[go: up one dir, main page]

ES2122472T3 - Derivados de eritromicina, su procedimiento de preparacion y su aplicacion como medicamentos. - Google Patents

Derivados de eritromicina, su procedimiento de preparacion y su aplicacion como medicamentos.

Info

Publication number
ES2122472T3
ES2122472T3 ES95400987T ES95400987T ES2122472T3 ES 2122472 T3 ES2122472 T3 ES 2122472T3 ES 95400987 T ES95400987 T ES 95400987T ES 95400987 T ES95400987 T ES 95400987T ES 2122472 T3 ES2122472 T3 ES 2122472T3
Authority
ES
Spain
Prior art keywords
erythromycin
medicines
derivatives
application
preparation procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95400987T
Other languages
English (en)
Inventor
Constantin Agouridas
Jean-Francois Chantot
Alexis Denis
D Ambrieres Solange Gouin
Martret Odile Le
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Marion Roussel
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel, Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel
Application granted granted Critical
Publication of ES2122472T3 publication Critical patent/ES2122472T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A LOS COMPUESTOS DE FORMULA (I) EN LAS QUE - R REPRESENTA UN RADICAL -(CH{SUB,2}){SUB,N}AR, - N REPRESENTA EL NUMERO 3,4 O 5 - AR REPRESENTA UN RADICAL HETEROCICLICO, EVENTUALMENTE SUSTITUIDO, - Z REPRESENTA UN ATOMO DE HIDROGENO O EL RESTO DE UN ACIDO. LOS COMPUESTOS DE FORMULA (I) PRESENTAN INTERESANTES PROPIEDADES ANTIBIOTICAS.
ES95400987T 1994-05-03 1995-05-02 Derivados de eritromicina, su procedimiento de preparacion y su aplicacion como medicamentos. Expired - Lifetime ES2122472T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9405368A FR2719587B1 (fr) 1994-05-03 1994-05-03 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Publications (1)

Publication Number Publication Date
ES2122472T3 true ES2122472T3 (es) 1998-12-16

Family

ID=9462785

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95400987T Expired - Lifetime ES2122472T3 (es) 1994-05-03 1995-05-02 Derivados de eritromicina, su procedimiento de preparacion y su aplicacion como medicamentos.

Country Status (42)

Country Link
US (2) US5635485A (es)
EP (1) EP0680967B1 (es)
JP (4) JP2992540B2 (es)
KR (1) KR100312267B1 (es)
CN (2) CN1052984C (es)
AP (1) AP558A (es)
AT (1) ATE172203T1 (es)
AU (1) AU684027B2 (es)
BG (1) BG63087B1 (es)
BR (1) BR9507700A (es)
CA (1) CA2189271C (es)
CZ (1) CZ293455B6 (es)
DE (2) DE69505296T2 (es)
DK (1) DK0680967T3 (es)
DZ (1) DZ1878A1 (es)
EE (1) EE03263B1 (es)
ES (1) ES2122472T3 (es)
FI (1) FI111263B (es)
FR (1) FR2719587B1 (es)
GE (1) GEP19991538B (es)
HU (2) HU219599B (es)
IL (1) IL113245A (es)
LU (1) LU90872I2 (es)
LV (1) LV11739B (es)
MA (1) MA23534A1 (es)
MD (1) MD1233C2 (es)
NL (1) NL300077I1 (es)
NO (2) NO308853B1 (es)
NZ (1) NZ285416A (es)
OA (1) OA10319A (es)
PL (1) PL182034B1 (es)
RO (1) RO113350B1 (es)
RU (1) RU2144036C1 (es)
SI (1) SI0680967T1 (es)
SK (1) SK281707B6 (es)
TJ (1) TJ313B (es)
TN (1) TNSN95049A1 (es)
TW (1) TW341573B (es)
UA (1) UA51618C2 (es)
WO (1) WO1995029929A1 (es)
YU (1) YU49235B (es)
ZA (1) ZA953501B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2306590A1 (es) * 2006-12-15 2008-11-01 Ercros Industrial,S .A. Formas cristalinas i y ii de telitromicina.

