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ES2108005T3 - 3-aminopirroles, procedimiento para su preparacion y su utilizacion como anti-convulsivos. - Google Patents

3-aminopirroles, procedimiento para su preparacion y su utilizacion como anti-convulsivos.

Info

Publication number
ES2108005T3
ES2108005T3 ES90121958T ES90121958T ES2108005T3 ES 2108005 T3 ES2108005 T3 ES 2108005T3 ES 90121958 T ES90121958 T ES 90121958T ES 90121958 T ES90121958 T ES 90121958T ES 2108005 T3 ES2108005 T3 ES 2108005T3
Authority
ES
Spain
Prior art keywords
aril
elevated
hetereoaril
elevado
aralquilo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90121958T
Other languages
English (en)
Inventor
Jurgen Dr Sc Liebscher
Alexander Dr Knoll
Alexej Dr Uschmajew
Andreas Dipl-Chem Rolfs
Dieter Dr Sc Lohmann
Gottfried Dr Faust
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva GmbH
Original Assignee
Arzneimittelwerk Dresden GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arzneimittelwerk Dresden GmbH filed Critical Arzneimittelwerk Dresden GmbH
Application granted granted Critical
Publication of ES2108005T3 publication Critical patent/ES2108005T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION TRATA DE 3-AMINOPIRROLES DE LA FORMULA I, CON EL SIGNIFICADO SIGUIENTE: R ELEVADO 1 H, ALCOHILO, CICLOALCOHILO, ARALQUILO, ARIL, HETEREOARIL, ACILO, ALCOXICARBONILO, AMINOCARBONILO O AMINOTIOCARBONILO, R (AL CUADRADO) H, ACILO, OXICARBONILO, ALCOXICARBONILO, ARILOXICARBONILO, AMINOCARBONILO, AMINOTIOCARBONILO, ARIL, HETERIOARIL, CIANO O NITRO. R ELEVADO 3 H, ARIL, CICLOARIL, ARALQUILO, ARIL O HETEREOARIL, R ELEVADO 4 ALQUILO, CICLOALQUILO, ARALQUILO, ARIL O HETEREOARIL O R ELEVADO 3 Y R ELEVADO 4 SIGNIFICAN JUNTOS ALCOHILOS, QUE TAMBIEN PUEDEN TENER AL IGUAL QUE CICLOS ATOMICOS OXIGENO, AZUFRE O NITROGENO, R ELEVADO 5 ARIL O HETEREOARIL Y R ELEVADO 6 H, ALQUILO, ARILO O HALOGENOS O R ELEVADO 5 Y R ELEVADO 6 JUNTAMENTE ALQUILOS. ADEMAS SE PUEDEN ELABORAR PARA SU EMPLEO COMO MEDICAMENTOS, ESPECIALMENTE CON UNA EFICACIA ANTICONVULSIVA O ANALGETICA. LA SINTESIS SE REALIZA DE FORMA VENTAJOSA POR MEDIO DE LA CICLIZACION DE CONTINUOS EN UNA CADENA ABIERTA O POR UNA MODIFICACION CORRESPONDIENTE A LOS PIRROLES
ES90121958T 1989-11-17 1990-11-16 3-aminopirroles, procedimiento para su preparacion y su utilizacion como anti-convulsivos. Expired - Lifetime ES2108005T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DD89334670A DD298912A5 (de) 1989-11-17 1989-11-17 Verfahren zur herstellung von 3-aminopyrrolen

Publications (1)

Publication Number Publication Date
ES2108005T3 true ES2108005T3 (es) 1997-12-16

Family

ID=5613902

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90121958T Expired - Lifetime ES2108005T3 (es) 1989-11-17 1990-11-16 3-aminopirroles, procedimiento para su preparacion y su utilizacion como anti-convulsivos.

