ES2128629T3 - Derivados de bencilpiperidina con afinidad elevada a puntos de enlace de receptores de aminoacidos. - Google Patents
Derivados de bencilpiperidina con afinidad elevada a puntos de enlace de receptores de aminoacidos.Info
- Publication number
- ES2128629T3 ES2128629T3 ES95116458T ES95116458T ES2128629T3 ES 2128629 T3 ES2128629 T3 ES 2128629T3 ES 95116458 T ES95116458 T ES 95116458T ES 95116458 T ES95116458 T ES 95116458T ES 2128629 T3 ES2128629 T3 ES 2128629T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- bencilpiperidine
- derivatives
- amino acid
- sup
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
DERIVADOS BENCILPIPERIDINA DE LA FORMULA I DONDE R 1 ES H, HAL O NITRO, R{SUP, 2} ES UN GRUPO BENCILO INSUSTITUIDO O SUSTITUIDO POR HAL EN AROMATICOS EN LA POSICION 2,3 O 4 DEL ANILLO PIPERIDINA, CON LA CONDICION DE QUE R{SUP, 2} NO ES IGUAL A 4 - BENCILO, CUANDO X SIGNIFICA - CO -, Y Y Z SIGNIFICA CH{SUB, 2} - Y R{SUP, 1} SIGNIFICA H, R{SUP, 3} ES H O A, X ES - CO - O - SO{SUB, 2} -, Y ES - CH{SUB, 2} -, - NH -, - O -, S -, O TAMBIEN - CO -, CUANDO X ES - CO - Y Z ES - NH -, - NA -, Z ES - CH{SUB, 2} -, - C(A){SUB, 2} -, - CH{SUB, 2}CH{SUB, 2} -, - CH = CH{SUB, 2} -, - CO -, - NH -, - NA -, - O -, O UN ENLACE, DONDE UNO DE LOS RESTOS X, Y Y Z PUEDEN SER - O -, - S -, O - NH -, SIN EMBARGO X - Y O Y - Z NO SON - O - O -, - S S -, - NH O -, - O - NH -, - NH - NH -, - O -, - S -, - SO -, A ES ALQUILO CON 1 - 6 ATOMOS DE C Y B ES O, H + OH, HAL ES F, CL, BR O I N ES 0,1,2 ASI COMO SUS SALES QUE MUESTRAN UNA ALTA AFINIDAD A LUGARES DE ENLACE DE RECEPTORES DE AMINOACIDOS Y SON APROPIADOS PARA TRATAMIENTO DE ENFERMEDADES NEURODEGENERATIVAS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4438810A DE4438810A1 (de) | 1994-10-31 | 1994-10-31 | Benzylpiperidinderivate |
| DE1995126269 DE19526269A1 (de) | 1995-07-19 | 1995-07-19 | Benzylpiperidinderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2128629T3 true ES2128629T3 (es) | 1999-05-16 |
Family
ID=25941544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95116458T Expired - Lifetime ES2128629T3 (es) | 1994-10-31 | 1995-10-19 | Derivados de bencilpiperidina con afinidad elevada a puntos de enlace de receptores de aminoacidos. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5698553A (es) |
| EP (1) | EP0709384B1 (es) |
| JP (1) | JPH08225569A (es) |
| KR (1) | KR100388593B1 (es) |
| CN (1) | CN1064358C (es) |
| AT (1) | ATE174915T1 (es) |
| AU (1) | AU703487B2 (es) |
| BR (1) | BR9505008A (es) |
| CA (1) | CA2161618A1 (es) |
| CZ (1) | CZ288039B6 (es) |
| DE (1) | DE59504622D1 (es) |
| DK (1) | DK0709384T3 (es) |
| ES (1) | ES2128629T3 (es) |
| FI (1) | FI955184L (es) |
| GR (1) | GR3029771T3 (es) |
| HU (1) | HUT76068A (es) |
| NO (1) | NO310023B1 (es) |
| PL (1) | PL182210B1 (es) |
| RU (1) | RU2160259C2 (es) |
| SK (1) | SK282476B6 (es) |
| TR (1) | TR199501331A2 (es) |
| TW (1) | TW394770B (es) |
| UA (1) | UA41927C2 (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0709384B1 (de) * | 1994-10-31 | 1998-12-23 | MERCK PATENT GmbH | Benzylpiperidinderivate mit hoher Affinität zu Bindungsstellen von Aminosäure-Rezeptoren |
| ZA9610736B (en) * | 1995-12-22 | 1997-06-27 | Warner Lambert Co | 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists |
| DE19643790A1 (de) * | 1996-10-30 | 1998-05-07 | Merck Patent Gmbh | Benzoxazol-Derivat |
| US6110935A (en) * | 1997-02-13 | 2000-08-29 | The Regents Of The University Of California | Benzofurazan compounds for enhancing glutamatergic synaptic responses |
| AU6852898A (en) * | 1997-04-17 | 1998-11-11 | Takeda Chemical Industries Ltd. | Thermogenic composition and benzazepine thermogenics |
