AR002932A1 - Solucion acuosa de interferon - Google Patents
Solucion acuosa de interferonInfo
- Publication number
- AR002932A1 AR002932A1 ARP960102079A AR10207996A AR002932A1 AR 002932 A1 AR002932 A1 AR 002932A1 AR P960102079 A ARP960102079 A AR P960102079A AR 10207996 A AR10207996 A AR 10207996A AR 002932 A1 AR002932 A1 AR 002932A1
- Authority
- AR
- Argentina
- Prior art keywords
- interferon solution
- aqueous interferon
- aqueous
- interferon
- solution
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Detergent Compositions (AREA)
Abstract
Una solución acuosa de interferón, que contiene: (a) un interferón alfa;(b) un detergente no iónico; (c) un tampón para ajustar el pH a 4,5 - 5,5;(d) alcohol bencílico; y opcionalmente, (e) un agente isotonizante.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95105166 | 1995-04-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR002932A1 true AR002932A1 (es) | 1998-05-27 |
Family
ID=8219166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960102079A AR002932A1 (es) | 1995-04-06 | 1996-04-03 | Solucion acuosa de interferon |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US5762923A (es) |
| EP (1) | EP0736303B1 (es) |
| JP (1) | JP2758154B2 (es) |
| KR (1) | KR100212346B1 (es) |
| CN (1) | CN1066065C (es) |
| AR (1) | AR002932A1 (es) |
| AT (1) | ATE183650T1 (es) |
| AU (1) | AU685356B2 (es) |
| BR (1) | BR9601276A (es) |
| CA (1) | CA2172664C (es) |
| CO (1) | CO4750807A1 (es) |
| CY (1) | CY2194B1 (es) |
| CZ (1) | CZ287626B6 (es) |
| DE (1) | DE69603894T2 (es) |
| DK (1) | DK0736303T3 (es) |
| ES (1) | ES2136910T3 (es) |
| GR (1) | GR3031775T3 (es) |
| HU (1) | HU227643B1 (es) |
| IL (1) | IL117752A (es) |
| MA (1) | MA23838A1 (es) |
| MY (1) | MY113594A (es) |
| NO (1) | NO316801B1 (es) |
| NZ (1) | NZ286300A (es) |
| PE (1) | PE38897A1 (es) |
| PL (1) | PL183873B1 (es) |
| RU (1) | RU2113845C1 (es) |
| SA (1) | SA96160728B1 (es) |
| SG (1) | SG52806A1 (es) |
| TR (1) | TR199600287A2 (es) |
| TW (1) | TW426523B (es) |
| ZA (1) | ZA962553B (es) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| US6402718B1 (en) | 1992-08-17 | 2002-06-11 | Medrad, Inc. | Front-loading medical injector and syringe for use therewith |
| US5951974A (en) * | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
| TW517067B (en) | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
| US20030190307A1 (en) | 1996-12-24 | 2003-10-09 | Biogen, Inc. | Stable liquid interferon formulations |
| NZ336548A (en) * | 1996-12-24 | 2001-09-28 | Biogen Inc | Stable liquid interferon formulations comprising an amino acid as the stabilising agent |
| AU754002B2 (en) * | 1998-03-26 | 2002-10-31 | Merck Sharp & Dohme Corp. | Formulations for protection of peg-interferon alpha conjugates |
| US6180096B1 (en) | 1998-03-26 | 2001-01-30 | Schering Corporation | Formulations for protection of peg-interferon alpha conjugates |
