ES2228118T3 - Procedimiento para controlar la accion de un farmaco inhibidor de proteasoma. - Google Patents
Procedimiento para controlar la accion de un farmaco inhibidor de proteasoma.Info
- Publication number
- ES2228118T3 ES2228118T3 ES99952027T ES99952027T ES2228118T3 ES 2228118 T3 ES2228118 T3 ES 2228118T3 ES 99952027 T ES99952027 T ES 99952027T ES 99952027 T ES99952027 T ES 99952027T ES 2228118 T3 ES2228118 T3 ES 2228118T3
- Authority
- ES
- Spain
- Prior art keywords
- proteasome
- activity
- sample
- mammal
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10491898P | 1998-10-20 | 1998-10-20 | |
| US104918P | 1998-10-20 | ||
| US13138199P | 1999-04-28 | 1999-04-28 | |
| US131381P | 1999-04-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2228118T3 true ES2228118T3 (es) | 2005-04-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99952027T Expired - Lifetime ES2228118T3 (es) | 1998-10-20 | 1999-10-19 | Procedimiento para controlar la accion de un farmaco inhibidor de proteasoma. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6613541B1 (fr) |
| EP (1) | EP1123412B1 (fr) |
| JP (1) | JP4503182B2 (fr) |
| KR (1) | KR20010080267A (fr) |
| CN (1) | CN1331752A (fr) |
| AT (1) | ATE278803T1 (fr) |
| AU (1) | AU762373B2 (fr) |
| BR (1) | BR9914648A (fr) |
| CA (1) | CA2347275C (fr) |
| DE (1) | DE69920940T2 (fr) |
| ES (1) | ES2228118T3 (fr) |
| HK (1) | HK1040533A1 (fr) |
| IL (2) | IL142647A0 (fr) |
| NZ (1) | NZ511197A (fr) |
| WO (1) | WO2000023614A1 (fr) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1326632B1 (fr) | 2000-10-12 | 2006-09-06 | Viromics Gmbh | Inhibiteurs du proteasome pour le traitement d'infections d'hepatite virale |
| DE10051716A1 (de) * | 2000-10-12 | 2002-04-25 | Ulrich Schubert | Mittel zur Hemmung der Freisetzung, Reifung und Replikation von Retroviren |
| EP1341414B1 (fr) | 2000-11-16 | 2013-01-02 | The Regents of The University of California | Taxon d'actinomycete marin utilise pour la decouverte de medicaments et de produits de fermentation |
| EP2388254B1 (fr) * | 2002-02-01 | 2016-08-10 | Promega Corporation | Analyse de protéase bioluminescente |
| ATE481104T1 (de) | 2002-04-05 | 2010-10-15 | Virologik Gmbh | Mittel zur behandlung von flaviviridae- infektionen |
| US7176232B2 (en) | 2002-06-24 | 2007-02-13 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
| DE10232902A1 (de) * | 2002-07-19 | 2004-01-29 | Bayer Cropscience Ag | Verfahren zum Identifizieren von Inhibitoren des 20S und 26S Proteasoms |
| US20050049294A1 (en) * | 2003-06-20 | 2005-03-03 | Michael Palladino | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
| CN101791306A (zh) | 2003-06-20 | 2010-08-04 | 加利福尼亚大学董事会 | 盐孢菌酰胺及其使用方法 |
| CA2530479C (fr) * | 2003-08-08 | 2010-01-19 | F. Hoffmann-La Roche Ag | Utilisation de la sous-unite 3 de proteine activatrice de proteasome (pse3) comme marqueur de cancer colorectal |
| US7576206B2 (en) | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| US7223745B2 (en) | 2003-08-14 | 2007-05-29 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| US7416854B2 (en) * | 2004-01-22 | 2008-08-26 | Promega Corporation | Luminogenic and nonluminogenic multiplex assay |
| US7553632B2 (en) * | 2004-01-22 | 2009-06-30 | Promega Corporation | Luminogenic and nonluminogenic multiplex assay |
| CN102174076A (zh) | 2004-04-15 | 2011-09-07 | 普罗特奥里克斯公司 | 用于抑制蛋白酶体酶的化合物 |
| US8198270B2 (en) * | 2004-04-15 | 2012-06-12 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
| JP2007535559A (ja) | 2004-04-30 | 2007-12-06 | ネレアス ファーマシューティカルズ インコーポレイテッド | [3.2.0]複素環式化合物及びその使用法 |