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001539A1 (en) * 1995-06-27 1997-01-16 Takeda Chemical Industries, Ltd. 4-acylamino(halogeno) alkyl-quinoline derivatives, their preparation and their use as melatonin agonists
FR2742757B1 (fr) 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
ATE296308T1 (de) * 1996-09-04 2005-06-15 Abbott Lab 6-o-substituierte ketoliden mit antibakteriellen wirkung
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US5780605A (en) * 1997-09-08 1998-07-14 Abbott Laboratories 6,9-bridged erythromycin derivatives
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2781484B1 (fr) * 1998-07-21 2001-08-10 Hoechst Marion Roussel Inc Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments
ES2243066T3 (es) * 1998-09-22 2005-11-16 Pfizer Products Inc. Antibioticos de carbamato y carbazato cetolida.
FR2785612A1 (fr) * 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
TW526202B (en) * 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
TR200102129T2 (tr) 1998-12-10 2002-01-21 Pfizer Products Inc. Karbamat ve karbazat ketolid antibiyotikleri.
KR20020002380A (ko) * 1999-01-27 2002-01-09 실버스타인 아써 에이. 케톨라이드 항생물질
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
ATE340183T1 (de) 1999-04-16 2006-10-15 Kosan Biosciences Inc Antiinfektiöse makrolidderivate
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
CN1373767A (zh) * 1999-04-16 2002-10-09 奥索-麦克尼尔药品公司 酮式大环内酯抗菌剂
US6939861B2 (en) * 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
HK1045523A1 (zh) * 1999-05-24 2002-11-29 辉瑞产品公司 13-甲基红霉素衍生物
FR2797875B1 (fr) * 1999-08-26 2001-10-19 Hoechst Marion Roussel Inc Agglomerats spheriques de telithromycine, leur procede de preparation et leur application dans la preparation de formes pharmaceutiques
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
ES2313975T3 (es) 2000-08-22 2009-03-16 Basilea Pharmaceutica Ag Nuevos macrolidos con actividad antibacteriana.
FR2821747B1 (fr) * 2001-03-09 2004-07-02 Ethypharm Lab Prod Ethiques Suspension de telithromycine a gout masque
JP4509553B2 (ja) * 2001-07-03 2010-07-21 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 抗菌活性を有するｃ１２修飾エリスロマイシンマクロライドおよびケトライド
US8063021B2 (en) * 2002-01-17 2011-11-22 Kosan Biosciences Incorporated Ketolide anti-infective compounds
US6995143B2 (en) 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
ES2325495T3 (es) 2002-07-08 2009-09-07 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Moleculas hibridas de macrolidos con moleculas anti-inflamatorias esteroideas y no esteroideas.
AU2003255851B2 (en) 2002-07-08 2009-07-23 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. New compounds, compositions and methods for treatment of inflammatory diseases and conditions
US20040013737A1 (en) * 2002-07-19 2004-01-22 Philippe Becourt Taste masked oral composition of telithromycin
WO2004009059A1 (en) * 2002-07-19 2004-01-29 Aventis Pharma S.A. Taste masked oral composition of telithromycin
US7091196B2 (en) 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
DE10305391A1 (de) * 2003-02-11 2004-08-19 Aventis Pharma Deutschland Gmbh Verfahren zur Herstellung von Pyridin-substituierten Aminoketal-Derivaten
US6916934B2 (en) * 2003-02-11 2005-07-12 Aventis Pharma Deutschland Gmbh Process for preparing pyridine-substituted amino ketal derivatives
EP1638549A4 (en) * 2003-03-10 2011-06-15 Optimer Pharmaceuticals Inc NEW ANTIBACTERIAL AGENTS
EP1618120A2 (en) * 2003-04-25 2006-01-25 Chiron Corporation Novel ketolide derivatives
EP1670808A1 (en) * 2003-09-12 2006-06-21 Chiron Corporation Antimicrobial derivatives
GB0402578D0 (en) * 2004-02-05 2004-03-10 Cambridge Theranostics Ltd Methods of treatment of atherosclerosis
EP1723159B1 (en) 2004-02-27 2019-06-12 Melinta Therapeutics, Inc. Macrocyclic compounds and methods of making and using the same
EP1742957B1 (en) * 2004-04-28 2007-09-12 Alembic Limited Process for the preparation of telithromycin
BRPI0513903A (pt) * 2004-07-28 2008-05-20 Ranbaxy Lab Ltd derivados de cetolìdeos úteis como agentes antimicrobianos, seus processos de preparação e composições farmacêuticas compreendendo os mesmos
WO2006046112A2 (en) * 2004-10-25 2006-05-04 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
DK1836211T3 (da) 2004-12-21 2010-05-17 Pfizer Prod Inc Makrolider
CN101116154A (zh) * 2005-02-08 2008-01-30 株式会社村田制作所 表面安装型负特性热敏电阻
FR2882522B1 (fr) 2005-02-25 2007-04-13 Aventis Pharma Sa Composition pharmaceutique solide comprenant de la telithromycine
WO2006129257A2 (en) * 2005-05-30 2006-12-07 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
WO2007039914A2 (en) * 2005-10-06 2007-04-12 Alembic Limited Novel polymorphs of telithromycin
WO2007049296A2 (en) * 2005-10-28 2007-05-03 Alembic Limited Amorphous form of telithromycin
WO2007059307A2 (en) * 2005-11-15 2007-05-24 Teva Pharmaceutical Industries Ltd. Crystalline and amorphous forms of telithromycin
US20090075916A1 (en) * 2005-11-23 2009-03-19 Upadhyay Dilip J Use of Macrolide Derivatives for Treating Acne
