[go: up one dir, main page]

ES2692918T3 - Métodos y composiciones para producir aldehídos grasos - Google Patents

Métodos y composiciones para producir aldehídos grasos Download PDF

Info

Publication number
ES2692918T3
ES2692918T3 ES15178817T ES15178817T ES2692918T3 ES 2692918 T3 ES2692918 T3 ES 2692918T3 ES 15178817 T ES15178817 T ES 15178817T ES 15178817 T ES15178817 T ES 15178817T ES 2692918 T3 ES2692918 T3 ES 2692918T3
Authority
ES
Spain
Prior art keywords
compositions
methods
fatty aldehydes
producing fatty
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES15178817T
Other languages
English (en)
Inventor
Murtaza F. Alibhai
Zhihao Hu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
REG Life Sciences LLC
Original Assignee
REG Life Sciences LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by REG Life Sciences LLC filed Critical REG Life Sciences LLC
Application granted granted Critical
Publication of ES2692918T3 publication Critical patent/ES2692918T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P30/00—Technologies relating to oil refining and petrochemical industry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Célula microbiana modificada por ingeniería genética para sobreexpresar (i) un polipéptido que tiene actividad ácido carboxílico reductasa y que tiene una secuencia de aminoácidos con al menos el 80% de identidad de secuencia con respecto a una secuencia de aminoácidos seleccionada del grupo que consiste en SEQ ID NO: 22, SEQ ID NO: 20 y SEQ ID NO: 18; y (ii) un polipéptido que tiene actividad tioesterasa de EC 3.1.2.14 o EC 3.1.1.5.
ES15178817T 2008-10-07 2009-10-07 Métodos y composiciones para producir aldehídos grasos Active ES2692918T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10344708P 2008-10-07 2008-10-07

Publications (1)

Publication Number Publication Date
ES2692918T3 true ES2692918T3 (es) 2018-12-05

Family

ID=42101196

Family Applications (2)

Application Number Title Priority Date Filing Date
ES09819847.6T Active ES2550467T3 (es) 2008-10-07 2009-10-07 Métodos y composiciones para producir aldehídos grasos
ES15178817T Active ES2692918T3 (es) 2008-10-07 2009-10-07 Métodos y composiciones para producir aldehídos grasos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES09819847.6T Active ES2550467T3 (es) 2008-10-07 2009-10-07 Métodos y composiciones para producir aldehídos grasos

Country Status (11)