| GB9725541D0 (en) * | 1997-12-02 | 1998-02-04 | Pharmacia & Upjohn Spa | Amino-benzothiazole derivatives |
| DE19812331A1 (de) | 1998-03-20 | 1999-09-23 | Merck Patent Gmbh | Piperidinderivate |
| US6340685B1 (en) | 1998-05-22 | 2002-01-22 | Scios, Inc. | Compounds and methods to treat cardiac failure and other disorders |
| US6130235A (en) * | 1998-05-22 | 2000-10-10 | Scios Inc. | Compounds and methods to treat cardiac failure and other disorders |
| US6867209B1 (en) | 1998-05-22 | 2005-03-15 | Scios, Inc. | Indole-type derivatives as inhibitors of p38 kinase |
| US6448257B1 (en) | 1998-05-22 | 2002-09-10 | Scios, Inc. | Compounds and methods to treat cardiac failure and other disorders |
| US6589954B1 (en) | 1998-05-22 | 2003-07-08 | Scios, Inc. | Compounds and methods to treat cardiac failure and other disorders |
| NZ508790A (en) * | 1998-05-22 | 2003-10-31 | Scios Inc | Heterocyclic compounds and methods to treat cardiac failure and other disorders |
| PE20000728A1 (es) | 1998-06-26 | 2000-08-21 | Cocensys Inc | Heterociclos 4-bencil piperidina alquilsulfoxido y su uso como antagonistas receptores subtipo-selectivo nmda |
| IL146309A (en) | 1999-05-21 | 2008-03-20 | Scios Inc | Derivatives of the indole type and pharmaceutical preparations containing them as inhibitors of kinase p38 |
| US6376514B1 (en) | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
| US6693099B2 (en) * | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| DE10120159A1 (de) * | 2001-04-25 | 2002-10-31 | Merck Patent Gmbh | NMDA-Antagonisten und NMDA-Agonisten zur Behandlung von Suchterkrankungen |
| WO2003035641A1 (en) * | 2001-10-22 | 2003-05-01 | Shionogi & Co., Ltd. | Novel carbamoylpyrrolidone derivative |
| DE10210779A1 (de) * | 2002-03-12 | 2003-10-09 | Merck Patent Gmbh | Cyclische Amide |
| DE10217006A1 (de) | 2002-04-16 | 2003-11-06 | Merck Patent Gmbh | Substituierte Indole |
| JP4459048B2 (ja) * | 2002-06-11 | 2010-04-28 | ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア | 垂直電界測定を使用する海底地質調査の方法およびシステム |
| ITTO20040124A1 (it) * | 2004-03-01 | 2004-06-01 | Medestea Internaz Srl | Nuovi impieghi in terapia di derivati di n-piperidina particolarmente per il trattamento di patologie neurodegenerative |
| JPWO2005097782A1 (ja) * | 2004-04-07 | 2007-08-16 | 協和醗酵工業株式会社 | ピペリジン誘導体 |
| PT2144506E (pt) * | 2007-01-03 | 2011-12-21 | Servier Lab | Composto de [1,2,3]-benzotriazinona substituída em posição 3 para aumentar as respostas glutamatérgicas nas sinapses |
| DE102007047737A1 (de) * | 2007-10-05 | 2009-04-30 | Merck Patent Gmbh | Piperidin- und Piperazinderivate |
| TWI410420B (zh) * | 2008-02-05 | 2013-10-01 | Dainippon Sumitomo Pharma Co | 苄基哌啶化合物 |
| EP2463286A4 (en) | 2009-08-04 | 2013-01-23 | Dainippon Sumitomo Pharma Co | BENZYLPIPERIDINVERBINDUNG |
| DE102009049211A1 (de) | 2009-10-13 | 2011-04-28 | Merck Patent Gmbh | Sulfoxide |
| JP5829510B2 (ja) * | 2010-12-21 | 2015-12-09 | 住友化学株式会社 | 高分子化合物及びそれを用いた発光素子 |
| US20130270486A1 (en) * | 2010-12-21 | 2013-10-17 | Sumitomo Chemical Company, Limited | Polymer compound and light-emitting device using same |
| KR102277538B1 (ko) * | 2015-06-08 | 2021-07-14 | 주식회사 대웅제약 | 신규한 헤테로 고리 화합물, 이의 제조 방법 및 이를 포함하는 약학적 조성물 |
| AR110963A1 (es) * | 2017-02-07 | 2019-05-22 | Dae Woong Pharma | Compuestos heterocíclicos, su método de preparación y composición farmacéutica que los comprende |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH17194A (en) * | 1980-03-06 | 1984-06-19 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives,and pharmaceutical composition containing the same |
| FI77852C (fi) * | 1981-02-17 | 1989-05-10 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat. |