| PT1069912E (pt) * | 1998-04-03 | 2007-09-14 | Novartis Vaccines & Diagnostic | Formulações injectáveis de igf contendo succinato como agente tampão |
| CN1230198C (zh) | 1998-05-15 | 2005-12-07 | 先灵公司 | 给首次接受抗病毒疗法的G慢性丙型肝炎感染患者施用包括利巴韦林和α干扰素的联合疗法 |
| CN1170543C (zh) * | 1998-06-08 | 2004-10-13 | 弗·哈夫曼-拉罗切有限公司 | PEG-IFN-α和三唑核苷在治疗慢性丙型肝炎中的用途 |
| JP4719357B2 (ja) * | 1998-07-23 | 2011-07-06 | アレス トレイディング ソシエテ アノニム | Fsh及びfsh変異体の製剤、製品及び方法 |
| US20030166525A1 (en) | 1998-07-23 | 2003-09-04 | Hoffmann James Arthur | FSH Formulation |
| US6783965B1 (en) | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
| PT2158923E (pt) | 1998-08-06 | 2013-06-04 | Univ Duke | Conjugados de peg-urato oxidase e sua utilização |
| AU2158000A (en) * | 1998-12-22 | 2000-07-12 | Schering Corporation | Treatment of hepatitis c virus infections with interleukin-10 |
| US6914128B1 (en) | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
| US6605273B2 (en) | 1999-04-08 | 2003-08-12 | Schering Corporation | Renal cell carcinoma treatment |
| AR023398A1 (es) | 1999-04-08 | 2002-09-04 | Schering Corp | Terapia para melanomas |
| US6923966B2 (en) * | 1999-04-08 | 2005-08-02 | Schering Corporation | Melanoma therapy |
| US6362162B1 (en) | 1999-04-08 | 2002-03-26 | Schering Corporation | CML Therapy |
| KR100399156B1 (ko) * | 1999-11-19 | 2003-09-26 | 주식회사 엘지생명과학 | α-인터페론의 용액제형 |
| CN1175901C (zh) * | 1999-12-06 | 2004-11-17 | 天津华立达生物工程有限公司 | 一种稳定的干扰素水溶液 |
| EP2275557A1 (en) | 2000-04-12 | 2011-01-19 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US7208167B2 (en) * | 2000-08-07 | 2007-04-24 | Sciclone Pharmaceuticals, Inc. | Treatment of hepatitis C with thymosin and peptide combination therapy |
| DE60139339D1 (de) | 2000-11-07 | 2009-09-03 | Novartis Vaccines & Diagnostic | Stabilisierte interferonzusammensetzungen |
| CN1245215C (zh) | 2001-02-28 | 2006-03-15 | 四川省生物工程研究中心 | 重组高效复合干扰素用作乙型肝炎表面抗原和e抗原抑制剂 |
| US8551469B2 (en) | 2001-02-28 | 2013-10-08 | Superlab Far East Limited | Treatment of tumors and viral diseases with recombinant interferon alpha |
| JP2002265383A (ja) * | 2001-03-14 | 2002-09-18 | Mitsubishi Pharma Corp | インターフェロンα注射用液状製剤 |
| US6887462B2 (en) | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
| WO2002083165A1 (fr) * | 2001-04-10 | 2002-10-24 | Sumitomo Pharmaceuticals Co., Ltd. | Preparations stables destinees a etre injectees |
| LT4947B (lt) | 2001-09-26 | 2002-08-26 | Biotechnologijos Institutas | Interferono alfa farmacinė kompozicija |
| EP2990417A1 (en) | 2001-12-21 | 2016-03-02 | Human Genome Sciences, Inc. | Albumin insulin fusion protein |
| JP5000848B2 (ja) | 2002-05-21 | 2012-08-15 | 第一三共株式会社 | グレリン含有医薬組成物 |
| RU2238758C2 (ru) * | 2002-07-24 | 2004-10-27 | Закрытое акционерное общество "Вектор-Медика" | Водный раствор интерферона-альфа-два человека для инъекций |
| EP1594530A4 (en) | 2003-01-22 | 2006-10-11 | Human Genome Sciences Inc | HYBRID PROTEINS OF ALBUMIN |