| US7579371B2 (en) | 2004-04-30 | 2009-08-25 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
| SG185963A1 (en) * | 2004-05-10 | 2012-12-28 | Onyx Therapeutics Inc | Compounds for enzyme inhibition |
| CA2584515A1 (fr) * | 2004-10-20 | 2006-04-27 | Proteolix, Inc. | Composes pour inhibition d'enzymes |
| WO2006060676A1 (fr) | 2004-12-03 | 2006-06-08 | Dana Farber Cancer Institute | Compositions et procedes destines au traitement des maladies neoplastiques |
| US7468383B2 (en) | 2005-02-11 | 2008-12-23 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| US20060193844A1 (en) * | 2005-02-28 | 2006-08-31 | Proteolix, Inc. | Methods for enzyme inhibition |
| US20070048812A1 (en) * | 2005-09-01 | 2007-03-01 | Moravec Richard A | Cell-based luminogenic and nonluminogenic proteasome assays |
| LT2623113T (lt) | 2005-11-09 | 2017-07-10 | Onyx Therapeutics, Inc. | Junginiai, skirti fermentų slopinimui |
| AR057227A1 (es) * | 2005-12-09 | 2007-11-21 | Centocor Inc | Metodo para usar antagonistas de il6 con inhibidores del proteasoma |
| PL2041158T3 (pl) | 2006-06-19 | 2013-08-30 | Onyx Therapeutics Inc | Peptydowe epoksyketony do hamowania proteasomu |
| US20080118940A1 (en) * | 2006-11-22 | 2008-05-22 | Maher Albitar | Proteasomal peptidase activity and the use thereof in clinical applications |
| US7824698B2 (en) | 2007-02-02 | 2010-11-02 | Nereus Pharmaceuticals, Inc. | Lyophilized formulations of Salinosporamide A |
| AU2008239654A1 (en) | 2007-04-13 | 2008-10-23 | Promega Corporation | Luminescent live and dead cell assay |
| ES2684340T3 (es) | 2007-10-04 | 2018-10-02 | Onyx Therapeutics, Inc. | Inhibidores de proteasa epoxi cetona de péptidos cristalinos y síntesis de cetoepóxidos de aminoácidos |
| US8394816B2 (en) | 2007-12-07 | 2013-03-12 | Irene Ghobrial | Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia |
| BRPI0912234A2 (pt) | 2008-05-12 | 2015-10-06 | Nereus Pharmaceuticals Inc | derivados de salinosporamida como inibidores de proteassomas |
| EP2349313A4 (fr) | 2008-10-21 | 2012-08-29 | Onyx Therapeutics Inc | Thérapie de combinaison avec des peptides époxycétones |
| TWI504598B (zh) | 2009-03-20 | 2015-10-21 | Onyx Therapeutics Inc | 結晶性三肽環氧酮蛋白酶抑制劑 |
| US20110053197A1 (en) * | 2009-08-25 | 2011-03-03 | Quest Diagnostics Investments Incorporated | Ubiquitin proteasome system profiling and the use thereof in clinical applications for cancer diagnosis |
| US20110053199A1 (en) * | 2009-08-25 | 2011-03-03 | Quest Diagnostics Investments Incorporated | Ubiquitin proteasome system profiling and the use thereof in clinical applications for cancer diagnosis |
| US20110053198A1 (en) * | 2009-08-25 | 2011-03-03 | Quest Diagnostics Investments Incorporated | Ubiquitin proteasome system profiling and the use thereof in clinical applications for proliferative hematological disorders |
| WO2011060179A1 (fr) | 2009-11-13 | 2011-05-19 | Onyx Therapeutics, Inc | Utilisation de peptides epoxycetones pour la suppression de la metastase |
| WO2011087822A1 (fr) | 2009-12-22 | 2011-07-21 | Cephalon, Inc. | Inhibiteurs du protéasome et leurs procédés de préparation, d'épuration et d'utilisation |
| EA201290844A1 (ru) | 2010-03-01 | 2013-03-29 | Оникс Терапьютикс, Инк. | Соединения для ингибирования иммунопротеасом |
| BR112012025264A2 (pt) | 2010-04-07 | 2019-09-24 | Onyx Therapeutics Inc | inibidor de imunoproteassoma de e´poxicetona peptídica cristalina. |
| US20140105921A1 (en) | 2012-07-09 | 2014-04-17 | Onyx Therapeutics, Inc. | Prodrugs of Peptide Epoxy Ketone Protease Inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5340736A (en) * | 1991-05-13 | 1994-08-23 | The President & Fellows Of Harvard College | ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting |
