[go: up one dir, main page]

ES2124397T3 - Compuestos con heterociclos fusionados, que contienen nitrogeno. - Google Patents

Compuestos con heterociclos fusionados, que contienen nitrogeno.

Info

Publication number
ES2124397T3
ES2124397T3 ES94910047T ES94910047T ES2124397T3 ES 2124397 T3 ES2124397 T3 ES 2124397T3 ES 94910047 T ES94910047 T ES 94910047T ES 94910047 T ES94910047 T ES 94910047T ES 2124397 T3 ES2124397 T3 ES 2124397T3
Authority
ES
Spain
Prior art keywords
pct
formula
image
group represented
containing nitrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94910047T
Other languages
English (en)
Inventor
Yasutaka Takase
Nobuhisa Watanabe
Hideyuki Adachi
Kohtarou Kodama
Hiroki Ishihara
Takao Saeki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of ES2124397T3 publication Critical patent/ES2124397T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN COMPUESTO HETEROCICLICO QUE CONTIENE NITROGENO Y QUE PRESENTA UNA ACTIVIDAD INHIBIDORA CONTRA EL CGMP-PDE. EL COMPUESTO QUEDA REPRESENTADO POR LA FORMULA (I) O POR UNA SAL FARMACOLOGICAMENTE ACEPTABLE DEL MISMO, EN LA QUE R{SUP,1} REPRESENTA UN GRUPO REPRESENTADO POR LA FORMULA: -NR{SUP,4}R{SUP,5} (EN LA QUE R{SUP,4} Y R{SUP,5} REPRESENTAN CADA UNO HIDROGENO, ALQUILO INFERIOR O SIMILARES) O SIMILAR; R{SUP,2} REPRESENTA UN GRUPO REPRESENTADO POR LA FORMULA (II) (EN LA QUE R{SUP,8} REPRESENTA UN GRUPO CARBOXILO QUE PUEDE ESTAR PROTEGIDO, O SIMILAR) O SIMILAR; Y R{SUP,3} REPRESENTA UN GRUPO REPRESENTADO POR LA FORMULA (III) (EN LA QUE R{SUP,6} Y R{SUP,7} REPRESENTAN CADA UNO HIDROGENO, ALQUILO INFERIOR O SIMILARES) O SIMILAR.
ES94910047T 1993-03-31 1994-03-18 Compuestos con heterociclos fusionados, que contienen nitrogeno. Expired - Lifetime ES2124397T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9513193 1993-03-31

Publications (1)

Publication Number Publication Date
ES2124397T3 true ES2124397T3 (es) 1999-02-01

Family

ID=14129274

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94910047T Expired - Lifetime ES2124397T3 (es) 1993-03-31 1994-03-18 Compuestos con heterociclos fusionados, que contienen nitrogeno.

Country Status (10)

Country Link
US (1) US5707998A (es)
EP (1) EP0691967B1 (es)
AT (1) ATE170519T1 (es)
AU (1) AU6264194A (es)
DE (1) DE69413019T2 (es)
DK (1) DK0691967T3 (es)
ES (1) ES2124397T3 (es)
HU (1) HUT73783A (es)
PH (1) PH31122A (es)
WO (1) WO1994022855A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869486A (en) * 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
TW381092B (en) * 1995-07-07 2000-02-01 Otsuka Pharma Co Ltd Novel benzimidazole derivatives for use in treating arteriosclerotic diseases
DK0757984T3 (da) * 1995-08-08 2003-03-03 Ono Pharmaceutical Co Hydroxamsyrederivater, der kan anvendes til inhibering af gelatinase
DE19644228A1 (de) * 1996-10-24 1998-04-30 Merck Patent Gmbh Thienopyrimidine
US6339099B1 (en) * 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors
ZA9810766B (en) 1997-11-28 1999-05-25 Mochida Pharm Co Ltd Novel compounds having cgmp-pde inhibitory activity
DE19819023A1 (de) 1998-04-29 1999-11-04 Merck Patent Gmbh Thienopyrimidine
DE10001021A1 (de) * 2000-01-13 2001-07-19 Merck Patent Gmbh Pharmazeutische Zubereitung
PE20020394A1 (es) 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
US6576644B2 (en) 2000-09-06 2003-06-10 Bristol-Myers Squibb Co. Quinoline inhibitors of cGMP phosphodiesterase
ME01267B (me) * 2004-05-06 2013-06-20 Warner Lambert Co 4-fenilaminokinazolin-6-ilamidi
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
WO2008009077A2 (en) * 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections
US9259426B2 (en) * 2006-07-20 2016-02-16 Gilead Sciences, Inc. 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
AR076024A1 (es) 2009-04-03 2011-05-11 Schering Corp Derivados de heterociclos biciclicos puenteados y metodos de uso de los mismos
US20170233345A1 (en) * 2014-08-14 2017-08-17 Bayer Pharma Aktiengesellschaft Substituted quinoline-4-carboxamides and use thereof
AU2016216673B2 (en) 2015-03-04 2017-02-02 Gilead Sciences, Inc. Toll like receptor modulator compounds
AU2017318601B2 (en) 2016-09-02 2020-09-03 Gilead Sciences, Inc. Toll like receptor modulator compounds
US10640499B2 (en) 2016-09-02 2020-05-05 Gilead Sciences, Inc. Toll like receptor modulator compounds
TWI751516B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202212339A (zh) 2019-04-17 2022-04-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
MA56022A (fr) * 2019-05-31 2022-04-06 Chiesi Farm Spa Dérivés d'amino quinazoline servant d'inhibiteurs de p2x3
TWI879779B (zh) 2019-06-28 2025-04-11 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0647540B2 (ja) * 1985-07-16 1994-06-22 エーザイ株式会社 虚血性心疾患・不整脈治療・予防剤
US5260461A (en) * 1988-01-11 1993-11-09 Massachusetts Institute Of Technology Ligands for ADH: cinchona alkaloids and moderately sized organic substituents linked through a planar aromatic spacer group
FR2643903A1 (fr) * 1989-03-03 1990-09-07 Union Pharma Scient Appl Nouveaux derives de benzimidazole, leurs procedes de preparation, intermediaires de synthese, compositions pharmaceutiques les contenant, utiles notamment pour le traitement des maladies cardiovasculaires, et des ulceres duodenaux
US5034393A (en) * 1989-07-27 1991-07-23 Dowelanco Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives
AU656154B2 (en) * 1990-11-06 1995-01-27 Astellas Pharma Inc. Fused pyrazine derivative
EP0510235A1 (en) * 1991-04-26 1992-10-28 Dong-A Pharm. Co., Ltd. Novel benzoxazine or benzothiazine derivatives and process for the preparation of the same
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
GB9300059D0 (en) * 1992-01-20 1993-03-03 Zeneca Ltd Quinazoline derivatives
JP2657760B2 (ja) * 1992-07-15 1997-09-24 小野薬品工業株式会社 ４−アミノキナゾリン誘導体およびそれを含有する医薬品
GB9314893D0 (en) * 1993-07-19 1993-09-01 Zeneca Ltd Quinazoline derivatives