| US7741268B2 (en) | 2003-04-02 | 2010-06-22 | Ares Trading S.A. | Liquid pharmaceutical formulations of FSH and LH together with a non-ionic surfactant |
| TWI272948B (en) * | 2003-05-01 | 2007-02-11 | Ares Trading Sa | HSA-free stabilized interferon liquid formulations |
| AR044302A1 (es) * | 2003-05-13 | 2005-09-07 | Ares Trading Sa | Formulaciones con proteinas liquidas estabilizadas en recipientes farmaceuticos |
| HRP20130242T1 (hr) | 2003-06-20 | 2013-04-30 | Ares Trading S.A. | Smrzavanjem osušene formulacije fsh/lh |
| DE10333317A1 (de) * | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
| AR045258A1 (es) * | 2003-08-21 | 2005-10-19 | Altana Pharma Ag | Un producto farmaceutico para inyeccion |
| US7585647B2 (en) | 2003-08-28 | 2009-09-08 | Guangwen Wei | Nucleic acid encoding recombinant interferon |
| BRPI0507169A (pt) | 2004-02-02 | 2007-06-26 | Ambrx Inc | polipeptìdeos do hormÈnio de crescimento humano modificados e seu usos |
| KR20070012464A (ko) | 2004-05-17 | 2007-01-25 | 아레스 트레이딩 에스.아. | 하이드로겔 인터페론 제제 |
| CN1993139B (zh) * | 2004-06-01 | 2011-02-16 | 阿雷斯贸易股份有限公司 | 稳定的干扰素液体制剂 |
| US7858082B2 (en) * | 2004-06-01 | 2010-12-28 | Ares Trading S.A. | Method of stabilizing proteins |
| RU2255729C1 (ru) * | 2004-07-26 | 2005-07-10 | Общество С Ограниченной Ответственностью "Фармапарк" | Препарат интерферона альфа в форме стабильного водного раствора для инъекций |
| US7632491B2 (en) | 2004-08-12 | 2009-12-15 | Schering Corporation | Stable pegylated interferon formulation |
| CN101022822B (zh) | 2004-08-24 | 2012-06-27 | 第一三共株式会社 | 生理学活性肽的液体制剂 |
| RU2270692C1 (ru) * | 2004-11-04 | 2006-02-27 | Валентина Васильевна Малиновская | Пролонгированный раствор интерферона |
| ES2538357T3 (es) | 2005-04-11 | 2015-06-19 | Crealta Pharmaceuticals Llc | Formas variantes de urato oxidasa y uso de las mismas |
| ES2302402B1 (es) | 2005-06-16 | 2009-05-08 | Proyecto De Biomedicina Cima, S.L. | Uso de una citoquina de la familia de interleuquina-6 en la preparacion de una composicion para administracion combinada con interferon-alfa. |
| EP1916997B1 (en) * | 2005-08-05 | 2018-04-18 | Amgen Inc. | Stable aqueous protein pharmaceutical formulations and their preparation |
| CU23432B6 (es) | 2005-11-02 | 2009-10-16 | Ct Ingenieria Genetica Biotech | Formulaciones estabilizadas que contienen a los interferones gamma y alfa en proporciones potenciadoras |
| WO2008026044A2 (en) * | 2006-08-31 | 2008-03-06 | Wockhardt Research Centre | Pharmaceutical compositions of bupropion |
| KR20150038227A (ko) | 2007-01-16 | 2015-04-08 | 애브비 인코포레이티드 | 건선의 치료방법 |
| WO2008145323A1 (en) * | 2007-05-31 | 2008-12-04 | F. Hoffmann-La Roche Ag | Pharmaceutical formulation for interferons |
| KR101502645B1 (ko) * | 2007-09-04 | 2015-03-13 | 바이오스티드 진 익스프레션 테크. 컴파니 리미티드 | 폴리에틸렌 글리콜에 의해 변형된 인터페론 알파 2b, 이의 제조 방법 및 용도 |
| PT2196475E (pt) * | 2007-09-04 | 2012-09-07 | Biosteed Gene Expression Tech Co Ltd | Interferão alfa-2a modificado por polietilenoglicol, seu processo de síntese e aplicação |
