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ES2228118T3 - Procedimiento para controlar la accion de un farmaco inhibidor de proteasoma. - Google Patents

Procedimiento para controlar la accion de un farmaco inhibidor de proteasoma.

Info

Publication number
ES2228118T3
ES2228118T3 ES99952027T ES99952027T ES2228118T3 ES 2228118 T3 ES2228118 T3 ES 2228118T3 ES 99952027 T ES99952027 T ES 99952027T ES 99952027 T ES99952027 T ES 99952027T ES 2228118 T3 ES2228118 T3 ES 2228118T3
Authority
ES
Spain
Prior art keywords
proteasome
activity
sample
mammal
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99952027T
Other languages
English (en)
Spanish (es)
Inventor
Gopalakrishna R. Vaddi
Ross L. Stein
Lawrence R. Dick
Vito J. Palombella
Eric S. Lightcap
Peter J. Elliott
Julian Adams
Teresa A. Mccormack
Stephen J. Brand
Dan R. Burns
Vincent Chau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2228118T3 publication Critical patent/ES2228118T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ES99952027T 1998-10-20 1999-10-19 Procedimiento para controlar la accion de un farmaco inhibidor de proteasoma. Expired - Lifetime ES2228118T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10491898P 1998-10-20 1998-10-20
US104918P 1998-10-20
US13138199P 1999-04-28 1999-04-28
US131381P 1999-04-28

Publications (1)

Publication Number Publication Date
ES2228118T3 true ES2228118T3 (es) 2005-04-01

Family

ID=26802081

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99952027T Expired - Lifetime ES2228118T3 (es) 1998-10-20 1999-10-19 Procedimiento para controlar la accion de un farmaco inhibidor de proteasoma.

Country Status (15)

Country Link
US (1) US6613541B1 (fr)
EP (1) EP1123412B1 (fr)
JP (1) JP4503182B2 (fr)
KR (1) KR20010080267A (fr)
CN (1) CN1331752A (fr)
AT (1) ATE278803T1 (fr)
AU (1) AU762373B2 (fr)
BR (1) BR9914648A (fr)
CA (1) CA2347275C (fr)
DE (1) DE69920940T2 (fr)
ES (1) ES2228118T3 (fr)
HK (1) HK1040533A1 (fr)
IL (2) IL142647A0 (fr)
NZ (1) NZ511197A (fr)
WO (1) WO2000023614A1 (fr)

Families Citing this family (43)

