ES2494015T3 - Composiciones para tratar nauseas y vómitos de origen central - Google Patents
Composiciones para tratar nauseas y vómitos de origen central Download PDFInfo
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- ES2494015T3 ES2494015T3 ES10805301.8T ES10805301T ES2494015T3 ES 2494015 T3 ES2494015 T3 ES 2494015T3 ES 10805301 T ES10805301 T ES 10805301T ES 2494015 T3 ES2494015 T3 ES 2494015T3
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- vomiting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Paints Or Removers (AREA)
Abstract
Una combinación de (i) netupitant o una sal farmacéuticamente aceptable del mismo, (ii) un antagonista de 5-HT3 o una sal farmacéuticamente aceptable del mismo, (iii) dexametasona, para su uso en el tratamiento de náuseas y vómitos durante cinco días consecutivos en un paciente que lo necesita, en la que: a) se administra dicho netupitant o una sal farmacéuticamente aceptable del mismo a dicho paciente el día uno, en una cantidad terapéuticamente eficaz que es eficaz para tratar náuseas y vómitos durante las fases aguda y tardía de emesis, y que entra en la circulación sistémica, cruza la barrera hematoencefálica y ocupa al menos el 70 % de receptores NK1 en el cuerpo estriado setenta y dos horas después de dicha administración; b) se administra el antagonista de 5-HT3 o una sal farmacéuticamente aceptable del mismo a dicho paciente el día uno, en una cantidad terapéuticamente eficaz, que es eficaz para tratar náuseas y vómitos durante las fases aguda y tardía; y c) se administra dexametasona a dicho paciente el día uno en una primera dosis que es ineficaz contra náuseas y vómitos cuando se administra sola, pero eficaz contra náuseas y vómitos cuando se administra en combinación con dicho netupitant, en la que la primera dosis comprende del 50 al 70 % de una dosis eficaz mínima cuando se administra sola.
Description
E10805301
12-08-2014
• Gravedad de las náuseas para la fase global, aguda y tardía; • Satisfacción global del paciente con el tratamiento antiemético por medio de VAS para cada intervalo de 24 horas.
Las tasas de respuesta completa se resumen en la tabla 5. El porcentaje de pacientes con respuesta completa sobre 0-120 horas después del inicio de la administración de cisplatino fue del 76,5 % en el grupo de palonosetrón solo y del 87,4 %, 87,6 %, y del 89,6 % en los grupos de netupitant 100 mg, 200 mg, y 300 mg, respectivamente. Las diferencias de palonosetrón solo fueron mayores del 10 % (del 10,9 % al 13,2 %). Todas las dosis de netupitant fueron estadísticamente superiores a palonosetrón solo (valor p = 0,004 para el grupo de combinación de netupitant 300 mg).
Tabla 5: Tasa de respuesta completa para la fase global, aguda y tardía: Población MFAS
- Criterio de valoración de eficacia
- Palo solo (n=136) Palo + Netu 100 mg (n=135) Palo + Netu 200 mg (n=137) Palo + Netu 300 mg (n=135) Régimen de aprepitant (N=134)
- RC, fase global, 0-120 h
- Porcentaje de pacientes
- 76,5 87,4 87,6 89,6 86,6
- Diferencia de Palo solo (%)
- 10,9 11,1 13,2 10,1
- Valor p (*)
- 0,018 0,017 0,004 0,027
- RC, fase aguda, 0-24 h
- Porcentaje de pacientes
- 89,7 93,3 92,7 98,5 94,8
- Diferencia de Palo solo (%)
- 3,6 3,0 8,8 5,1
- Valor p (*)
- 0,278 0,383 0,007 0,114
- RC, fase tardía, 25-120 h
- Porcentaje de pacientes
- 80,1 90,4 91,2 90,4 88,8
- Diferencia de Palo solo (%)
- 10,2 11,1 10,2 8,7
- Valor p (*)
- 0,018 0,010 0,018 0,043
(*) valor p del análisis de regresión logística, valor p de aprepitant del análisis de regresión logística a posteriori.
10 La tabla 6 resume los principales criterios de valoración secundarios. En la fase global, el 76,5 % de los pacientes en el grupo de palonosetrón solo no experimentó emesis, mientras que el 87,4, 87,6, y 91,1 % de los pacientes no experimentó emesis en los grupos de combinación de netupitant 100 mg, 200 mg y 300 mg, respectivamente (p<0,05 para todas las dosis).
