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ES2116572T3 - PATCH FOR PERCUTANEOUS ADMINISTRATION OF SUBSTANCES WITH CHEMICALLY BASIC CONTENT, PHARMACEUTICALLY EFFECTIVE AND VOLATILE, AND A METHOD FOR ITS MANUFACTURE. - Google Patents

PATCH FOR PERCUTANEOUS ADMINISTRATION OF SUBSTANCES WITH CHEMICALLY BASIC CONTENT, PHARMACEUTICALLY EFFECTIVE AND VOLATILE, AND A METHOD FOR ITS MANUFACTURE.

Info

Publication number
ES2116572T3
ES2116572T3 ES94900072T ES94900072T ES2116572T3 ES 2116572 T3 ES2116572 T3 ES 2116572T3 ES 94900072 T ES94900072 T ES 94900072T ES 94900072 T ES94900072 T ES 94900072T ES 2116572 T3 ES2116572 T3 ES 2116572T3
Authority
ES
Spain
Prior art keywords
matrix
substances
volatile
content
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94900072T
Other languages
Spanish (es)
Inventor
Karin Wolter
Walter Muller
Gunter Simon
Christa Nalbach
Rainer Hoffmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Application granted granted Critical
Publication of ES2116572T3 publication Critical patent/ES2116572T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN EMPLASTO PARA ADMINISTRACION TRANSDERMAL DE SUSTANCIAS DE CONTENIDO BASICAMENTE QUIMICO, VOLATILES, CON ACTIVIDAD FARMACEUTICA, QUE CONTIENE UN SISTEMA DE MULTIPLES ELEMENTOS, ABARCANDO: (A) UNA MATRIZ, EN LA QUE ESTA DISTRIBUIDA COMO SUSTANCIA ACTIVA LA SUSTANCIA VOLATIL ANTES INDICADA O UNA DE SUS SALES ACEPTABLES FISIOLOGICAMENTE, DONDE LA MATRIZ CONTIENE UN PEGAMENTO DE ADHERENCIA, (B) UN ELEMENTO DE UNA COMPOSICION DE PEGAMENTO DE ADHERENCIA, QUE CONTIENE GRUPOS BASICOS -EN EL CASO DE QUE (A) CONTIENE UNA SAL-, QUE LIBERA LA BASE LIBRE A PARTIR DE SU SAL, (C) UNA CAPA DE REVERSO IMPERMEABLE PARA LAS SUSTANCIAS DE CONTENIDO DIFUNDIBLE DE (A) Y (B) Y (D) UNA SUSTANCIA DE CONTENIDO DIFUNDIBLE DE LA LAMINA DE ADHERENCIA IMPERMEABLE DE (A) Y (B), DONDE LA MATRIZ (A) O AL MENOS UNA PARTE DE (B), RESPECTIVAMENTE, EN EL CASO DE QUE LA MATRIZ O UNA PARTE DEL (B) TENGA CONTACTO CON LA LAMINA (D) DE RETIRADA, CON UNA CAPACIDAD DE ADHERENCIA (TACK) DE TAL MODO, QUE ESSUFICIENTE PARA LA FIJACION DEL EMPLASTO SOBRE LA PIEL. CADA PARTE APLICADA ENTRE LA MATRIZ (A) Y LA LAMINA (D) DE RETIRADA ES SUSTANCIA ACTIVA, CON PREFERENCIA DEPRENIL O UNA DE SUS SALES O AMBAS COSAS DE FORMA PERMEABLE. LA INVENCION SE REFIERE ADEMAS A UN PROCEDIMIENTO PARA LA ELABORACION DE UN EMPLASTO DE ESTE TIPO.THE INVENTION IS REFERRED TO A PLASTIC FOR TRANSDERMAL ADMINISTRATION OF SUBSTANCES OF BASIC CHEMICAL CONTENT, VOLATILE, WITH PHARMACEUTICAL ACTIVITY, CONTAINING A SYSTEM OF MULTIPLE ELEMENTS, INCLUDING: (A) A MATRIX, IS DISTRIBUTED AS A SUBSTANCE. ABOVE INDICATED OR ONE OF ITS PHYSIOLOGICALLY ACCEPTABLE SALTS, WHERE THE MATRIX CONTAINS AN ADHESION GLUE, (B) AN ELEMENT OF A COMPOSITION OF ADHESION GLUE, IN CASE THAT (A) CONTAINS A SALT-, WHICH RELEASES THE FREE BASE FROM ITS SALT, (C) A WATERPROOF REVERSE LAYER FOR THE DIFFUSABLE CONTENT SUBSTANCES OF (A) AND (B) AND (D) A DIFFERIBLE CONTENT SUBSTANCE OF THE WATERPROOF ADHESION SHEET OF ( A) AND (B), WHERE THE MATRIX (A) OR AT LEAST A PART OF (B), RESPECTIVELY, IN CASE THE MATRIX OR A PART OF (B) HAS CONTACT WITH THE WITHDRAWAL SHEET (D), WITH SUCH AN ADHERENCE CAPACITY (TACK), WHAT E ENOUGH TO FIX THE PLASTER ON THE SKIN. EACH PART APPLIED BETWEEN THE MATRIX (A) AND THE WITHDRAWAL SHEET (D) IS AN ACTIVE SUBSTANCE, WITH PREPRENILE PREFERENCE OR ONE OF ITS SALTS OR BOTH THINGS IN A PERMEABLE WAY. THE INVENTION FURTHER REFERS TO A PROCEDURE FOR THE PREPARATION OF A PLASTER OF THIS TYPE.