| JPS57142972A (en) * | 1981-02-27 | 1982-09-03 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
| FR2640266B2 (fr) * | 1988-07-12 | 1992-07-10 | Synthelabo | Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique |
| JPH0753913B2 (ja) * | 1990-11-14 | 1995-06-07 | 新日本製鐵株式会社 | 有機複合めっき鋼板の製造方法 |
| US5338361A (en) * | 1991-11-04 | 1994-08-16 | Measurex Corporation | Multiple coat measurement and control apparatus and method |
| FR2688504B1 (fr) * | 1992-03-13 | 1995-05-05 | Synthelabo | Derives de 2-(piperidin-1-yl)ethanol, leur preparation et leur application en therapeutique. |
| EP0709384B1 (de) * | 1994-10-31 | 1998-12-23 | MERCK PATENT GmbH | Benzylpiperidinderivate mit hoher Affinität zu Bindungsstellen von Aminosäure-Rezeptoren |
-
1995
- 1995-10-19 EP EP95116458A patent/EP0709384B1/de not_active Expired - Lifetime
- 1995-10-19 AT AT95116458T patent/ATE174915T1/de not_active IP Right Cessation
- 1995-10-19 DK DK95116458T patent/DK0709384T3/da active
- 1995-10-19 ES ES95116458T patent/ES2128629T3/es not_active Expired - Lifetime
- 1995-10-19 DE DE59504622T patent/DE59504622D1/de not_active Expired - Fee Related
- 1995-10-24 AU AU34435/95A patent/AU703487B2/en not_active Ceased
- 1995-10-26 UA UA95104699A patent/UA41927C2/uk unknown
- 1995-10-27 CA CA002161618A patent/CA2161618A1/en not_active Abandoned
- 1995-10-27 TR TR95/01331A patent/TR199501331A2/xx unknown
- 1995-10-27 CZ CZ19952816A patent/CZ288039B6/cs not_active IP Right Cessation
- 1995-10-30 PL PL95311185A patent/PL182210B1/pl unknown
- 1995-10-30 CN CN95118553A patent/CN1064358C/zh not_active Expired - Fee Related
- 1995-10-30 BR BR9505008A patent/BR9505008A/pt not_active IP Right Cessation
- 1995-10-30 SK SK1355-95A patent/SK282476B6/sk unknown
- 1995-10-30 FI FI955184A patent/FI955184L/fi unknown
- 1995-10-30 NO NO954349A patent/NO310023B1/no not_active IP Right Cessation
- 1995-10-30 RU RU95118727/04A patent/RU2160259C2/ru not_active IP Right Cessation
- 1995-10-30 US US08/550,105 patent/US5698553A/en not_active Expired - Fee Related
- 1995-10-31 JP JP7283446A patent/JPH08225569A/ja not_active Withdrawn
- 1995-10-31 HU HU9503101A patent/HUT76068A/hu unknown
- 1995-10-31 KR KR1019950038388A patent/KR100388593B1/ko not_active Expired - Fee Related
- 1995-11-01 TW TW084111695A patent/TW394770B/zh active
-
1999
- 1999-03-23 GR GR990400858T patent/GR3029771T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| UA41927C2 (uk) | 2001-10-15 |
| CZ288039B6 (cs) | 2001-04-11 |
| SK282476B6 (sk) | 2002-02-05 |
| SK135595A3 (en) | 1996-06-05 |
| DE59504622D1 (de) | 1999-02-04 |
| TW394770B (en) | 2000-06-21 |
| FI955184A0 (fi) | 1995-10-30 |
| KR100388593B1 (ko) | 2003-09-19 |
| CN1128762A (zh) | 1996-08-14 |
| CN1064358C (zh) | 2001-04-11 |
| EP0709384A1 (de) | 1996-05-01 |
| RU2160259C2 (ru) | 2000-12-10 |
| KR960014119A (ko) | 1996-05-22 |
| DK0709384T3 (da) | 1999-08-23 |
| FI955184A7 (fi) | 1996-05-01 |
| HUT76068A (en) | 1997-06-30 |
| GR3029771T3 (en) | 1999-06-30 |
| BR9505008A (pt) | 1997-10-14 |
| PL311185A1 (en) | 1996-05-13 |
| CA2161618A1 (en) | 1996-05-01 |
| NO310023B1 (no) | 2001-05-07 |
| PL182210B1 (pl) | 2001-11-30 |
| EP0709384B1 (de) | 1998-12-23 |
| CZ281695A3 (en) | 1996-05-15 |
| NO954349L (no) | 1996-05-02 |
| US5698553A (en) | 1997-12-16 |
| NO954349D0 (no) | 1995-10-30 |
| HU9503101D0 (en) | 1995-12-28 |
| AU3443595A (en) | 1996-05-09 |
| TR199501331A2 (tr) | 1996-06-21 |
| FI955184L (fi) | 1996-05-01 |
| AU703487B2 (en) | 1999-03-25 |
| JPH08225569A (ja) | 1996-09-03 |
| ATE174915T1 (de) | 1999-01-15 |
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| FG2A | Definitive protection |
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