Country Link
US (1) US8097439B2 (es)
EP (2) EP2352824B1 (es)
JP (1) JP2012504963A (es)
KR (2) KR101840354B1 (es)
CN (2) CN102232110B (es)
AU (1) AU2009302325A1 (es)
BR (1) BRPI0920650A2 (es)
CA (2) CA2738938C (es)
ES (2) ES2550467T3 (es)
MX (1) MX2011003597A (es)
WO (1) WO2010042664A2 (es)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100242345A1 (en) 2006-05-19 2010-09-30 LS9, Inc Production of fatty acids & derivatives thereof
US8110670B2 (en) 2006-05-19 2012-02-07 Ls9, Inc. Enhanced production of fatty acid derivatives
JP2010528627A (ja) * 2007-06-01 2010-08-26 ソラザイム、インク 微生物による油の生産
US8355671B2 (en) * 2008-01-04 2013-01-15 Kopin Corporation Method and apparatus for transporting video signal over Bluetooth wireless interface
MX2010012192A (es) 2008-05-16 2011-04-26 Ls9 Inc Metodos y composiciones para producir hidrocarburos.
MX2011003597A (es) 2008-10-07 2011-06-20 Ls9 Inc Metodos y composiciones para producir aldehidos grasos.
EP2796559B1 (en) 2008-10-28 2018-09-12 REG Life Sciences, LLC Microbial cell for producing fatty alcohols
ES2583639T3 (es) 2008-11-28 2016-09-21 Terravia Holdings, Inc. Producción de aceites específicos en microorganismos heterótrofos
US8835137B2 (en) 2008-12-23 2014-09-16 Matrix Genetics, Llc Modified photosynthetic microorganisms with reduced glycogen and their use in producing carbon-based products
CN110129296A (zh) 2008-12-23 2019-08-16 Reg生命科学有限责任公司 硫酯酶相关的方法和组合物
CN102459622B (zh) 2009-04-27 2020-08-18 基因组股份公司 脂肪酸酯的产生
EP2424989A2 (en) * 2009-05-01 2012-03-07 The Regents of The University of California Product of fatty acid esters from biomass polymers
WO2010135624A2 (en) * 2009-05-22 2010-11-25 Codexis, Inc. Engineered biosynthesis of fatty alcohols
WO2011038134A1 (en) 2009-09-25 2011-03-31 Ls9, Inc. Production of fatty acid derivatives
WO2011038364A1 (en) 2009-09-27 2011-03-31 Opx Biotechnologies, Inc. Method for producing 3-hydroxypropionic acid and other products
US8530221B2 (en) 2010-01-14 2013-09-10 Ls9, Inc. Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells
WO2011100667A1 (en) 2010-02-14 2011-08-18 Ls9, Inc. Surfactant and cleaning compositions comprising microbially produced branched fatty alcohols
US8980613B2 (en) 2010-04-06 2015-03-17 Matrix Genetics, Llc Modified photosynthetic microorganisms for producing lipids
AR084377A1 (es) 2010-04-08 2013-05-15 Ls9 Inc Metodos y composiciones relacionados con enzimas de alcohol graso biosintetico
SG10201504197SA (en) 2010-05-28 2015-06-29 Solazyme Inc Food Compositions Comprising Tailored Oils
CA2803380A1 (en) 2010-07-15 2012-01-19 The Procter & Gamble Company A personal care composition comprising a near-terminal branched compound
CA2807561C (en) 2010-08-06 2022-04-12 Mascoma Corporation Production of malonyl-coa derived products via anaerobic pathways
US8372610B2 (en) 2010-09-15 2013-02-12 Ls9, Inc. Production of odd chain fatty acid derivatives in recombinant microbial cells
US20120108692A1 (en) 2010-10-27 2012-05-03 John Collins Dyer Preparation of foam materials derived from renewable resources
EP3521408B1 (en) 2010-11-03 2021-12-22 Corbion Biotech, Inc. Genetically-engineered chlorella or prototheca microbe and oil produced therefrom
CA2823928C (en) 2011-01-14 2020-09-22 Ls9, Inc. Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells
CN110066836A (zh) 2011-02-02 2019-07-30 柯碧恩生物技术公司 产自重组产油微生物的定制油
WO2012138423A1 (en) 2011-02-17 2012-10-11 The Procter & Gamble Company Compositions comprising mixtures of c10-c13 alkylphenyl sulfonates
