ES2288791B1 - Procedimiento de obtencion de un hidrolizado de colageno. hidrolizado enzimatico de colageno obtenible por el procedimiento y usos del mismo. - Google Patents
Procedimiento de obtencion de un hidrolizado de colageno. hidrolizado enzimatico de colageno obtenible por el procedimiento y usos del mismo. Download PDFInfo
- Publication number
- ES2288791B1 ES2288791B1 ES200600304A ES200600304A ES2288791B1 ES 2288791 B1 ES2288791 B1 ES 2288791B1 ES 200600304 A ES200600304 A ES 200600304A ES 200600304 A ES200600304 A ES 200600304A ES 2288791 B1 ES2288791 B1 ES 2288791B1
- Authority
- ES
- Spain
- Prior art keywords
- collagen
- hydrolyzate
- enzymatic
- obtaining
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000008186 Collagen Human genes 0.000 title claims abstract description 124
- 108010035532 Collagen Proteins 0.000 title claims abstract description 124
- 229920001436 collagen Polymers 0.000 title claims abstract description 123
- 230000002255 enzymatic effect Effects 0.000 title claims abstract description 49
- 238000000034 method Methods 0.000 title claims abstract description 47
- 108090000790 Enzymes Proteins 0.000 claims abstract description 49
- 102000004190 Enzymes Human genes 0.000 claims abstract description 49
- 238000000605 extraction Methods 0.000 claims abstract description 24
- 239000006227 byproduct Substances 0.000 claims abstract description 23
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 18
- 229920000159 gelatin Polymers 0.000 claims abstract description 16
- 235000019322 gelatine Nutrition 0.000 claims abstract description 16
- 230000008569 process Effects 0.000 claims abstract description 16
- 108010010803 Gelatin Proteins 0.000 claims abstract description 15
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 15
- 238000001914 filtration Methods 0.000 claims abstract description 13
- 238000005115 demineralization Methods 0.000 claims abstract description 9
- 230000002328 demineralizing effect Effects 0.000 claims abstract description 9
- 239000008273 gelatin Substances 0.000 claims abstract description 9
- 230000007071 enzymatic hydrolysis Effects 0.000 claims abstract description 8
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 claims abstract description 8
- 239000012736 aqueous medium Substances 0.000 claims abstract description 6
- 238000001035 drying Methods 0.000 claims abstract description 6
- 235000013376 functional food Nutrition 0.000 claims description 36
- 235000015872 dietary supplement Nutrition 0.000 claims description 35
- 239000000047 product Substances 0.000 claims description 29
- 238000002360 preparation method Methods 0.000 claims description 24
- 239000012528 membrane Substances 0.000 claims description 16
- 230000004075 alteration Effects 0.000 claims description 15
- 150000001875 compounds Chemical class 0.000 claims description 15
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 15
- 239000011707 mineral Substances 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 11
- 239000011148 porous material Substances 0.000 claims description 11
- 241001465754 Metazoa Species 0.000 claims description 10
- 210000001188 articular cartilage Anatomy 0.000 claims description 10
- 239000002253 acid Substances 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- 239000011782 vitamin Substances 0.000 claims description 9
- 235000013343 vitamin Nutrition 0.000 claims description 9
- 229940088594 vitamin Drugs 0.000 claims description 9
- 229930003231 vitamin Natural products 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000003963 antioxidant agent Substances 0.000 claims description 7
- 230000006870 function Effects 0.000 claims description 7
- 230000036541 health Effects 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 210000001519 tissue Anatomy 0.000 claims description 7
- 239000002671 adjuvant Substances 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 6
- 241000124008 Mammalia Species 0.000 claims description 5
- 230000003078 antioxidant effect Effects 0.000 claims description 5
- 239000005515 coenzyme Substances 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 239000000419 plant extract Substances 0.000 claims description 5