EP1957508A2 (en) * 2005-11-23 2008-08-20 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
US20090130225A1 (en) * 2005-11-23 2009-05-21 Anjan Chakrabarti Macrolides derivatives as antibacterial agents
US7595300B2 (en) 2005-12-13 2009-09-29 Kosan Biosciences Incorporated 7-quinolyl ketolide antibacterial agents
GB0600238D0 (en) * 2006-01-06 2006-02-15 Sandoz Ag Organic compounds
US8097708B2 (en) * 2006-02-07 2012-01-17 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound
EP2056844A4 (en) 2006-08-24 2010-11-24 Wockhardt Research Center NEW MACROLIDS AND KETOLIDS WITH ANTIMICROBIAL EFFECT
WO2008023383A1 (en) * 2006-08-25 2008-02-28 Alembic Limited Novel process for the preparation of telithromycin
WO2009019868A1 (ja) 2007-08-06 2009-02-12 Taisho Pharmaceutical Co., Ltd. １０ａ、１２位架橋型１０ａ－アザライド化合物
US20090075917A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched telithromycin
EP2937019B1 (en) 2007-09-20 2017-11-08 Herman Miller, Inc. Load support structure
US9453042B2 (en) 2007-10-25 2016-09-27 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
WO2009053259A1 (en) * 2007-10-25 2009-04-30 Sandoz Ag Process for the production of telithromycin
JPWO2009139181A1 (ja) 2008-05-15 2011-09-15 大正製薬株式会社 ４員環構造を有する１０ａ−アザライド化合物
HRP20160222T1 (hr) 2008-10-24 2016-04-08 Cempra Pharmaceuticals, Inc. Biozaštite uporabom makrolida koji sadrže triazol
BRPI1011959A2 (pt) 2009-05-27 2016-04-26 Wockhardt Research Center compostos de cetolídeo tendo atividade antimicrobiana.
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
EP2475253B1 (en) 2009-09-10 2016-10-26 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
JP5711352B2 (ja) 2010-03-22 2015-04-30 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライドの結晶形、およびその使用
CN102917708B (zh) 2010-05-20 2015-11-25 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
US9815863B2 (en) 2010-09-10 2017-11-14 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
KR101657751B1 (ko) 2010-12-09 2016-09-19 욱크하르트 리미티드 케토라이드 화합물
AR085286A1 (es) 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
US9206214B2 (en) 2011-03-01 2015-12-08 Wockhardt Ltd. Process for preparation of ketolide intermediates
CN103619863B (zh) 2011-03-22 2016-03-16 沃克哈特有限公司 酮内酯化合物的制备方法
IN2014DN08939A (es) 2012-03-27 2015-05-22 Cempra Pharmaceuticals Inc
CA2905975A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
EP2968384A4 (en) 2013-03-15 2017-02-15 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
CN105524132B (zh) * 2014-09-30 2019-07-02 中国医学科学院药物研究所 含有喹啉取代基的红霉素a酮内酯类抗生素衍生物、其制备方法及应用
DE102015201783A1 (de) 2015-02-02 2016-08-04 Friedrich Baur Verfahren zur Herstellung eines Füllstoffs aus Textilfasern sowie Textil mit einem solchen Füllstoff
CN107129514B (zh) * 2016-03-02 2019-12-13 中国医学科学院药物研究所 红霉素a酮内酯类抗生素衍生物、其制备方法及应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT342770B (de) * 1975-04-07 1978-04-25 Thomae Gmbh Dr K Verfahren zur herstellung neuer erythromycinderivate
DE2833140A1 (de) * 1978-07-28 1980-02-07 Boehringer Sohn Ingelheim Neue n-substituierte heterocyclen
US4434174A (en) * 1980-02-11 1984-02-28 Berlex Laboratories, Inc. Treating cardiovascular diseases with N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
IE810250L (en) * 1980-02-11 1981-08-11 Berlex Lab N-(3-phenoxy-2-hydroxypropyl) benzimidazole -1-¹alkanamines.
US4568687A (en) * 1983-02-28 1986-02-04 American Cyanamid Company N-[2-4-(1H-Imidazol-1-yl)alkyl]-arylamides and pharmaceutical compositions
ZA84949B (en) * 1983-04-06 1984-09-26 American Cyanamid Co Substituted-n-(2-4-(1h-imidazol-1-yl)alkyl)substituted amides
US4489089A (en) * 1983-04-06 1984-12-18 American Cyanamid Company Substituted N-[ω-(1H-imidazol-1-yl)alkyl]-amides
AU573828B2 (en) * 1984-05-17 1988-06-23 E.R. Squibb & Sons, Inc. Tetrahydronaphthalenols
GB8425104D0 (en) * 1984-10-04 1984-11-07 Ici America Inc Amide derivatives
DE3540376A1 (de) * 1985-11-14 1987-05-21 Bayer Ag Verfahren zur inhibierung der wasserstoffinduzierten korrosion von metallischen werkstoffen
ATE106884T1 (de) * 1986-10-29 1994-06-15 Pfizer Verfahren zur herstellung von 2-(1-pentyl-3- guanidino)-4-(2-methyl-4-imidazolyl)thiazol und dessen kristallinisches dihydrochlorid-trihydrat.
DE3930669A1 (de) * 1989-09-14 1991-03-28 Basf Ag Verfahren zur herstellung von uretdiongruppen aufweisenden polyisocyanaten
JP2899028B2 (ja) * 1989-12-01 1999-06-02 協和醗酵工業株式会社 ジベンゾオキセピン誘導体
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of erythromycin derivatives
ES2104889T3 (es) * 1990-11-28 1997-10-16 Taisho Pharmaceutical Co Ltd Derivado de 6-o-metileritromicina a.
FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
TW370529B (en) * 1992-12-17 1999-09-21 Pfizer Pyrazolopyrimidines
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2306590A1 (es) * 2006-12-15 2008-11-01 Ercros Industrial,S .A. Formas cristalinas i y ii de telitromicina.
ES2306590B1 (es) * 2006-12-15 2009-08-07 Ercros Industrial,S .A. Formas cristalinas i y ii de telitromicina.

