[go: up one dir, main page]

ES2104566T3 - Reactivos para la determinacion de drogas. - Google Patents

Reactivos para la determinacion de drogas.

Info

Publication number
ES2104566T3
ES2104566T3 ES90104055T ES90104055T ES2104566T3 ES 2104566 T3 ES2104566 T3 ES 2104566T3 ES 90104055 T ES90104055 T ES 90104055T ES 90104055 T ES90104055 T ES 90104055T ES 2104566 T3 ES2104566 T3 ES 2104566T3
Authority
ES
Spain
Prior art keywords
reagents
drugs
determination
drug
immuno
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90104055T
Other languages
English (en)
Inventor
Salvatore Joseph Salamone
Stephen Vitone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2104566T3 publication Critical patent/ES2104566T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y10S436/816—Alkaloids, amphetamines, and barbiturates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/807—Hapten conjugated with peptide or protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y10S530/816—Attached to the carrier via a bridging agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pyrrole Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBEN NUEVOS REACTIVOS PARA LA DETECCION POR INMUNOENSAYO DE DROGAS EN FLUIDOS CORPORALES, SU PREPARACION Y USO. LOS REACTIVOS SEGUN EL PRESENTE INVENTO CORRESPONDEN A LA FORMULA P ( A MENTE SELECTIVO PARA LA DETERMINACION DE LA PRESENCIA DE LA DROGA OBJETIVO O METABOLITO DE DROGA. A ES UN GRUPO ENLAZADOR-ESPACIADOR ACTIVADOR QUE TIENE UNA MITAD DE ENLACE DE N-HIDROXISUCCINIMIDA O ISOCIANATO DERIVADA. P ES UN POLI(AMINO ACIDO) O POLIMERO CAPAZ DE ENLACE COVALENTE CON A, Y N ES MENOR DE L.
ES90104055T 1989-03-10 1990-03-02 Reactivos para la determinacion de drogas. Expired - Lifetime ES2104566T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32194689A 1989-03-10 1989-03-10

Publications (1)

Publication Number Publication Date
ES2104566T3 true ES2104566T3 (es) 1997-10-16

Family

ID=23252745

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90104055T Expired - Lifetime ES2104566T3 (es) 1989-03-10 1990-03-02 Reactivos para la determinacion de drogas.

Country Status (12)

