ES2113886T3 - Agentes anticancerosos basados en 1,2-dihidro-3h-dibenzisoquinolein-1,3-dionas. - Google Patents
Agentes anticancerosos basados en 1,2-dihidro-3h-dibenzisoquinolein-1,3-dionas.Info
- Publication number
- ES2113886T3 ES2113886T3 ES91911663T ES91911663T ES2113886T3 ES 2113886 T3 ES2113886 T3 ES 2113886T3 ES 91911663 T ES91911663 T ES 91911663T ES 91911663 T ES91911663 T ES 91911663T ES 2113886 T3 ES2113886 T3 ES 2113886T3
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- taken together
- independently hydrogen
- aryl
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 2
- -1 methoxy, hydroxy Chemical group 0.000 abstract 2
- 239000000126 substance Chemical group 0.000 abstract 2
- BGFHMYJZJZLMHW-UHFFFAOYSA-N 4-[2-[[2-(1-benzothiophen-3-yl)-9-propan-2-ylpurin-6-yl]amino]ethyl]phenol Chemical compound N1=C(C=2C3=CC=CC=C3SC=2)N=C2N(C(C)C)C=NC2=C1NCCC1=CC=C(O)C=C1 BGFHMYJZJZLMHW-UHFFFAOYSA-N 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- GRHZLQBPAJAHDM-SPRQWYLLSA-N [(3as,4r,6ar)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] n-[(2s,4s,5s)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]carbamate Chemical compound CC1=CC=CC(C)=C1OCC(=O)N[C@H]([C@@H](O)C[C@H](CC=1C=CC=CC=1)NC(=O)O[C@@H]1[C@@H]2CCO[C@@H]2OC1)CC1=CC=CC=C1 GRHZLQBPAJAHDM-SPRQWYLLSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A UN COMPUESTO UTIL EN EL TRATAMIENTO DE TUMORES QUE TIENE LA FORMULA (I), EN DONDE R8, R6 Y R10 SON INDEPENDIENTEMENTE HIDROGENO, ALQUIL INFERIOR, ALCANOIL INFERIOR, FORMIL, HALOGENO, NITRO, NR2R3, OR1 O SR1, METOXIDO, HIDROXIDO, CIANO CO2H, SO2NR1R2, O CONR1R2; R1, R2 Y R3 SON INDEPENDIENTEMENTE HIDROGENO, ALQUIL INFERIOR, ALQUIL INFERIOR DE ARIL, ARIL, FORMIL O ALCANOIL INFERIOR; R9, R11, R10 Y R7 SON INDEPENDIENTEMENTE HIDROGENO, ALQUIL INFERIOR O R9 Y R11 TOMADAS JUNTO CON LOS ATOMOS DE CARBONO A LOS CUALES ESTAN UNIDAS FORMAN UN GRUPO FENIL O R9 O R10 TOMADAS JUNTO CON LOS ATOMOS DE CARBONO A LOS CUALES ESTAN UNIDAS FORMAN UN GRUPO FENIL, O R7 Y R10 TOMADAS JUNTO CON LOS ATOMOS DE CARBONO A LOS CUALES ESTAN UNIDAS FORMAN UN GRUPO FENIL; A ES (CR4R5)M3, CICLOALQUIL INFERIOR O ARIL O UN ENLACE QUIMICO; CADA R4 Y R5 SON INDEPENDIENTEMENTE HIDROGENO O ALQUIL INFERIOR; R12 Y R13 SON INDEPENDIENTEMENTE HIDROGENO O ALQUIL INFERIOR QUE ESTA INSUBSTITUIDO O SUBSTITUIDOCON HIDROXIDO, MERCAPTO, ALCOXIDO INFERIOR, ALQUILCARBONILOXIDO INFERIOR, CARBOXIDO, O CARBOALCOXIDO INFERIOR, O R12 Y R13 TOMADAS JUNTO CON EL NITROGENO AL CUAL ESTAN UNIDAS FORMAN UN ANILLO HETEROCICLICO DE ENTRE 3 Y 6 MIEMBROS; D ES UN ENLACE QUIMICO O TOMADA JUNTO CON NR12 FORMA UN ANILLO HETEROCICLICO DE 5 O 6 MIEMBROS; N1 Y N2 SON INDEPENDIENTEMENTE 0, 1 O 2; Y N3 ES 0, 1, 2, 3, 4 O 5.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54359690A | 1990-06-26 | 1990-06-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2113886T3 true ES2113886T3 (es) | 1998-05-16 |
Family
ID=24168698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91911663T Expired - Lifetime ES2113886T3 (es) | 1990-06-26 | 1991-06-19 | Agentes anticancerosos basados en 1,2-dihidro-3h-dibenzisoquinolein-1,3-dionas. |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0536208B1 (es) |
| JP (1) | JP2992769B2 (es) |
| AT (1) | ATE162526T1 (es) |
| AU (1) | AU643539B2 (es) |