ES94900072T 1992-10-22 1993-10-20 PATCH FOR PERCUTANEOUS ADMINISTRATION OF SUBSTANCES WITH CHEMICALLY BASIC CONTENT, PHARMACEUTICALLY EFFECTIVE AND VOLATILE, AND A METHOD FOR ITS MANUFACTURE. Expired - Lifetime ES2116572T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92118036A EP0593807A1 (en) 1992-10-22 1992-10-22 Patch for transdermal administration of volatile pharmaceutically active ingredients of chemically basic nature and a process for preparation

Publications (1)

Publication Number Publication Date
ES2116572T3 true ES2116572T3 (en) 1998-07-16

Family

ID=8210159

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94900072T Expired - Lifetime ES2116572T3 (en) 1992-10-22 1993-10-20 PATCH FOR PERCUTANEOUS ADMINISTRATION OF SUBSTANCES WITH CHEMICALLY BASIC CONTENT, PHARMACEUTICALLY EFFECTIVE AND VOLATILE, AND A METHOD FOR ITS MANUFACTURE.

Country Status (24)

Country Link
EP (2) EP0593807A1 (en)
JP (1) JP3731016B2 (en)
KR (1) KR100261913B1 (en)
AT (1) ATE165001T1 (en)
AU (1) AU674902B2 (en)
CA (1) CA2146645C (en)
CZ (1) CZ290122B6 (en)
DE (1) DE59308413D1 (en)
DK (1) DK0665745T3 (en)
ES (1) ES2116572T3 (en)
FI (1) FI112325B (en)
HR (1) HRP931308A2 (en)
HU (1) HU221594B (en)
IL (1) IL107360A (en)
MY (1) MY109783A (en)
NO (1) NO311404B1 (en)
NZ (1) NZ257829A (en)
PH (1) PH30790A (en)
PL (1) PL173552B1 (en)
SI (1) SI9300559A (en)
SK (1) SK51595A3 (en)
WO (1) WO1994008571A2 (en)
YU (1) YU48350B (en)
ZA (1) ZA937807B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4433191A1 (en) * 1994-09-17 1996-03-21 Lohmann Therapie Syst Lts Self-adhesive plaster for delivering active substance to the environment of a wearer
US6033682A (en) 1995-01-13 2000-03-07 Somerset Pharmaceuticals, Inc. S(+) desmethylselegiline and its use in therapeutic methods and pharmaceutical compositions
US6348208B1 (en) 1995-01-13 2002-02-19 Somerset Pharmaceuticals, Inc. Methods and pharmaceutical compositions employing desmethylselegiline
US6299901B1 (en) 1995-01-13 2001-10-09 Somerset Pharmaceuticals, Inc. Methods and pharmaceutical compositions employing desmethylselegiline
US6319954B1 (en) 1995-01-13 2001-11-20 Somerset Pharmaceuticals, Inc. S-(+)-desmethylselegiline and its use in the therapeutic methods and pharmaceutical compositions
US6316022B1 (en) * 1995-06-07 2001-11-13 Noven Pharmaceuticals, Inc. Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures
CA2223588C (en) * 1995-06-07 2004-01-06 Noven Pharmaceuticals, Inc. Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures
WO1997006788A1 (en) * 1995-08-14 1997-02-27 Janssen Pharmaceutica N.V. Transdermal administration of vorozole
DE19533772C1 (en) * 1995-09-12 1998-01-02 Hexal Ag Tacrine / selegiline patch
US7150881B2 (en) 1997-06-26 2006-12-19 Mylan Technologies, Inc. Adhesive mixture for transdermal delivery of highly plasticizing drugs
DE19733981A1 (en) * 1997-08-06 1999-02-11 Lohmann Therapie Syst Lts Transdermal therapeutic system (TTS) for the delivery of active ingredient through the skin to an organism and method for application to the skin