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EP1326632B1 (fr) 2000-10-12 2006-09-06 Viromics Gmbh Inhibiteurs du proteasome pour le traitement d'infections d'hepatite virale
DE10051716A1 (de) * 2000-10-12 2002-04-25 Ulrich Schubert Mittel zur Hemmung der Freisetzung, Reifung und Replikation von Retroviren
EP1341414B1 (fr) 2000-11-16 2013-01-02 The Regents of The University of California Taxon d'actinomycete marin utilise pour la decouverte de medicaments et de produits de fermentation
EP2388254B1 (fr) * 2002-02-01 2016-08-10 Promega Corporation Analyse de protéase bioluminescente
ATE481104T1 (de) 2002-04-05 2010-10-15 Virologik Gmbh Mittel zur behandlung von flaviviridae- infektionen
US7176232B2 (en) 2002-06-24 2007-02-13 The Regents Of The University Of California Salinosporamides and methods for use thereof
DE10232902A1 (de) * 2002-07-19 2004-01-29 Bayer Cropscience Ag Verfahren zum Identifizieren von Inhibitoren des 20S und 26S Proteasoms
US20050049294A1 (en) * 2003-06-20 2005-03-03 Michael Palladino Methods of using [3.2.0] heterocyclic compounds and analogs thereof
CN101791306A (zh) 2003-06-20 2010-08-04 加利福尼亚大学董事会 盐孢菌酰胺及其使用方法
CA2530479C (fr) * 2003-08-08 2010-01-19 F. Hoffmann-La Roche Ag Utilisation de la sous-unite 3 de proteine activatrice de proteasome (pse3) comme marqueur de cancer colorectal
US7576206B2 (en) 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7223745B2 (en) 2003-08-14 2007-05-29 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7416854B2 (en) * 2004-01-22 2008-08-26 Promega Corporation Luminogenic and nonluminogenic multiplex assay
US7553632B2 (en) * 2004-01-22 2009-06-30 Promega Corporation Luminogenic and nonluminogenic multiplex assay
CN102174076A (zh) 2004-04-15 2011-09-07 普罗特奥里克斯公司 用于抑制蛋白酶体酶的化合物
US8198270B2 (en) * 2004-04-15 2012-06-12 Onyx Therapeutics, Inc. Compounds for proteasome enzyme inhibition
JP2007535559A (ja) 2004-04-30 2007-12-06 ネレアス ファーマシューティカルズ インコーポレイテッド [3.2.0]複素環式化合物及びその使用法
US7579371B2 (en) 2004-04-30 2009-08-25 Nereus Pharmaceuticals, Inc. Methods of using [3.2.0] heterocyclic compounds and analogs thereof
SG185963A1 (en) * 2004-05-10 2012-12-28 Onyx Therapeutics Inc Compounds for enzyme inhibition
CA2584515A1 (fr) * 2004-10-20 2006-04-27 Proteolix, Inc. Composes pour inhibition d'enzymes
WO2006060676A1 (fr) 2004-12-03 2006-06-08 Dana Farber Cancer Institute Compositions et procedes destines au traitement des maladies neoplastiques
US7468383B2 (en) 2005-02-11 2008-12-23 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US20060193844A1 (en) * 2005-02-28 2006-08-31 Proteolix, Inc. Methods for enzyme inhibition
US20070048812A1 (en) * 2005-09-01 2007-03-01 Moravec Richard A Cell-based luminogenic and nonluminogenic proteasome assays
LT2623113T (lt) 2005-11-09 2017-07-10 Onyx Therapeutics, Inc. Junginiai, skirti fermentų slopinimui
AR057227A1 (es) * 2005-12-09 2007-11-21 Centocor Inc Metodo para usar antagonistas de il6 con inhibidores del proteasoma
PL2041158T3 (pl) 2006-06-19 2013-08-30 Onyx Therapeutics Inc Peptydowe epoksyketony do hamowania proteasomu
US20080118940A1 (en) * 2006-11-22 2008-05-22 Maher Albitar Proteasomal peptidase activity and the use thereof in clinical applications
US7824698B2 (en) 2007-02-02 2010-11-02 Nereus Pharmaceuticals, Inc. Lyophilized formulations of Salinosporamide A
AU2008239654A1 (en) 2007-04-13 2008-10-23 Promega Corporation Luminescent live and dead cell assay
ES2684340T3 (es) 2007-10-04 2018-10-02 Onyx Therapeutics, Inc. Inhibidores de proteasa epoxi cetona de péptidos cristalinos y síntesis de cetoepóxidos de aminoácidos
US8394816B2 (en) 2007-12-07 2013-03-12 Irene Ghobrial Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia
BRPI0912234A2 (pt) 2008-05-12 2015-10-06 Nereus Pharmaceuticals Inc derivados de salinosporamida como inibidores de proteassomas
EP2349313A4 (fr) 2008-10-21 2012-08-29 Onyx Therapeutics Inc Thérapie de combinaison avec des peptides époxycétones
TWI504598B (zh) 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
US20110053197A1 (en) * 2009-08-25 2011-03-03 Quest Diagnostics Investments Incorporated Ubiquitin proteasome system profiling and the use thereof in clinical applications for cancer diagnosis
US20110053199A1 (en) * 2009-08-25 2011-03-03 Quest Diagnostics Investments Incorporated Ubiquitin proteasome system profiling and the use thereof in clinical applications for cancer diagnosis
US20110053198A1 (en) * 2009-08-25 2011-03-03 Quest Diagnostics Investments Incorporated Ubiquitin proteasome system profiling and the use thereof in clinical applications for proliferative hematological disorders
WO2011060179A1 (fr) 2009-11-13 2011-05-19 Onyx Therapeutics, Inc Utilisation de peptides epoxycetones pour la suppression de la metastase
WO2011087822A1 (fr) 2009-12-22 2011-07-21 Cephalon, Inc. Inhibiteurs du protéasome et leurs procédés de préparation, d'épuration et d'utilisation
EA201290844A1 (ru) 2010-03-01 2013-03-29 Оникс Терапьютикс, Инк. Соединения для ингибирования иммунопротеасом
BR112012025264A2 (pt) 2010-04-07 2019-09-24 Onyx Therapeutics Inc inibidor de imunoproteassoma de e´poxicetona peptídica cristalina.
US20140105921A1 (en) 2012-07-09 2014-04-17 Onyx Therapeutics, Inc. Prodrugs of Peptide Epoxy Ketone Protease Inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340736A (en) * 1991-05-13 1994-08-23 The President & Fellows Of Harvard College ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting
WO1994017816A1 (fr) 1993-02-10 1994-08-18 The President And Fellows Of Harvard College Role de la proteolyse dependant de l'ubiquitine atp dans la presentation de l'antigene restreint chm-1 et inhibiteurs utilises a cet effet
US5693617A (en) * 1994-03-15 1997-12-02 Proscript, Inc. Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein
US6660268B1 (en) 1994-03-18 2003-12-09 The President And Fellows Of Harvard College Proteasome regulation of NF-KB activity
US5574017A (en) 1994-07-05 1996-11-12 Gutheil; William G. Antibacterial agents
US6083903A (en) * 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
US5614649A (en) 1994-11-14 1997-03-25 Cephalon, Inc. Multicatalytic protease inhibitors
US5804560A (en) * 1995-01-06 1998-09-08 Sibia Neurosciences, Inc. Peptide and peptide analog protease inhibitors
US6335358B1 (en) * 1995-04-12 2002-01-01 President And Fellows Of Harvard College Lactacystin analogs
CA2219867A1 (fr) 1997-10-31 1999-04-30 Jiangping Wu Utilisation d'inhibiteurs du proteasome dans le traitement du cancer, de l'inflammation, des maladies auto-immunes, du rejet de greffe et du choc septique
US6617171B2 (en) * 1998-02-27 2003-09-09 The General Hospital Corporation Methods for diagnosing and treating autoimmune disease
EP1088100A2 (fr) * 1998-06-13 2001-04-04 Zarpex Biosciences Limited Activite de proteasomes

Also Published As

Publication number Publication date
WO2000023614A1 (fr) 2000-04-27
WO2000023614A8 (fr) 2000-07-13
DE69920940D1 (de) 2004-11-11
IL142647A (en) 2006-04-10
CN1331752A (zh) 2002-01-16
BR9914648A (pt) 2001-11-27
CA2347275A1 (fr) 2000-04-27
AU6433399A (en) 2000-05-08
JP2002527114A (ja) 2002-08-27
EP1123412B1 (fr) 2004-10-06
KR20010080267A (ko) 2001-08-22
AU762373B2 (en) 2003-06-26
HK1040533A1 (zh) 2002-06-14
US6613541B1 (en) 2003-09-02
IL142647A0 (en) 2002-03-10
EP1123412A1 (fr) 2001-08-16
ATE278803T1 (de) 2004-10-15
JP4503182B2 (ja) 2010-07-14
CA2347275C (fr) 2010-03-09
DE69920940T2 (de) 2005-11-17
NZ511197A (en) 2003-08-29

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