Tabla 6: Resumen de los resultados de eficacia secundaria: porcentaje de pacientes. Población MFAS
- Criterio de valoración de eficacia
- Palo solo (n=136) Palo + Netu 100 mg (n=135) Palo + Netu 200 mg (n=137) Palo + Netu 300 mg (n=135) Régimen de aprepitant (N=134) Palo + Aprep 285 mg (N=41) **
- Sin emesis
- Global
- 76,5 87,4* 87,6* 91,1* 87,3*
- Aguda
- 89,7 93,3 92,7 98,5* 94,8
- Tardía
- 80,1 90,4* 91,2* 91,9* 89,6*
- Sin rescate
- Global
- 95,6 97,8 100 98,5 97,8
- Aguda
- 97,8 99,3 100 100 100
- Tardía
- 97,1 97,8 100 98,5 97,8
- Sin náuseas
- Global
- 50,7 54,8 62,0 61,5 58,2 32
- Aguda
- 75,0 72,6 77,4 80,0 77,6 59
- Tardía
- 53,7 59,3 65,0 68,1* 60,4 41
- Sin náuseas significativas
- Global
- 79,4 80,0 86,1 89,6* 85,8 56
- Aguda
- 93,4 94,1 94,2 98,5* 94,0 79
- Tardía
- 80,9 81,5 89,8* 90,4* 88,1 59
- Control total
- Global
- 50,0 54,8 61,3 59,3 56,0
- Aguda
- 71,3 71,9 76,6 80,0 74,6
- Tardía
- 52,2 59,3 65,0* 65,9* 58,2
- Protección completa
- Global
- 69,9 76,3 80,3* 83,0* 78,4 51
- Aguda
- 87,5 89,6 88,3 97,0* 89,6 76
14
Claims (1)
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imagen1 imagen2 imagen3 imagen4
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26247009P | 2009-11-18 | 2009-11-18 | |
| US262470P | 2009-11-18 | ||
| US38270910P | 2010-09-14 | 2010-09-14 | |
| US382709P | 2010-09-14 | ||
| PCT/IB2010/003106 WO2011061622A1 (en) | 2009-11-18 | 2010-11-18 | Compositions for treating centrally mediated nausea and vomiting |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2494015T3 true ES2494015T3 (es) | 2014-09-12 |
Family
ID=43608757
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10805301.8T Active ES2494015T3 (es) | 2009-11-18 | 2010-11-18 | Composiciones para tratar nauseas y vómitos de origen central |
| ES14151676.5T Active ES2559475T3 (es) | 2009-11-18 | 2010-11-18 | Composiciones para tratar náuseas y vómitos de origen central |
| ES14151683.1T Active ES2595077T3 (es) | 2009-11-18 | 2010-11-18 | Composiciones para tratar náuseas y vómitos mediados centralmente |
| ES14151678.1T Active ES2623503T3 (es) | 2009-11-18 | 2010-11-18 | Composiciones para tratar náuseas y vómitos mediados centralmente |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14151676.5T Active ES2559475T3 (es) | 2009-11-18 | 2010-11-18 | Composiciones para tratar náuseas y vómitos de origen central |
| ES14151683.1T Active ES2595077T3 (es) | 2009-11-18 | 2010-11-18 | Composiciones para tratar náuseas y vómitos mediados centralmente |
| ES14151678.1T Active ES2623503T3 (es) | 2009-11-18 | 2010-11-18 | Composiciones para tratar náuseas y vómitos mediados centralmente |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US12042494B2 (es) |
| EP (3) | EP2727590B1 (es) |
| JP (1) | JP5890780B2 (es) |
| KR (1) | KR101615108B1 (es) |
| CN (6) | CN106421793B (es) |
| AP (1) | AP3083A (es) |
| AU (1) | AU2010320598B2 (es) |
| BR (1) | BR112012011485B1 (es) |
| CA (1) | CA2778301C (es) |
| CL (1) | CL2012001276A1 (es) |
| CO (1) | CO6551693A2 (es) |
| CR (1) | CR20120216A (es) |
| CU (1) | CU24048B1 (es) |
| CY (1) | CY1118062T1 (es) |
| DK (2) | DK2361090T3 (es) |
| DO (1) | DOP2012000138A (es) |
| EA (1) | EA026815B1 (es) |
| EC (1) | ECSP12011907A (es) |
| ES (4) | ES2494015T3 (es) |
| GE (1) | GEP20156226B (es) |
| GT (1) | GT201200156A (es) |
| HK (2) | HK1214148A1 (es) |
| HR (3) | HRP20140759T1 (es) |
| HU (1) | HUE029677T2 (es) |
| IL (1) | IL219576A (es) |
| LT (1) | LT2722045T (es) |
| MA (1) | MA33810B1 (es) |
| MX (1) | MX2012005347A (es) |
| MY (1) | MY159393A (es) |
| NI (1) | NI201200090A (es) |
| NZ (1) | NZ599439A (es) |
| PE (1) | PE20121483A1 (es) |
| PH (1) | PH12012500887A1 (es) |
| PL (3) | PL2361090T3 (es) |
| PT (2) | PT2361090E (es) |
| RS (2) | RS55206B1 (es) |
| SI (2) | SI2361090T1 (es) |
| SM (1) | SMT201400112B (es) |
| TN (1) | TN2012000170A1 (es) |
| WO (1) | WO2011061622A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2722045B1 (en) | 2009-11-18 | 2016-07-06 | Helsinn Healthcare SA | Compositions for treating centrally mediated nausea and vomiting |
