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AR061667A1 - Arilamidas sustituidas con tetrazol - Google Patents

Arilamidas sustituidas con tetrazol

Info

Publication number
AR061667A1
AR061667A1 ARP070102859A ARP070102859A AR061667A1 AR 061667 A1 AR061667 A1 AR 061667A1 AR P070102859 A ARP070102859 A AR P070102859A AR P070102859 A ARP070102859 A AR P070102859A AR 061667 A1 AR061667 A1 AR 061667A1
Authority
AR
Argentina
Prior art keywords
alkyl
hydrogen
optionally substituted
cycloalkyl
heteroaryl
Prior art date
Application number
ARP070102859A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR061667A1 publication Critical patent/AR061667A1/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se proporcionan también métodos de uso de los compuestos para tratar enfermedades con antagonistas de receptores P2X3 y/o P2X2/3 y métodos para la obtencion de los compuestos Reivindicacion 1: Un compuesto de la formula (1) o una sal farmacéuticamente aceptable de los mismos, en la que: R1 es tetrazolilo opcionalmente sustituido; R2 es fenilo opcionalmente sustituido, piridinilo opcionalmente sustituido, pirimidinilo opcionalmente sustituido, piridazilo opcionalmente sustituido o tiofenilo opcionalmente sustituido; R3 es hidrogeno; alquilo C1-6, hetero-alquilo C1-6 o ciano; R4 es hidrogeno; alquilo C1-6 o hetero-alquilo C1-6, o R3 y R4 junto con el átomo al que están unidos forman un anillo carbocíclico C3-6, R5 es alquilo C1-6, hetero-alquilo C1-6, haloalquilo C1-6, N-(alquil C1-6)-amino; N,N-di-(alquil C1-6)-amino; cicloalquilo C3-7, arilo; heteroarilo; heterociclilo; (cicloalquil C3-7)-alquilo C1-6, heteroaril-alquilo C1-6, heterociclil-alquilo C1-6, ariloxi- alquilo C1-6, -(CRaRb)m-C(O)-R8, en el que m es el numero 0 o 1; Ra y Rb con independencia entre sí son hidrogeno o alquilo C1-6 y R8 es hidrogeno; alquilo C1-6, hetero-alquilo C1-6, cicloalquilo C3-7, arilo; heteroarilo; heterociclilo; (cicloalquil C3-7)-alquilo C1-6, aril-alquilo C1-6, heteroarilalquilo C1-6, heterociclil-alquilo C1-6, cicloalquiloxi C3-7, ariloxi; heteroariloxi; heterocicliloxj; cicloalquiloxi C3-7-alquilo C1-6, ariloxi-alquilo C1-6, heteroariloxi-alquilo C1-6, heterocicliloxi-alquilo C1-6 o -NR9R10, en el que R9 es hidrogeno o alquilo C1-6, y R10 es hidrogeno; alquilo C1-6, hetero-alquilo C1-6, cicloalquilo C3-7, arilo; heteroarilo; heterociclilo; (cicloalquil C3-7)-alquilo C1-6, aril-alquilo C1-6, heteroaril-alquilo C1-6 o heterociclil-alquilo C1-6, o R4 y R5 junto con el átomo al que están unidos forman un anillo carbocíclico C3-6 que está opcionalmente sustituido por hidroxi; o R4 y R5 junto con el átomo al que están unidos forman un anillo heterocíclico C4-6 que contiene uno o dos heteroátomos elegidos con independencia entre O, N y S; o R3, R4 y R5 junto con el átomo al que están unidos forman un heteroarilo de seis eslabones que contiene uno o do átomos de nitrogeno, y que está opcionalmente sustituido por halogeno, amino o alquilo C1-6; R6 es alquilo C1-6, alquiloxi C1-6, halogeno; haloalquilo C1-6 o ciano; con la condicion de que cuando R1 es tetrazol-1-ilo, R2 es 4-metil-fenilo, R3 es metilo, R4 es hidrogeno y es hidrogeno, entonces R5 no sea furan-2-ilo.
ARP070102859A 2006-06-29 2007-06-27 Arilamidas sustituidas con tetrazol AR061667A1 (es)

