ES2110086T3 - Indoles sustituidos como antagonistas de la angiotensina ii. - Google Patents
Indoles sustituidos como antagonistas de la angiotensina ii.Info
- Publication number
- ES2110086T3 ES2110086T3 ES93906123T ES93906123T ES2110086T3 ES 2110086 T3 ES2110086 T3 ES 2110086T3 ES 93906123 T ES93906123 T ES 93906123T ES 93906123 T ES93906123 T ES 93906123T ES 2110086 T3 ES2110086 T3 ES 2110086T3
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- hydrogen
- angiotensin
- antagonists
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940123413 Angiotensin II antagonist Drugs 0.000 title 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 102000015427 Angiotensins Human genes 0.000 abstract 1
- 108010064733 Angiotensins Proteins 0.000 abstract 1
- -1 LOWER ALKYL Inorganic materials 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical compound [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LOS COMPUESTOS DE LA FORMULA (I), (II) O (III) EN DONDE: R1 ES ALKILO INFERIOR CUANDO R2 ES V; O R2 ES ALKILO INFERIOR CUANDO R1 ES V; EN DONDE: V ES (A); R3 ES HIDROGENO O ALKILO INFERIOR; X ES HIDROGENO, ALKILO INFERIOR, HALOGENO, C(O)CF3, -CO2R4 O -C(O)NR5R6; Y ES HIDROGENO, ALKILO INFERIOR, ALCOXI INFERIOR, HIDROXI, HALOGENO O -CO2R4; Z ES HIDROGENO, ALKILO INFERIOR, ALCOXI INFERIOR O HALOGENO; CON LA CONDICION DE QUE Y Y Z NO PUEDEN ESTAR ENLAZADOS AL ATOMO DE NITROGENO DE LA FORMULA (II); EN QUE R4 ES HIDROGENO O ALKILO INFERIOR; R5 ES HIDROGENO, ALKILO INFERIOR O CH2CO2R4; R6 ES HIDROGENO O ALKILO INFERIOR; O R5 Y R6 JUNTOS Y CON EL NITROGENO AL QUE ESTAN UNIDOS REPRESENTAN UN HETEROCICLO; R7 ES (B); (C); (D); (E); (F); (G); (H) O (J); EN QUE: R8 ES -CO2H O 1H-TETRAZOL-5-ILO; Y W ES OXIGENO, AZUFRE O -NR-, EN DONDE R ES HIDROGENO O ALKILO INFERIOR; Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, PRESENTAN PROPIEDADES FARMACOLOGICAS UTILES Y SON PARTICULARMENTE UTILES COMO ANTAGONISTAS DE LA ANGIOTENSINA (II).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/882,390 US5212195A (en) | 1992-05-13 | 1992-05-13 | Substituted indole antagonists derivatives which are angiotensin II |
| US08/004,869 US5380739A (en) | 1992-05-13 | 1993-02-04 | Substituted indole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2110086T3 true ES2110086T3 (es) | 1998-02-01 |
Family
ID=26673598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93906123T Expired - Lifetime ES2110086T3 (es) | 1992-05-13 | 1993-02-26 | Indoles sustituidos como antagonistas de la angiotensina ii. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0640080B1 (es) |
| JP (1) | JP3332234B2 (es) |
| CN (1) | CN1039714C (es) |
| AT (1) | ATE159524T1 (es) |
| AU (1) | AU672599B2 (es) |
| CA (1) | CA2135605A1 (es) |
| DE (1) | DE69314786T2 (es) |
| DK (1) | DK0640080T3 (es) |
| ES (1) | ES2110086T3 (es) |
| FI (1) | FI110512B (es) |
| GR (1) | GR3025118T3 (es) |
| HU (2) | HU221616B1 (es) |
| IL (1) | IL104869A (es) |
| MX (1) | MX9301088A (es) |
| NO (1) | NO308535B1 (es) |
| NZ (2) | NZ249729A (es) |
| WO (1) | WO1993023391A1 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6569539B2 (en) | 1996-10-30 | 2003-05-27 | Tetra Level Holdings & Finance S.A. | Gas barrier packaging laminate method for production thereof and packaging containers |
| US6828344B1 (en) | 1998-02-25 | 2004-12-07 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| IL137718A0 (en) * | 1998-02-25 | 2001-10-31 | Genetics Inst | Inhibitors of phospholipase enzymes |
| US6916841B2 (en) | 1998-02-25 | 2005-07-12 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| WO2001043746A1 (en) * | 1999-12-14 | 2001-06-21 | Nippon Shinyaku Co., Ltd. | Medicinal composition |
| JP4118682B2 (ja) * | 2000-12-14 | 2008-07-16 | アルキミカ、ゲゼルシャフト、ミット、ベシュレンクテル、ハフツング | ホルミルフェニルボロン酸の製造法 |
| EP1431278A4 (en) * | 2001-09-28 | 2006-01-25 | Ihara Chemical Ind Co | METHOD FOR PRODUCING (2-NITROPHENYL) ACETONITRILE DERIVATIVES AND ASSOCIATED INTERMEDIATES |
| US7101875B2 (en) | 2001-12-03 | 2006-09-05 | Wyeth | Methods for treating arthritic disorders |
| US6984735B2 (en) | 2001-12-03 | 2006-01-10 | Wyeth | Process for making an aldehyde |