Country Link
US (1) US5618926A (es)
EP (1) EP0386644B1 (es)
JP (1) JP3009170B2 (es)
AT (1) ATE154135T1 (es)
AU (1) AU624686B2 (es)
CA (1) CA2011722C (es)
DE (1) DE69030829T2 (es)
DK (1) DK0386644T3 (es)
ES (1) ES2104566T3 (es)
NO (1) NO178007C (es)
NZ (1) NZ232854A (es)
ZA (1) ZA901808B (es)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5155212A (en) * 1986-05-21 1992-10-13 Abbott Laboratories Phencyclidine and phencyclidine metabolites assay, tracers, immunogens, antibodies and reagent kit
US5612034A (en) * 1990-10-03 1997-03-18 Redcell, Inc. Super-globuling for in vivo extended lifetimes
EP0555336B1 (en) * 1990-10-22 1996-07-24 Abbott Laboratories Homobifunctional agents for coupling enzymes and the like to antibodies and the like
EP0517327B1 (en) * 1991-06-07 2001-08-16 Johnson & Johnson Clinical Diagnostics, Inc. Immunoassay with labeled hapten analogues
US5284948A (en) * 1991-06-07 1994-02-08 Eastman Kodak Company Drug hapten analogues for immunoassays
US5304479A (en) * 1991-12-06 1994-04-19 Diagnostic Reagents, Inc. Phencyclidine compounds and assays for its determination
US5302715A (en) * 1992-04-06 1994-04-12 Biosite Diagnostics, Inc. Benzodiazepine derivatives
CA2096495C (en) * 1992-06-16 2002-07-09 Kathy Palmer Ordonez Dual analyte immunoassay
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
CA2167362A1 (en) * 1995-02-10 1996-08-11 Alexei Dmitri Klimov Apparatus and method for conducting a binding assay on an absorbent carrier material
DK0814843T3 (da) * 1995-03-31 2004-03-29 Xenova Res Ltd Haptenbærerkonjugater til anvendelse i behandling af stofmisbrug
US5840307A (en) * 1995-03-31 1998-11-24 Immulogic Pharmacuetical Corp. Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation
DE19630102A1 (de) * 1996-07-25 1998-01-29 Boehringer Mannheim Gmbh Neue aktivierte Amphetamine
WO1998059234A1 (en) * 1997-06-24 1998-12-30 The University Of Wyoming Method and apparatus for detection of a controlled substance
US6770488B1 (en) 1999-03-19 2004-08-03 The University Of Wyoming Practical method and apparatus for analyte detection with colloidal particles
US6262265B1 (en) * 1999-06-18 2001-07-17 Microgenics Corporation Non-hydrolyzable analogs of heroin metabolites suitable for use in immunoassay
US6664061B2 (en) 1999-06-25 2003-12-16 Amersham Biosciences Ab Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix
US6811998B2 (en) 1999-06-25 2004-11-02 Roche Diagnostics Operations, Inc. Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase
US6921638B2 (en) 1999-06-25 2005-07-26 Amersham Biosciences Ab Hydrogel-based microarray signal amplification methods and devices therefor
US6372813B1 (en) 1999-06-25 2002-04-16 Motorola Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays
GB2361473C (en) * 2000-03-08 2005-06-28 Microgenics Corp Ecstasy-class analogs and use of same in detection of ecstasy-class compounds
US6534325B1 (en) 2000-06-30 2003-03-18 Roche Diagnostics Corporation Immunoassay for the detection of amphetamines, methamphetamines and methylenedioxy designer amphetamines
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
AU2002241602A1 (en) * 2000-11-16 2002-06-11 Burstein Technologies, Inc. Methods and apparatus for detecting and quantifying lymphocytes with optical biodiscs
US6472228B2 (en) 2000-12-04 2002-10-29 Lifepoint, Inc. Composition and methods for synthesis of novel tracers for detecting amphetamine and methamphetamine in samples
US6368814B1 (en) * 2000-12-22 2002-04-09 Roche Diagnostics Corporation Tricyclic antidepressant derivatives and immunoassay
US7141416B2 (en) * 2001-07-12 2006-11-28 Burstein Technologies, Inc. Multi-purpose optical analysis optical bio-disc for conducting assays and various reporting agents for use therewith
US20060014697A1 (en) * 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
US7169752B2 (en) * 2003-09-30 2007-01-30 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
WO2003021222A2 (en) * 2001-08-31 2003-03-13 Burstein Technologies, Inc. Capture layer assemblies for cellular assays including related optical analysis discs and methods
CN1659439A (zh) * 2001-09-07 2005-08-24 伯斯坦技术公司 利用光学生物盘系统基于细胞核形态学的白血细胞类型的识别和定量
AU2002360284B2 (en) 2001-10-18 2006-11-02 Nektar Therapeutics Polymer conjugates of opioid antagonists
AU2002352735A1 (en) * 2001-11-20 2003-06-10 Burstein Technologies, Inc. Optical bio-discs and microfluidic devices for analysis of cells
US20050003459A1 (en) * 2002-01-30 2005-01-06 Krutzik Siegfried Richard Multi-purpose optical analysis disc for conducting assays and related methods for attaching capture agents
US6858672B2 (en) * 2002-06-20 2005-02-22 Basell Poliolefine Italia S.P.A. Safe process for making polymers containing N-phenylimide groups
JP4644192B2 (ja) 2003-07-01 2011-03-02 エフ．ホフマン−ラ ロシュ アーゲー 電気化学的アフィニティーバイオセンサーシステム及び方法
US7060847B2 (en) * 2003-07-18 2006-06-13 Roche Diagnostics Operations, Inc. Ecstasy-class derivatives, immunogens, and antibodies and their use in detecting ecstasy-class drugs
US20060182692A1 (en) 2003-12-16 2006-08-17 Fishburn C S Chemically modified small molecules
NZ594834A (en) * 2003-12-16 2013-03-28 Nektar Therapeutics Method of preparing PEGylated protein molecules
US7220842B2 (en) * 2004-04-05 2007-05-22 Dade Behring Inc. Immunoassays for buprenorphine and norbuprenorphine
US20060024748A1 (en) * 2004-07-29 2006-02-02 Saladax Biomedical Inc. Cytoxan antibodies and immunoassay
US7238791B1 (en) * 2005-12-16 2007-07-03 Roche Diagnostics Operations, Inc. 6-monoacetylmorphine derivatives useful in immunoassay
WO2009015291A1 (en) * 2007-07-26 2009-01-29 Agamatrix, Inc. Electrochemical analyte detection apparatus and method
US8133743B2 (en) * 2007-10-19 2012-03-13 Roche Diagnostics Operations, Inc. Phenobarbital derivatives useful in immunoassay
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
CA3155334A1 (en) 2010-10-22 2012-04-26 T2 Biosystems, Inc. NMR SYSTEMS AND METHODS FOR RAPID ANALYTE DETECTION
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
CN102621296A (zh) * 2012-01-06 2012-08-01 天津医科大学 一种带有间隔臂的羧化聚苯乙烯微球上偶联蛋白质的方法
WO2013158281A1 (en) 2012-04-20 2013-10-24 T2 Biosystems, Inc. Compositions and methods for detection of candida species
AU2017210033B2 (en) 2016-01-21 2022-09-29 T2 Biosystems, Inc. NMR methods and systems for the rapid detection of bacteria

