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ES2431163T3 - Inhibidores de PIM quinasa y métodos para su uso - Google Patents

Inhibidores de PIM quinasa y métodos para su uso Download PDF

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Publication number
ES2431163T3
ES2431163T3 ES08731299T ES08731299T ES2431163T3 ES 2431163 T3 ES2431163 T3 ES 2431163T3 ES 08731299 T ES08731299 T ES 08731299T ES 08731299 T ES08731299 T ES 08731299T ES 2431163 T3 ES2431163 T3 ES 2431163T3
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ES
Spain
Prior art keywords
substituted
cycloalkyl
alkyl
amino
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08731299T
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English (en)
Inventor
Matthew Burger
Mika Lindvall
Wooseok Han
Jiong Lan
Gisele Nishiguchi
Cynthia Shafer
Cornelia Bellamacina
Kay Huh
Gordana Atallah
Christopher Mcbride
William Antonios-Mccrea, Jr.
Tatiana Zavorotinskaya
Annette Walter
Pablo Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
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Novartis AG
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Publication date
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Publication of ES2431163T3 publication Critical patent/ES2431163T3/es
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un compuesto de Fórmula II, o un estereoisómero, tautómero, o sal farmacéuticamente aceptable de los mismos, **Fórmula** en donde, Y es cicloalquilo, heterocicloalquilo, arilo o heteroarilo sustituidos o no sustituidos; Z3 se seleccionan a partir de CR2 y N; R1 se selecciona a partir del grupo que consiste en hidrógeno, halógeno, alquilo, cicloalquilo, -CN, -NO2, y -NHR3; cada R2 se selecciona independientemente a partir del grupo que consiste en hidrógeno, halógeno, hidroxilo, nitro, ciano, SO3H y alquilo, alquenilo, alquinilo, alcoxilo, amino, aminocarbonilo, aminotiocarboniio, aminocarbonilamino, aminotiocarboniIamino, aminocarboniloxi, aminosuifonilo, aminosulfoniloxi, aminosulfonilamino, amidino, carboxilo, carboxil éster, (carboxiI éster)amino, (carboxiI éster)oxi, sulfonilo, sulfoniloxi, tioacilo, tiol, alquiltio, arilo, heteroarilo, cicloalquilo, hetero cicloalquilo, cicloalquilo parcialmente saturado, ariloxi, heteroariloxi, heterocicliloxi, cicloalquiloxi, acilo, aciIamino, y aciloxi sustituidos o no sustituidos; R3 se selecciona a partir del grupo que consiste de hidrógeno, -CO-R4 y alquilo, cicloalquilo, heterociclilo, arilo, y heteroarilo sustituidos o no sustituidos; y R4 se selecciona a partir del grupo que consiste de alquilo, alquilo sustituido, alcoxi, alcoxi sustituido, amino, amino sustituido, y aIquiIamino.
ES08731299T 2007-03-01 2008-03-03 Inhibidores de PIM quinasa y métodos para su uso Active ES2431163T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US89244407P 2007-03-01 2007-03-01
US892444P 2007-03-01
US2377708P 2008-01-25 2008-01-25
US23777 2008-01-25
PCT/US2008/055724 WO2008106692A1 (en) 2007-03-01 2008-03-03 Pim kinase inhibitors and methods of their use

Publications (1)

Publication Number Publication Date
ES2431163T3 true ES2431163T3 (es) 2013-11-25

Family

ID=39433847

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08731299T Active ES2431163T3 (es) 2007-03-01 2008-03-03 Inhibidores de PIM quinasa y métodos para su uso

Country Status (12)

Country Link
US (1) US8822497B2 (es)
EP (1) EP2132177B1 (es)
JP (1) JP5330274B2 (es)
KR (1) KR101514853B1 (es)
CN (1) CN101679266B (es)
AU (1) AU2008221263B2 (es)
BR (1) BRPI0808523A2 (es)
CA (1) CA2679659C (es)
EA (1) EA019951B1 (es)
ES (1) ES2431163T3 (es)
MX (1) MX2009009304A (es)
WO (1) WO2008106692A1 (es)

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* Cited by examiner, † Cited by third party
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CA2679659C (en) 2016-01-19
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US8822497B2 (en) 2014-09-02
AU2008221263A1 (en) 2008-09-04
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