[go: up one dir, main page]

ES2117715T3 - Mejoras introducidas en agentes de contrastes. - Google Patents

Mejoras introducidas en agentes de contrastes.

Info

Publication number
ES2117715T3
ES2117715T3 ES93919497T ES93919497T ES2117715T3 ES 2117715 T3 ES2117715 T3 ES 2117715T3 ES 93919497 T ES93919497 T ES 93919497T ES 93919497 T ES93919497 T ES 93919497T ES 2117715 T3 ES2117715 T3 ES 2117715T3
Authority
ES
Spain
Prior art keywords
contrast agents
size distribution
containing gas
microcapsules
aldehyde
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93919497T
Other languages
English (en)
Inventor
Jo Klaveness
P L Rongved
John Henrik Johansen
Per Antonius Foss
Anders Hogset
Anne Marie Hvoslef
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Nycomed Imaging AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929219595A external-priority patent/GB9219595D0/en
Priority claimed from GB929220638A external-priority patent/GB9220638D0/en
Priority claimed from GB929220639A external-priority patent/GB9220639D0/en
Application filed by Nycomed Imaging AS filed Critical Nycomed Imaging AS
Application granted granted Critical
Publication of ES2117715T3 publication Critical patent/ES2117715T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)

Abstract

AGENTES DE CONTRASTE PROTEINAS EN MICROCAPSULAS QUE CONTIENEN PRECURSOR DE GAS O GAS, P. EJ. PARA USO EN REPRESENTACION DE IMAGENES MR Y/O ULTRASONIDOS, EN QUE LA MATRIZ DE PROTEINA ES ENTRECRUZADA POR REACCION CON UN ALDEHIDO BIFUNCIONAL (P. EJ. UN DIALDEHIDO TAL COMO GLUTARALDEHIDO O UN ALDEHIDO (ALFA),(BETA)-INSATURADO TAL COMO ACROLEINA) EN UN MEDIO ACUOSO EN PH SUSTANCIALMENTE NEUTRO QUE EXHIBE ESTABILIDAD MEJORADA EN VIVO Y ALMACENADA, PARTICULARMENTE SI LA MATRIZ SE HACE TAMBIEN REACCIONAR CON UNA BASE DE SCHIFF QUE REDUCE AGENTE TAL COMO UN BOROHIDRURO. MODIFICACION DE LA DISTRIBUCION DE TAMAÑO DE TALES AGENTES PROTEINICOS DE CONTRASTE QUE CONTIENE GAS, P. EJ. PARA REDUCIR EL TAMAÑO MEDIO DE LAS MICROCAPSULAS, MEJORA ADICIONALMENTE SU ESTABILIDAD Y PERMITE PREPARACION DE NUEVOS AGENTES DE CONTRASTE QUE TIENEN UNA DISTRIBUCION DE TAMAÑO DE MICROCAPSULA PARTICULARMENTE REDUCIDA.
ES93919497T 1992-09-16 1993-09-03 Mejoras introducidas en agentes de contrastes. Expired - Lifetime ES2117715T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929219595A GB9219595D0 (en) 1992-09-16 1992-09-16 Improvements in or relating to contrast agents
GB929220638A GB9220638D0 (en) 1992-09-30 1992-09-30 Improvements in or relating to contrast agents
GB929220639A GB9220639D0 (en) 1992-09-30 1992-09-30 Improvements in or relating to contrast agents

Publications (1)

Publication Number Publication Date
ES2117715T3 true ES2117715T3 (es) 1998-08-16

Family

ID=27266368

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93919497T Expired - Lifetime ES2117715T3 (es) 1992-09-16 1993-09-03 Mejoras introducidas en agentes de contrastes.

Country Status (13)