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3917582A (en) * 1973-06-13 1975-11-04 Syva Corp Isothiocyanate and thiourea derivatives of benzoyl ecgonine conjugated to polypeptides
US3888864A (en) * 1973-06-29 1975-06-10 Hoffmann La Roche Amino lower alkyl ether derivatives of opium alkaloids
US4101549A (en) * 1976-05-26 1978-07-18 Hoffmann-La Roche Inc. Aminophenyl esters of 5-carboxyalkyl barbituric acids
US4340736A (en) * 1976-05-26 1982-07-20 Hoffmann-La Roche Inc. Diagnostic test for barbiturates
IL49685A (en) * 1976-05-31 1978-10-31 Technion Res & Dev Foundation Specific binding assay method for determining the concentration of materials and reagent means therefor
US4196185A (en) * 1978-06-05 1980-04-01 Hoffmann-La Roche Inc. Immunoassay for phencyclidine
US4223013A (en) * 1978-12-29 1980-09-16 Syva Company Amitriptyline conjugates to antigenic proteins and enzymes
US4275160A (en) * 1979-07-06 1981-06-23 Syva Company Imipramine derivatives and poly(amino acid) conjugates
US4351760A (en) * 1979-09-07 1982-09-28 Syva Company Novel alkyl substituted fluorescent compounds and polyamino acid conjugates
US4318846A (en) * 1979-09-07 1982-03-09 Syva Company Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers
US4262089A (en) * 1980-04-07 1981-04-14 Syva Company Theophylline antigens and antibodies
DE3066975D1 (en) * 1980-08-04 1984-04-19 Syva Co Propranolol antigen conjugates and antibodies and method of using them
US4366241A (en) * 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4401765A (en) * 1981-09-01 1983-08-30 E. I. Du Pont De Nemours And Company Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays
US4424150A (en) * 1982-04-02 1984-01-03 Syva Company Acetaminophen analogs, antigens, and antibodies
DE3382795T2 (de) * 1982-05-18 1996-02-15 University Of Florida, Gainesville, Fla. Gehirnspezifische arzneimittelabgabe.
US4629691A (en) * 1983-08-01 1986-12-16 Syntex (U.S.A.) Inc. Tricyclic antidepressant conjugates with antigens and enzymes
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
EP0199042A1 (en) * 1985-03-26 1986-10-29 Abbott Laboratories Procainamide assay, tracers, immunogens and antibodies
US4680338A (en) * 1985-10-17 1987-07-14 Immunomedics, Inc. Bifunctional linker
EP0279308B1 (en) * 1987-02-17 1996-08-28 Abbott Laboratories Fluorescence polarization immunoassay for tetrahydrocannabinoids
US4791067A (en) * 1987-06-25 1988-12-13 Fisher Scientific Co. Agglutination immunoassay for hapten involving monoclonal antibody of IgA class reagent