Also Published As

Publication number Publication date
DE69413019D1 (de) 1998-10-08
HUT73783A (en) 1996-09-30
WO1994022855A1 (en) 1994-10-13
PH31122A (en) 1998-02-23
US5707998A (en) 1998-01-13
DK0691967T3 (da) 1999-06-07
HU9501939D0 (en) 1995-09-28
EP0691967B1 (en) 1998-09-02
EP0691967A1 (en) 1996-01-17
AU6264194A (en) 1994-10-24
ATE170519T1 (de) 1998-09-15
DE69413019T2 (de) 1999-06-02

Similar Documents

Publication Publication Date Title
ES2124397T3 (es) Compuestos con heterociclos fusionados, que contienen nitrogeno.
DE69327541D1 (en) 4-arylmethyloxymethyl piperidine als tachykinin antagonisten
BR9206161A (pt) Derivados fluoroalcoxibenzilamino de heterociclos contendo nitrogénio
ES2159558T3 (es) Derivados de guanidina como inhibidores del intercambio na+/h+ en las celulas.
NZ502370A (en) Guanidine mimics for use as factor Xa inhibitors
GB9120641D0 (en) Heterocyclic compounds
EP0669324A4 (en) CHINAZOLIN DERIVATIVES.
NO20031490D0 (no) Alifatisk nitrogenholdig 5-kantet ring-forbindelse
NZ296594A (en) 1-(aminoalkylphenyl)guanidine and isothiourea derivatives
ATE182891T1 (de) Indazolderivate
CA2307581A1 (en) Heterocyclic compounds having nos inhibiting action
ES2093091T3 (es) Derivado de glutation.
TW427993B (en) New cephem compounds
ATE172455T1 (de) Herbizide verbindungen
GB9313330D0 (en) New compound and its preparation
ES2102327A1 (es) Nuevos derivados de 2,2,6,6-tetrametilpiperidina para utilizarse como agentes estabilizantes para materiales organicos contra la luz, el calor, y la oxidacion. n
CA2211681A1 (en) Novel pyridonecarboxylic acid derivatives or salts thereof and antibacterial agents comprising the same as active ingredient
EP1020459A4 (en) CIS DISUBSTITUTED AMINOCYCLOALKYL PYRROLIDINE DERIVATIVES
BG106117A (en) Novel 8a- and 9a-15-membered lactams
ES2140524T3 (es) Derivados de metotrexato.
DE69726437D1 (de) Benzothiophenderivate, ihre herstellung und verwendung als urokinase-inhibitoren
MX9802192A (es) Derivados novedosos del acido piridona carboxilico o sus sales, y agentes antibacterianos que contienen los mismos como sus componentes efectivos.
ES2182298T3 (es) Sulfoniloxadiazolonas y su empleo como microbicidas.
MX9708155A (es) Inhibicion de la fotodescomposicion de 2-oxindoles 3-sustituidos.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 691967

Country of ref document: ES