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Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101165936B1 (ko) * 2006-11-09 2012-07-19 에프. 호프만-라 로슈 아게 티아졸 및 옥사졸-치환된 아릴아마이드
US8501933B2 (en) 2006-11-09 2013-08-06 Roche Palo Alto Llc Thiazole and oxazole-substituted arylamides as P2X3 and P2X2/3 antagonists
MX2010003156A (es) * 2007-10-04 2010-04-01 Hoffmann La Roche Derivados de aril amida substituida con tetrazol y usos de los mismos.
CA2703915C (en) * 2007-10-31 2015-02-24 Merck Sharp & Dohme Corp. P2x3 receptor antagonists for treatment of pain
US8247401B2 (en) * 2007-10-31 2012-08-21 Merck Sharp & Dohme Corp. P2X3 receptor antagonists for treatment of pain
AU2008337665B2 (en) * 2007-12-17 2014-01-16 F. Hoffmann-La Roche Ag Tetrazole-substituted arylamide derivatives and their use as P2x3 and/or P2x2/3 purinergic receptor antagonists
AU2013273626B2 (en) * 2007-12-17 2016-04-28 F.Hoffmann-La Roche Ag Triazole-substituted arylamide derivatives and their use as P2X3 and /or P2X2/3 purinergic receptor antagonists
ES2570628T3 (es) * 2007-12-17 2016-05-19 Hoffmann La Roche Nuevas arilamidas con sustitución imidazol
KR101284510B1 (ko) * 2007-12-17 2013-07-23 에프. 호프만-라 로슈 아게 트리아졸 치환된 아릴아미드 유도체 및 ｐ２ｘ３ 및/또는 ｐ２ｘ２／３ 퓨린성 수용체 길항제로서의 용도
PL2234976T3 (pl) * 2007-12-17 2013-09-30 Hoffmann La Roche Nowe aryloamidy podstawione pirazolem
US8946439B2 (en) 2008-02-29 2015-02-03 Evotec Ag Amide compounds, compositions and uses thereof
US20110237578A1 (en) * 2008-09-18 2011-09-29 Zhi-Liang Wei Amide compounds, compositions and uses thereof
US8598209B2 (en) * 2008-10-31 2013-12-03 Merck Sharp & Dohme Corp. P2X3, receptor antagonists for treatment of pain
BRPI0922645A2 (pt) * 2008-12-16 2019-09-24 Hoffmann La Roche "arilamidas tiadiazol substituídas".
ES2660892T3 (es) 2009-03-23 2018-03-26 Merck Sharp & Dohme Corp. Antagonistas del receptor P2X3 para el tratamiento del dolor
JP2012521428A (ja) 2009-03-23 2012-09-13 メルク・シャープ・エンド・ドーム・コーポレイション 疼痛治療用のｐ２ｘ３受容体アンタゴニスト
US8946231B2 (en) 2009-03-23 2015-02-03 Merck Sharp & Dohme Corp. P2X3, receptor antagonists for treatment of pain
EP2246259B1 (en) 2009-04-29 2012-12-12 Eurocopter Deutschland GmbH Rotor wing with integrated tension-torque-transmission element and method for its production
JP5685203B2 (ja) 2009-05-29 2015-03-18 ラクオリア創薬株式会社 カルシウムチャネル遮断薬またはナトリウムチャネル遮断薬としてのアリール置換カルボキサミド誘導体
TW201103904A (en) * 2009-06-11 2011-02-01 Hoffmann La Roche Janus kinase inhibitor compounds and methods
CA2754654A1 (en) * 2009-06-22 2010-12-29 F. Hoffmann-La Roche Ag Novel oxazolone and pyrrolidinone-substituted arylamides
ES2450891T3 (es) * 2009-06-22 2014-03-25 F. Hoffmann-La Roche Ag Bifenilamidas útiles como moduladores de receptores P2X3 y/o P2X2/3
CA2761921A1 (en) 2009-06-22 2010-12-29 F. Hoffmann-La Roche Ag Indole, indazole and benzimidazole arylamides
KR20130087002A (ko) * 2010-06-04 2013-08-05 알바니 몰레큘라 리써치, 인크. 글리신 수송체-1 저해제, 그의 제조 방법 및 그의 용도
WO2014117274A1 (en) * 2013-01-31 2014-08-07 Neomed Institute Imidazopyridine compounds and uses thereof
US10183937B2 (en) 2014-12-09 2019-01-22 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides
JP6544665B2 (ja) 2014-12-09 2019-07-17 バイエル アクチェンゲゼルシャフトＢａｙｅｒ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ １，３−チアゾール−２−イル置換ベンズアミド
CN107207449B (zh) * 2015-04-23 2020-11-10 豪夫迈·罗氏有限公司 用于治疗精神障碍的四唑衍生物
EP3303299B1 (en) * 2015-06-04 2019-04-24 H. Hoffnabb-La Roche Ag Imidazole derivatives
WO2017060202A1 (en) * 2015-10-06 2017-04-13 F. Hoffmann-La Roche Ag Triazole derivatives
EP3411365B1 (en) 2016-02-02 2019-11-20 H. Hoffnabb-La Roche Ag Pyrazol-pyridine derivatives as eaat3 inhibitors
TWI679197B (zh) * 2016-05-05 2019-12-11 瑞士商伊蘭科動物健康公司 雜芳基-1,2,4-三唑及雜芳基-三唑化合物
EP3464246B1 (en) * 2016-05-27 2020-07-08 H. Hoffnabb-La Roche Ag Pyrazol compounds as eaat3 inhibitors
EP3526201B1 (en) 2016-10-14 2020-11-18 H. Hoffnabb-La Roche Ag Imidazole compounds as eaat3 inhibitors
TWI741040B (zh) * 2016-10-20 2021-10-01 德商拜耳作物科學公司 製備3-烷基硫基-2-氯-n-(1-烷基-1h-四唑-5-基)-4-三氟甲基苯甲醯胺之方法
RU2650780C1 (ru) 2016-12-06 2018-04-17 Общество с ограниченной ответственностью "Анальгетики будущего" Пептидный модулятор пуринергических рецепторов
WO2020239953A1 (en) 2019-05-31 2020-12-03 Chiesi Farmaceutici S.P.A. Pyridopyrimidines derivatives as p2x3 inhibitors
GEP20257823B (en) 2019-05-31 2025-11-10 Chiesi Farm Spa Amino quinazoline derivatives as p2x3 inhibitors
CN116601149A (zh) 2020-11-27 2023-08-15 奇斯药制品公司 作为p2x3抑制剂的氨基喹唑啉衍生物
KR20230113289A (ko) 2020-11-27 2023-07-28 키에시 파르마슈티시 엣스. 피. 에이. P2x3 억제제로서 프탈라진 유도체
AU2021386684A1 (en) 2020-11-27 2023-05-25 Chiesi Farmaceutici S.P.A. (aza)quinoline 4-amines derivatives as p2x3 inhibitors
AR131715A1 (es) * 2023-01-30 2025-04-23 Eurofarma Laboratorios S A AMIDAS BLOQUEADORAS DE Nav 1.7 Y/O Nav 1.8, SUS PROCESOS DE OBTENCIÓN, COMPOSICIONES, USOS, MÉTODOS DE TRATAMIENTO DE LOS MISMOS Y KITS