| WO1994017816A1 (fr) | 1993-02-10 | 1994-08-18 | The President And Fellows Of Harvard College | Role de la proteolyse dependant de l'ubiquitine atp dans la presentation de l'antigene restreint chm-1 et inhibiteurs utilises a cet effet |
| US5693617A (en) * | 1994-03-15 | 1997-12-02 | Proscript, Inc. | Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein |
| US6660268B1 (en) | 1994-03-18 | 2003-12-09 | The President And Fellows Of Harvard College | Proteasome regulation of NF-KB activity |
| US5574017A (en) | 1994-07-05 | 1996-11-12 | Gutheil; William G. | Antibacterial agents |
| US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| US5614649A (en) | 1994-11-14 | 1997-03-25 | Cephalon, Inc. | Multicatalytic protease inhibitors |
| US5804560A (en) * | 1995-01-06 | 1998-09-08 | Sibia Neurosciences, Inc. | Peptide and peptide analog protease inhibitors |
| US6335358B1 (en) * | 1995-04-12 | 2002-01-01 | President And Fellows Of Harvard College | Lactacystin analogs |
| CA2219867A1 (fr) | 1997-10-31 | 1999-04-30 | Jiangping Wu | Utilisation d'inhibiteurs du proteasome dans le traitement du cancer, de l'inflammation, des maladies auto-immunes, du rejet de greffe et du choc septique |
| US6617171B2 (en) * | 1998-02-27 | 2003-09-09 | The General Hospital Corporation | Methods for diagnosing and treating autoimmune disease |
| EP1088100A2 (fr) * | 1998-06-13 | 2001-04-04 | Zarpex Biosciences Limited | Activite de proteasomes |
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1999
- 1999-10-19 WO PCT/US1999/024356 patent/WO2000023614A1/fr not_active Ceased
- 1999-10-19 EP EP99952027A patent/EP1123412B1/fr not_active Expired - Lifetime
- 1999-10-19 BR BR9914648-7A patent/BR9914648A/pt not_active IP Right Cessation
- 1999-10-19 DE DE69920940T patent/DE69920940T2/de not_active Expired - Lifetime
- 1999-10-19 AU AU64333/99A patent/AU762373B2/en not_active Expired
- 1999-10-19 US US09/419,551 patent/US6613541B1/en not_active Expired - Lifetime
- 1999-10-19 IL IL14264799A patent/IL142647A0/xx active IP Right Grant
- 1999-10-19 HK HK02101045.1A patent/HK1040533A1/zh unknown
- 1999-10-19 CN CN99813797A patent/CN1331752A/zh active Pending
- 1999-10-19 CA CA002347275A patent/CA2347275C/fr not_active Expired - Lifetime
- 1999-10-19 AT AT99952027T patent/ATE278803T1/de not_active IP Right Cessation
- 1999-10-19 JP JP2000577321A patent/JP4503182B2/ja not_active Expired - Lifetime
- 1999-10-19 NZ NZ511197A patent/NZ511197A/en unknown
- 1999-10-19 KR KR1020017004966A patent/KR20010080267A/ko not_active Withdrawn
- 1999-10-19 ES ES99952027T patent/ES2228118T3/es not_active Expired - Lifetime
-
2001
- 2001-04-17 IL IL142647A patent/IL142647A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000023614A1 (fr) | 2000-04-27 |
| WO2000023614A8 (fr) | 2000-07-13 |
| DE69920940D1 (de) | 2004-11-11 |
| IL142647A (en) | 2006-04-10 |
| CN1331752A (zh) | 2002-01-16 |
| BR9914648A (pt) | 2001-11-27 |
| CA2347275A1 (fr) | 2000-04-27 |
| AU6433399A (en) | 2000-05-08 |
| JP2002527114A (ja) | 2002-08-27 |
| EP1123412B1 (fr) | 2004-10-06 |
| KR20010080267A (ko) | 2001-08-22 |
| AU762373B2 (en) | 2003-06-26 |
| HK1040533A1 (zh) | 2002-06-14 |
| US6613541B1 (en) | 2003-09-02 |
| IL142647A0 (en) | 2002-03-10 |
| EP1123412A1 (fr) | 2001-08-16 |
| ATE278803T1 (de) | 2004-10-15 |
| JP4503182B2 (ja) | 2010-07-14 |
| CA2347275C (fr) | 2010-03-09 |
| DE69920940T2 (de) | 2005-11-17 |
| NZ511197A (en) | 2003-08-29 |
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