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ES2526094T3 - Procedimiento para estabilizar formas de administración farmacéuticas que contienen microorganismos - Google Patents

Procedimiento para estabilizar formas de administración farmacéuticas que contienen microorganismos Download PDF

Info

Publication number
ES2526094T3
ES2526094T3 ES06777115.4T ES06777115T ES2526094T3 ES 2526094 T3 ES2526094 T3 ES 2526094T3 ES 06777115 T ES06777115 T ES 06777115T ES 2526094 T3 ES2526094 T3 ES 2526094T3
Authority
ES
Spain
Prior art keywords
pharmaceutical administration
procedure
alcohols
forms containing
administration forms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES06777115.4T
Other languages
English (en)
Inventor
Markus Rudolph
Stefan Henke
Iris Manneck
Holger Peitz
Andrea Christ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37450762&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2526094(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of ES2526094T3 publication Critical patent/ES2526094T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Procedimiento para estabilizar una forma de administración farmacéutica sólida que contiene al menos un cultivo de microorganismos, caracterizado porque la forma de administración farmacéutica sólida se encuentra en un envase de polímero, en cuya/s pared/es interior/es se ha incorporado, al menos parcialmente, como mínimo una sustancia canalizante junto con al menos un absorbente, donde las sustancia canalizantes que se encuentran presentes son poliglicoles, alcoholes etilvinílicos, glicerina, alcoholes poliviniletílicos, polvinilpirrolidona, vinilpirrolidona, N-metilpirrolidona, polisacáridos, sacáridos y/o alcoholes de azúcar, y como absorbentes se encuentran presentes un tamiz molecular o gel de sílice.

Description

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Claims (1)

  1. imagen1
ES06777115.4T 2005-09-29 2006-08-30 Procedimiento para estabilizar formas de administración farmacéuticas que contienen microorganismos Active ES2526094T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05021254 2005-09-29
EP05021254 2005-09-29
PCT/EP2006/008468 WO2007036278A2 (de) 2005-09-29 2006-08-30 Verfahren zur stabilisierung von pharmazeutischen darreichungsformen enthaltend mikroorganismen

Publications (1)

Publication Number Publication Date
ES2526094T3 true ES2526094T3 (es) 2015-01-05

Family

ID=37450762

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06777115.4T Active ES2526094T3 (es) 2005-09-29 2006-08-30 Procedimiento para estabilizar formas de administración farmacéuticas que contienen microorganismos

Country Status (17)

Country Link
US (1) US9072784B2 (es)
EP (1) EP1928426B1 (es)
JP (1) JP2009509983A (es)
KR (1) KR20080059605A (es)
CN (1) CN101272770A (es)
AU (1) AU2006296797B8 (es)
BR (1) BRPI0616429B1 (es)
CA (1) CA2623968C (es)
CY (1) CY1115838T1 (es)
DK (1) DK1928426T3 (es)
EA (1) EA014825B1 (es)
ES (1) ES2526094T3 (es)
PL (1) PL1928426T3 (es)
PT (1) PT1928426E (es)
SI (1) SI1928426T1 (es)
WO (1) WO2007036278A2 (es)
ZA (1) ZA200803666B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080095752A1 (en) * 2006-10-20 2008-04-24 Win-Chin Chiang Method for extending the shelf-life of powdered nutritional formulations which contain viable probiotics
WO2008086852A1 (de) * 2007-01-20 2008-07-24 Merck Patent Gmbh Packung enthaltend weichkapseln
WO2010023248A1 (en) * 2008-08-28 2010-03-04 Chr. Hansen A/S Bacterial Composition
CN101865595A (zh) * 2009-04-14 2010-10-20 瑞阳制药有限公司 分子筛的新用途及固体药物干燥方法
US20110070334A1 (en) * 2009-09-20 2011-03-24 Nagendra Rangavajla Probiotic Stabilization
US9011909B2 (en) 2010-09-03 2015-04-21 Wisconsin Pharmacal Company, Llc Prebiotic suppositories
JP5940869B2 (ja) * 2012-04-20 2016-06-29 日清ファルマ株式会社 腸内環境改善有核錠製剤及びハードカプセル製剤
JP6243276B2 (ja) * 2014-03-31 2017-12-06 株式会社ファンケル 原薬の耐酸性を向上させたハードカプセル製剤
CA2951739C (en) 2014-07-01 2023-09-19 Tntgamble, Inc. Bi-layer dual release probiotic tablets
CN104988084B (zh) * 2015-02-28 2017-10-20 江南大学 一株产菊糖的格氏乳杆菌及其用途
ITUB20152151A1 (it) * 2015-07-14 2017-01-14 Ergon Srl Compressa ad elevata concentrazione di fermenti lattici
EP3556226B1 (de) * 2018-04-20 2021-01-20 Raab Vitalfood GmbH Komplex-synbiotikum zum aufbau einer gesunden darmflora
SG11202110641XA (en) 2019-04-15 2021-10-28 Inst Dinvestigacions Biomediques August Pi I Sunyer Idibaps Long-term stable live fecal microbiota composition