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL109570A0 (en) * 1993-05-17 1994-08-26 Fujisawa Pharmaceutical Co Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
JPH10501122A (ja) * 1994-05-27 1998-02-03 グラクソ、グループ、リミテッド Ｐ▲下２ｘ▼レセプター（プリノセプターファミリー）
US6133434A (en) * 1997-04-28 2000-10-17 Glaxo Group Limited Purinergic receptor
JP2000281664A (ja) * 1999-03-30 2000-10-10 Otsuka Pharmaceut Co Ltd チアゾール誘導体
ES2250126T3 (es) 1999-06-30 2006-04-16 H. Lundbeck A/S Antagonistas selectivos del npy(y5).
AU2001268711A1 (en) 2000-06-23 2002-01-08 Bristol-Myers Squibb Pharma Company Heteroaryl-phenyl substituted factor xa inhibitors
DE10055713A1 (de) 2000-11-10 2002-05-23 Dingwei Tim Yu Neue Klasse von Antifungimitteln
PA8557501A1 (es) * 2001-11-12 2003-06-30 Pfizer Prod Inc Benzamida, heteroarilamida y amidas inversas
TW200304374A (en) * 2001-11-30 2003-10-01 Smithkline Beecham Plc Novel compounds
US20030236439A1 (en) 2002-01-30 2003-12-25 Gregory Agoston Non-steroidal analogs of 2-methoxyestradiol
CA2480856A1 (en) * 2002-04-05 2003-10-23 Merck & Co., Inc. Substituted aryl amides
US7078423B2 (en) * 2002-07-18 2006-07-18 Inotek Pharmaceuticals Corporation 5-Aryltetrazole compounds, compositions thereof, and uses therefor
CA2466288A1 (en) 2002-07-18 2004-01-29 Sri International Methods of treating conditions associated with an edg-1 receptor
DE10312963A1 (de) * 2003-03-24 2004-10-07 Aventis Pharma Deutschland Gmbh Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament
AU2004232936B2 (en) 2003-04-18 2008-10-30 Merck & Co., Inc. Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers
AU2005259835B2 (en) * 2004-07-02 2011-07-07 The Walter And Eliza Hall Institute Of Medical Research Alpha-helical mimetics
WO2007020194A1 (en) * 2005-08-15 2007-02-22 F. Hoffmann-La Roche Ag Piperidine and piperazine derivatives as p2x3 antagonists

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