MX2013009546A (es) 2011-02-17 2013-11-22 Procter & Gamble Alquilfenil sulfonatos lineales de base biologica.
CA2830215C (en) 2011-03-14 2018-07-10 Easel Biotechnologies, Llc Microbial synthesis of aldehydes and corresponding alcohols
WO2012154329A1 (en) 2011-04-01 2012-11-15 Ls9, Inc. Methods and compositions for improved production of fatty acids and derivatives thereof
WO2012154626A1 (en) 2011-05-06 2012-11-15 Solazyme, Inc. Genetically engineered microorganisms that metabolize xylose
US20130034884A1 (en) * 2011-06-22 2013-02-07 Genomatica, Inc. Microorganisms for producing 1,4-butanediol and methods related thereto
DE102011110946A1 (de) 2011-08-15 2016-01-21 Evonik Degussa Gmbh Biotechnologisches Syntheseverfahren von omegafunktionalisierten Carbonsäuren und Carbonsäure-Estern aus einfachen Kohlenstoffquellen
DE102011110945A1 (de) 2011-08-15 2013-02-21 Evonik Degussa Gmbh Biotechnologisches Syntheseverfahren von organischen Verbindungen mit alkIL-Genprodukt
EP2748326A4 (en) * 2011-08-22 2015-08-12 Joule Unltd Technologies Inc IMPROVED COMPOSITIONS AND METHODS FOR BIOSYNTHESIS OF 1-ALKENEN IN MANIPULATED MICROORGANISMS
CN103975070A (zh) 2011-09-27 2014-08-06 艾克森美孚研究与工程公司 酰基-酰基载体蛋白(acyl-acp)蜡酯合酶
KR20170096226A (ko) 2011-11-03 2017-08-23 이젤 바이오테크날러지스, 엘엘씨 미생물에 의한 ｎ-부티르알데하이드의 생성
PT2814972T (pt) 2012-02-24 2020-06-16 Exxonmobil Res & Eng Co Produção melhorada de ácidos gordos e derivados de ácidos gordos por micro-organismos recombinantes
US9096834B2 (en) 2012-02-24 2015-08-04 Exxonmobil Research And Engineering Company Recombinant microorganisms comprising thioesterase and lysophosphatidic acid acyltransferase genes for fatty acid production
US8962299B2 (en) 2012-02-29 2015-02-24 Exxonmobil Research And Engineering Company Four-gene pathway for wax ester synthesis
BR122019026142B1 (pt) 2012-04-02 2021-12-14 Genomatica, Inc Célula hospedeira recombinante
ES2786633T3 (es) 2012-04-02 2020-10-13 Genomatica Inc Enzimas CAR y producción mejorada de alcoholes grasos
US9163267B2 (en) 2012-04-11 2015-10-20 REG Life Sciences, LLC Metathesis transformations of microbially-produced fatty acids and fatty acid derivatives
MX354883B (es) 2012-04-13 2018-03-23 Reg Life Sciences Llc Produccion microbiana de alcanolamidas y amidoaminas y usos de las mismas.
US9719114B2 (en) 2012-04-18 2017-08-01 Terravia Holdings, Inc. Tailored oils
BR112014025719A8 (pt) 2012-04-18 2017-10-03 Solazyme Inc Óleos customizados
US9181568B2 (en) 2012-04-23 2015-11-10 Exxonmobil Research And Engineering Company Cell systems and methods for improving fatty acid synthesis by expression of dehydrogenases
DE102012207921A1 (de) 2012-05-11 2013-11-14 Evonik Industries Ag Mehrstufiges Syntheseverfahren mit Synthesegas
BR112015002940A2 (pt) 2012-08-10 2018-04-24 Opx Biotechnologies Inc microorganismos e métodos para a produção de ácidos graxos e produtos derivados de ácidos graxos.
KR20230020007A (ko) 2012-09-14 2023-02-09 게노마티카 인코포레이티드 개선된 에스테르 신타아제 특성을 갖는 효소 변이체
WO2014093505A2 (en) 2012-12-12 2014-06-19 Ls9, Inc. Acp-mediated production of fatty acid derivatives
EP2746400A1 (de) * 2012-12-21 2014-06-25 Evonik Industries AG Herstellung von Aminen und Diaminen aus einer Carbonsäure oder Dicarbonsäure oder eines Monoesters davon
CN110387352A (zh) 2013-01-16 2019-10-29 Reg生命科学有限责任公司 具有改善特性的酰基-acp还原酶
US9567615B2 (en) 2013-01-29 2017-02-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US9816079B2 (en) 2013-01-29 2017-11-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US9447438B2 (en) 2013-03-15 2016-09-20 Cargill, Incorporated Acetyl-coA carboxylases
