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ES2105924A1 - Derivados de indol. - Google Patents

Derivados de indol.

Info

Publication number
ES2105924A1
ES2105924A1 ES09300771A ES9300771A ES2105924A1 ES 2105924 A1 ES2105924 A1 ES 2105924A1 ES 09300771 A ES09300771 A ES 09300771A ES 9300771 A ES9300771 A ES 9300771A ES 2105924 A1 ES2105924 A1 ES 2105924A1
Authority
ES
Spain
Prior art keywords
group
indole
carboxylic acid
amino
acid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09300771A
Other languages
English (en)
Other versions
ES2105924B1 (es
Inventor
Alfredo Cugola
Giovanni Gavirachi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline SpA
Original Assignee
Glaxo SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo SpA filed Critical Glaxo SpA
Publication of ES2105924A1 publication Critical patent/ES2105924A1/es
Application granted granted Critical
Publication of ES2105924B1 publication Critical patent/ES2105924B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

DERIVADOS DE INDOL. LA INVENCION SE REFIERE AL COMPUESTO DE FORMULA (I), EN DONDE A REPRESENTA UN GRUPO ETENILO NO SUSTITUIDO EN LA CONFIGURACION TRANS (E) O UNA SAL ACEPTABLE FISIOLOGICAMENTE O UN ESTER METABOLICAMENTE LABIL DEL MISMO, LOS CUALES, SON ANTAGONISTAS DE AMINO ACIDOS EXCITATORIOS, A PROCEDIMIENTOS PARA SU PREPARACION Y SU EMPLEO EN MEDICINA.
ES09300771A 1992-04-16 1993-04-15 Derivados de indol. Expired - Lifetime ES2105924B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929208492A GB9208492D0 (en) 1992-04-16 1992-04-16 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
ES2105924A1 true ES2105924A1 (es) 1997-10-16
ES2105924B1 ES2105924B1 (es) 1998-07-01

Family

ID=10714220

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09300771A Expired - Lifetime ES2105924B1 (es) 1992-04-16 1993-04-15 Derivados de indol.

Country Status (41)

Country Link
US (4) US5374648A (es)
EP (1) EP0568136A1 (es)
JP (2) JPH07505407A (es)
KR (1) KR100264114B1 (es)
CN (1) CN1042331C (es)
AP (1) AP480A (es)
AT (1) AT403917B (es)
AU (1) AU666927B2 (es)
BE (1) BE1006343A5 (es)
BG (1) BG62136B1 (es)
BR (1) BR1100323A (es)
CA (3) CA2094075A1 (es)
CH (1) CH685630A5 (es)
CY (1) CY2038B1 (es)
CZ (1) CZ285799B6 (es)
DK (1) DK169890B1 (es)
ES (1) ES2105924B1 (es)
FI (1) FI106198B (es)
FR (1) FR2690919B1 (es)
GB (2) GB9208492D0 (es)
GE (1) GEP19991704B (es)
GR (1) GR1001619B (es)
HK (1) HK95797A (es)
HU (2) HU217964B (es)
IL (1) IL105412A (es)
IS (1) IS3994A (es)
IT (1) IT1265325B1 (es)
LU (1) LU88248A1 (es)
MX (1) MX9302195A (es)
MY (1) MY112232A (es)
NO (1) NO301879B1 (es)
NZ (1) NZ247413A (es)
OA (1) OA10103A (es)
PL (1) PL176451B1 (es)
RO (1) RO113242B1 (es)
RU (1) RU2129544C1 (es)
SE (1) SE504336C2 (es)
SK (1) SK281941B6 (es)
TW (1) TW224457B (es)
WO (1) WO1993021153A1 (es)
ZA (1) ZA932642B (es)