- 230000037396 body weight Effects 0.000 claims description 4
- 239000000725 suspension Substances 0.000 claims description 4
- 230000002996 emotional effect Effects 0.000 claims description 3
- 239000003456 ion exchange resin Substances 0.000 claims description 3
- 229920003303 ion-exchange polymer Polymers 0.000 claims description 3
- 238000010979 pH adjustment Methods 0.000 claims description 3
- 230000002378 acidificating effect Effects 0.000 claims description 2
- 150000007513 acids Chemical class 0.000 claims description 2
- 208000027499 body ache Diseases 0.000 claims description 2
- 150000003722 vitamin derivatives Chemical class 0.000 claims 2
- 230000035807 sensation Effects 0.000 claims 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract description 2
- 229940088598 enzyme Drugs 0.000 description 40
- 235000010755 mineral Nutrition 0.000 description 12
- 235000013305 food Nutrition 0.000 description 11
- 239000011347 resin Substances 0.000 description 10
- 229920005989 resin Polymers 0.000 description 10
- MTDHILKWIRSIHB-UHFFFAOYSA-N (5-azaniumyl-3,4,6-trihydroxyoxan-2-yl)methyl sulfate Chemical compound NC1C(O)OC(COS(O)(=O)=O)C(O)C1O MTDHILKWIRSIHB-UHFFFAOYSA-N 0.000 description 9
- 229960002849 glucosamine sulfate Drugs 0.000 description 9
- 210000000845 cartilage Anatomy 0.000 description 8
- 235000016709 nutrition Nutrition 0.000 description 7
- 238000011282 treatment Methods 0.000 description 7
- 235000013618 yogurt Nutrition 0.000 description 7
- 230000007062 hydrolysis Effects 0.000 description 6
- 238000006460 hydrolysis reaction Methods 0.000 description 6
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 230000006872 improvement Effects 0.000 description 5
- 239000004365 Protease Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- VHRGRCVQAFMJIZ-UHFFFAOYSA-N cadaverine Chemical compound NCCCCCN VHRGRCVQAFMJIZ-UHFFFAOYSA-N 0.000 description 4
- 235000015110 jellies Nutrition 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- KIDHWZJUCRJVML-UHFFFAOYSA-N putrescine Chemical compound NCCCCN KIDHWZJUCRJVML-UHFFFAOYSA-N 0.000 description 4
- 210000003491 skin Anatomy 0.000 description 4
- 239000013589 supplement Substances 0.000 description 4
- 235000002918 Fraxinus excelsior Nutrition 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- 244000299461 Theobroma cacao Species 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 239000002956 ash Substances 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 235000008160 pyridoxine Nutrition 0.000 description 3
- 239000011677 pyridoxine Substances 0.000 description 3
- 230000035943 smell Effects 0.000 description 3
- 239000008279 sol Substances 0.000 description 3
- 229940011671 vitamin b6 Drugs 0.000 description 3
- 208000036487 Arthropathies Diseases 0.000 description 2
- 108010004032 Bromelains Proteins 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 239000005909 Kieselgur Substances 0.000 description 2
- 108090000526 Papain Proteins 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 239000005700 Putrescine Substances 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 238000000889 atomisation Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 235000019835 bromelain Nutrition 0.000 description 2
- 235000019219 chocolate Nutrition 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 239000000306 component Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000009849 deactivation Effects 0.000 description 2
- 235000021185 dessert Nutrition 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 235000012041 food component Nutrition 0.000 description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 229940055729 papain Drugs 0.000 description 2
- 235000019834 papain Nutrition 0.000 description 2
- 239000005373 porous glass Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000006041 probiotic Substances 0.000 description 2
- 235000018291 probiotics Nutrition 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000001694 spray drying Methods 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- WSWCOQWTEOXDQX-MQQKCMAXSA-M (E,E)-sorbate Chemical compound C\C=C\C=C\C([O-])=O WSWCOQWTEOXDQX-MQQKCMAXSA-M 0.000 description 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241000206761 Bacillariophyta Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 102000000503 Collagen Type II Human genes 0.000 description 1