| WO2009055343A2 (en) * | 2007-10-22 | 2009-04-30 | Schering Corporation | Fully human anti-vegf antibodies and methods of using |
| EA201070773A1 (ru) | 2007-12-20 | 2010-12-30 | Мерк Сероно С. А. | Составы пэг-интерферона-бета |
| BRPI0915093A2 (pt) | 2008-06-13 | 2015-10-27 | Proyecto Biomedicina Cima Sl | conjugados para a administração de compostos biologicamente ativos |
| US20110195912A1 (en) * | 2008-09-17 | 2011-08-11 | Nektar Therapeutics | Oligomer-Protease Inhibitor Conjugates |
| US9377454B2 (en) | 2009-06-25 | 2016-06-28 | Crealta Pharmaceuticals Llc | Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy |
| CN102101886A (zh) | 2009-12-18 | 2011-06-22 | 四川辉阳生命工程股份有限公司 | 构象改变的重组干扰素晶体、其三维结构及应用 |
| RU2447083C1 (ru) * | 2010-07-20 | 2012-04-10 | Закрытое Акционерное Общество "Биокад" | НОВЫЙ ФУНКЦИОНАЛЬНО АКТИВНЫЙ ВЫСОКООЧИЩЕННЫЙ СТАБИЛЬНЫЙ КОНЪЮГАТ ИНТЕРФЕРОНА α С ПОЛИЭТИЛЕНГЛИКОЛЕМ, ПРЕДСТАВЛЕННЫЙ ОДНИМ ПОЗИЦИОННЫМ ИЗОМЕРОМ ПЭГ-NαH-ИФН, С УМЕНЬШЕННОЙ ИММУНОГЕННОСТЬЮ, С ПРОЛОНГИРОВАННЫМ БИОЛОГИЧЕСКИМ ДЕЙСТВИЕМ, ПРИГОДНЫЙ ДЛЯ МЕДИЦИНСКОГО ПРИМЕНЕНИЯ, И ИММУНОБИОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ |
| KR101303388B1 (ko) * | 2010-10-26 | 2013-09-03 | 한미사이언스 주식회사 | 지속형 인터페론 알파 결합체의 액상 제제 |
| CN102526758B (zh) * | 2012-02-23 | 2013-02-13 | 北京三元基因工程有限公司 | 一种聚乙二醇化干扰素稳定的水溶液 |
| TWI718086B (zh) | 2013-01-07 | 2021-02-11 | 英屬維爾京群島商遠東超級實驗室有限公司 | 通過干擾素的經皮和/或經粘膜給藥治療骨癌、皮膚癌、皮下癌、粘膜癌和/或粘膜下癌的方法和組合物 |
| US9388239B2 (en) | 2014-05-01 | 2016-07-12 | Consejo Nacional De Investigation Cientifica | Anti-human VEGF antibodies with unusually strong binding affinity to human VEGF-A and cross reactivity to human VEGF-B |
| CN107073080A (zh) * | 2014-09-23 | 2017-08-18 | 豪夫迈·罗氏有限公司 | 包含α‑型干扰素的稳定的不含苄醇的水溶液制剂 |
| JP2019535819A (ja) | 2016-11-11 | 2019-12-12 | ホライゾン ファーマ リューマトロジー リミテッド ライアビリティ カンパニーHorizon Pharma Rheumatology Llc | プレドニゾンおよびウリカーゼ分子の併用療法ならびにその使用 |
| WO2020160325A1 (en) | 2019-01-30 | 2020-08-06 | Horizon Pharma Rheumatology Llc | Reducing immunogenicity to pegloticase |
| US12121566B2 (en) | 2019-01-30 | 2024-10-22 | Horizon Therapeutics Usa, Inc. | Methods for treating gout |
| RU2768656C1 (ru) * | 2021-09-10 | 2022-03-24 | Илья Александрович Марков | Противовирусное средство в жидкой форме и способ его приготовления |
| US12269875B2 (en) | 2023-08-03 | 2025-04-08 | Jeff R. Peterson | Gout flare prevention methods using IL-1BETA blockers |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61277633A (ja) * | 1985-05-31 | 1986-12-08 | Toray Ind Inc | インタ−フエロン組成物 |
| RU2007184C1 (ru) * | 1985-11-25 | 1994-02-15 | Научно-исследовательский институт эпидемиологии и микробиологии им.Н.Ф.Гамалеи РАМН | Способ лечения сальмонеллезной инфекции |
| EP0284249A1 (en) * | 1987-03-13 | 1988-09-28 | Interferon Sciences, Inc. | Lyophilized lymphokine composition |
| IL88233A (en) * | 1987-11-03 | 1993-08-18 | Genentech Inc | Gamma interferon formulation |