US9290749B2 (en) 2013-03-15 2016-03-22 Solazyme, Inc. Thioesterases and cells for production of tailored oils
US9783836B2 (en) 2013-03-15 2017-10-10 Terravia Holdings, Inc. Thioesterases and cells for production of tailored oils
KR20220053681A (ko) 2013-06-14 2022-04-29 게노마티카 인코포레이티드 오메가-수산화 지방산 유도체를 생성하는 방법들
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
WO2015010103A2 (en) 2013-07-19 2015-01-22 Opx Biotechnologies, Inc. Microorganisms and methods for the production of fatty acids and fatty acid derived products
KR20160060643A (ko) 2013-08-19 2016-05-30 알이지 라이프 사이언시스, 엘엘씨 부분 정제된 폐글리세롤의 생성
US9469586B2 (en) 2013-08-19 2016-10-18 REG Life Sciences, LLC Production of partially refined waste glycerol
EP2964756B1 (en) 2013-09-13 2017-05-03 REG Life Sciences, LLC Improved acetyl-coa carboxylase variants
MX369685B (es) 2013-10-04 2019-11-19 Terravia Holdings Inc Aceites adaptables.
PL2886651T3 (pl) 2013-10-21 2018-11-30 Ajinomoto Co., Inc. Sposób wytwarzania l-aminokwasu
CN105793412B (zh) * 2013-12-04 2022-05-06 株式会社益力多本社 微生物的耐酸性调节方法
WO2015085271A1 (en) 2013-12-05 2015-06-11 REG Life Sciences, LLC Microbial production of fatty amines
CA2944558A1 (en) 2014-04-10 2015-10-15 REG Life Sciences, LLC Semisynthetic routes to organic compounds
WO2015195697A1 (en) 2014-06-16 2015-12-23 REG Life Sciences, LLC Omega-hydroxylase-related fusion polypeptides with improved properties
EP3620517A3 (en) 2014-07-10 2020-07-29 Corbion Biotech, Inc. Ketoacyl acp synthase genes and uses thereof
CN106574238B (zh) 2014-07-18 2021-09-21 基因组股份公司 微生物的脂肪二醇产生
US9765368B2 (en) 2014-07-24 2017-09-19 Terravia Holdings, Inc. Variant thioesterases and methods of use
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
CN107208103A (zh) 2014-09-18 2017-09-26 泰拉瑞亚控股公司 酰基‑acp硫酯酶及其突变体
CA2897454C (en) 2015-07-03 2023-03-14 Governing Council Of The University Of Toronto Microorganisms and methods for biosynthesis of adipic acid
WO2017101987A1 (en) 2015-12-15 2017-06-22 REG Life Sciences, LLC Omega-hydroxylase-related fusion polypeptide variants with improved properties
US11136603B2 (en) * 2016-07-25 2021-10-05 Inv Nylon Chemicals Americas, Llc Materials and methods for directing carbon flux and increased production of 7-aminoheptanoic acid or 6-aminohexanoic acid
KR102456406B1 (ko) 2016-09-14 2022-10-19 게노마티카 인코포레이티드 1,3-지방 디올 화합물 및 그 유도체
CN110494566A (zh) 2017-02-02 2019-11-22 嘉吉公司 产生c6-c10脂肪酸衍生物的经遗传修饰的细胞
CN106947727B (zh) * 2017-02-20 2019-08-16 波顿（上海）生物技术有限公司 一种基因工程菌及其构建方法与生产香兰素的方法
CN108624628B (zh) * 2017-03-22 2022-09-13 中国科学院天津工业生物技术研究所 催化甲酸合成甲醛car酶的制备及其应用
KR102677413B1 (ko) 2017-04-03 2024-06-24 게노마티카 인코포레이티드 중쇄 지방산 유도체의 생산을 위해 개선된 활성을 갖는 티오에스테라제 변이체
WO2019209187A1 (en) * 2018-04-25 2019-10-31 Vidyasirimedhi Institute Of Science And Technology A luciferase reporter system and an assay for gene expression profiling using the same
EP3794017A4 (en) 2018-05-17 2022-03-09 Lumen Bioscience, Inc. ARTHROSPIRA PLATENSIS ORAL VACCINE DELIVERY PLATFORM
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
US12252513B2 (en) 2018-07-16 2025-03-18 Lumen Bioscience, Inc. Thermostable phycobiliproteins produced from recombinant arthrospira
EP3844179A4 (en) 2018-08-31 2022-08-31 Genomatica, Inc. XYLR MUTANT FOR IMPROVED XYLOSE UTILIZATION OR IMPROVED CO-UTILIZATION OF GLUCOSE AND XYLOSE
US10808265B2 (en) 2018-09-26 2020-10-20 Nantbio, Inc. Microbes and methods for improved conversion of a feedstock