- 108010041390 Collagen Type II Proteins 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 206010058314 Dysplasia Diseases 0.000 description 1
- YTRPTVLTUWVLKO-ZDUSSCGKSA-N Ficine Natural products CN1CCC[C@H]1C1=C(O)C=C(O)C2=C1OC(C=1C=CC=CC=1)=CC2=O YTRPTVLTUWVLKO-ZDUSSCGKSA-N 0.000 description 1
- 244000307700 Fragaria vesca Species 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- OHSHFZJLPYLRIP-BMZHGHOISA-M Riboflavin sodium phosphate Chemical compound [Na+].OP(=O)([O-])OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O OHSHFZJLPYLRIP-BMZHGHOISA-M 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 235000009470 Theobroma cacao Nutrition 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000005349 anion exchange Methods 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- 230000000035 biogenic effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
- 229960002079 calcium pantothenate Drugs 0.000 description 1
- 238000005341 cation exchange Methods 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000011950 custard Nutrition 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 235000011850 desserts Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 235000018823 dietary intake Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000007919 dispersible tablet Substances 0.000 description 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- YTRPTVLTUWVLKO-UHFFFAOYSA-N ficine Chemical compound CN1CCCC1C1=C(O)C=C(O)C2=C1OC(C=1C=CC=CC=1)=CC2=O YTRPTVLTUWVLKO-UHFFFAOYSA-N 0.000 description 1
- 239000005428 food component Substances 0.000 description 1
- 239000005417 food ingredient Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 235000013310 margarine Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 235000017807 phytochemicals Nutrition 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229930000223 plant secondary metabolite Natural products 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229940075554 sorbate Drugs 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200600304A ES2288791B1 (es) | 2006-02-10 | 2006-02-10 | Procedimiento de obtencion de un hidrolizado de colageno. hidrolizado enzimatico de colageno obtenible por el procedimiento y usos del mismo. |
| PCT/EP2007/000330 WO2007090504A1 (fr) | 2006-02-10 | 2007-01-16 | Collagene hydrolyse et ses utilisations |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200600304A ES2288791B1 (es) | 2006-02-10 | 2006-02-10 | Procedimiento de obtencion de un hidrolizado de colageno. hidrolizado enzimatico de colageno obtenible por el procedimiento y usos del mismo. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2288791A1 ES2288791A1 (es) | 2008-01-16 |
| ES2288791B1 true ES2288791B1 (es) | 2008-12-01 |
Family
ID=37806687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES200600304A Expired - Fee Related ES2288791B1 (es) | 2006-02-10 | 2006-02-10 | Procedimiento de obtencion de un hidrolizado de colageno. hidrolizado enzimatico de colageno obtenible por el procedimiento y usos del mismo. |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES2288791B1 (fr) |
| WO (1) | WO2007090504A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2319049B1 (es) * | 2007-06-15 | 2010-02-10 | Masterfarm, S.L. | Composicion que comprende hidrolizado de colageno y acido hialuronico para la mejora de dificultades funcionales consecutivas a alteraciones de los cartilagos articulares. |
| CN101643766B (zh) * | 2009-08-27 | 2011-09-14 | 烟台龙普生物科技有限责任公司 | 新鲜动物皮制取水解胶原蛋白的方法 |
| DE102014108502A1 (de) * | 2014-06-17 | 2015-12-17 | Gelita Ag | Zusammensetzung in Form von kompaktierten Partikeln und deren Verwendung |
| EP3432860B1 (fr) * | 2016-03-22 | 2022-12-21 | Avicenna Nutraceutical, LLC | Compositions de collagène hydrolysé et leurs procédés de fabrication |
| FR3058142B1 (fr) * | 2016-10-28 | 2023-11-24 | Gelatines Weishardt | Composition de peptides de collagene de peau de poisson et son utilisation a titre de medicament |