| US7605156B2 (en) | 2001-12-03 | 2009-10-20 | Wyeth | Methods for the use of inhibitors of cytosolic phospholipase A2 |
| US6635771B2 (en) | 2001-12-03 | 2003-10-21 | Wyeth | N-benzhydryl indole compounds |
| US7713964B2 (en) | 2001-12-03 | 2010-05-11 | Wyeth Llc | Methods for treating asthmatic conditions |
| US6797708B2 (en) | 2001-12-03 | 2004-09-28 | Wyeth | Inhibitors of cytosolic phospholipase A2 |
| US7129264B2 (en) * | 2003-04-16 | 2006-10-31 | Bristol-Myers Squibb Company | Biarylmethyl indolines and indoles as antithromboembolic agents |
| TW200718687A (en) | 2005-05-27 | 2007-05-16 | Wyeth Corp | Inhibitors of cytosolic phospholipase A2 |
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| MX2010007661A (es) * | 2008-01-31 | 2010-08-03 | Sanofi Aventis | Azaindol-3-carboxamidas ciclicas, su preparacion y su uso como productos farmaceuticos. |
| EP2247575B1 (en) * | 2008-01-31 | 2016-03-23 | Sanofi | Cyclic indole-3-carboxamides, their preparation and their use as pharmaceuticals |
| CN101940568B (zh) * | 2010-08-17 | 2012-11-14 | 合肥博太医药生物技术发展有限公司 | 吲哚-3-甲醇、二吲哚甲烷及其衍生物在制备治疗蒽环抗癌药引起的心脏衰竭药物中的应用 |
| CN107056781A (zh) * | 2017-05-18 | 2017-08-18 | 康化（上海）新药研发有限公司 | 一种(E)‑5‑甲基‑1H‑吡咯并[2,3‑b]吡啶‑3‑甲醛肟的合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2016710A1 (en) * | 1989-05-15 | 1990-11-15 | Prasun K. Chakravarty | Substituted benzimidazoles as angiotensin ii antagonists |
| IL94390A (en) * | 1989-05-30 | 1996-03-31 | Merck & Co Inc | The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them |
| US5124335A (en) * | 1991-01-30 | 1992-06-23 | Merck & Co., Inc. | Substituted pyrollo-fused 6 membered heterocycles as angiotensin ii antagonists |
-
1993
- 1993-02-26 NZ NZ249729A patent/NZ249729A/en unknown
- 1993-02-26 JP JP52017993A patent/JP3332234B2/ja not_active Expired - Fee Related
- 1993-02-26 NZ NZ299146A patent/NZ299146A/en unknown
- 1993-02-26 CA CA002135605A patent/CA2135605A1/en not_active Abandoned
- 1993-02-26 WO PCT/US1993/001533 patent/WO1993023391A1/en not_active Ceased
- 1993-02-26 DK DK93906123.0T patent/DK0640080T3/da active
- 1993-02-26 IL IL104869A patent/IL104869A/xx not_active IP Right Cessation
- 1993-02-26 HU HU9403238A patent/HU221616B1/hu not_active IP Right Cessation
- 1993-02-26 ES ES93906123T patent/ES2110086T3/es not_active Expired - Lifetime
- 1993-02-26 CN CN93102401A patent/CN1039714C/zh not_active Expired - Fee Related
- 1993-02-26 EP EP93906123A patent/EP0640080B1/en not_active Expired - Lifetime
- 1993-02-26 AT AT93906123T patent/ATE159524T1/de not_active IP Right Cessation
- 1993-02-26 AU AU37274/93A patent/AU672599B2/en not_active Ceased
- 1993-02-26 DE DE69314786T patent/DE69314786T2/de not_active Expired - Fee Related
- 1993-02-26 MX MX9301088A patent/MX9301088A/es not_active IP Right Cessation
-
1994
- 1994-11-11 NO NO944311A patent/NO308535B1/no not_active IP Right Cessation
- 1994-11-11 FI FI945319A patent/FI110512B/fi active
-
1995
- 1995-02-17 HU HU95P/P00076P patent/HU210709A9/hu unknown
-
1997
- 1997-10-23 GR GR970401901T patent/GR3025118T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI945319A0 (fi) | 1994-11-11 |
| JP3332234B2 (ja) | 2002-10-07 |
| HUT68056A (en) | 1995-05-29 |
| NZ299146A (en) | 2000-06-23 |
| AU672599B2 (en) | 1996-10-10 |
| FI945319A7 (fi) | 1994-11-11 |
| IL104869A (en) | 1997-11-20 |
| JPH07506826A (ja) | 1995-07-27 |
| NZ249729A (en) | 1996-12-20 |
| DK0640080T3 (da) | 1998-05-25 |
| AU3727493A (en) | 1993-12-13 |
| DE69314786T2 (de) | 1998-02-19 |
| IL104869A0 (en) | 1993-06-10 |
| CA2135605A1 (en) | 1993-11-25 |
| FI110512B (fi) | 2003-02-14 |
| EP0640080B1 (en) | 1997-10-22 |
| CN1078469A (zh) | 1993-11-17 |
| WO1993023391A1 (en) | 1993-11-25 |
| EP0640080A1 (en) | 1995-03-01 |
| NO308535B1 (no) | 2000-09-25 |
| GR3025118T3 (en) | 1998-01-30 |
| NO944311L (no) | 1994-11-14 |
| DE69314786D1 (de) | 1997-11-27 |
| HU210709A9 (en) | 1995-06-28 |
| NO944311D0 (no) | 1994-11-11 |
| CN1039714C (zh) | 1998-09-09 |
| HU221616B1 (hu) | 2002-12-28 |
| ATE159524T1 (de) | 1997-11-15 |
| MX9301088A (es) | 1993-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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