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5000000A (en) 1988-08-31 1991-03-19 University Of Florida Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes
US5028539A (en) 1988-08-31 1991-07-02 The University Of Florida Ethanol production using engineered mutant E. coli
US5482846A (en) 1988-08-31 1996-01-09 University Of Florida Ethanol production in Gram-positive microbes
US5424202A (en) 1988-08-31 1995-06-13 The University Of Florida Ethanol production by recombinant hosts
US7053267B2 (en) 1990-03-16 2006-05-30 Calgene Llc Plant seed oils
AU7791991A (en) 1990-04-24 1991-11-11 Stratagene Methods for phenotype creation from multiple gene populations
US5807893A (en) 1993-11-18 1998-09-15 Voelker; Toni Alois Plant thioesterases and use for modification of fatty acid composition in plant seed oils
US5602030A (en) 1994-03-28 1997-02-11 University Of Florida Research Foundation Recombinant glucose uptake system
US6428767B1 (en) 1995-05-12 2002-08-06 E. I. Du Pont De Nemours And Company Method for identifying the source of carbon in 1,3-propanediol
US5939250A (en) 1995-12-07 1999-08-17 Diversa Corporation Production of enzymes having desired activities by mutagenesis
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
US20080178519A1 (en) 1996-11-18 2008-07-31 Bp Oil International Limited Fuel composition
US7211418B2 (en) * 1999-01-14 2007-05-01 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
JP3571354B2 (ja) 1999-01-18 2004-09-29 三菱電機株式会社 圧接型半導体装置
CN1277843C (zh) 2001-02-22 2006-10-04 巴斯德研究院 分枝杆菌比较基因组学作为鉴定分枝杆菌病的诊断、预防或治疗靶的工具
US7314974B2 (en) 2002-02-21 2008-01-01 Monsanto Technology, Llc Expression of microbial proteins in plants for production of plants with improved properties
AU2003225644A1 (en) 2002-03-01 2003-09-16 Monsanto Technology Llc Wax ester synthase dna sequence, protein and uses thereof
ATE538197T1 (de) * 2002-04-19 2012-01-15 Cognis Ip Man Gmbh Fettalkoholoxidase-gene und -proteine aus candida tropicalis und damit verbundene verfahren
US7273966B2 (en) * 2002-12-19 2007-09-25 Monsanto Technology Llc Elevation of fatty acid synthase levels in plants
US7056714B2 (en) * 2003-03-11 2006-06-06 University Of Iowa Research Foundation, Inc. Carboxylic acid reductase polypeptide, nucleotide sequence encoding same and methods of use
US7608700B2 (en) 2004-03-08 2009-10-27 North Carolina State University Lactobacillus acidophilus nucleic acid sequences encoding stress-related proteins and uses therefor
CN1283357C (zh) * 2004-09-08 2006-11-08 厦门大学 用于制备芳香醛或脂肪醛的催化剂及其制备方法
WO2006130529A1 (en) 2005-05-31 2006-12-07 Pierce Biotechnology, Inc. Extraction of cellular components with fatty acid derivatives
FR2888034B1 (fr) 2005-06-29 2010-10-08 Philippe Magnier Dispositif de prevention contre l'explosion d'un transformateur electrique
US8110670B2 (en) 2006-05-19 2012-02-07 Ls9, Inc. Enhanced production of fatty acid derivatives
JP5933909B2 (ja) * 2006-05-19 2016-06-15 アールイージー ライフ サイエンシズ リミテッド ライアビリティ カンパニー 脂肪酸およびその誘導体の生産
US20100242345A1 (en) 2006-05-19 2010-09-30 LS9, Inc Production of fatty acids & derivatives thereof
US7491854B2 (en) 2006-05-31 2009-02-17 Archer-Daniels-Midland Company Enzymatic method of making aldehydes from fatty acids
DE102006054324A1 (de) 2006-11-17 2008-05-21 Robert Bosch Gmbh Verfahren zur bildbasierten Vermessung
CA3178593A1 (en) * 2007-03-28 2008-10-02 Genomatica, Inc. Enhanced production of fatty acid derivatives
AU2008304180B2 (en) 2007-09-27 2014-02-27 Genomatica, Inc. Reduction of the toxic effect of impurities from raw materials by extractive fermentation
CN102015995B (zh) 2008-03-03 2014-10-22 焦耳无限科技公司 产生碳基目的产物的二氧化碳固定工程微生物
JP5755884B2 (ja) 2008-03-05 2015-07-29 ジェノマティカ， インコーポレイテッド 第一級アルコールを産生する生物
MX2010012192A (es) 2008-05-16 2011-04-26 Ls9 Inc Metodos y composiciones para producir hidrocarburos.
MX2011003597A (es) 2008-10-07 2011-06-20 Ls9 Inc Metodos y composiciones para producir aldehidos grasos.
EP2796559B1 (en) 2008-10-28 2018-09-12 REG Life Sciences, LLC Microbial cell for producing fatty alcohols
CN110129296A (zh) 2008-12-23 2019-08-16 Reg生命科学有限责任公司 硫酯酶相关的方法和组合物
WO2011062987A2 (en) 2009-11-17 2011-05-26 Ls9, Inc. Methods and compositions for producing hydrocarbons