| EP4572607A1 (fr) * | 2022-12-28 | 2025-06-25 | Rousselot BV | Formulation de cryoconservation comprenant un hydrolysat de collagène |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992017503A1 (fr) * | 1991-04-05 | 1992-10-15 | Collagen Casing Einar Sjölander Ab | Procede de fabrication de collagene et collagene produit par ledit procede, ainsi que son utilisation |
| WO1996005851A1 (fr) * | 1994-08-23 | 1996-02-29 | Dgf Stoess Ag | Utilisation de collagene hydrolyse, sans gout, et substance contenant ledit collagene |
| WO1997002837A1 (fr) * | 1995-07-07 | 1997-01-30 | Autoimmune, Inc. | Methode de traitement de la polyarthrite rhumatoide a l'aide d'une dose faible de collagene de type ii |
| CA2212649A1 (fr) * | 1997-08-08 | 1999-02-08 | Biocell Technology, Llc | Collagene de type ii hydrolyse et son utilisation |
-
2006
- 2006-02-10 ES ES200600304A patent/ES2288791B1/es not_active Expired - Fee Related
-
2007
- 2007-01-16 WO PCT/EP2007/000330 patent/WO2007090504A1/fr not_active Ceased
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992017503A1 (fr) * | 1991-04-05 | 1992-10-15 | Collagen Casing Einar Sjölander Ab | Procede de fabrication de collagene et collagene produit par ledit procede, ainsi que son utilisation |
| WO1996005851A1 (fr) * | 1994-08-23 | 1996-02-29 | Dgf Stoess Ag | Utilisation de collagene hydrolyse, sans gout, et substance contenant ledit collagene |
| WO1997002837A1 (fr) * | 1995-07-07 | 1997-01-30 | Autoimmune, Inc. | Methode de traitement de la polyarthrite rhumatoide a l'aide d'une dose faible de collagene de type ii |
| CA2212649A1 (fr) * | 1997-08-08 | 1999-02-08 | Biocell Technology, Llc | Collagene de type ii hydrolyse et son utilisation |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2288791A1 (es) | 2008-01-16 |
| WO2007090504A1 (fr) | 2007-08-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR20120096537A (ko) | 일회용 용기 및 이의 용도 | |
| KR20200066319A (ko) | 개선된 생체이용률을 갖는 약초 조성물 | |
| JP2004123760A (ja) | 生体活性剤の改良された細胞取り込み | |
| MX2010006955A (es) | Preparaciones con extractos de escaramujo y metodo para producir extractos de escaramujo. | |
| ES2328756T3 (es) | Uso de un compuesto que contiene yodo para producir un producto alimenticio yodado para prevenir dolencias causadas por funcionamientos defectuosos de la glandula tiroides. | |
| EP3115047B1 (fr) | Agent prévenant la débilité | |
| EP1273239B1 (fr) | Utilisations d'une composition de gélatine de poisson partiellement hydrolysée | |
| ES2288791B1 (es) | Procedimiento de obtencion de un hidrolizado de colageno. hidrolizado enzimatico de colageno obtenible por el procedimiento y usos del mismo. | |
| JP5696720B2 (ja) | 飲料 | |
| WO2014069660A1 (fr) | Agent facilitant l'écoulement du sang | |
| CN105250199A (zh) | 含珍珠粉的可食用面膜 | |
| ES2282164T3 (es) | Metodo para preparar peptidos ricos en triptofano. | |
| WO2017119481A1 (fr) | Composition contenant un dipeptide cyclique pour la prévention de maladie neurologiques | |
| WO2008049942A1 (fr) | Hydrolysat enzymatique de collagène et procédé d'obtention | |
| ES3031588T3 (en) | Use of collagen hydrolysate as an active ingredient in ameliorating sleep | |
| ES2992560T3 (es) | Preparación farmacéutica o de suplemento alimenticio basada en alfa-lactoalbúmina | |
| JP7057150B2 (ja) | 内服液 | |
| US20220062318A1 (en) | Heat stress relieving agent | |
| CN102715606A (zh) | 一种饮料 | |
| EP0073173B1 (fr) | Produits extraits d'animaux marins invertébrés, leur préparation et leurs utilisations pour usage pharmaceutique,en diététique et en cosmétologie | |
| TWI377914B (fr) | ||
| WO2013164992A1 (fr) | Agent stimulant la régénération de cartilage | |
| JP2016149946A (ja) | 飲料 | |
| CN118176011A (zh) | 用于预防和/或治疗重症监护后综合征(pics)的胶原蛋白水解物 | |
| WO2005087022A1 (fr) | Composition alimentaire ayant un effet antistress |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 20080116 Kind code of ref document: A1 |
|
| FG2A | Definitive protection |
Ref document number: 2288791B1 Country of ref document: ES |
|
| PC2A | Transfer of patent |
Owner name: OPKO LAB EUROPE, S.L. Effective date: 20160107 |
|
| FD2A | Announcement of lapse in spain |
Effective date: 20211123 |