Country Status (10)

Country Link
US (2) US5502051A (es)
EP (1) EP0431371B1 (es)
JP (1) JPH07113015B2 (es)
DD (1) DD298912A5 (es)
DE (1) DE59010759D1 (es)
ES (1) ES2108005T3 (es)
FI (1) FI102169B1 (es)
HU (1) HUT56343A (es)
RU (2) RU2060991C1 (es)
YU (1) YU48469B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4227479A1 (de) * 1992-08-20 1994-02-24 Dresden Arzneimittel Verfahren zur Herstellung von 1-unsubstituierten 3-Aminopyrrolen
US5837719A (en) * 1995-08-10 1998-11-17 Merck & Co., Inc. 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use
US5792778A (en) * 1995-08-10 1998-08-11 Merck & Co., Inc. 2-substituted aryl pyrroles, compositions containing such compounds and methods of use
WO1997016441A1 (en) * 1995-10-31 1997-05-09 Merck & Co., Inc. Substituted aryl pyrroles, compositions containing such compounds and methods of use
US5908858A (en) 1996-04-05 1999-06-01 Sankyo Company, Limited 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses
DE19629976A1 (de) * 1996-07-25 1998-01-29 Dresden Arzneimittel Verwendung von 4-(p-Halogenphenyl)-3-morpholinopyrrol-2-carbonsäuremethylester zur Prophylaxe und Behandlung der Folgen der akuten und chronischen zerebralen Minderdurchblutung sowie neurodegenerativer Erkrankungen
US5776954A (en) * 1996-10-30 1998-07-07 Merck & Co., Inc. Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
US7122666B2 (en) * 1999-07-21 2006-10-17 Sankyo Company, Limited Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
RU2175844C1 (ru) * 2001-01-24 2001-11-20 Северо-Кавказский научно-исследовательский институт сахарной свеклы и сахара Способ получения пищевого волокна из свекловичного жома
CA2446957A1 (en) * 2001-05-15 2002-11-21 Warner-Lambert Company Llc Compaction process for manufacture of sodium phenytoin dosage form
EP2170062A4 (en) 2007-07-12 2010-12-29 Tragara Pharmaceuticals Inc METHOD AND COMPOSITIONS FOR THE TREATMENT OF CANCER DISORDERS, TUMORS AND TUMOR-DISORDED DISEASES
US9944597B2 (en) 2013-09-16 2018-04-17 The Board Of Regents Of The University Of Texas System Polysubstituted pyrroles having microtubule-disrupting, cytotoxic and antitumor activities and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198502A (en) * 1973-08-22 1980-04-15 Gruppo Lepetit S.P.A. Aminopyrrole derivatives
US4632935A (en) * 1984-05-30 1986-12-30 The Upjohn Company Omega-(hydroxy-, ether and ester)-alkyl-2-amino-cycloalkyl- and cycloalkenyl amides as analgesics
US4748183A (en) * 1986-06-13 1988-05-31 Warner-Lambert Company N-1H-tetrazol-5-yl-2-thiophene carboxamides, N-1H-tetrazol-5-yl-2-pyrrole carboxamides, N-1H-tetrazol-5-yl-2-furan carboxamides, and anti-allergic and anti-inflammatory use thereof

Also Published As

Publication number Publication date
RU2060991C1 (ru) 1996-05-27
RU2120796C1 (ru) 1998-10-27
YU217390A (sh) 1993-05-28
US5502051A (en) 1996-03-26
HU907176D0 (en) 1991-05-28
EP0431371B1 (de) 1997-09-10
FI905689A0 (fi) 1990-11-16
JPH03271271A (ja) 1991-12-03
US5684160A (en) 1997-11-04
FI102169B (fi) 1998-10-30
EP0431371A1 (de) 1991-06-12
JPH07113015B2 (ja) 1995-12-06
FI102169B1 (fi) 1998-10-30
YU48469B (sh) 1998-08-14
HUT56343A (en) 1991-08-28
FI905689L (fi) 1991-05-18
DD298912A5 (de) 1992-03-19
DE59010759D1 (de) 1997-10-16

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