Also Published As

Publication number Publication date
NO178007B (no) 1995-09-25
AU624686B2 (en) 1992-06-18
JPH03200763A (ja) 1991-09-02
DE69030829T2 (de) 1998-01-15
ATE154135T1 (de) 1997-06-15
EP0386644A2 (en) 1990-09-12
NZ232854A (en) 1993-03-26
DK0386644T3 (da) 1997-10-13
EP0386644A3 (en) 1992-10-07
NO178007C (no) 1996-01-03
CA2011722A1 (en) 1990-09-10
ZA901808B (en) 1990-12-28
NO901122D0 (no) 1990-03-09
CA2011722C (en) 2001-06-19
NO901122L (no) 1990-09-11
AU5123190A (en) 1990-11-22
US5618926A (en) 1997-04-08
DE69030829D1 (de) 1997-07-10
EP0386644B1 (en) 1997-06-04
JP3009170B2 (ja) 2000-02-14

Similar Documents

Publication Publication Date Title
ES2104566T3 (es) Reactivos para la determinacion de drogas.
ES2075883T3 (es) Proteinas antigeno de nucleo de hepadnavirus quimericas.
ES2133137T3 (es) Sistema de catalizador de carbonilacion.
GB8507779D0 (en) Drug carrier
BR8805697A (pt) Marcador para uso em um sistema de inspecao de artigos,metodo de fabricacao do mesmo,metodo e sistema para detectar a presenca de um artigo em uma zona de interrogacao e metodo de desativacao de um marcador de inspecao de artigos
BR9810231A (pt) Processo para produção de dispersões sólidas de paroxetina
BR8906988A (pt) Tetrapiptidio,peptidio,composicao farmaceutica,processo para uso de peptidio e reagente para diagnostico
AR030707A1 (es) 9-ALFA-CLORO-6-ALFA-FLUOR-17-ALFA-HIDROXI-16-METIL-17-BETA-METOXICARBONIL-ANDROST-1,4-DIENOS, UN PROCESO PARA SU PREPARACIoN , COMPOSICION FARMACEUTICA, Y EL USO DEL MISMO PARA LA FABRICACION DE MEDICAMENTO
ES2062994T3 (es) Procedimiento para la determinacion de anticuerpos.
ES2026534T3 (es) Dispositivo para liberacion de drogas, su preparacion y uso.
ES2065935T3 (es) Anticuerpos monoclonales de raton para hiv-i p24 y su uso en ensayos de diagnostico.
ES2138584T3 (es) Sistema de suministro de farmacos que implica la reaccion entre una proteina o un polipeptido y un polimero biodegradable hidrofobo.
AR036984A1 (es) Un polimero inmunomodulador aislado, una composicion farmaceutica, un polisacarido inmunomodulador aislado, uso de polimeros inmunomoduladores para la manufactura de medicamentos para la modulacion especifica de procesos de inmunidad, un sistema para seleccionar y designar un polimero inmunomodulado
DE69020862D1 (de) Anlage zur Verabreichung steriler Flüssigkeiten, insbesondere pharmazeutischer, nahrhafter oder energetischer Flüssigkeiten.
SV1999000049A (es) Nuevas dihidropirimidinas 2 heterociclicamente sustituidas ref. lea 32793-sv
ES2045216T3 (es) Inmunoensayo y derivados polimeros de igg para la compensacion de factores de perturbacion en el inmunoensayo.
BR9808769A (pt) Construção de gene, uso de uma construção de gene, sistema de dois componentes emparelhados, designado para o uso em um hospedeiro mamìfero, e, processo para transferência de um medicamento citotóxico para um sìtio
UY26370A1 (es) "imidazo-5-il-aminas bicíclicas, medicamentos que las contienen, su uso para la preparación de medicamentos y procedimiento para su preparación".
ES2000660A6 (es) Un procedimiento quimioluminiscente para uso en un procedimiento de deteccion de analitos
ES2148512T3 (es) Complejos de inclusion multicomponentes de alta solubilidad que constan de una sustancia farmaceutica acidica, una ciclodextrina y una base.
AR029509A1 (es) Una composicion farmaceutica en base a un compuesto de platino (iv) y el uso de dicho compuesto para preparar medicamentos antitumorales
AR030662A1 (es) Beta-tio-alfa-aminoacidos, procedimiento para su fabricacion, medicamentos que contienen estos compuestos y el uso de los tioaminoacidos para la preparacion de medicamentos
ES2078733T3 (es) Metodo para la deteccion de anticuerpos anti-arn.
BR0107604A (pt) Pró-catalisador sólido, sistema catalisador, e, processo para a polimerização de pelo menos uma ou mais olefinas
SE8601563D0 (sv) Matrismaterial, forfarande for framstellning derav och anvendning derav

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 386644

Country of ref document: ES