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60227664A (ja) * 1984-04-24 1985-11-12 Mishima Shokuhin Kk ビフイズス菌含有ふりかけおよびその製造方法
JPS61103445A (ja) 1984-10-24 1986-05-21 三菱瓦斯化学株式会社 脱酸素剤包装容器
JPH07322824A (ja) * 1994-05-30 1995-12-12 Snow Brand Food Co Ltd ヨーグルト風味を呈するフローズンデザート用粉末ミックス
US6279736B1 (en) * 1995-04-19 2001-08-28 Capitol Specialty Plastics, Inc. Barrier pack having an absorbing agent applied to the interior of the pack
BR9608007A (pt) * 1995-04-19 1999-11-30 Capitol Vial Inc Recipiente dotado de faculdades dessecantes, e, processo de co-moldagem de um recipiente dotado de faculdades dessecantes.
US6486231B1 (en) * 1995-04-19 2002-11-26 Csp Technologies, Inc. Co-continuous interconnecting channel morphology composition
US6316520B1 (en) * 1995-04-19 2001-11-13 Capitol Specialty Plastics, Inc. Monolithic polymer composition having a releasing material
US5911937A (en) * 1995-04-19 1999-06-15 Capitol Specialty Plastics, Inc. Desiccant entrained polymer
GB9705456D0 (en) * 1997-03-17 1997-05-07 Ucb Sa Yoghurt production process
SE9703669D0 (sv) * 1997-10-08 1997-10-08 Moelnlycke Ab Alster och beredning innefattande mjölksyrabakterier
ES2173372T3 (es) * 1997-12-19 2002-10-16 Merck Patent Gmbh Comprimidos multicapa que contienen microorganismos probioticos, como por ejemplo latobacilos o bifidobacterias.
SE9902207L (sv) * 1999-06-11 2000-12-12 Sca Hygiene Prod Ab Användning av fukttät förpackning för absorberande alster innehållande fuktkänsliga tillsatser
EP1072258A1 (de) * 1999-07-28 2001-01-31 Greither, Peter Eine Kapsel für die Freisetzung von Bakterien, enthaltend ein Bakterienlyophilisat und ein Verfahren zu ihrer Herstellung
SE0104199L (sv) * 2001-12-13 2003-06-14 Sca Hygiene Prod Ab Ny produkt
GB0330009D0 (en) * 2003-12-24 2004-01-28 Ferrosan As Probiotic tablet formulations

Also Published As

Publication number Publication date
AU2006296797B8 (en) 2012-06-28
BRPI0616429B1 (pt) 2021-10-13
CA2623968C (en) 2014-12-09
CA2623968A1 (en) 2007-04-05
KR20080059605A (ko) 2008-06-30
EP1928426A2 (de) 2008-06-11
EA200800698A1 (ru) 2008-12-30
ZA200803666B (en) 2009-02-25
US9072784B2 (en) 2015-07-07
CN101272770A (zh) 2008-09-24
BRPI0616429A2 (pt) 2011-06-21
WO2007036278A8 (de) 2007-06-21
EP1928426B1 (de) 2014-10-01
AU2006296797B2 (en) 2012-05-24
US20080219961A1 (en) 2008-09-11
CY1115838T1 (el) 2017-01-25
DK1928426T3 (en) 2014-12-01
AU2006296797A1 (en) 2007-04-05
WO2007036278A2 (de) 2007-04-05
JP2009509983A (ja) 2009-03-12
EA014825B1 (ru) 2011-02-28
SI1928426T1 (sl) 2015-01-30
PT1928426E (pt) 2014-12-02
PL1928426T3 (pl) 2015-04-30
WO2007036278A3 (de) 2007-08-16

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