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ES2688285T3 - Genes de protoporfirinógeno oxidasa (PPX) mutado - Google Patents

Genes de protoporfirinógeno oxidasa (PPX) mutado Download PDF

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Publication number
ES2688285T3
ES2688285T3 ES11815228T ES11815228T ES2688285T3 ES 2688285 T3 ES2688285 T3 ES 2688285T3 ES 11815228 T ES11815228 T ES 11815228T ES 11815228 T ES11815228 T ES 11815228T ES 2688285 T3 ES2688285 T3 ES 2688285T3
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Spain
Prior art keywords
substitution
ppx
seq
amino acid
position corresponding
Prior art date
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ES11815228T
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English (en)
Inventor
Gregory F.W. Gocal
Peter R. Beetham
Aura De Schopke
Sarah Dumm
James Pearce
Christian Schopke
Keith A. Walker
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Cibus Europe BV
Cibus US LLC
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Cibus Europe BV
Cibus US LLC
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8213—Targeted insertion of genes into the plant genome by homologous recombination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8274—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for herbicide resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/03—Oxidoreductases acting on the CH-CH group of donors (1.3) with oxygen as acceptor (1.3.3)
    • C12Y103/03004—Protoporphyrinogen oxidase (1.3.3.4)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Catching Or Destruction (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Una planta resistente a uno o más herbicidas inhibidores de PPX, comprendiendo dicha planta un gen de protoporfirinógeno IX oxidasa (PPX) mutado, en la que dicho gen codifica una proteína que comprende una sustitución en la posición de aminoácido correspondiente a la posición 144 de la SEQ ID NO: 1, y una sustitución en la posición de aminoácido correspondiente a la posición 220 de la SEQ ID NO: 1, en la que la sustitución en la posición de aminoácido correspondiente a la posición 144 de la SEQ ID NO: 1 es una sustitución de arginina por cisteína o leucina o histidina; y en la que la sustitución en la posición de aminoácido correspondiente a la posición 220 de la SEQ ID NO: 1 es una sustitución de alanina por treonina, en la que la planta no se obtiene exclusivamente mediante un procedimiento esencialmente biológico.
ES11815228T 2010-08-03 2011-08-02 Genes de protoporfirinógeno oxidasa (PPX) mutado Active ES2688285T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37043610P 2010-08-03 2010-08-03
PCT/US2011/046330 WO2012018862A2 (en) 2010-08-03 2011-08-02 Mutated protoporphyrinogen ix oxidase (ppx) genes

Publications (1)

Publication Number Publication Date
ES2688285T3 true ES2688285T3 (es) 2018-10-31

Family

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ES11815228T Active ES2688285T3 (es) 2010-08-03 2011-08-02 Genes de protoporfirinógeno oxidasa (PPX) mutado

Country Status (21)

Country Link
EP (3) EP2600710B1 (es)
JP (6) JP6058536B2 (es)
KR (1) KR101920503B1 (es)
CN (3) CN103327809B (es)
AU (1) AU2011285830B2 (es)
BR (1) BR112013002543B1 (es)
CA (3) CA2807035C (es)
CL (1) CL2013000341A1 (es)
DK (1) DK2600710T3 (es)
EA (2) EA202090661A1 (es)
ES (1) ES2688285T3 (es)
IL (3) IL294685A (es)
IN (1) IN2013MN00188A (es)
LT (1) LT2600710T (es)
MX (3) MX376540B (es)
NZ (2) NZ607627A (es)
PL (1) PL2600710T3 (es)
SI (1) SI2600710T1 (es)
UA (1) UA112969C2 (es)
WO (1) WO2012018862A2 (es)
ZA (5) ZA201301067B (es)

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CA3206344A1 (en) * 2013-03-15 2014-09-18 Cibus Us Llc Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
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CN110093325B (zh) * 2019-02-27 2020-12-29 华中师范大学 烟草线粒体的原卟啉原氧化酶突变体及其编码基因和应用
CN115247157A (zh) * 2021-04-02 2022-10-28 青岛清原化合物有限公司 对ppo抑制剂类除草剂具有耐受性的ppo多肽及应用
CN118956784A (zh) * 2021-04-02 2024-11-15 青岛清原种子科学有限公司 对ppo抑制剂类除草剂具有耐受性的ppo多肽及应用
CN115354039A (zh) * 2021-05-02 2022-11-18 青岛清原化合物有限公司 在生物体内创制新基因的方法及应用

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EP2600710A4 (en) 2014-01-22
JP6396958B2 (ja) 2018-09-26
EP2600710A2 (en) 2013-06-12
DK2600710T3 (en) 2018-10-22
MX2013001299A (es) 2013-10-28
KR101920503B1 (ko) 2018-11-20
ZA201903183B (en) 2022-11-30
EP4534659A2 (en) 2025-04-09
JP6058536B2 (ja) 2017-01-11
IL224535B (en) 2019-05-30
JP2023183416A (ja) 2023-12-27
CA3084764C (en) 2023-10-10
CN103327809A (zh) 2013-09-25
IL294685A (en) 2022-09-01
IL266730A (en) 2019-07-31
BR112013002543B1 (pt) 2020-10-27
CA2807035C (en) 2020-09-01
JP7354205B2 (ja) 2023-10-02
CN113957091A (zh) 2022-01-21
JP2025143393A (ja) 2025-10-01
JP2022023150A (ja) 2022-02-07
BR112013002543A2 (pt) 2017-07-04
ZA201703129B (en) 2021-08-25
JP7707250B2 (ja) 2025-07-14
EA202090661A1 (ru) 2020-09-30
JP2019004899A (ja) 2019-01-17
IL266730B (en) 2022-08-01
JP6965219B2 (ja) 2021-11-10
JP2016220685A (ja) 2016-12-28
IN2013MN00188A (es) 2015-05-29
CA2807035A1 (en) 2012-02-09
CN113957091B (zh) 2024-08-16
CA3210405A1 (en) 2012-02-09
NZ607627A (en) 2015-10-30
ZA202205535B (en) 2024-09-25
AU2011285830B2 (en) 2015-09-24
ZA201301067B (en) 2017-08-30
CN107384911B (zh) 2021-06-01
CN107384911A (zh) 2017-11-24
EA201390034A1 (ru) 2013-09-30
JP2013545434A (ja) 2013-12-26
KR20130093615A (ko) 2013-08-22
LT2600710T (lt) 2018-12-10
WO2012018862A3 (en) 2012-05-31
CA3084764A1 (en) 2012-02-09
UA112969C2 (uk) 2016-11-25
MX348704B (es) 2017-06-26
CN103327809B (zh) 2017-04-26
PL2600710T3 (pl) 2019-02-28
NZ761237A (en) 2024-08-30
EP4534659A3 (en) 2025-08-27
NZ811395A (en) 2025-11-28
MX2020011389A (es) 2020-11-24
AU2011285830A1 (en) 2013-03-21
ZA202403837B (en) 2025-08-27
CL2013000341A1 (es) 2013-12-13
MX376540B (es) 2025-03-07
WO2012018862A2 (en) 2012-02-09
SI2600710T1 (sl) 2019-01-31
EP3441469A1 (en) 2019-02-13
EP3441469B1 (en) 2024-11-20
EA035397B1 (ru) 2020-06-05
EP2600710B1 (en) 2018-08-01

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