patents

Compuesto destinado a la absorción bucal de nicotina con el objetivo de dejar de fumar Download PDF

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Publication number
ES2606546T3
ES2606546T3 ES10721627.7T ES10721627T ES2606546T3 ES 2606546 T3 ES2606546 T3 ES 2606546T3 ES 10721627 T ES10721627 T ES 10721627T ES 2606546 T3 ES2606546 T3 ES 2606546T3
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Spain
Prior art keywords
weight
concentration
nicotine
group
flavanones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10721627.7T
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English (en)
Inventor
Dobromil KOSÍK
Milan Dittrich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heglund AS
Original Assignee
Heglund AS
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Filing date
Publication date
Priority claimed from CZ20090080A external-priority patent/CZ200980A3/cs
Application filed by Heglund AS filed Critical Heglund AS
Application granted granted Critical
Publication of ES2606546T3 publication Critical patent/ES2606546T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Addiction (AREA)
  • Dispersion Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

El compuesto destinado a la aplicación bucal de nicotina al sistema circulatorio y a la distribución al sistema nervioso central, aplicable en forma coloidal o en forma de un dispositivo atomizador con el fin de dejar de fumar o de su sustitución en el caso de ser las condiciones para fumar desfavorables. De conformidad con la invención en referencia, el compuesto se destaca por el hecho, de que contiene una solución de nicotina en forma de base y/o de sus sales con un ácido orgánico en una concentración de 0,10 a 4,00% del peso, la concentración más apropiada es de 0,20 a 1,00% del peso. Además contiene materias que tienen efecto mucolítico del grupo de acetilcisteina en una concentración de 3,00 a 30,0% del peso y/o fitocomplejos que poseen efecto mucolítico, adquiridos mediante la extracción de las plantas seleccionadas del grupo Primula veris, Primula elatior, Hedera helix, Eucalyptus globulus nebo Liquiritia glabra en una concentración de0,50 a 15,00% del peso de fitocomplejo con un efecto antioxidante seleccionado del grupo de flavonas, flavonoles, flavanones flavanonoles, isoflavonas, neoflavonoides, antocianidinas, pro-antociadinas y de sus oligómeros y polímeros, adquiridos mediante la extracción de las plantas Camellia sinensis, Curcuma longa, Rosmarinus officinalis, Sylibium marianum, Vitis vinifera, Ginkgo biloba, Euterpe oleracea, Vaccinium myrtillus, Morinda citrifolia, Malpighia glabra, las cuales contienen además un retardador (amortiguador) que modifica la acidez a un rango de pH de 7,0 a 9,0.

Description

imagen1
imagen2
imagen3
imagen4
Ejemplos de realización:
Ejemplos 1, 2 y 3:
Componente:
Composición (% del peso)
Muestra nro.. 1
Muestra nro. 2 Muestra nro. 3
Nicotina
1,00 2,00 3,00
Ácido cítrico
0,95 1,55 2,10
Acetilcisteina
25,00 15,00 5,00
Ascorbil fosfato de sodio
3,00 5,00
Sorbato de potasio
0,10 0,10 0,10
Benzoato de sodio
0,10 0,10 0,10
Sucralosa
0,07 0,08 0,10
Glicerina
5,00 10,00 15,00
Grape seeda extrakt
1,50 0,75
Perfume
0,10 0,20 0,35
Aceite de ricina hidrogenado pegilado
0,12 0,12 0,12
Hidróxido de sodio
q.s. pH 7,0 - 9,0 q.s. pH 7,0 - 9,0 q.s. pH 7,0 - 9,0
Agua
do 100,00g do 100,00g do 100,00g
Procedimiento de preparación: en el agua se disuelven componentes que se agregan individualmente de manera
5 paulatina. La solución se filtra según sea necesario y se vierte en recipientes de presión, dotados de una válvula dosificadora o en recipientes cerrados provistos de una válvula dosificadora, impulsada por una bomba de accionamiento manual.
Aprovechamiento industrial
De conformidad con la invención, el compuesto puede ser fabricado por la industria farmacéutica. El preparado 10 resulta apropiado para la absorción transmucosa de nicotina con el objetivo de dejar de fumar.
6

Claims (1)

  1. imagen1
ES10721627.7T 2009-02-11 2010-02-03 Compuesto destinado a la absorción bucal de nicotina con el objetivo de dejar de fumar Active ES2606546T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CZ20090080A CZ200980A3 (cs) 2009-02-11 2009-02-11 Kompozice urcená k bukální absorpci nikotinu za úcelem odvykání kourení
CZ20090080 2009-02-11
CZ2009829 2009-12-09
CZ20090829 2009-12-09
PCT/CZ2010/000011 WO2010091649A2 (en) 2009-02-11 2010-02-03 A composition for buccal absorption of nicotine for the purpose of smoking cessation

Publications (1)

Publication Number Publication Date
ES2606546T3 true ES2606546T3 (es) 2017-03-24

Family

ID=69162740

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10721627.7T Active ES2606546T3 (es) 2009-02-11 2010-02-03 Compuesto destinado a la absorción bucal de nicotina con el objetivo de dejar de fumar

Country Status (14)

Country Link
US (2) US20110293535A1 (es)
EP (1) EP2395974B1 (es)
JP (1) JP2012517402A (es)
KR (1) KR20110114552A (es)
CN (1) CN102316850A (es)
AU (1) AU2010213244A1 (es)
CA (1) CA2751271A1 (es)
EA (1) EA201100896A1 (es)
ES (1) ES2606546T3 (es)
IL (1) IL212720A (es)
PT (1) PT2395974T (es)
SG (1) SG171870A1 (es)
WO (1) WO2010091649A2 (es)
ZA (1) ZA201103096B (es)

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Also Published As

Publication number Publication date
JP2012517402A (ja) 2012-08-02
EP2395974A2 (en) 2011-12-21
PT2395974T (pt) 2016-12-14
CA2751271A1 (en) 2010-08-19
ZA201103096B (en) 2011-12-28
CN102316850A (zh) 2012-01-11
WO2010091649A3 (en) 2010-11-11
WO2010091649A4 (en) 2010-12-29
EP2395974B1 (en) 2016-09-07
WO2010091649A2 (en) 2010-08-19
IL212720A0 (en) 2011-07-31
AU2010213244A1 (en) 2010-08-19
SG171870A1 (en) 2011-07-28
US20110293535A1 (en) 2011-12-01
IL212720A (en) 2016-02-29
US20200022905A1 (en) 2020-01-23
EA201100896A1 (ru) 2012-01-30
KR20110114552A (ko) 2011-10-19

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