WO1999022678A1 (en) * 1997-11-04 1999-05-14 Clear Sport Ltd. Improvements relating to adhesive devices such as strips, tapes, patches and the like, for application to the human body
DE69902520T2 (en) 1998-03-16 2003-04-10 Somerset Pharmaceuticals, Inc. USE OF SELEGILIN OR DESMETHYLSELEGILIN TO TREAT WOUNDS, BURNS AND SKIN DAMAGE
DE19814083C2 (en) 1998-03-30 2002-02-07 Lohmann Therapie Syst Lts Process for the production of transdermal therapeutic systems using basic alkali metal salts for converting active substance salts into the free bases
DE19814257A1 (en) 1998-03-31 1999-10-07 Asta Medica Ag effervescent formulations
DE19826592A1 (en) * 1998-06-15 1999-12-16 Lohmann Therapie Syst Lts Process for producing a laminate consisting of individual layers
DE19950066A1 (en) * 1999-10-16 2001-04-26 Lohmann Therapie Syst Lts Transdermal therapeutic system based on polyacrylate matrix carrier comprises tulobuterol hydrochloride
EP1441708B1 (en) 2001-11-05 2009-04-08 Krele Pharmaceuticals LLC Compositions and methods for increasing compliance with therapies using aldehyde dehydrogenase inhibitors and treating alcoholism
BRPI0814697B8 (en) * 2007-07-10 2021-05-25 Agile Therapeutics Inc drug delivery device
US20100087768A1 (en) 2008-10-02 2010-04-08 Forlano Paula Transdermal drug delivery system for liquid active ingredient
WO2011139420A2 (en) 2010-04-30 2011-11-10 Teikoku Pharma Usa, Inc. Propynylaminoindan transdermal compositions
KR101853082B1 (en) * 2011-03-24 2018-04-27 테이코쿠 팔마 유에스에이, 인코포레이티드 Transdermal compositions comprising an active agent layer and an active agent conversion layer
KR20150059177A (en) 2012-11-02 2015-05-29 테이코쿠 팔마 유에스에이, 인코포레이티드 Propynylaminoindan transdermal compositions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3797494A (en) * 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
GB8807504D0 (en) * 1988-03-29 1988-05-05 Sandoz Ltd Improvements in/relating to organic compounds

Also Published As

Publication number Publication date
PL173552B1 (en) 1998-03-31
WO1994008571A2 (en) 1994-04-28
IL107360A0 (en) 1994-01-25
CA2146645C (en) 2004-06-29
JP3731016B2 (en) 2006-01-05
ATE165001T1 (en) 1998-05-15
HU221594B (en) 2002-11-28
NO951523L (en) 1995-04-21
AU674902B2 (en) 1997-01-16
HRP931308A2 (en) 1994-12-31
KR950703939A (en) 1995-11-17
NZ257829A (en) 1996-11-26
CA2146645A1 (en) 1994-04-28
SI9300559A (en) 1994-06-30
DK0665745T3 (en) 1999-02-08
PL308292A1 (en) 1995-07-24
FI951887A7 (en) 1995-04-20
FI112325B (en) 2003-11-28
NO311404B1 (en) 2001-11-26
EP0665745B1 (en) 1998-04-15
MY109783A (en) 1997-06-30
HU9501125D0 (en) 1995-06-28
DE59308413D1 (en) 1998-05-20
CZ102295A3 (en) 1995-11-15
JPH08502279A (en) 1996-03-12
PH30790A (en) 1997-10-17
KR100261913B1 (en) 2000-08-01
IL107360A (en) 1998-06-15
EP0593807A1 (en) 1994-04-27
CZ290122B6 (en) 2002-06-12
YU67293A (en) 1996-02-19
AU5462794A (en) 1994-05-09
EP0665745A1 (en) 1995-08-09
HUT71684A (en) 1996-01-29
ZA937807B (en) 1994-05-16
FI951887A0 (en) 1995-04-20
NO951523D0 (en) 1995-04-21
YU48350B (en) 1998-07-10
WO1994008571A3 (en) 1994-05-26
SK51595A3 (en) 1997-03-05

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