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ES2114040T3 - Purificacion bioquimica de simvastatina. - Google Patents

Purificacion bioquimica de simvastatina.

Info

Publication number
ES2114040T3
ES2114040T3 ES93904928T ES93904928T ES2114040T3 ES 2114040 T3 ES2114040 T3 ES 2114040T3 ES 93904928 T ES93904928 T ES 93904928T ES 93904928 T ES93904928 T ES 93904928T ES 2114040 T3 ES2114040 T3 ES 2114040T3
Authority
ES
Spain
Prior art keywords
derived therefrom
atcc
acid
salt
lovastatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93904928T
Other languages
English (en)
Inventor
Michael J Conder
Gregory L Tewalt
Steven J Cianciosi
Eric T Pisk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25261964&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2114040(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2114040T3 publication Critical patent/ES2114040T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/46—Unsaturated compounds containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

EN LA SINTESIS DE SIMVASTATIN POR METILACION DIRECTA DE LOVASTATIN, HIDROLISIS SELECTIVA DE LOVASTATIN RESIDUAL, ACIDO O SAL DE LOVASTATINA MEDIANTE TRATAMIENTO CON UNA BACTERIA U HONGO CAPAZ DE HIDROLIZAR LA CADENA LATERAL DE 2-METIL-BUTIRILOXI O UN MUTANTE DE ESTE MICROBIO O UN EXTRACTO LIBRE DE CELULAS DERIVADO DE EL, O UNA HIDROLASA DERIVADA PRODUCE ACIDO 7-[1'',2'',6'',7'',8'',8A''(R)-HEXAHIDRO2''(S),6''(R)-DIMETIL-8''(S)-HIDROXI-1''(S)NAFTIL]-3(R),5(R)-DIHIDROXIHEPTANOICO, EL ACIDO TRIOL, O LA SAL TRIOL QUE SE PUEDE SEPARAR FACILMENTE DEL SIMVASTATIN, O ANTES O DESPUES DE LA LACTONIZACION A FORMA DE LACTONA. ESTE PROCESO PRODUCE SIMVASTATIN DE PUREZA Y RENDIMIENTO ALTOS.
ES93904928T 1992-02-07 1993-01-29 Purificacion bioquimica de simvastatina. Expired - Lifetime ES2114040T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/832,545 US5223415A (en) 1990-10-15 1992-02-07 Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid)

Publications (1)

Publication Number Publication Date
ES2114040T3 true ES2114040T3 (es) 1998-05-16

Family

ID=25261964

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93904928T Expired - Lifetime ES2114040T3 (es) 1992-02-07 1993-01-29 Purificacion bioquimica de simvastatina.

Country Status (15)