Also Published As

Publication number Publication date
EP2975122B1 (en) 2018-06-06
CN102232110B (zh) 2016-01-06
KR20170031795A (ko) 2017-03-21
CN105274043B (zh) 2019-07-30
EP2352824A4 (en) 2013-01-16
AU2009302325A1 (en) 2010-04-15
CA2738938A1 (en) 2010-04-15
CA3038491A1 (en) 2010-04-15
JP2012504963A (ja) 2012-03-01
US20100105955A1 (en) 2010-04-29
US8097439B2 (en) 2012-01-17
WO2010042664A3 (en) 2010-06-24
KR101840354B1 (ko) 2018-03-20
KR20110066973A (ko) 2011-06-17
EP2975122A2 (en) 2016-01-20
BRPI0920650A2 (pt) 2019-08-27
EP2352824A2 (en) 2011-08-10
CN102232110A (zh) 2011-11-02
CA2738938C (en) 2019-04-30
WO2010042664A2 (en) 2010-04-15
MX2011003597A (es) 2011-06-20
EP2975122A3 (en) 2016-02-24
KR101717569B1 (ko) 2017-03-17
ES2550467T3 (es) 2015-11-10
CN105274043A (zh) 2016-01-27
EP2352824B1 (en) 2015-09-02

Similar Documents

Publication Publication Date Title
ES2692918T3 (es) Métodos y composiciones para producir aldehídos grasos
ES2541217T3 (es) Diferenciación de células madre mesenquimales
ES2540858T3 (es) Composición farmacéutica para el tratamiento y/o la prevención de cáncer
BRPI1011934A8 (pt) Composição
IN2012DN01652A (es)
EP3333258A3 (en) Method for degrading or converting cellulosic material
AR072967A1 (es) Polipeptidos del factor de estimulacion de la colonia de granulocitos bovino (bg-csf) modificados y sus usos
MX2011012585A (es) Metodos para incrementar la degradacion o conversion de material celulosico.
PH12014500590A1 (en) Antimicrobial formulations with pelargonic acid
CL2013003416A1 (es) Secuencia de peptidos quiméricos que comprende dsspl o dasph composiciones , usos y metodo para mejorar metabolismo de glucosa.
AR067953A1 (es) Metodo para producir leche uht tratada enzimaticamente
PE20110310A1 (es) Axmi-115, axmi-113, axmi-005, axmi-163 y axmi-184: proteinas insecticidas
MY158663A (en) Fermentation broth formulations
MX2014013333A (es) Variantes de enzima quimosina mejoradas.
CY1119916T1 (el) Ανοσογονικη συνθεση
ES2721309T3 (es) Composición para preparar tagatosa y método para preparar tagatosa a partir de fructosa
AR083354A1 (es) Polipeptidos variantes cbh i (celobiohidrolasas i) con reducida inhibicion de producto
WO2010111344A3 (en) Methods and microorganisms for production of c4-dicarboxylic acids
AR087885A1 (es) Enzimas utiles para la industria alimenticia
AR111373A1 (es) Enzimas de lactasa con propiedades mejoradas
BR112022000026A2 (pt) Métodos e composições compreendendo nível reduzido de proteínas de células hospedeiras
MY193587A (en) Genetically modified microorganism for improved production of fine chemicals on sucrose
WO2010002160A3 (ko) 돼지의 알파에스 1 카제인 유전자, 그 프로모터 및 그의 용도
PH12017502323B1 (en) Novel xylanase
AR092618A1 (es) Proceso para preparar gelatina