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GB9304500D0 (en) * 1993-03-05 1993-04-21 Glaxo Spa Heterocyclic compounds
HU216633B (hu) * 1993-05-27 1999-07-28 Merrel Pharmaceuticals Inc. NMDA-antagonista hatású 3-(indol-3-il)-propénsav-származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
US5519048A (en) * 1993-05-27 1996-05-21 Merrell Pharmaceuticals Inc. 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof
GB9319243D0 (en) * 1993-09-17 1993-11-03 Glaxo Spa Heterocyclic compounds
GB9321221D0 (en) * 1993-10-14 1993-12-01 Glaxo Spa Heterocyclic compounds
TW280819B (es) * 1993-11-17 1996-07-11 Sumitomo Pharma
US5563157B1 (en) * 1994-10-31 1999-02-02 Hoecst Marion Roussel Inc Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof
GB9502695D0 (en) * 1995-02-11 1995-03-29 Glaxo Spa Pharmaceutical composition
GB9504361D0 (en) * 1995-03-04 1995-04-26 Glaxo Spa Heterocyclic compounds
US6030968A (en) * 1996-09-17 2000-02-29 The Regents Of The University Of California Positive AMPA receptor modulation to enhance brain neurotrophic factor expression
KR20000048715A (ko) * 1996-09-30 2000-07-25 게리 디. 스트리트, 스티븐 엘. 네스비트 Ｎｍｄａ (ｎ-메틸-ｄ-아스파르테이트) 길항제
US5922752A (en) * 1997-06-11 1999-07-13 Hoechst Marion Roussell, Inc. NMDA (n-methyl-d-aspartate) antagonists
ES2219000T3 (es) * 1998-03-26 2004-11-16 Fujisawa Pharmaceutical Co., Ltd. Preparacion de liberacion sostenida de un compuesto macrolido.
MXPA03000861A (es) * 2000-07-31 2004-04-05 Dainippon Pharmaceutical Co Remedios para la demencia que contienen derivados de 2-abril-8-oxodihidropurina como ingrediente activo.
WO2003039540A2 (en) * 2001-11-09 2003-05-15 Sepracor Inc. D-amino acid oxidase inhibitors for learning and memory
CA2468544A1 (en) * 2001-12-10 2003-06-19 Amgen Inc. Vanilloid receptor ligands
PA8579701A1 (es) * 2002-08-23 2005-05-24 Pfizer Prod Inc Profarmaco inhibidor de beta-lactamasa
DE10306202A1 (de) * 2003-02-13 2004-08-26 Grünenthal GmbH Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen
WO2004108733A1 (en) * 2003-06-05 2004-12-16 Pfizer Products Inc. Beta-lactamase inhibitor prodrug
RU2247563C1 (ru) * 2003-06-16 2005-03-10 Пятигорская государственная фармацевтическая академия Способ получения твердой лекарственной формы, содержащей глюкозамина гидрохлорид
US7671072B2 (en) * 2003-11-26 2010-03-02 Pfizer Inc. Aminopyrazole derivatives as GSK-3 inhibitors
AU2004312530A1 (en) * 2003-12-29 2005-07-21 Sepracor Inc. Pyrrole and pyrazole DAAO inhibitors
RU2281755C2 (ru) * 2004-04-19 2006-08-20 Пятигорская государственная фармацевтическая академия Композиция - лекарственная форма противоартрозного средства глюкозамина гидрохлорида для ректального применения
US20060002999A1 (en) * 2004-06-17 2006-01-05 Forest Laboratories, Inc. Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
WO2007006003A2 (en) 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
KR101294014B1 (ko) * 2006-01-06 2013-08-09 선오비온 파마슈티컬스 인코포레이티드 모노아민 재흡수 저해제로서의 시클로알킬아민
ES2566479T3 (es) 2006-01-06 2016-04-13 Sunovion Pharmaceuticals Inc. Inhibidores de reabsorción de monoamina con base en tetralona
EP2816024B8 (en) 2006-03-31 2018-04-04 Sunovion Pharmaceuticals Inc. Chiral amines
US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
EP1942104A1 (en) 2006-12-20 2008-07-09 sanofi-aventis Heteroarylcyclopropanecarboxamides and their use as pharmaceuticals
ZA200904686B (en) 2007-01-18 2010-09-29 Sepracor Inc Inhibitiors of D-amino acid oxidase
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
CN101686672A (zh) 2007-05-31 2010-03-31 塞普拉柯公司 苯基取代的环烷胺作为一元胺再摄取抑制剂
US20090247644A1 (en) * 2008-03-28 2009-10-01 Forest Laboratories Holdings Limited Memantine formulations
WO2010017418A1 (en) * 2008-08-07 2010-02-11 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
EA201101307A1 (ru) 2009-03-10 2012-03-30 Сантен Фармасьютикал Ко., Лтд. Профилактические или терапевтические средства для расстройств зрительного нерва, содержащие производные 4,6-дихлор-1н-индол-2-карбоновой кислоты или их соли в качестве активных ингредиентов
US20110034434A1 (en) * 2009-08-07 2011-02-10 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US9737531B2 (en) 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
CA2946153C (en) 2014-04-30 2022-06-14 Yufeng Jane Tseng Use of known compounds as d-amino acid oxidase inhibitors
US11370775B2 (en) 2016-09-14 2022-06-28 Yufeng Jane Tseng Substituted benzimidazole derivatives as D-amino acid oxidase (DAAO) inhibitors
KR102609676B1 (ko) 2017-06-12 2023-12-05 글리테크 엘엘씨. Nmda 길항제 및 d2/5ht2a 또는 선택적 5ht2a 길항제를 이용한 우울증의 치료
CN112707874A (zh) * 2020-12-29 2021-04-27 广东中科药物研究有限公司 一种抗病毒化合物及其制备方法