Country Link
US (1) US5223415A (es)
EP (1) EP0625208B1 (es)
JP (1) JP3278438B2 (es)
CN (1) CN1053219C (es)
AT (1) ATE164886T1 (es)
AU (1) AU3585393A (es)
CA (1) CA2129661C (es)
DE (1) DE69317880T2 (es)
DK (1) DK0625208T3 (es)
ES (1) ES2114040T3 (es)
LV (1) LV12241B (es)
MX (1) MX9300634A (es)
TW (1) TW387941B (es)
WO (1) WO1993016188A1 (es)
YU (1) YU48701B (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05236980A (ja) * 1991-12-17 1993-09-17 Sankyo Co Ltd トランス−４−ヒドロキシ−ｌ−プロリンの製造法
US5420024A (en) * 1993-05-11 1995-05-30 Merck & Co., Inc. Process for synthesis of acylated HMG-CoA reductase inhibitors from a lactone diol precursor using Candida cylindracea
US5763653A (en) * 1997-03-13 1998-06-09 Ranbaxy Laboratories, Ltd. Key intermediates in the manufacture of simvastatin
CA2185961A1 (en) * 1996-09-19 1998-03-20 K.S. Keshava Murthy Process for producing simvastatin
US5763646A (en) * 1997-03-13 1998-06-09 Ranbaxy Laboratories, Ltd. Process for manufacturing simvastatin from lovastatin or mevinolinic acid
SI9800057A (sl) 1998-02-26 1999-08-31 Krka, Tovarna Zdravil, D.D. Postopek za pripravo simvastatina in njegovih derivatov
CA2240983A1 (en) 1998-06-18 1999-12-18 Yong Tao Process to manufacture simvastatin and intermediates
SI20070A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Nove soli inhibitorjev HMG-CoA reduktaze
SI1154979T1 (en) * 1999-02-03 2005-10-31 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
CA2365869A1 (en) * 1999-03-08 2000-09-14 Richard D. Tillyer Crystalline hydrated dihydroxy open-acid simvastatin calcium salt
US6569461B1 (en) * 1999-03-08 2003-05-27 Merck & Co., Inc. Dihydroxy open-acid and salts of HMG-CoA reductase inhibitors
CA2388182A1 (en) 1999-10-27 2001-05-03 Merck & Co., Inc. Lactonization process
KR100342789B1 (ko) 1999-10-29 2002-07-04 김용규 니스타틴에 내성을 갖는 아스퍼질러스속 미생물 및 그를 이용한 트리올 헵타노익산의 제조방법
CA2389616A1 (en) * 1999-11-03 2001-05-10 Howard J. Smith & Associates Pty Ltd. Liver selective therapy
US6573385B1 (en) 1999-11-11 2003-06-03 Biocon India Limited Process for manufacturing simvastatin and novel intermediates thereof
AU2127500A (en) 1999-11-11 2001-06-06 Biocon India Limited Process for manufacturing simvastatin and the novel intermediates
GB0003305D0 (en) * 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
US6686481B2 (en) * 2000-07-27 2004-02-03 Plus Chemicals, B.V. Highly purified simvastatin compositions
WO2002020457A1 (en) * 2000-09-06 2002-03-14 Merck & Co., Inc. Dihydroxy open-acid salt of simvastatin
NL1017548C2 (nl) 2001-03-09 2002-09-10 Synthon Bv Een lactonisatie proces.
KR100435142B1 (ko) * 2002-01-09 2004-06-09 한미약품 주식회사 개선된 심바스타틴의 제조방법
KR100435078B1 (ko) * 2002-02-08 2004-06-09 종근당바이오 주식회사 심바스타틴의 정제방법
JP3884694B2 (ja) * 2002-02-08 2007-02-21 ユニケミカル株式会社 粘度変化検知用素子、それを用いた粘度変化検知用攪拌回転子、及びそれらを用いた攪拌装置
US6603022B1 (en) 2002-05-10 2003-08-05 Biocon India Limited Process for manufacturing Simvastatin and novel intermediates thereof
US7700329B2 (en) * 2003-10-21 2010-04-20 Brian Morgan Methods for making simvastatin and intermediates
US20050239885A1 (en) * 2004-04-22 2005-10-27 Glenmark Pharmaceuticals Limited Processes for the preparation of simvastatin
KR20070052760A (ko) * 2004-08-06 2007-05-22 트렌스폼 파마수티컬스 인코퍼레이티드 신규한 페노피브레이트 제제 및 관련된 치료방법
RU2382642C2 (ru) * 2004-08-06 2010-02-27 Трансформ Фармасьютикалз, Инк. Новые фармацевтические композиции статина и связанные с ними способы лечения
