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AR002932A1 - Solucion acuosa de interferon - Google Patents

Solucion acuosa de interferon

Info

Publication number
AR002932A1
AR002932A1 ARP960102079A AR10207996A AR002932A1 AR 002932 A1 AR002932 A1 AR 002932A1 AR P960102079 A ARP960102079 A AR P960102079A AR 10207996 A AR10207996 A AR 10207996A AR 002932 A1 AR002932 A1 AR 002932A1
Authority
AR
Argentina
Prior art keywords
interferon solution
aqueous interferon
aqueous
interferon
solution
Prior art date
Application number
ARP960102079A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR002932A1 publication Critical patent/AR002932A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • A61K38/212IFN-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Detergent Compositions (AREA)

Abstract

Una solución acuosa de interferón, que contiene: (a) un interferón alfa;(b) un detergente no iónico; (c) un tampón para ajustar el pH a 4,5 - 5,5;(d) alcohol bencílico; y opcionalmente, (e) un agente isotonizante.
ARP960102079A 1995-04-06 1996-04-03 Solucion acuosa de interferon AR002932A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95105166 1995-04-06

Publications (1)

Publication Number Publication Date
AR002932A1 true AR002932A1 (es) 1998-05-27

Family

ID=8219166

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960102079A AR002932A1 (es) 1995-04-06 1996-04-03 Solucion acuosa de interferon

Country Status (31)

Country Link
US (1) US5762923A (es)
EP (1) EP0736303B1 (es)
JP (1) JP2758154B2 (es)
KR (1) KR100212346B1 (es)
CN (1) CN1066065C (es)
AR (1) AR002932A1 (es)
AT (1) ATE183650T1 (es)
AU (1) AU685356B2 (es)
BR (1) BR9601276A (es)
CA (1) CA2172664C (es)
CO (1) CO4750807A1 (es)
CY (1) CY2194B1 (es)
CZ (1) CZ287626B6 (es)
DE (1) DE69603894T2 (es)
DK (1) DK0736303T3 (es)
ES (1) ES2136910T3 (es)
GR (1) GR3031775T3 (es)
HU (1) HU227643B1 (es)
IL (1) IL117752A (es)
MA (1) MA23838A1 (es)
MY (1) MY113594A (es)
NO (1) NO316801B1 (es)
NZ (1) NZ286300A (es)
PE (1) PE38897A1 (es)
PL (1) PL183873B1 (es)
RU (1) RU2113845C1 (es)
SA (1) SA96160728B1 (es)
SG (1) SG52806A1 (es)
TR (1) TR199600287A2 (es)
TW (1) TW426523B (es)
ZA (1) ZA962553B (es)