| US5997856A (en) * | 1988-10-05 | 1999-12-07 | Chiron Corporation | Method and compositions for solubilization and stabilization of polypeptides, especially proteins |
| JPH0651642B2 (ja) * | 1988-11-14 | 1994-07-06 | 大塚製薬株式会社 | インターフェロン経鼻投与用製剤 |
| KR900701310A (ko) * | 1988-11-14 | 1990-12-01 | 오스카 아끼히꼬 | 인터페론 경비투여용 제제 |
| CA2033714A1 (en) * | 1990-01-25 | 1991-07-26 | Alberto Ferro | Pharmaceutical preparations |
| DE4126983A1 (de) * | 1991-08-15 | 1993-02-18 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke |
| US5382657A (en) * | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
| IL109350A (en) * | 1993-05-12 | 2001-01-28 | Genentech Inc | Stable liquid compositions of gamma interferon |
-
1996
- 1996-03-22 TW TW085103497A patent/TW426523B/zh not_active IP Right Cessation
- 1996-03-22 JP JP8066118A patent/JP2758154B2/ja not_active Expired - Lifetime
- 1996-03-26 CA CA002172664A patent/CA2172664C/en not_active Expired - Lifetime
- 1996-03-29 ZA ZA962553A patent/ZA962553B/xx unknown
- 1996-03-30 EP EP96105142A patent/EP0736303B1/en not_active Expired - Lifetime
- 1996-03-30 DK DK96105142T patent/DK0736303T3/da active
- 1996-03-30 ES ES96105142T patent/ES2136910T3/es not_active Expired - Lifetime
- 1996-03-30 DE DE69603894T patent/DE69603894T2/de not_active Expired - Lifetime
- 1996-03-30 AT AT96105142T patent/ATE183650T1/de active
- 1996-04-01 PE PE1996000231A patent/PE38897A1/es not_active IP Right Cessation
- 1996-04-01 AU AU50446/96A patent/AU685356B2/en not_active Expired
- 1996-04-01 IL IL11775296A patent/IL117752A/xx not_active IP Right Cessation
- 1996-04-01 NZ NZ286300A patent/NZ286300A/en not_active IP Right Cessation
- 1996-04-01 MA MA24195A patent/MA23838A1/fr unknown
- 1996-04-01 NO NO19961322A patent/NO316801B1/no not_active IP Right Cessation
- 1996-04-02 CO CO96016207A patent/CO4750807A1/es unknown
- 1996-04-03 HU HU9600857A patent/HU227643B1/hu unknown
- 1996-04-03 SG SG1996010030A patent/SG52806A1/en unknown
- 1996-04-03 AR ARP960102079A patent/AR002932A1/es unknown
- 1996-04-04 CN CN96100545A patent/CN1066065C/zh not_active Expired - Lifetime
- 1996-04-04 KR KR1019960010123A patent/KR100212346B1/ko not_active Expired - Lifetime
- 1996-04-04 CZ CZ1996994A patent/CZ287626B6/cs not_active IP Right Cessation
- 1996-04-04 MY MYPI96001275A patent/MY113594A/en unknown
- 1996-04-04 US US08/627,563 patent/US5762923A/en not_active Expired - Lifetime
- 1996-04-04 TR TR96/00287A patent/TR199600287A2/xx unknown
- 1996-04-04 BR BR9601276A patent/BR9601276A/pt not_active IP Right Cessation
- 1996-04-05 PL PL96313655A patent/PL183873B1/pl unknown
- 1996-04-05 RU RU96107889A patent/RU2113845C1/ru active
- 1996-04-08 SA SA96160728A patent/SA96160728B1/ar unknown
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1999
- 1999-11-05 GR GR990402866T patent/GR3031775T3/el unknown
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2000
- 2000-09-07 CY CY0000045A patent/CY2194B1/xx unknown
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