AU2005271413A1 (en) * 2004-08-06 2006-02-16 Transform Pharmaceuticals, Inc. Novel statin pharmaceutical compositions and related methods of treatment
US20090042979A1 (en) * 2004-08-06 2009-02-12 Transform Pharmaceuticals Inc. Novel Statin Pharmaceutical Compositions and Related Methods of Treatment
CN1754870A (zh) * 2004-09-30 2006-04-05 淮北市辉克药业有限公司 辛伐他汀的制备方法
JPWO2006126718A1 (ja) * 2005-05-27 2008-12-25 田辺三菱製薬株式会社 ピラゾロピリミジン誘導体
WO2007020079A2 (en) * 2005-08-17 2007-02-22 Synthon B.V. Orally disintegratable simvastatin tablets
US20110059493A1 (en) * 2007-08-27 2011-03-10 Brian Morgan Methods for Making Simvastatin and Intermediates
PL212182B1 (pl) * 2007-11-19 2012-08-31 Inst Chemii Organicznej Polska Akademia Nauk Sposób wykrywania i/lub oznaczania aktywności enzymatycznej esterazy lowastatyny z użyciem substratu fluoro/chromogennego, zestaw do wykrywania i/lub oznaczania aktywności esterazy lowastatyny oraz zastosowanie substratu fluoro/chromogennego do pozaustrojowego wykrywania i/lub oznaczania aktywności enzymatycznej
PL211815B1 (pl) 2007-11-19 2012-06-29 Inst Chemii Organicznej Polska Akademia Nauk Enzym esteraza lowastatyny osadzony na nośniku nierozpuszczalnym w wodzie, sposób osadzania enzymu, zastosowanie enzymu esterazy lowastatyny osadzonego na nosniku nierozpuszczalnym w wodzie, przepływowy reaktor biokatalityczny ze złożem oraz sposób wytwarzania i/lub oczyszczania symwastatyny
CN102690254B (zh) * 2008-05-09 2014-06-04 上海医药工业研究院 辛伐他汀铵盐中间体及其制备方法
CN101575287B (zh) * 2008-05-09 2013-04-03 上海医药工业研究院 一种辛伐他汀铵盐的合成方法及所用中间体及其制备方法
CN110604731B (zh) * 2019-08-29 2023-03-17 广东海洋大学深圳研究院 化合物Aspergillusidone G在制备神经保护药物中的应用
CN111057713A (zh) * 2019-12-18 2020-04-24 广东省微生物研究所（广东省微生物分析检测中心） 一种适用于埃德菌FS110的CRISPR/Cas9载体及其构建方法和应用
CN114031496B (zh) * 2021-11-30 2024-09-27 广东蓝宝制药有限公司 一种高纯度普伐他汀1,1,3,3-四甲基丁胺的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4293496A (en) * 1980-02-04 1981-10-06 Merck & Co., Inc. 6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
DK149080C (da) * 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
US4582915A (en) * 1983-10-11 1986-04-15 Merck & Co., Inc. Process for C-methylation of 2-methylbutyrates
DE3480923D1 (de) * 1983-10-11 1990-02-08 Merck & Co Inc Verfahren zur c-methylierung von 2-methylbutyraten.
JPS60176595A (ja) * 1984-02-21 1985-09-10 Akira Endo 生理活性物質ｍｌ−２３６ａ及びモナコリンｊの製造法
US4916239A (en) * 1988-07-19 1990-04-10 Merck & Co., Inc. Process for the lactonization of mevinic acids and analogs thereof
EP0381478A1 (en) * 1989-02-01 1990-08-08 Merck & Co. Inc. Process for the preparation of 6-alpha-hydroxymethyl lovastatin derivatives
US4965200A (en) * 1989-06-23 1990-10-23 Merck & Co., Inc. Process for the preparation of 3-keto, 5-hydroxy simvastatin analogs

Also Published As

Publication number Publication date
WO1993016188A1 (en) 1993-08-19
CN1083111A (zh) 1994-03-02
JP3278438B2 (ja) 2002-04-30
JPH07505768A (ja) 1995-06-29
LV12241A (en) 1999-03-20
DE69317880D1 (de) 1998-05-14
CA2129661C (en) 2001-07-31
CN1053219C (zh) 2000-06-07
LV12241B (en) 1999-08-20
US5223415A (en) 1993-06-29
CA2129661A1 (en) 1993-08-19
EP0625208B1 (en) 1998-04-08
YU7193A (sh) 1996-07-24
YU48701B (sh) 1999-07-28
AU3585393A (en) 1993-09-03
DK0625208T3 (da) 1998-05-11
MX9300634A (es) 1994-06-30
DE69317880T2 (de) 1998-12-24
TW387941B (en) 2000-04-21
EP0625208A1 (en) 1994-11-23
ATE164886T1 (de) 1998-04-15

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