Also Published As

Publication number Publication date
MD1233C2 (ro) 2000-10-31
FI964395L (fi) 1996-10-31
HUT75698A (en) 1997-05-28
JP3998828B2 (ja) 2007-10-31
NO308853B1 (no) 2000-11-06
CN1229082A (zh) 1999-09-22
DE10299001I2 (de) 2012-07-05
JPH11152296A (ja) 1999-06-08
MX9605208A (es) 1997-09-30
NO2001027I1 (no) 2002-01-28
WO1995029929A1 (fr) 1995-11-09
CA2189271C (fr) 2005-12-27
JP2992540B2 (ja) 1999-12-20
HU219599B (hu) 2001-05-28
FR2719587A1 (fr) 1995-11-10
OA10319A (fr) 1997-10-07
ATE172203T1 (de) 1998-10-15
FR2719587B1 (fr) 1996-07-12
US5635485A (en) 1997-06-03
NO964654D0 (no) 1996-11-04
DE69505296T2 (de) 1999-04-22
NL300077I1 (nl) 2002-03-01
US6100404A (en) 2000-08-08
EP0680967A1 (fr) 1995-11-08
UA51618C2 (uk) 2002-12-16
FI111263B (fi) 2003-06-30
SK140296A3 (en) 1998-04-08
GEP19991538B (en) 1999-03-05
HU9904687D0 (en) 2000-03-28
SK281707B6 (sk) 2001-07-10
JP2007269810A (ja) 2007-10-18
AU2449995A (en) 1995-11-29
CN1052984C (zh) 2000-05-31
TNSN95049A1 (fr) 1996-02-06
SI0680967T1 (en) 1999-02-28
CZ321496A3 (en) 1997-08-13
BG63087B1 (bg) 2001-03-30
DZ1878A1 (fr) 2002-02-17
AP558A (en) 1996-11-07
YU27095A (sh) 1998-05-15
CN1151746A (zh) 1997-06-11
JPH0853489A (ja) 1996-02-27
HU227493B1 (en) 2011-07-28
HU9603038D0 (en) 1997-01-28
DE10299001I1 (de) 2012-07-05
PL317071A1 (en) 1997-03-03
AU684027B2 (en) 1997-11-27
LU90872I2 (fr) 2002-03-12
CA2189271A1 (fr) 1995-11-09
JP4750755B2 (ja) 2011-08-17
CZ293455B6 (cs) 2004-05-12
EP0680967B1 (fr) 1998-10-14
FI964395A0 (fi) 1996-10-31
BG100951A (en) 1997-08-29
TW341573B (en) 1998-10-01
EE03263B1 (et) 2000-04-17
NZ285416A (en) 1997-07-27
DK0680967T3 (da) 1999-06-23
PL182034B1 (pl) 2001-10-31
NO964654L (no) 1996-11-04
TJ313B (en) 2001-08-06
JP4658902B2 (ja) 2011-03-23
RU2144036C1 (ru) 2000-01-10
MD1233B1 (en) 1999-05-31
YU49235B (sh) 2004-12-31
HK1010732A1 (en) 1999-06-25
JP2007045847A (ja) 2007-02-22
AP9500744A0 (en) 1995-07-31
LV11739B (en) 1997-08-20
CN1088709C (zh) 2002-08-07
KR100312267B1 (ko) 2002-06-22
LV11739A (lv) 1997-04-20
IL113245A (en) 1999-11-30
BR9507700A (pt) 1997-08-19
ZA953501B (en) 1996-05-02
IL113245A0 (en) 1995-07-31
RO113350B1 (ro) 1998-06-30
DE69505296D1 (de) 1998-11-19
MA23534A1 (fr) 1995-12-31

