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ES2655614T3 - Composiciones nanoestructuradas de aprepitant, procedimiento para su preparación y composiciones farmacéuticas que las contienen - Google Patents

Composiciones nanoestructuradas de aprepitant, procedimiento para su preparación y composiciones farmacéuticas que las contienen Download PDF

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Publication number
ES2655614T3
ES2655614T3 ES11736150.1T ES11736150T ES2655614T3 ES 2655614 T3 ES2655614 T3 ES 2655614T3 ES 11736150 T ES11736150 T ES 11736150T ES 2655614 T3 ES2655614 T3 ES 2655614T3
Authority
ES
Spain
Prior art keywords
aprepitant
unit
procedure
preparation
nanostructured
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11736150.1T
Other languages
English (en)
Inventor
Genovéva FILIPCSEI
Zsolt ÖTVÖS
Gábor HELTOVICS
Ferenc Darvas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanoform Cardiovascular Therapeutics Ltd
Original Assignee
Nanoform Cardiovascular Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanoform Cardiovascular Therapeutics Ltd filed Critical Nanoform Cardiovascular Therapeutics Ltd
Application granted granted Critical
Publication of ES2655614T3 publication Critical patent/ES2655614T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Una composición nanoestructurada de aprepitant que comprende aprepitant, dodecilsulfato de sodio y Soluplus, que se obtiene por las siguientes etapas en un reactor de flujo continuo basado en microfluidos: a) se disuelven en etanol aprepitant, dodecilsulfato de sodio y Soluplus; b) la solución de la etapa a) se pasa a la unidad del reactor utilizando una unidad de alimentación; c) mientras tanto, utilizando una segunda unidad de alimentación, se pasa agua destilada a la unidad de mezclado, donde el agua destilada se mezcla con la solución que contiene el aprepitant procedente de la primera unidad del reactor, en donde el caudal de la primera unidad de alimentación es de 3,0 mL/min y el caudal de la segunda unidad de alimentación es de 40,0 mL/min;

Description

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Claims (1)

  1. imagen1
ES11736150.1T 2010-06-18 2011-06-17 Composiciones nanoestructuradas de aprepitant, procedimiento para su preparación y composiciones farmacéuticas que las contienen Active ES2655614T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HUP1000325 2010-06-18
HU1000325A HUP1000325A2 (en) 2010-06-18 2010-06-18 Nanostructured aprepitant compositions and process for their preparation
PCT/HU2011/000057 WO2011158053A1 (en) 2010-06-18 2011-06-17 Nanostructured aprepitant compositions, process for the preparation thereof and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ES2655614T3 true ES2655614T3 (es) 2018-02-20

Family

ID=89989787

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11736150.1T Active ES2655614T3 (es) 2010-06-18 2011-06-17 Composiciones nanoestructuradas de aprepitant, procedimiento para su preparación y composiciones farmacéuticas que las contienen

Country Status (12)

Country Link
US (1) US9504652B2 (es)
EP (1) EP2582697B1 (es)
JP (1) JP2013528642A (es)
CN (1) CN103097379A (es)
AU (1) AU2011266808B2 (es)
DK (1) DK2582697T3 (es)
ES (1) ES2655614T3 (es)
HU (2) HUP1000325A2 (es)
RU (1) RU2595841C2 (es)
SG (1) SG186377A1 (es)
UA (1) UA113390C2 (es)
WO (1) WO2011158053A1 (es)

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WO2017155020A1 (ja) 2016-03-10 2017-09-14 大日本住友製薬株式会社 微細粒子含有組成物およびその製法
GR1009002B (el) * 2016-03-22 2017-03-31 Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων Φαρμακευτικο σκευασμα περιεχον εναν αντιεμετικο παραγοντα και μεθοδος για την παρασκευη αυτου
GR1009209B (el) * 2016-11-17 2018-02-05 Φαρματεν Αβεε Φαρμακευτικο σκευασμα περιεχον εναν αντιεμετικο παραγοντα και μεθοδος για την παρασκευη αυτου
US11065265B2 (en) 2018-05-18 2021-07-20 Spes Pharmaceuticals Inc. Compositions of fosaprepitant and methods of preparation
CN110787125B (zh) * 2018-08-02 2021-07-13 北京化工大学 一种阿瑞匹坦纳米制剂及其制备方法
WO2020121006A2 (en) * 2018-10-19 2020-06-18 Innostudio Inc. Method and apparatus to produce nanoparticles in an ostwald ripening flow device with tubes of variable path length
CN116077462B (zh) * 2022-12-01 2025-05-16 北京诺康达医药科技股份有限公司 阿瑞匹坦微丸及其制备方法和包含它的制剂
CN116283947A (zh) * 2023-02-07 2023-06-23 成都医学院 一种阿瑞匹坦共晶及其制备方法和用途

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Also Published As

Publication number Publication date
AU2011266808A1 (en) 2013-02-07
EP2582697A1 (en) 2013-04-24
US9504652B2 (en) 2016-11-29
US20130209521A1 (en) 2013-08-15
RU2013102030A (ru) 2014-07-27
AU2011266808B2 (en) 2016-02-04
RU2595841C2 (ru) 2016-08-27
WO2011158053A1 (en) 2011-12-22
JP2013528642A (ja) 2013-07-11
CN103097379A (zh) 2013-05-08
SG186377A1 (en) 2013-01-30
HUE037747T2 (hu) 2018-09-28
EP2582697B1 (en) 2017-09-27
HUP1000325A2 (en) 2012-01-30
HU1000325D0 (en) 2010-08-30
UA113390C2 (xx) 2017-01-25
DK2582697T3 (en) 2018-01-15

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