| RS55206B1 (sr) | 2009-11-18 | 2017-01-31 | Helsinn Healthcare Sa | Kompozicije za lečenje centralno posredovane mučnine i povraćanja |
| US9782397B2 (en) | 2011-07-04 | 2017-10-10 | Irbm Science Park S.P.A. | Treatment of corneal neovascularization |
| ES2579616T3 (es) * | 2011-10-18 | 2016-08-12 | Helsinn Healthcare Sa | Combinaciones terapéuticas de netupitant y palonosetrón |
| US9403772B2 (en) | 2011-11-29 | 2016-08-02 | Helsinn Healthcare Sa | 4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium as a neurokinin receptor modulator |
| US8426450B1 (en) | 2011-11-29 | 2013-04-23 | Helsinn Healthcare Sa | Substituted 4-phenyl pyridines having anti-emetic effect |
| CN103520725B (zh) * | 2012-07-05 | 2017-10-24 | 海思科医药集团股份有限公司 | 一种治疗呕吐的药物组合物 |
| PT3265087T (pt) | 2015-03-04 | 2020-10-15 | Vanda Pharmaceuticals Inc | Método de tratamento com tradipitant |
| CN106902086B (zh) * | 2015-12-23 | 2020-10-20 | 江苏恒瑞医药股份有限公司 | 一种包含奈妥匹坦的固体组合物 |
| GB201618425D0 (en) * | 2016-11-01 | 2016-12-14 | Acacia Pharma Ltd | method |
| GB201702250D0 (en) | 2017-02-10 | 2017-03-29 | Acacia Pharma Ltd | Method |
| CN108721214B (zh) * | 2017-04-14 | 2020-06-16 | 和龙 | 奈妥吡坦和帕洛诺司琼复方纳米粒溶液、纳米粒及制备方法和用途 |
| CN108853010A (zh) * | 2017-05-15 | 2018-11-23 | 和龙 | 奈妥吡坦环糊精包合物、复方组合制剂及其制备方法和用途 |
| CN109200018A (zh) * | 2017-07-04 | 2019-01-15 | 南京诺瑞特医药科技有限公司 | 含有奈妥吡坦的微乳制剂 |
| SI3710000T1 (sl) * | 2017-11-17 | 2025-07-31 | Vanda Pharmaceuticals Inc. | Tradipitant za uporabo pri zdravljenju gastropareze |
| CA3089656A1 (en) * | 2018-02-02 | 2019-08-08 | Eustralis Pharmaceuticals Limited (Trading As Pressura Neuro) | Oral formulations and uses thereof |
| EP4385497A1 (en) | 2022-12-12 | 2024-06-19 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Antioxidant-free fixed dose combination of netupitant and palonosetron |
| EP4633608A1 (en) | 2022-12-12 | 2025-10-22 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Antioxidant-free fixed dose combination of netupitant and palonosetron |
| EP4385500A1 (en) | 2022-12-12 | 2024-06-19 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Fixed dose combination comprising netupitant and palonosetron |
| AU2023393578A1 (en) | 2022-12-12 | 2025-07-03 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Fixed dose combination comprising netupitant and palonosetron |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
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| HU218654B (hu) | 1989-11-28 | 2000-10-28 | Syntex (U.S.A.) Inc. | Triciklusos vegyületek, ezeket hatóanyagként tartalmazó gyógyászati készítmények és eljárás előállításukra |
| US5510486A (en) | 1994-07-26 | 1996-04-23 | Syntex (U.S.A.) Inc. | Process for preparing 2-(1-azabicyclo 2.2.2!oct-3-yl)-2,3,3A,4,5,6-hexahydro-1H-benz de!isoquinolin-1-one |
| US6297395B1 (en) | 1995-11-10 | 2001-10-02 | The Secretary Of State For Defence In Her Brittanic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland | Calixarenes and their use for sequestration of metals |
| DK1035115T3 (da) | 1999-02-24 | 2005-01-24 | Hoffmann La Roche | 4-phenylpyridinderivater og anvendelse deraf som NK-1-receptorantagonister |
| IL153834A0 (en) | 2000-07-14 | 2003-07-31 | Hoffmann La Roche | N-oxides as nk1 receptor antagonist prodrugs of 4-phenyl-pyridine derivatives |
| DK1349541T3 (da) | 2000-12-14 | 2007-01-08 | Hoffmann La Roche | Selvemulgerende lipidmatrix (SELM) |
| JP5690461B2 (ja) | 2002-11-15 | 2015-03-25 | ヘルシン ヘルスケア ソシエテ アノニム | 化学療法誘導嘔吐を治療するためのパロノセトロン |
| JO2735B1 (en) | 2003-01-30 | 2013-09-15 | هيلسين هيلث كير أس ايه. | Liquid pharmaceutical formations of balloonosterone |
| MY143789A (en) | 2003-02-18 | 2011-07-15 | Helsinn Healthcare Sa | Use of palonosetron treating post- operative nausea and vomiting |
| CA2521369A1 (en) * | 2003-04-08 | 2004-10-28 | Progenics Pharmaceuticals, Inc. | The use of peripheral opiois antagonists, especially methylnaltrexone to treat irritable bowel syndrome |
| RU2007129642A (ru) | 2005-02-25 | 2009-03-27 | Ф.Хоффманн-Ля Рош Аг (Ch) | Таблетки с улучшенным распределением лекарственного вещества |
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