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ES2131037T3 - Procedimiento de preparacion de lovastatina. - Google Patents

Procedimiento de preparacion de lovastatina.

Info

Publication number
ES2131037T3
ES2131037T3 ES96934242T ES96934242T ES2131037T3 ES 2131037 T3 ES2131037 T3 ES 2131037T3 ES 96934242 T ES96934242 T ES 96934242T ES 96934242 T ES96934242 T ES 96934242T ES 2131037 T3 ES2131037 T3 ES 2131037T3
Authority
ES
Spain
Prior art keywords
lovastatin
grades
divided
organic solvent
preparation procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96934242T
Other languages
English (en)
Other versions
ES2131037T1 (es
Inventor
Dimcho Ivanov Dimov
Georgy Asenov Grozdanov
Nedelcho Genov Petkov
Dimitra Tsoneva Todorova
Albena Stefanova Dimitrova
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BalkanPharma Razgrad AD
Original Assignee
BalkanPharma Razgrad AD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from BG100197A external-priority patent/BG62651B1/bg
Priority claimed from BG100316A external-priority patent/BG63011B1/bg
Application filed by BalkanPharma Razgrad AD filed Critical BalkanPharma Razgrad AD
Publication of ES2131037T1 publication Critical patent/ES2131037T1/es
Application granted granted Critical
Publication of ES2131037T3 publication Critical patent/ES2131037T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

LA INVENCION SE REFIERE A UN METODO DE APLICACION EN LA INDUSTRIA FARMACEUTICA. DE ACUERDO CON ESTE METODO, LA LOVASTATINA SE OBTIENE A PARTIR DE UN CALDO DE CULTIVO POR FILTRADO A VALORES DE PH 9,5 (DIVIDIDO POR) 13,0; INCLUIDA EN UNA MASA SOLIDA, ES PRECIPITADA DE LA SUSTANCIA FILTRADA OBTENIDA, A UN PH 2,5 (DIVIDIDO POR) 4,0, EN PRESENCIA DE UN FILTRO INERTE, ANTIOXIDANTE Y NO MISCIBLE CON UN DISOLVENTE ORGANICO EN AGUA. SE EXTRAE Y SE LACTONIZA EN UN MEDIO DE UN DISOLVENTE ORGANICO QUE CONTIENE CLORO. ESTE ULTIMO SE CONCENTRA Y EL RESIDUO SE DISUELVE EN UNA MEZCLA DE DISOLVENTES CON DISTINTA POLARIDAD. DESPUES DE ENFRIAR A TEMPERATURAS ENTRE 10 (GRADOS) C Y -30 (GRADOS) C, LA LOVASTATINA SE CRISTALIZA, SE SECA Y SE VUELVE A CRISTALIZAR VARIAS VECES.
ES96934242T 1995-12-06 1996-10-22 Procedimiento de preparacion de lovastatina. Expired - Lifetime ES2131037T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BG100197A BG62651B1 (bg) 1995-12-06 1995-12-06 Метод за изолиране и пречистване на ловастатин
BG100316A BG63011B1 (bg) 1996-01-29 1996-01-29 метод за получаване на ловастатин

Publications (2)

Publication Number Publication Date
ES2131037T1 ES2131037T1 (es) 1999-07-16
ES2131037T3 true ES2131037T3 (es) 2001-12-16

Family

ID=25663364

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96934242T Expired - Lifetime ES2131037T3 (es) 1995-12-06 1996-10-22 Procedimiento de preparacion de lovastatina.

Country Status (8)

Country Link
EP (1) EP0877742B1 (es)
AU (1) AU7271696A (es)
CA (1) CA2243592C (es)
DE (2) DE877742T1 (es)
EA (1) EA000954B1 (es)
ES (1) ES2131037T3 (es)
UA (1) UA44922C2 (es)
WO (1) WO1997020834A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9800046A (sl) * 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
CA2320163C (en) * 1998-12-10 2008-09-23 Kaneka Corporation Process for producing simvastatin
SK282679B6 (sk) * 1999-04-16 2002-11-06 Biotika, A. S. Spôsob izolácie lovastatínu z vyfermentovanej pôdy
EP1265884A4 (en) 2000-03-03 2003-05-21 Plus Chemical S A PROCESS FOR THE PURIFICATION OF LOVASTATIN AND SIMVASTATIN FOR REDUCING THE CONTENT OF DIMER IMPURITIES
IN192861B (es) 2000-06-30 2004-05-22 Ranbaxy Lab Ltd
ES2204285B1 (es) * 2002-05-20 2005-03-01 Ercros Industrial, S.A. Procedimiento para el aislamiento y purificacion de lovastatina.
WO2005035515A1 (en) * 2003-10-14 2005-04-21 Lupin Limited A method for the manufacture of lovastatin
WO2005095374A1 (en) 2004-03-30 2005-10-13 Lupin Ltd. An improved method for manufacture of 4-hydroxy pyran-2-one derivatives
WO2009013764A2 (en) * 2007-07-24 2009-01-29 Jubilant Organosys Limited Process for producing 6(r)-[2-(8'(s)-2 ',2 '-dimethylbutyryloxy-2'(s),6'(r)-dimethyl-1,2,6,7', 8',8a'(r)- hexahydronaphthyl-l'(s))ethyl]-4(r)-hydroxy-3,4,5,6- tetrahydro-2h-pyran-2-one
CN103012344B (zh) * 2011-09-28 2014-11-12 北大方正集团有限公司 从洛伐他汀结晶母液中回收洛伐他汀的方法
EP2597092A1 (en) 2011-11-24 2013-05-29 Sterling Biotech Limited A process for purification of lovastatin
CN102875505B (zh) * 2012-08-02 2015-08-05 丽珠集团新北江制药股份有限公司 一种美伐他汀的提取精制工艺
CN106083789A (zh) * 2016-06-07 2016-11-09 山东鲁抗医药股份有限公司 从发酵液中沉淀分离提取洛伐他汀的方法
CN108976190B (zh) * 2017-12-21 2020-09-04 北大方正集团有限公司 一种从洛伐他汀结晶母液中回收洛伐他汀的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance

Also Published As

Publication number Publication date
WO1997020834A1 (en) 1997-06-12
CA2243592C (en) 2001-12-25
EP0877742A1 (en) 1998-11-18
DE877742T1 (de) 1999-07-22
UA44922C2 (uk) 2002-03-15
EP0877742B1 (en) 2001-08-16
DE69614571D1 (de) 2001-09-20
CA2243592A1 (en) 1997-06-12
DE69614571T2 (de) 2002-06-27
ES2131037T1 (es) 1999-07-16
EA000954B1 (ru) 2000-08-28
EA199800522A1 (ru) 1999-02-25
AU7271696A (en) 1997-06-27

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