Country Link
US (1) US5718884A (es)
EP (2) EP0835664A3 (es)
JP (1) JPH08501776A (es)
CN (1) CN1048410C (es)
AT (1) ATE167805T1 (es)
AU (1) AU689086B2 (es)
CA (1) CA2144749A1 (es)
DE (1) DE69319438T2 (es)
DK (1) DK0660724T3 (es)
ES (1) ES2117715T3 (es)
FI (1) FI951210A7 (es)
NO (1) NO950986D0 (es)
WO (1) WO1994006477A1 (es)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5922304A (en) * 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
MX9205298A (es) * 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
US6875420B1 (en) 1991-09-17 2005-04-05 Amersham Health As Method of ultrasound imaging
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
US5716597A (en) * 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
EP1550464A1 (en) * 1993-07-30 2005-07-06 IMCOR Pharmaceutical Co. Stabilized microbubble composition for ultrasound
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
NO940711D0 (no) * 1994-03-01 1994-03-01 Nycomed Imaging As Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging
US5540909A (en) 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
US5804162A (en) * 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
AU1354497A (en) * 1995-12-21 1997-07-14 Drexel University Hollow polymer microcapsules and method of producing
ATE345682T1 (de) 1996-05-01 2006-12-15 Imarx Pharmaceutical Corp In vitro verfahren zum einbringen von nukleinsäuren in eine zelle
DE19626530A1 (de) * 1996-07-02 1998-01-15 Byk Gulden Lomberg Chem Fab MR-Kontrastmittelzubereitungen
US6108637A (en) 1996-09-03 2000-08-22 Nielsen Media Research, Inc. Content display monitor
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US6083484A (en) 1996-10-17 2000-07-04 Molecular Biosystems, Inc. Microparticles stabilized by polynuclear chromium complexes and their use as ultrasound contrast agents
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US7462366B2 (en) * 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7131997B2 (en) * 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
US7094369B2 (en) * 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US7053134B2 (en) * 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
CA2418229A1 (en) * 2002-05-16 2003-11-16 Rohan Dharmakumar Microbubble construct for sensitivity enhanced mr manometry
CA2492339A1 (en) 2002-06-12 2003-12-24 Boston Scientific Limited Bulking agents
US7449236B2 (en) * 2002-08-09 2008-11-11 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US7842377B2 (en) * 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US7883490B2 (en) * 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
US7588825B2 (en) * 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
US7976823B2 (en) * 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
US20050074406A1 (en) * 2003-10-03 2005-04-07 Scimed Life Systems, Inc. Ultrasound coating for enhancing visualization of medical device in ultrasound images
US7901770B2 (en) * 2003-11-04 2011-03-08 Boston Scientific Scimed, Inc. Embolic compositions
US7736671B2 (en) * 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US20050238870A1 (en) * 2004-04-22 2005-10-27 Marcia Buiser Embolization
US7311861B2 (en) * 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
US8012457B2 (en) * 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
US7727555B2 (en) * 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7858183B2 (en) * 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US20070004973A1 (en) * 2005-06-15 2007-01-04 Tan Sharon M L Tissue treatment methods
US8123693B2 (en) 2005-06-20 2012-02-28 Conceptus, Inc. Methods and devices for determining lumen occlusion
US9463426B2 (en) * 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
US20070083219A1 (en) * 2005-10-12 2007-04-12 Buiser Marcia S Embolic coil introducer sheath locking mechanisms
US8007509B2 (en) * 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
US8152839B2 (en) * 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US20070142859A1 (en) * 2005-12-19 2007-06-21 Boston Scientific Scimed, Inc. Embolic coils
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US7501179B2 (en) * 2005-12-21 2009-03-10 Boston Scientific Scimed, Inc. Block copolymer particles
US7947368B2 (en) * 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
US20070142560A1 (en) * 2005-12-21 2007-06-21 Young-Ho Song Block copolymer particles
DE102006023456A1 (de) * 2006-05-18 2007-11-22 Siemens Ag Kontrastmittel für die Röntgen- und Computertomographie-Diagnostik
US20070299461A1 (en) * 2006-06-21 2007-12-27 Boston Scientific Scimed, Inc. Embolic coils and related components, systems, and methods
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
US20080145658A1 (en) * 2006-12-15 2008-06-19 Boston Scientific Scimed, Inc. Freeze Thaw Methods For Making Polymer Particles
US8585616B2 (en) * 2009-10-09 2013-11-19 Conceptus, Inc. Methods and apparatus for determining fallopian tube occlusion
KR101853948B1 (ko) * 2013-07-05 2018-05-02 사회복지법인 삼성생명공익재단 X-선 조영제 및 기포 촉진제를 함유하는 조영 조성물 및 그 제조방법
CN104174040A (zh) * 2014-08-13 2014-12-03 中国科学院宁波材料技术与工程研究所 一种造影材料、其制备方法及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4452773A (en) * 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US5284646A (en) * 1986-07-03 1994-02-08 Advanced Magnetics Inc. Hepatocyte specific receptor mediated endocytosis type magnetic resonance imaging contrast agents
DE3709851A1 (de) * 1987-03-24 1988-10-06 Silica Gel Gmbh Adsorptions Te Nmr-diagnostische fluessigkeitszusammensetzungen
DE4004430A1 (de) * 1990-02-09 1991-08-14 Schering Ag Aus polyaldehyden aufgebaute kontrastmittel
EP0504340B1 (en) * 1990-10-05 1995-06-21 BRACCO International B.V. Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography

Also Published As

Publication number Publication date
FI951210A0 (fi) 1995-03-15
EP0660724A1 (en) 1995-07-05
EP0835664A2 (en) 1998-04-15
EP0660724B1 (en) 1998-07-01
FI951210L (fi) 1995-05-10
DK0660724T3 (da) 1998-11-02
JPH08501776A (ja) 1996-02-27
AU689086B2 (en) 1998-03-26
EP0835664A3 (en) 1998-08-12
NO950986L (no) 1995-03-14
CN1048410C (zh) 2000-01-19
CN1088114A (zh) 1994-06-22
ATE167805T1 (de) 1998-07-15
HK1003293A1 (en) 1998-10-23
NO950986D0 (no) 1995-03-14
FI951210A7 (fi) 1995-05-10
WO1994006477A1 (en) 1994-03-31
CA2144749A1 (en) 1994-03-31
AU4973493A (en) 1994-04-12
DE69319438T2 (de) 1998-12-03
DE69319438D1 (de) 1998-08-06
US5718884A (en) 1998-02-17

Similar Documents

Publication Publication Date Title
ES2117715T3 (es) Mejoras introducidas en agentes de contrastes.
AR002932A1 (es) Solucion acuosa de interferon
ES2518926T3 (es) Conjugados de etilendicisteína y un análogo de glucosa
ES2160716T3 (es) Procedimiento para estabilizar la respuesta de un biosensor.
HUP0000143A2 (hu) Kétfázisú eljárások esszenciális aminosavak felhalmozódásának növelésére magokban
MX9400185A (es) Composicion inyectable acuosa, empleada para obtener imagenes durante examenes con rayos x.
ES2185705T3 (es) Proteina bifuncional, preparacion y uso.
NO954320L (no) Lyosfærer omfattende gonadotropin
ES2056817T3 (es) Transformacion de trichoderma.
CO4970769A1 (es) Composiciones insolubles de insulina do de insulina para el control de la glucosa en la sangre y el proceso para la preparacion de las composiciones
AR023529A1 (es) Una composicion champu acondicionadora del cabello y un metodo para acondicionar el cabello
PT1140014E (pt) Sistema de distribuicao osmotico que possui embolo com utilizacao eficaz de espaco
ATE56942T1 (de) N,n-dimethyl-1-(1-(4-chlorophenyl)-cyclobutyl>- methylbutylamin-hydrochlorid, monohydrat und pharmazeutische zusammensetzungen, welche diese enthalten.
DE68923621D1 (de) Absorbierendes material.
IT1240314B (it) Formulazioni acquose stabilizzate di piccoli peptidi.
AR015884A1 (es) Una composicion cosmetica para su uso en aplicaciones para el cuidado personal, que comprende un portador y una biguanida polimerica, uso de la misma y uso de una biguanida polimerica.
ATE107697T1 (de) Biologische eindämmung.
ES2133285T3 (es) Polipeptidos hidrosolubles que tienen una alta afinidad para los interferones alfa y beta.
ES2087869T3 (es) Proteinas modificadas; interferones alfa y beta modificados, proteinas fosforiladas y analogos, secuencias de adn, y sus aplicaciones.
ES2146214T3 (es) Vacunas para actinobacillus pleuropneumoniae.
ES2176216T3 (es) Particulas de ceramica y su preparacion.
EP1304123A3 (en) Methods for the modulation of the growth of collateral arteries and/or other arteries from preexisting arteriolar connections
ES2045768T3 (es) Composiciones topicas que contienen defibrotida.
ATE109129T1 (de) Nichtionisches röntgenkontrastmittel mit hohem jodgehalt.
BR0000604A (pt) Composição pronta para o uso, processo de tintura das fibras queratìnicas e dispositivo com vários compartimentos

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 660724

Country of ref document: ES