Similar Documents

Publication Publication Date Title
ES2122472T3 (es) Derivados de eritromicina, su procedimiento de preparacion y su aplicacion como medicamentos.
ES2176698T3 (es) Nuevos derivados de la eritromicina, su procedimiento de preparacion y su aplicacion como medicamentos.
ES2082755T3 (es) Derivados de acido 3-desmetil-mevalonico, procedimiento para su preparacion, preparados farmaceuticos a base de estos compuestos, su utilizacion asi como productos intermedios.
ES2077138T3 (es) Derivados de aminocumarano, su produccion y su uso.
DK118286D0 (da) Terapeutisk aktive nucleosider, deres anvendelse og farmaceutiske kompositioner indeholdende forbindelserne
YU113690A (sh) Postupak za dobivanje askorbinske kiseline
FI891283A0 (fi) Ifosfamid-mesna-lyofilisat och foerfarande foer dess framstaellning.
SE8801513D0 (sv) Farmaceutisk komposition
EG14365A (en) Derives de l'imidazole et medicaments qui en contiennent
DE3665711D1 (de) Novel guanidinomethylbenzoic acid derivatives
ES2032335T3 (es) Nuevos derivados flavonoides 2-piperazinil-2-oxo-etilen sustituidos, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen.
FR2660657B1 (fr) Nouveaux derives du 3-aminochromane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
ES2016464A6 (es) Procedimiento para preparar derivados de 2', 5' -oligoadenilato.
ATE119521T1 (de) Butenoinsäure-derivate.
DE3888066D1 (de) Saccharid-Derivate.
ES2069765T3 (es) Nuevos derivados del acido 2,2-dimetil-ciclopropenocarboxilico que llevan en posicion 3 una cadena halogenada saturada, su procedimiento de preparacion y su aplicacion en la sintesis de productos plaguicidas.
DK329189D0 (da) Glycerolderivat og dets farmakologiske anvendelse
DE69519895D1 (de) Pyrimidinderivate und pharmazeutische Zusammensetzungen
ATE123497T1 (de) Substituierte pyridin-verbindungen, ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen.
NO911798D0 (no) 3'-deamino-4'-deoksy-4'-amino-8-fluorantracykliner og deres fremstilling.
SE8001981L (sv) Kompositioner for behandling av glaukom
MX9804752A (es) Conjugados covalentes de lipidos-acidos fosfonocarboxilicos, la produccion de los mismos asi como su uso como agentes farmaceuticos antivirales .
NO20000054D0 (no) Polyhydroksyalkylpyrazinderivater, deres fremstilling og medisiner inneholdende forbindelsene
ES2073919T3 (es) Derivados de piperidina 1,3,4-trisubstituidos, su obtencion y empleo.
ES2059097T3 (es) Derivados de la ergolina.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 680967

Country of ref document: ES

SPCF Request for supplementary protection certificate filed

Free format text: TELITROMICINA (KETEK)

Spc suppl protection certif: C200200001

Filing date: 20020109

SPCG Supplementary protection certificate granted

Free format text: TELITROMICINA (KETEK)

Spc suppl protection certif: C200200001

Filing date: 20020109

Expiry date: 20160709

Effective date: 20040202