Citations (4)

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US4960786A (en) * 1989-04-24 1990-10-02 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
EP0396124A2 (en) * 1989-05-05 1990-11-07 G.D. Searle & Co. Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders
WO1992001670A1 (en) * 1990-07-16 1992-02-06 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
WO1992016205A2 (en) * 1991-03-18 1992-10-01 Warner-Lambert Company Novel derivatives of 2-carboxyndoles having pharmaceutical activity

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US3010971A (en) * 1960-08-04 1961-11-28 Smith Kline French Lab Cyclopropylamine derivatives and processes for their preparation
DK500285A (da) * 1984-11-02 1986-05-03 Glaxo Group Ltd Cephalosporinantibiotika
US5145845A (en) * 1991-05-14 1992-09-08 Warner-Lambert Co. Substituted 2-carboxylindoles having pharmaceutical activity

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US4960786A (en) * 1989-04-24 1990-10-02 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
EP0396124A2 (en) * 1989-05-05 1990-11-07 G.D. Searle & Co. Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders
WO1992001670A1 (en) * 1990-07-16 1992-02-06 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
WO1992016205A2 (en) * 1991-03-18 1992-10-01 Warner-Lambert Company Novel derivatives of 2-carboxyndoles having pharmaceutical activity

Also Published As

Publication number Publication date
DK43193A (da) 1993-10-17
GB9307808D0 (en) 1993-06-02
US5374648A (en) 1994-12-20
FI944800L (fi) 1994-10-12
WO1993021153A1 (en) 1993-10-28
HU217964B (hu) 2000-05-28
AU3692393A (en) 1993-10-21
FI106198B (fi) 2000-12-15
SK124194A3 (en) 1995-05-10
CA2094076A1 (en) 1993-10-17
CH685630A5 (fr) 1995-08-31
BG62136B1 (bg) 1999-03-31
GR1001619B (el) 1994-07-29
PL176451B1 (pl) 1999-05-31
NO943913L (no) 1994-12-14
CZ285799B6 (cs) 1999-11-17
JPH07505407A (ja) 1995-06-15
CZ254394A3 (en) 1995-07-12
RO113242B1 (ro) 1998-05-29
CN1085212A (zh) 1994-04-13
OA10103A (en) 1996-12-18
ZA932642B (en) 1994-01-10
HUT70526A (en) 1995-10-30
SE9301241L (sv) 1993-10-17
FI944800A0 (fi) 1994-10-12
RU2129544C1 (ru) 1999-04-27
MY112232A (en) 2001-05-31
CN1042331C (zh) 1999-03-03
AP480A (en) 1996-03-22
CA2094073A1 (en) 1993-10-17
SE9301241D0 (sv) 1993-04-15
NO301879B1 (no) 1997-12-22
JPH0649027A (ja) 1994-02-22
TW224457B (es) 1994-06-01
GB9208492D0 (en) 1992-06-03
NO943913D0 (no) 1994-10-14
FR2690919B1 (fr) 1995-05-05
DK169890B1 (da) 1995-03-27
SE504336C2 (sv) 1997-01-13
US5373018A (en) 1994-12-13
AT403917B (de) 1998-06-25
AP9300524A0 (en) 1993-04-30
ES2105924B1 (es) 1998-07-01
CA2094075A1 (en) 1993-10-17
HU9402975D0 (en) 1995-02-28
ATA75293A (de) 1997-11-15
NZ247413A (en) 1995-12-21
HK95797A (en) 1997-08-08
RU94045915A (ru) 1996-09-10
IL105412A (en) 1998-02-22
SK281941B6 (sk) 2001-09-11
EP0568136A1 (en) 1993-11-03
BE1006343A5 (fr) 1994-07-26
IT1265325B1 (it) 1996-10-31
KR100264114B1 (ko) 2000-11-01
GB2266091B (en) 1995-08-09
IL105412A0 (en) 1993-08-18
BG99111A (bg) 1995-05-31
US5510367A (en) 1996-04-23
LU88248A1 (fr) 1994-03-01
GEP19991704B (en) 1999-08-05
FR2690919A1 (fr) 1993-11-12
DK43193D0 (da) 1993-04-15
CY2038B1 (en) 1998-04-30
MX9302195A (es) 1994-03-31
US5374649A (en) 1994-12-20
ITRM930236A1 (it) 1994-10-15
BR1100323A (pt) 2000-06-27
ITRM930236A0 (it) 1993-04-15
GB2266091A (en) 1993-10-20
AU666927B2 (en) 1996-02-29
IS3994A (is) 1993-10-17
HU211826A9 (en) 1995-12-28

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