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US6402718B1 (en) 1992-08-17 2002-06-11 Medrad, Inc. Front-loading medical injector and syringe for use therewith
US5951974A (en) * 1993-11-10 1999-09-14 Enzon, Inc. Interferon polymer conjugates
TW517067B (en) 1996-05-31 2003-01-11 Hoffmann La Roche Interferon conjugates
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
NZ336548A (en) * 1996-12-24 2001-09-28 Biogen Inc Stable liquid interferon formulations comprising an amino acid as the stabilising agent
AU754002B2 (en) * 1998-03-26 2002-10-31 Merck Sharp & Dohme Corp. Formulations for protection of peg-interferon alpha conjugates
US6180096B1 (en) 1998-03-26 2001-01-30 Schering Corporation Formulations for protection of peg-interferon alpha conjugates
PT1069912E (pt) * 1998-04-03 2007-09-14 Novartis Vaccines & Diagnostic Formulações injectáveis de igf contendo succinato como agente tampão
CN1230198C (zh) 1998-05-15 2005-12-07 先灵公司 给首次接受抗病毒疗法的G慢性丙型肝炎感染患者施用包括利巴韦林和α干扰素的联合疗法
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CN1175901C (zh) * 1999-12-06 2004-11-17 天津华立达生物工程有限公司 一种稳定的干扰素水溶液
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DE60139339D1 (de) 2000-11-07 2009-09-03 Novartis Vaccines & Diagnostic Stabilisierte interferonzusammensetzungen
CN1245215C (zh) 2001-02-28 2006-03-15 四川省生物工程研究中心 重组高效复合干扰素用作乙型肝炎表面抗原和e抗原抑制剂
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PT2196475E (pt) * 2007-09-04 2012-09-07 Biosteed Gene Expression Tech Co Ltd Interferão alfa-2a modificado por polietilenoglicol, seu processo de síntese e aplicação
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BRPI0915093A2 (pt) 2008-06-13 2015-10-27 Proyecto Biomedicina Cima Sl conjugados para a administração de compostos biologicamente ativos
US20110195912A1 (en) * 2008-09-17 2011-08-11 Nektar Therapeutics Oligomer-Protease Inhibitor Conjugates
US9377454B2 (en) 2009-06-25 2016-06-28 Crealta Pharmaceuticals Llc Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
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RU2447083C1 (ru) * 2010-07-20 2012-04-10 Закрытое Акционерное Общество "Биокад" НОВЫЙ ФУНКЦИОНАЛЬНО АКТИВНЫЙ ВЫСОКООЧИЩЕННЫЙ СТАБИЛЬНЫЙ КОНЪЮГАТ ИНТЕРФЕРОНА α С ПОЛИЭТИЛЕНГЛИКОЛЕМ, ПРЕДСТАВЛЕННЫЙ ОДНИМ ПОЗИЦИОННЫМ ИЗОМЕРОМ ПЭГ-NαH-ИФН, С УМЕНЬШЕННОЙ ИММУНОГЕННОСТЬЮ, С ПРОЛОНГИРОВАННЫМ БИОЛОГИЧЕСКИМ ДЕЙСТВИЕМ, ПРИГОДНЫЙ ДЛЯ МЕДИЦИНСКОГО ПРИМЕНЕНИЯ, И ИММУНОБИОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ
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Also Published As

Publication number Publication date
PL313655A1 (en) 1996-10-14
KR960037063A (ko) 1996-11-19
CA2172664C (en) 2000-10-03
HUP9600857A2 (en) 1997-08-28
PE38897A1 (es) 1997-10-04
SG52806A1 (en) 1998-09-28
NO961322L (no) 1996-10-07
EP0736303A3 (en) 1997-02-26
US5762923A (en) 1998-06-09
NO316801B1 (no) 2004-05-18
MA23838A1 (fr) 1996-12-31
SA96160728B1 (ar) 2005-05-04
JP2758154B2 (ja) 1998-05-28
DE69603894D1 (de) 1999-09-30
EP0736303B1 (en) 1999-08-25
MY113594A (en) 2002-04-30
PL183873B1 (pl) 2002-07-31
RU2113845C1 (ru) 1998-06-27
CN1066065C (zh) 2001-05-23
NZ286300A (en) 1997-05-26
NO961322D0 (no) 1996-04-01
CY2194B1 (en) 2002-11-08
HUP9600857A3 (en) 1998-01-28
ZA962553B (en) 1996-10-07
KR100212346B1 (ko) 1999-08-02
ATE183650T1 (de) 1999-09-15
CZ287626B6 (en) 2001-01-17
GR3031775T3 (en) 2000-02-29
CO4750807A1 (es) 1999-03-31
HU9600857D0 (en) 1996-05-28
DK0736303T3 (da) 2000-01-10
TW426523B (en) 2001-03-21
IL117752A0 (en) 1996-08-04
CZ99496A3 (en) 1996-10-16
AU685356B2 (en) 1998-01-15
HK1012232A1 (en) 1999-07-30
CA2172664A1 (en) 1996-10-07
ES2136910T3 (es) 1999-12-01
TR199600287A2 (tr) 1997-03-21
DE69603894T2 (de) 2000-04-20
JPH08283176A (ja) 1996-10-29
HU227643B1 (en) 2011-10-28
IL117752A (en) 2000-11-21
CN1141808A (zh) 1997-02-05
AU5044696A (en) 1996-10-17
BR9601276A (pt) 1998-01-13
EP0736303A2 (en) 1996-10-09

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