| CA (1) | CA2085598C (es) |
| DE (1) | DE69128788T2 (es) |
| ES (1) | ES2113886T3 (es) |
| IE (1) | IE912200A1 (es) |
| WO (1) | WO1992000281A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5635506A (en) * | 1990-06-26 | 1997-06-03 | Research Corporation Technologies, Inc. | 1, 2-dihydro-3H-dibenzisoquinoline-1,3-dione anticancer agents |
| EP0660824A1 (en) * | 1992-09-11 | 1995-07-05 | Research Corporation Technologies | 1,2 DIHYDRO-3-H-DIBENZ(de,h) ISOQUINOLINE 1,3 DIONE AND THEIR USE AS ANTICANCER AGENTS |
| US5703089A (en) * | 1994-04-28 | 1997-12-30 | Knoll Aktiengesellschaft | Dihydrodibenzisoquinolinediones |
| CA2188833A1 (en) * | 1994-04-28 | 1995-11-09 | Miguel Fernandez Brana | Dihydrodibenzo(de,h)isoquinolines derivatives and their use as anti-cancer agents |
| WO1996038446A1 (en) * | 1995-05-31 | 1996-12-05 | Eisai Co., Ltd. | Fused polycyclic heterocycle derivatives |
| CN1067686C (zh) * | 1995-05-31 | 2001-06-27 | 卫材株式会社 | 稠合多环式杂环衍生物 |
| US6291425B1 (en) | 1999-09-01 | 2001-09-18 | Guilford Pharmaceuticals Inc. | Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage |
| WO2008033891A2 (en) * | 2006-09-12 | 2008-03-20 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Azonafide derived tumor and cancer targeting compounds |
| DE102007038422A1 (de) | 2007-08-14 | 2009-02-19 | Heinz Prof. Dr. Langhals | Aceanthren- und Anthracencarbonsäureimide |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1253252A (en) * | 1914-04-15 | 1918-01-15 | Basf Ag | Bluish-green vat dyes and process of making them. |
| US3940398A (en) * | 1975-01-23 | 1976-02-24 | E. R. Squibb & Sons, Inc. | 2-[[4-(Azine or diazine or triazine)-1-piperazinyl]alkyl]-1H-benz[de]isoquinoline-1,3(2H)-diones |
| ES459497A1 (es) * | 1977-06-04 | 1978-04-16 | Made Labor Sa | Un metodo para la preparacion industrial de naftalimidas y sus derivados. |
| US4665071A (en) * | 1984-02-21 | 1987-05-12 | Warner-Lambert Company | 3,6-disubstituted-1,8-naphthalimides and methods for their production and use |
-
1991
- 1991-06-19 DE DE69128788T patent/DE69128788T2/de not_active Expired - Fee Related
- 1991-06-19 AT AT91911663T patent/ATE162526T1/de not_active IP Right Cessation
- 1991-06-19 WO PCT/US1991/004364 patent/WO1992000281A1/en not_active Ceased
- 1991-06-19 CA CA002085598A patent/CA2085598C/en not_active Expired - Fee Related
- 1991-06-19 ES ES91911663T patent/ES2113886T3/es not_active Expired - Lifetime
- 1991-06-19 EP EP91911663A patent/EP0536208B1/en not_active Expired - Lifetime
- 1991-06-19 AU AU80501/91A patent/AU643539B2/en not_active Ceased
- 1991-06-19 JP JP3511780A patent/JP2992769B2/ja not_active Expired - Fee Related
- 1991-06-25 IE IE220091A patent/IE912200A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2085598C (en) | 2002-09-17 |
| AU643539B2 (en) | 1993-11-18 |
| JPH05508639A (ja) | 1993-12-02 |
| DE69128788T2 (de) | 1998-06-10 |
| JP2992769B2 (ja) | 1999-12-20 |
| EP0536208B1 (en) | 1998-01-21 |
| AU8050191A (en) | 1992-01-23 |
| IE912200A1 (en) | 1992-01-01 |
| EP0536208A4 (en) | 1993-05-05 |
| WO1992000281A1 (en) | 1992-01-09 |
| EP0536208A1 (en) | 1993-04-14 |
| DE69128788D1 (de) | 1998-02-26 |
| CA2085598A1 (en) | 1991-12-27 |
| ATE162526T1 (de) | 1998-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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